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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-9 6711 denotes Melatonin
T2 0-9 D008550 denotes Melatonin
T3 0-9 D008550 denotes Melatonin
T4 0-9 CHEBI:16796 denotes Melatonin
T5 32-38 UBERON:0027368 denotes matrix
T7 32-58 P14780 denotes matrix metalloproteinase-9
T8 32-58 P41246 denotes matrix metalloproteinase-9
T9 32-58 P41245 denotes matrix metalloproteinase-9
T10 32-58 P50282 denotes matrix metalloproteinase-9
T11 32-58 PR:000010491 denotes matrix metalloproteinase-9
T12 32-58 P52176 denotes matrix metalloproteinase-9
T13 32-58 O18733 denotes matrix metalloproteinase-9
T6 32-58 D020780 denotes matrix metalloproteinase-9
T14 60-63 CHEBI:340824 denotes MMP
T17 60-63 CHEBI:59761 denotes MMP
T18 60-65 PR:P50282 denotes MMP-9
T19 60-65 PR:P14780 denotes MMP-9
T20 60-65 P14780 denotes MMP-9
T21 60-65 PR:P41245 denotes MMP-9
T22 60-65 P41246 denotes MMP-9
T23 60-65 P41245 denotes MMP-9
T24 60-65 PR:P52176 denotes MMP-9
T25 60-65 P50282 denotes MMP-9
T27 60-65 PR:000010491 denotes MMP-9
T28 60-65 P52176 denotes MMP-9
T29 60-65 O18733 denotes MMP-9
T26 60-65 GO:0004229 denotes MMP-9
T30 101-112 P33574 denotes plasminogen
T31 101-112 P20918 denotes plasminogen
T32 101-112 P06867 denotes plasminogen
T34 101-112 P83169 denotes plasminogen
T35 101-112 Q01177 denotes plasminogen
T36 101-112 PR:000012867 denotes plasminogen
T37 101-112 Q5R8X6 denotes plasminogen
T38 101-112 P81286 denotes plasminogen
T39 101-112 P06868 denotes plasminogen
T40 101-112 Q7M323 denotes plasminogen
T41 101-112 P12545 denotes plasminogen
T43 101-112 P80010 denotes plasminogen
T44 101-112 O18783 denotes plasminogen
T45 101-112 P80009 denotes plasminogen
T46 101-112 Q29485 denotes plasminogen
T47 101-112 P00747 denotes plasminogen
T33 101-112 CHEBI:8259 denotes plasminogen
T42 101-112 D010958 denotes plasminogen
T48 113-120 CHEBI:8258 denotes plasmin
T49 113-120 D005341 denotes plasmin
T52 143-146 PR:O04529 denotes MMP
T50 143-146 CHEBI:340824 denotes MMP
T53 143-146 CHEBI:59761 denotes MMP
T51 143-146 GO:0004235 denotes MMP
T54 147-156 CHEBI:35222 denotes inhibitor
T55 160-164 PR:000005054 denotes mice
T57 160-164 O89094 denotes mice
T56 160-164 D051379 denotes mice
T58 160-164 10095 denotes mice
T59 194-211 D002545 denotes cerebral ischemia
T60 194-211 D002545 denotes cerebral ischemia
T63 232-241 6711 denotes melatonin
T64 232-241 D008550 denotes melatonin
T65 232-241 D008550 denotes melatonin
T66 232-241 CHEBI:16796 denotes melatonin
T67 253-259 UBERON:0027368 denotes matrix
T69 253-279 P14780 denotes matrix metalloproteinase-9
T70 253-279 P41246 denotes matrix metalloproteinase-9
T71 253-279 P41245 denotes matrix metalloproteinase-9
T72 253-279 P50282 denotes matrix metalloproteinase-9
T73 253-279 PR:000010491 denotes matrix metalloproteinase-9
T74 253-279 P52176 denotes matrix metalloproteinase-9
T75 253-279 O18733 denotes matrix metalloproteinase-9
T68 253-279 D020780 denotes matrix metalloproteinase-9
T76 281-284 CHEBI:340824 denotes MMP
