PubMed:20648600 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20648600","sourcedb":"PubMed","sourceid":"20648600","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20648600","text":"High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.\nThis study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a group of patients co-infected with HIV and hepatitis B virus (HBV). A cross-sectional study of 847 patients with HIV was conducted. Patients provided blood samples for HBsAg detection. The load of HBV was determined using an \"in-house\" real-time polymerase chain reaction. HBV genotypes/subgenotypes, antiviral resistance, basal core promoter (BCP), and precore mutations were detected by DNA sequencing. Twenty-eight patients with co-infection were identified. The distribution of HBV genotypes among these patients was A (n = 9; 50%), D (n = 4; 22.2%), G (n = 3; 16.7%), and F (n = 2; 11.1%). Eighteen patients were treated with LAM and six patients were treated with LAM plus TDF. The length of exposure to LAM and TDF varied from 4 to 216 months. LAM resistance substitutions (rtL180M + rtM204V) were detected in 10 (50%) of the 20 patients with viremia. This pattern and an accompanying rtV173L mutation was found in four patients. Three patients with the triple polymerase substitution pattern (rtV173L + rtL180M + rtM204V) had associated changes in the envelope gene (sE164D + sI195M). Mutations in the BCP region (A1762T, G1764A) and in the precore region (G1896A, G1899A) were also found. No putative TDF resistance substitution was detected. The data suggest that prolonged LAM use is associated with the emergence of particular changes in the HBV genome, including substitutions that may elicit a vaccine escape phenotype. No putative TDF resistance change was detected after prolonged use of TDF.","tracks":[{"project":"TEST-DiseaseOrPhenotypicFeature","denotations":[{"id":"T1","span":{"begin":97,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":279,"end":290},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":668,"end":680},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1086,"end":1093},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D006509"},{"id":"A2","pred":"#label","subj":"T2","obj":"D006509"},{"id":"A3","pred":"#label","subj":"T3","obj":"D060085"},{"id":"A4","pred":"#label","subj":"T4","obj":"D014766"},{"subj":"T1","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T2","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T3","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"},{"subj":"T4","pred":"source","obj":"TEST-DiseaseOrPhenotypicFeature"}]},{"project":"TEST-ChemicalEntity","denotations":[{"id":"T1","span":{"begin":18,"end":28},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":173,"end":183},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":185,"end":188},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":194,"end":203},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":205,"end":208},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":404,"end":409},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":867,"end":870},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":906,"end":909},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":915,"end":918},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":946,"end":949},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":954,"end":957},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":987,"end":990},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":1446,"end":1449},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1520,"end":1523},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":1644,"end":1651},"obj":"ChemicalEntity"},{"id":"T32","span":{"begin":1682,"end":1685},"obj":"ChemicalEntity"},{"id":"T33","span":{"begin":1740,"end":1743},"obj":"ChemicalEntity"}],"attributes":[{"id":"A23","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A28","pred":"ID:","subj":"T28","obj":"C050016"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A16","pred":"ID:","subj":"T16","obj":"C050016"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A18","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A20","pred":"ID:","subj":"T20","obj":"C050016"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A19","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A32","pred":"ID:","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C050016"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A5","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D000068698"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A8","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A9","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A13","pred":"ID:","subj":"T13","obj":"C050016"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A15","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A31","pred":"ID:","subj":"T31","obj":"D014612"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D006514"},{"id":"A12","pred":"ID:","subj":"T11","obj":"ChemicalEntity"},{"id":"A33","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A24","pred":"ID:","subj":"T24","obj":"C050016"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A26","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"subj":"T1","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T2","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T3","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T6","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T10","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T11","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T13","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T16","