T79 281-284 CHEBI:59761 denotes MMP
T80 281-286 PR:P50282 denotes MMP-9
T81 281-286 PR:P14780 denotes MMP-9
T82 281-286 P14780 denotes MMP-9
T83 281-286 PR:P41245 denotes MMP-9
T84 281-286 P41246 denotes MMP-9
T85 281-286 P41245 denotes MMP-9
T86 281-286 PR:P52176 denotes MMP-9
T87 281-286 P50282 denotes MMP-9
T89 281-286 PR:000010491 denotes MMP-9
T90 281-286 P52176 denotes MMP-9
T91 281-286 O18733 denotes MMP-9
T88 281-286 GO:0004229 denotes MMP-9
T92 362-379 D002545 denotes cerebral ischemia
T93 362-379 D002545 denotes cerebral ischemia
T96 448-459 P33574 denotes plasminogen
T97 448-459 P20918 denotes plasminogen
T98 448-459 P06867 denotes plasminogen
T100 448-459 P83169 denotes plasminogen
T101 448-459 Q01177 denotes plasminogen
T102 448-459 PR:000012867 denotes plasminogen
T103 448-459 Q5R8X6 denotes plasminogen
T104 448-459 P81286 denotes plasminogen
T105 448-459 P06868 denotes plasminogen
T106 448-459 Q7M323 denotes plasminogen
T107 448-459 P12545 denotes plasminogen
T109 448-459 P80010 denotes plasminogen
T110 448-459 O18783 denotes plasminogen
T111 448-459 P80009 denotes plasminogen
T112 448-459 Q29485 denotes plasminogen
T113 448-459 P00747 denotes plasminogen
T99 448-459 CHEBI:8259 denotes plasminogen
T108 448-459 D010958 denotes plasminogen
T114 460-467 CHEBI:8258 denotes plasmin
T115 460-467 D005341 denotes plasmin
T116 490-494 D020782 denotes MMPs
T117 495-504 CHEBI:35222 denotes inhibitor
T118 520-529 6711 denotes melatonin
T119 520-529 D008550 denotes melatonin
T120 520-529 D008550 denotes melatonin
T121 520-529 CHEBI:16796 denotes melatonin
T122 539-542 CHEBI:340824 denotes MMP
T125 539-542 CHEBI:59761 denotes MMP
T126 539-544 PR:P50282 denotes MMP-9
T127 539-544 PR:P14780 denotes MMP-9
T128 539-544 P14780 denotes MMP-9
T129 539-544 PR:P41245 denotes MMP-9
T130 539-544 P41246 denotes MMP-9
T131 539-544 P41245 denotes MMP-9
T132 539-544 PR:P52176 denotes MMP-9
T133 539-544 P50282 denotes MMP-9
T135 539-544 PR:000010491 denotes MMP-9
T136 539-544 P52176 denotes MMP-9
T137 539-544 O18733 denotes MMP-9
T134 539-544 GO:0004229 denotes MMP-9
T138 557-561 PR:000005054 denotes Mice
T140 557-561 O89094 denotes Mice
T139 557-561 D051379 denotes Mice
T141 557-561 10095 denotes Mice
T143 585-593 D007511 denotes ischemia
T144 585-593 D007511 denotes ischemia
T145 629-651 UBERON:0001627 denotes middle cerebral artery
T146 636-651 D002539 denotes cerebral artery
T148 636-651 D002539 denotes cerebral artery
T151 653-662 D008550 denotes Melatonin
T152 653-662 D008550 denotes Melatonin
T153 653-662 CHEBI:16796 denotes Melatonin
T154 653-668 332183 denotes Melatonin (5 mg
T155 729-745 D020520 denotes Brain infarction
T156 729-745 D020520 denotes Brain infarction
T160 792-812 GO:0031012 denotes Extracellular matrix
T161 806-812 UBERON:0027368 denotes matrix
T162 870-877 D007797 denotes laminin
T166 878-885 PR:000000001 denotes protein
T164 878-885 CHEBI:36080 denotes protein
T165 878-885 CHEBI:11122 denotes protein
T167 878-885 SO:0000104 denotes protein
T163 878-885 GO:0003675 denotes protein
T168 918-921 CHEBI:340824 denotes MMP
T171 918-921 CHEBI:59761 denotes MMP
T172 918-923 PR:P08253 denotes MMP-2
T173 918-923 Q9GLE5 denotes MMP-2
T174 918-923 P08253 denotes MMP-2
T175 918-923 Q90611 denotes MMP-2
T177 918-923 PR:Q8MPP3 denotes MMP-2
T178 918-923 P33436 denotes MMP-2
T179 918-923 PR:Q90611 denotes MMP-2
T180 918-923 PR:P33436 denotes MMP-2
T181 918-923 PR:000010479 denotes MMP-2
T182 918-923 PR:P33434 denotes MMP-2
T183 918-923 P33434 denotes MMP-2
T184 918-923 P50757 denotes MMP-2
T176 918-923 GO:0004228 denotes MMP-2
T185 928-931 CHEBI:340824 denotes MMP
T188 928-931 CHEBI:59761 denotes MMP
T189 928-933 PR:P50282 denotes MMP-9
T190 928-933 PR:P14780 denotes MMP-9
T191 928-933 P14780 denotes MMP-9
T192 928-933 PR:P41245 denotes MMP-9
T193 928-933 P41246 denotes MMP-9
T194 928-933 P41245 denotes MMP-9
T195 928-933 PR:P52176 denotes MMP-9
T196 928-933 P50282 denotes MMP-9
T198 928-933 PR:000010491 denotes MMP-9
T199 928-933 P52176 denotes MMP-9
T200 928-933 O18733 denotes MMP-9
T197 928-933 GO:0004229 denotes MMP-9
T201 953-960 4716 denotes gelatin
T202 953-960 D005780 denotes gelatin
T203 953-960 CHEBI:5291 denotes gelatin
T204 1057-1063 UBERON:0000479 denotes tissue
T205 1068-1077 D014568 denotes urokinase
T206 1078-1089 P33574 denotes plasminogen
T207 1078-1089 P20918 denotes plasminogen
T208 1078-1089 P06867 denotes plasminogen
T210 1078-1089 P83169 denotes plasminogen
T211 1078-1089 Q01177 denotes plasminogen
T212 1078-1089 PR:000012867 denotes plasminogen
T213 1078-1089 Q5R8X6 denotes plasminogen
T214 1078-1089 P81286 denotes plasminogen
T215 1078-1089 P06868 denotes plasminogen
T216 1078-1089 Q7M323 denotes plasminogen
T217 1078-1089 P12545 denotes plasminogen
T219 1078-1089 P80010 denotes plasminogen
T220 1078-1089 O18783 denotes plasminogen
T221 1078-1089 P80009 denotes plasminogen
T222 1078-1089 Q29485 denotes plasminogen
T223 1078-1089 P00747 denotes plasminogen
T224 1078-1100 D010960 denotes plasminogen activators
T228 1102-1105 Q28198 denotes tPA
T230 1102-1105 Q5R8J0 denotes tPA
T231 1102-1105 P19637 denotes tPA
T232 1102-1105 P00750 denotes tPA
T233 1102-1105 Q8SQ23 denotes tPA
T235 1102-1105 PR:000012825 denotes tPA
T236 1102-1105 P11214 denotes tPA
T225 1102-1105 CHEBI:53394 denotes tPA
T226 1102-1105 CHEBI:15702 denotes tPA
T227 1102-1105 CHEBI:61432 denotes tPA
T229 1102-1105 CHEBI:37537 denotes tPA
T234 1102-1105 GO:0031299 denotes tPA
T237 1110-1113 P06869 denotes uPA
T238 1110-1113 P29598 denotes uPA
T239 1110-1113 Q5RF29 denotes uPA
T240 1110-1113 PR:000013171 denotes uPA
T241 1110-1113 P04185 denotes uPA
T242 1110-1113 PR:000012826 denotes uPA
T243 1110-1113 Q8MHY7 denotes uPA
T244 1110-1113 P00749 denotes uPA
T245 1110-1113 PR:Q96NZ9 denotes uPA
T246 1110-1113 Q05589 denotes uPA
T248 1110-1113 P16227 denotes uPA
T249 1110-1113 PR:Q80XD8 denotes uPA
T250 1110-1113 P15120 denotes uPA
T247 1110-1113 GO:0008243 denotes uPA
T251 1133-1144 P33574 denotes plasminogen
T252 1133-1144 P20918 denotes plasminogen