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T19","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T20","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T23","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T24","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T27","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T28","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T31","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T32","pred":"source","obj":"TEST-ChemicalEntity"},{"subj":"T33","pred":"source","obj":"TEST-ChemicalEntity"}]},{"project":"TEST-OrganismTaxon","denotations":[{"id":"T1","span":{"begin":63,"end":71},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":89,"end":92},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":245,"end":253},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":271,"end":274},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":279,"end":302},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":335,"end":343},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":349,"end":352},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":368,"end":376},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":433,"end":436},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":509,"end":512},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":654,"end":662},"obj":"OrganismTaxon"},{"id":"T12","span":{"begin":718,"end":721},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":744,"end":752},"obj":"OrganismTaxon"},{"id":"T14","span":{"begin":840,"end":848},"obj":"OrganismTaxon"},{"id":"T15","span":{"begin":879,"end":887},"obj":"OrganismTaxon"},{"id":"T16","span":{"begin":1072,"end":1080},"obj":"OrganismTaxon"},{"id":"T17","span":{"begin":1163,"end":1171},"obj":"OrganismTaxon"},{"id":"T18","span":{"begin":1179,"end":1187},"obj":"OrganismTaxon"},{"id":"T19","span":{"begin":1590,"end":1593},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T2","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T3","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T4","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T5","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T6","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T7","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T8","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T9","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T10","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T11","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T12","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T13","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T14","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T15","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T16","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T17","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T18","pred":"source","obj":"TEST-OrganismTaxon"},{"subj":"T19","pred":"source","obj":"TEST-OrganismTaxon"}]},{"project":"Test-SequenceVariant","denotations":[{"id":"T1","span":{"begin":1358,"end":1364},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":1366,"end":1372},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":1401,"end":1407},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":1409,"end":1415},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-SequenceVariant"},{"subj":"T2","pred":"source","obj":"Test-SequenceVariant"},{"subj":"T3","pred":"source","obj":"Test-SequenceVariant"},{"subj":"T4","pred":"source","obj":"Test-SequenceVariant"}]},{"project":"Test-GeneOrGeneProduct","denotations":[{"id":"T1","span":{"begin":1296,"end":1304},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"Test-GeneOrGeneProduct"}]},{"project":"Test-merged","denotations":[{"id":"T4","span":{"begin":1086,"end":1093},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":668,"end":680},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T1","span":{"begin":97,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":1590,"end":1593},"obj":"OrganismTaxon"},{"id":"T18","span":{"begin":1179,"end":1187},"obj":"OrganismTaxon"},{"id":"T17","span":{"begin":1163,"end":1171},"obj":"OrganismTaxon"},{"id":"T16","span":{"begin":1072,"end":1080},"obj":"OrganismTaxon"},{"id":"T15","span":{"begin":879,"end":887},"obj":"OrganismTaxon"},{"id":"T14","span":{"begin":840,"end":848},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":744,"end":752},"obj":"OrganismTaxon"},{"id":"T12","span":{"begin":718,"end":721},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":654,"end":662},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":509,"end":512},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":433,"end":436},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":368,"end":376},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":349,"end":352},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":335,"end":343},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":279,"end":302},"obj":"OrganismTaxon"},{"id":"T4926","span":{"begin":271,"end":274},"obj":"OrganismTaxon"},{"id":"T96270","span":{"begin":245,"end":253},"obj":"OrganismTaxon"},{"id":"T94231","span":{"begin":89,"end":92},"obj":"OrganismTaxon"},{"id":"T84556","span":{"begin":63,"end":71},"obj":"OrganismTaxon"},{"id":"T77588","span":{"begin":1296,"end":1304},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1740,"end":1743},"obj":"ChemicalEntity"},{"id":"T32","span":{"begin":1682,"end":1685},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":1644,"end":1651},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1520,"end":1523},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":1446,"end":1449},