T253 1133-1144 P06867 denotes plasminogen
T255 1133-1144 P83169 denotes plasminogen
T256 1133-1144 Q01177 denotes plasminogen
T257 1133-1144 PR:000012867 denotes plasminogen
T258 1133-1144 Q5R8X6 denotes plasminogen
T259 1133-1144 P81286 denotes plasminogen
T260 1133-1144 P06868 denotes plasminogen
T261 1133-1144 Q7M323 denotes plasminogen
T262 1133-1144 P12545 denotes plasminogen
T264 1133-1144 P80010 denotes plasminogen
T265 1133-1144 O18783 denotes plasminogen
T266 1133-1144 P80009 denotes plasminogen
T267 1133-1144 Q29485 denotes plasminogen
T268 1133-1144 P00747 denotes plasminogen
T254 1133-1144 CHEBI:8259 denotes plasminogen
T263 1133-1144 D010958 denotes plasminogen
T270 1155-1161 862460 denotes casein
T269 1155-1161 CHEBI:3448 denotes casein
T271 1155-1161 D002364 denotes casein
T290 1185-1206 P17811 denotes plasminogen activator
T291 1185-1206 D010960 denotes plasminogen activator
T292 1207-1216 CHEBI:35222 denotes inhibitor
T293 1218-1221 P22777 denotes PAI
T294 1218-1221 P13909 denotes PAI
T295 1218-1221 P05121 denotes PAI
T296 1218-1221 P50449 denotes PAI
T297 1218-1221 P79335 denotes PAI
T299 1218-1221 P20961 denotes PAI
T300 1218-1221 PR:000014702 denotes PAI
T298 1218-1221 CVCL_0479 denotes PAI
T301 1218-1221 CVCL_J288 denotes PAI
T302 1227-1233 UBERON:0000479 denotes tissue
T303 1234-1244 CHEBI:35222 denotes inhibitors
T306 1248-1251 PR:O04529 denotes MMP
T304 1248-1251 CHEBI:340824 denotes MMP
T307 1248-1251 CHEBI:59761 denotes MMP
T305 1248-1251 GO:0004235 denotes MMP
T312 1253-1259 P81546 denotes TIMP-1
T313 1253-1259 O02722 denotes TIMP-1
T314 1253-1259 P49061 denotes TIMP-1
T315 1253-1259 P50122 denotes TIMP-1
T316 1253-1259 P20614 denotes TIMP-1
T317 1253-1259 P12032 denotes TIMP-1
T318 1253-1259 P35624 denotes TIMP-1
T319 1253-1259 P20414 denotes TIMP-1
T320 1253-1259 Q95KL9 denotes TIMP-1
T321 1253-1259 Q5RC60 denotes TIMP-1
T322 1253-1259 PR:P30120 denotes TIMP-1
T323 1253-1259 P30120 denotes TIMP-1
T324 1253-1259 PR:000016352 denotes TIMP-1
T326 1253-1259 PR:P12032 denotes TIMP-1
T327 1253-1259 PR:P01033 denotes TIMP-1
T328 1253-1259 P01033 denotes TIMP-1
T325 1253-1259 D019715 denotes TIMP-1
T329 1374-1391 D002545 denotes Cerebral ischemia
T330 1374-1391 D002545 denotes Cerebral ischemia
T333 1422-1425 CHEBI:340824 denotes MMP
T336 1422-1425 CHEBI:59761 denotes MMP
T337 1422-1427 PR:P50282 denotes MMP-9
T338 1422-1427 PR:P14780 denotes MMP-9
T339 1422-1427 P14780 denotes MMP-9
T340 1422-1427 PR:P41245 denotes MMP-9
T341 1422-1427 P41246 denotes MMP-9
T342 1422-1427 P41245 denotes MMP-9
T343 1422-1427 PR:P52176 denotes MMP-9
T344 1422-1427 P50282 denotes MMP-9
T346 1422-1427 PR:000010491 denotes MMP-9
T347 1422-1427 P52176 denotes MMP-9
T348 1422-1427 O18733 denotes MMP-9
T345 1422-1427 GO:0004229 denotes MMP-9
T349 1511-1520 6711 denotes melatonin
T350 1511-1520 D008550 denotes melatonin
T351 1511-1520 D008550 denotes melatonin
T352 1511-1520 CHEBI:16796 denotes melatonin
T353 1565-1568 CHEBI:340824 denotes MMP
T356 1565-1568 CHEBI:59761 denotes MMP
T357 1565-1570 PR:P50282 denotes MMP-9
T358 1565-1570 PR:P14780 denotes MMP-9
T359 1565-1570 P14780 denotes MMP-9
T360 1565-1570 PR:P41245 denotes MMP-9
T361 1565-1570 P41246 denotes MMP-9
T362 1565-1570 P41245 denotes MMP-9
T363 1565-1570 PR:P52176 denotes MMP-9
T364 1565-1570 P50282 denotes MMP-9
T366 1565-1570 PR:000010491 denotes MMP-9
T367 1565-1570 P52176 denotes MMP-9
T368 1565-1570 O18733 denotes MMP-9
T365 1565-1570 GO:0004229 denotes MMP-9
T369 1628-1633 UBERON:6110636 denotes brain
T370 1628-1633 UBERON:0000955 denotes brain
T371 1628-1644 D020520 denotes brain infarction
T372 1628-1644 D020520 denotes brain infarction
T375 1696-1703 D007797 denotes laminin
T380 1704-1711 SO:0000104 denotes protein
T379 1704-1711 PR:000000001 denotes protein
T376 1704-1711 GO:0003675 denotes protein
T377 1704-1711 CHEBI:36080 denotes protein
T378 1704-1711 CHEBI:11122 denotes protein
T381 1731-1740 6711 denotes melatonin
T382 1731-1740 D008550 denotes melatonin
T383 1731-1740 D008550 denotes melatonin
T384 1731-1740 CHEBI:16796 denotes melatonin
T385 1750-1753 CHEBI:340824 denotes MMP
T388 1750-1753 CHEBI:59761 denotes MMP
T389 1750-1755 PR:P50282 denotes MMP-9
T390 1750-1755 PR:P14780 denotes MMP-9
T391 1750-1755 P14780 denotes MMP-9
T392 1750-1755 PR:P41245 denotes MMP-9
T393 1750-1755 P41246 denotes MMP-9
T394 1750-1755 P41245 denotes MMP-9
T395 1750-1755 PR:P52176 denotes MMP-9
T396 1750-1755 P50282 denotes MMP-9
T398 1750-1755 PR:000010491 denotes MMP-9
T399 1750-1755 P52176 denotes MMP-9
T400 1750-1755 O18733 denotes MMP-9
T397 1750-1755 GO:0004229 denotes MMP-9
T401 1794-1797 P06869 denotes uPA
T402 1794-1797 P29598 denotes uPA
T403 1794-1797 Q5RF29 denotes uPA
T404 1794-1797 PR:000013171 denotes uPA
T405 1794-1797 P04185 denotes uPA
T406 1794-1797 PR:000012826 denotes uPA
T407 1794-1797 Q8MHY7 denotes uPA
T408 1794-1797 P00749 denotes uPA
T409 1794-1797 PR:Q96NZ9 denotes uPA
T410 1794-1797 Q05589 denotes uPA
T412 1794-1797 P16227 denotes uPA
T413 1794-1797 PR:Q80XD8 denotes uPA
T414 1794-1797 P15120 denotes uPA
T411 1794-1797 GO:0008243 denotes uPA
T419 1838-1844 P81546 denotes TIMP-1
T420 1838-1844 O02722 denotes TIMP-1
T421 1838-1844 P49061 denotes TIMP-1
T422 1838-1844 P50122 denotes TIMP-1
T423 1838-1844 P20614 denotes TIMP-1
T424 1838-1844 P12032 denotes TIMP-1
T425 1838-1844 P35624 denotes TIMP-1
T426 1838-1844 P20414 denotes TIMP-1
T427 1838-1844 Q95KL9 denotes TIMP-1
T428 1838-1844 Q5RC60 denotes TIMP-1
T429 1838-1844 PR:P30120 denotes TIMP-1
T430 1838-1844 P30120 denotes TIMP-1
T431 1838-1844 PR:000016352 denotes TIMP-1
T433 1838-1844 PR:P12032 denotes TIMP-1
T434 1838-1844 PR:P01033 denotes TIMP-1
T435 1838-1844 P01033 denotes TIMP-1
T432 1838-1844 D019715 denotes TIMP-1
T436 1860-1863 P22777 denotes PAI
T437 1860-1863 P13909 denotes PAI
T438 1860-1863 P05121 denotes PAI
T439 1860-1863 P50449 denotes PAI
T440 1860-1863 P79335 denotes PAI
T442 1860-1863 P20961 denotes PAI
T443 1860-1863 PR:000014702 denotes PAI
T441 1860-1863 CVCL_0479 denotes PAI