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":987,"end":990},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":954,"end":957},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":946,"end":949},"obj":"ChemicalEntity"},{"id":"T21807","span":{"begin":915,"end":918},"obj":"ChemicalEntity"},{"id":"T78797","span":{"begin":906,"end":909},"obj":"ChemicalEntity"},{"id":"T30923","span":{"begin":867,"end":870},"obj":"ChemicalEntity"},{"id":"T51554","span":{"begin":404,"end":409},"obj":"ChemicalEntity"},{"id":"T36773","span":{"begin":205,"end":208},"obj":"ChemicalEntity"},{"id":"T54841","span":{"begin":194,"end":203},"obj":"ChemicalEntity"},{"id":"T54654","span":{"begin":185,"end":188},"obj":"ChemicalEntity"},{"id":"T22494","span":{"begin":173,"end":183},"obj":"ChemicalEntity"},{"id":"T58543","span":{"begin":18,"end":28},"obj":"ChemicalEntity"},{"id":"T80885","span":{"begin":1409,"end":1415},"obj":"SequenceVariant"},{"id":"T3620","span":{"begin":1401,"end":1407},"obj":"SequenceVariant"},{"id":"T26696","span":{"begin":1366,"end":1372},"obj":"SequenceVariant"},{"id":"T89313","span":{"begin":1358,"end":1364},"obj":"SequenceVariant"}],"attributes":[{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A28","pred":"ID:","subj":"T28","obj":"C050016"},{"id":"A5","pred":"ID:","subj":"T54654","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A35001","pred":"ID:","subj":"T54654","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A60716","pred":"ID:","subj":"T54654","obj":"C050016"},{"id":"A15","pred":"ID:","subj":"T30923","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A14","pred":"ID:","subj":"T30923","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A13","pred":"ID:","subj":"T30923","obj":"C050016"},{"id":"A19","pred":"ID:","subj":"T21807","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A26","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A24","pred":"ID:","subj":"T24","obj":"C050016"},{"id":"A4136","pred":"ID:","subj":"T58543","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A3","pred":"#label","subj":"T3","obj":"D060085"},{"id":"A9","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A8","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A7","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A6","pred":"ID:","subj":"T54841","obj":"D000068698"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A20","pred":"ID:","subj":"T20","obj":"C050016"},{"id":"A12","pred":"ID:","subj":"T51554","obj":"ChemicalEntity"},{"id":"A11","pred":"ID:","subj":"T51554","obj":"D006514"},{"id":"A4","pred":"#label","subj":"T4","obj":"D014766"},{"id":"A10","pred":"ID:","subj":"T36773","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A1","pred":"#label","subj":"T1","obj":"D006509"},{"id":"A32","pred":"ID:","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A31","pred":"ID:","subj":"T31","obj":"D014612"},{"id":"A18","pred":"ID:","subj":"T78797","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A17","pred":"ID:","subj":"T78797","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A16","pred":"ID:","subj":"T78797","obj":"C050016"},{"id":"A33","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A65730","pred":"ID:","subj":"T22494","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A23","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"subj":"T4","pred":"source","obj":"Test-merged"},{"subj":"T3","pred":"source","obj":"Test-merged"},{"subj":"T1","pred":"source","obj":"Test-merged"},{"subj":"T19","pred":"source","obj":"Test-merged"},{"subj":"T18","pred":"source","obj":"Test-merged"},{"subj":"T17","pred":"source","obj":"Test-merged"},{"subj":"T16","pred":"source","obj":"Test-merged"},{"subj":"T15","pred":"source","obj":"Test-merged"},{"subj":"T14","pred":"source","obj":"Test-merged"},{"subj":"T13","pred":"source","obj":"Test-merged"},{"subj":"T12","pred":"source","obj":"Test-merged"},{"subj":"T11","pred":"source","obj":"Test-merged"},{"subj":"T10","pred":"source","obj":"Test-merged"},{"subj":"T9","pred":"source","obj":"Test-merged"},{"subj":"T8","pred":"source","obj":"Test-merged"},{"subj":"T7","pred":"source","obj":"Test-merged"},{"subj":"T6","pred":"source","obj":"Test-merged"},{"subj":"T5","pred":"source","obj":"Test-merged"},{"subj":"T4926","pred":"source","obj":"Test-merged"},{"subj":"T96270","pred":"source","obj":"Test-merged"},{"subj":"T94231","pred":"source","obj":"Test-merged"},{"subj":"T84556","pred":"source","obj":"Test-merged"},{"subj":"T77588","pred":"source","obj":"Test-merged"},{"subj":"T33","pred":"source","obj":"Test-merged"},{"subj":"T32","pred":"source","obj":"Test-merged"},{"subj":"T31","pred":"source","obj":"Test-merged"},{"subj":"T28","pred":"source","obj":"Test-merged"},{"subj":"T27","pred":"source","obj":"Test-merged"},{"subj":"T24","pred":"source","obj":"Test-merged"},{"subj":"T23","pred":"source","obj":"Test-merged"},{"subj":"T20","pred":"source","obj":"Test-merged"},{"subj":"T21807","pred":"source","obj":"Test-merged"},{"subj":"T78797","pred":"source","obj":"Test-merged"},{"subj":"T30923","pred":"source","obj":"Test-merged"},{"subj":"T51554","pred":"source","obj":"Test-merged"},{"subj":"T36773","pred":"source","obj":"Test-merged"},{"subj":"T54841","pred":"source","obj":"Test-merged"},{"subj":"T54654","pred":"source","obj":"Test-merged"},{"subj":"T22494","pred":"source","obj":"Test-merged"},{"subj":"T58543","pred":"source","obj":"Test-merged"},{"subj":"T80885","pred":"source","obj":"Test-merged"},{"subj":"T3620","pred":"source","obj":"Test-merged"},{"subj":"T26696","pred":"source","obj":"Test-merged"},{"subj":"T89313","pred":"source","obj":"Test-merged"}]},{"project":"Test-merged-2","denotations":[{"id":"T89313","span":{"begin":1358,"end":1364},"obj":"SequenceVariant"},{"