T444 1860-1863 CVCL_J288 denotes PAI
T445 1927-1936 6711 denotes melatonin
T446 1927-1936 D008550 denotes melatonin
T447 1927-1936 D008550 denotes melatonin
T448 1927-1936 CHEBI:16796 denotes melatonin
T449 1991-1994 CHEBI:340824 denotes MMP
T452 1991-1994 CHEBI:59761 denotes MMP
T453 1991-1996 PR:P50282 denotes MMP-9
T454 1991-1996 PR:P14780 denotes MMP-9
T455 1991-1996 P14780 denotes MMP-9
T456 1991-1996 PR:P41245 denotes MMP-9
T457 1991-1996 P41246 denotes MMP-9
T458 1991-1996 P41245 denotes MMP-9
T459 1991-1996 PR:P52176 denotes MMP-9
T460 1991-1996 P50282 denotes MMP-9
T462 1991-1996 PR:000010491 denotes MMP-9
T463 1991-1996 P52176 denotes MMP-9
T464 1991-1996 O18733 denotes MMP-9
T461 1991-1996 GO:0004229 denotes MMP-9
T465 2063-2066 PR:A5I0I2 denotes add
T466 2063-2066 PR:P22333 denotes add
T467 2063-2066 PR:Q54KF3 denotes add

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 213-392 DRI_Outcome denotes We have shown that melatonin attenuated matrix metalloproteinase-9 (MMP-9) activation and decreased the risk of hemorrhagic transformation following cerebral ischemia-reperfusion.
T2 393-519 DRI_Outcome denotes Herein, we investigate the possible involvement of the plasminogen/plasmin system and endogenous MMPs inhibitor underlying the
T3 545-556 DRI_Outcome denotes inhibition.
T4 557-652 DRI_Background denotes Mice were subjected to 1-hr ischemia and 48-hr reperfusion of the right middle cerebral artery.
T5 653-728 DRI_Background denotes Melatonin (5 mg/kg) or vehicle was intravenously injected upon reperfusion.
T6 729-791 DRI_Background denotes Brain infarction and hemorrhagic transformation were measured.
T7 792-886 DRI_Approach denotes Extracellular matrix damage was determined by Western immunoblot analysis for laminin protein.
T8 887-1025 DRI_Background denotes The activity and expression of MMP-2 and MMP-9 were determined by gelatin zymography, in situ zymography, and Western immunoblot analysis.
T9 1026-1173 DRI_Background denotes In addition, the activities of tissue and urokinase plasminogen activators (tPA and uPA) were evaluated by plasminogen-dependent casein zymography.
T10 1174-1373 DRI_Background denotes Endogenous plasminogen activator inhibitor (PAI) and tissue inhibitors of MMP (TIMP-1) were investigated using enzyme-linked immunosorbent assay (ELISA) and Western immunoblot analysis, respectively.
T11 1374-1488 DRI_Background denotes Cerebral ischemia-reperfusion induced increased MMP-9 activity and expression at 12-48 hr after reperfusion onset.
T12 1489-1725 DRI_Outcome denotes Relative to controls, melatonin-treated animals had significantly decreased MMP-9 activity and expression (P<0.05), in addition to reduced brain infarction and hemorrhagic transformation as well as improved laminin protein preservation.
T13 1726-1730 DRI_Outcome denotes This
T14 1756-1896 DRI_Outcome denotes inhibition was accompanied by reduced uPA activity (P<0.05), as well as increased TIMP-1 expression and PAI activity (P<0.05, respectively).
T15 1897-1977 DRI_Challenge denotes These results demonstrate the melatonin's pluripotent mechanisms for attenuating
T16 1997-2123 DRI_Challenge denotes activation and neurovascular damage, and further support it as an add-on to thrombolytic therapy for ischemic stroke patients.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 362-379 HP_0002637 denotes cerebral ischemia
T2 1374-1391 HP_0002637 denotes Cerebral ischemia
T3 2098-2113 HP_0002140 denotes ischemic stroke
T4 2107-2113 HP_0001297 denotes stroke

Allie

Id Subject Object Predicate Lexical cue
SS1_20663046_0_0 32-58 expanded denotes matrix metalloproteinase-9
SS2_20663046_0_0 60-65 abbr denotes MMP-9
SS1_20663046_1_0 253-279 expanded denotes matrix metalloproteinase-9
SS2_20663046_1_0 281-286 abbr denotes MMP-9
SS1_20663046_9_0 1185-1216 expanded denotes plasminogen activator inhibitor
SS2_20663046_9_0 1218-1221 abbr denotes PAI
SS1_20663046_9_1 1285-1318 expanded denotes enzyme-linked immunosorbent assay
SS2_20663046_9_1 1320-1325 abbr denotes ELISA
AE1_20663046_0_0 SS1_20663046_0_0 SS2_20663046_0_0 abbreviatedTo matrix metalloproteinase-9,MMP-9
AE1_20663046_1_0 SS1_20663046_1_0 SS2_20663046_1_0 abbreviatedTo matrix metalloproteinase-9,MMP-9
AE1_20663046_9_0 SS1_20663046_9_0 SS2_20663046_9_0 abbreviatedTo plasminogen activator inhibitor,PAI
AE1_20663046_9_1 SS1_20663046_9_1 SS2_20663046_9_1 abbreviatedTo enzyme-linked immunosorbent assay,ELISA

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-212 DRI_Background denotes Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia.
T2 213-392 DRI_Outcome denotes We have shown that melatonin attenuated matrix metalloproteinase-9 (MMP-9) activation and decreased the risk of hemorrhagic transformation following cerebral ischemia-reperfusion.
T3 393-519 DRI_Outcome denotes Herein, we investigate the possible involvement of the plasminogen/plasmin system and endogenous MMPs inhibitor underlying the
T4 520-544 Token_Label.OUTSIDE denotes melatonin-mediated MMP-9
T5 545-556 DRI_Outcome denotes inhibition.
T6 557-652 DRI_Background denotes Mice were subjected to 1-hr ischemia and 48-hr reperfusion of the right middle cerebral artery.
T7 653-728 DRI_Background denotes Melatonin (5 mg/kg) or vehicle was intravenously injected upon reperfusion.
T8 729-791 DRI_Background denotes Brain infarction and hemorrhagic transformation were measured.
T9 792-886 DRI_Approach denotes Extracellular matrix damage was determined by Western immunoblot analysis for laminin protein.
T10 887-1025 DRI_Background denotes The activity and expression of MMP-2 and MMP-9 were determined by gelatin zymography, in situ zymography, and Western immunoblot analysis.
T11 1026-1173 DRI_Background denotes In addition, the activities of tissue and urokinase plasminogen activators (tPA and uPA) were evaluated by plasminogen-dependent casein zymography.
T12 1174-1373 DRI_Background denotes Endogenous plasminogen activator inhibitor (PAI) and tissue inhibitors of MMP (TIMP-1) were investigated using enzyme-linked immunosorbent assay (ELISA) and Western immunoblot analysis, respectively.
T13 1374-1488 DRI_Background denotes Cerebral ischemia-reperfusion induced increased MMP-9 activity and expression at 12-48 hr after reperfusion onset.
T14 1489-1725 DRI_Outcome denotes Relative to controls, melatonin-treated animals had significantly decreased MMP-9 activity and expression (P<0.05), in addition to reduced brain infarction and hemorrhagic transformation as well as improved laminin protein preservation.
T15 1726-1730 DRI_Outcome denotes This
T16 1731-1755 Token_Label.OUTSIDE denotes melatonin-mediated MMP-9
T17 1756-1896 DRI_Outcome denotes inhibition was accompanied by reduced uPA activity (P<0.05), as well as increased TIMP-1 expression and PAI activity (P<0.05, respectively).
T18 1897-1977 DRI_Challenge denotes These results demonstrate the melatonin's pluripotent mechanisms for attenuating
T19 1978-1996 Token_Label.OUTSIDE denotes postischemic MMP-9
T20 1997-2123 DRI_Challenge denotes activation and neurovascular damage, and further support it as an add-on to thrombolytic therapy for ischemic stroke patients.