id":"T26696","span":{"begin":1366,"end":1372},"obj":"SequenceVariant"},{"id":"T3620","span":{"begin":1401,"end":1407},"obj":"SequenceVariant"},{"id":"T80885","span":{"begin":1409,"end":1415},"obj":"SequenceVariant"},{"id":"T58543","span":{"begin":18,"end":28},"obj":"ChemicalEntity"},{"id":"T22494","span":{"begin":173,"end":183},"obj":"ChemicalEntity"},{"id":"T54654","span":{"begin":185,"end":188},"obj":"ChemicalEntity"},{"id":"T54841","span":{"begin":194,"end":203},"obj":"ChemicalEntity"},{"id":"T36773","span":{"begin":205,"end":208},"obj":"ChemicalEntity"},{"id":"T51554","span":{"begin":404,"end":409},"obj":"ChemicalEntity"},{"id":"T30923","span":{"begin":867,"end":870},"obj":"ChemicalEntity"},{"id":"T78797","span":{"begin":906,"end":909},"obj":"ChemicalEntity"},{"id":"T21807","span":{"begin":915,"end":918},"obj":"ChemicalEntity"},{"id":"T20","span":{"begin":946,"end":949},"obj":"ChemicalEntity"},{"id":"T23","span":{"begin":954,"end":957},"obj":"ChemicalEntity"},{"id":"T24","span":{"begin":987,"end":990},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":1446,"end":1449},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":1520,"end":1523},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":1644,"end":1651},"obj":"ChemicalEntity"},{"id":"T32","span":{"begin":1682,"end":1685},"obj":"ChemicalEntity"},{"id":"T33","span":{"begin":1740,"end":1743},"obj":"ChemicalEntity"},{"id":"T77588","span":{"begin":1296,"end":1304},"obj":"GeneOrGeneProduct"},{"id":"T84556","span":{"begin":63,"end":71},"obj":"OrganismTaxon"},{"id":"T94231","span":{"begin":89,"end":92},"obj":"OrganismTaxon"},{"id":"T96270","span":{"begin":245,"end":253},"obj":"OrganismTaxon"},{"id":"T4926","span":{"begin":271,"end":274},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":279,"end":302},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":335,"end":343},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":349,"end":352},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":368,"end":376},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":433,"end":436},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":509,"end":512},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":654,"end":662},"obj":"OrganismTaxon"},{"id":"T12","span":{"begin":718,"end":721},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":744,"end":752},"obj":"OrganismTaxon"},{"id":"T14","span":{"begin":840,"end":848},"obj":"OrganismTaxon"},{"id":"T15","span":{"begin":879,"end":887},"obj":"OrganismTaxon"},{"id":"T16","span":{"begin":1072,"end":1080},"obj":"OrganismTaxon"},{"id":"T17","span":{"begin":1163,"end":1171},"obj":"OrganismTaxon"},{"id":"T18","span":{"begin":1179,"end":1187},"obj":"OrganismTaxon"},{"id":"T19","span":{"begin":1590,"end":1593},"obj":"OrganismTaxon"},{"id":"T1","span":{"begin":97,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":279,"end":290},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":668,"end":680},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1086,"end":1093},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"ID:","subj":"T30923","obj":"C050016"},{"id":"A14","pred":"ID:","subj":"T30923","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A15","pred":"ID:","subj":"T30923","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A31","pred":"ID:","subj":"T31","obj":"D014612"},{"id":"A4136","pred":"ID:","subj":"T58543","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A19","pred":"ID:","subj":"T21807","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A11","pred":"ID:","subj":"T51554","obj":"D006514"},{"id":"A12","pred":"ID:","subj":"T51554","obj":"ChemicalEntity"},{"id":"A2","pred":"#label","subj":"T2","obj":"D006509"},{"id":"A23","pred":"ID:","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A10","pred":"ID:","subj":"T36773","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A3","pred":"#label","subj":"T3","obj":"D060085"},{"id":"A33","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A6","pred":"ID:","subj":"T54841","obj":"D000068698"},{"id":"A7","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A8","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A9","pred":"ID:","subj":"T54841","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A20","pred":"ID:","subj":"T20","obj":"C050016"},{"id":"A21","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A22","pred":"ID:","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A24","pred":"ID:","subj":"T24","obj":"C050016"},{"id":"A25","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A26","pred":"ID:","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A60716","pred":"ID:","subj":"T54654","obj":"C050016"},{"id":"A35001","pred":"ID:","subj":"T54654","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A5","pred":"ID:","subj":"T54654","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A28","pred":"ID:","subj":"T28","obj":"C050016"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A65730","pred":"ID:","subj":"T22494","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A32","pred":"ID:","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A16","pred":"ID:","subj":"T78797","obj":"C050016"},{"id":"A17","pred":"ID:","subj":"T78797","obj":"http://purl.obolibrary.org/obo/CHEBI_59524"},{"id":"A18","pred":"ID:","subj":"T78797","obj":"http://purl.obolibrary.org/obo/CHEBI_63577"},{"id":"A4","pred":"#label","subj":"T4","obj":"D014766"},{"id":"A1","pred":"#label","subj":"T1","obj":"D006509"},{"subj":"T89313","pred":"source","obj":"Test-merged-2"},{"subj":"T26696","pred":"source","obj":"Test-merged-2"},{"subj":"T3620","pred":"source","obj":"Test-merged-2"},{"subj":"T80885","pred":"source","obj":"Test-merged-2"},{"subj":"T58543","pred":"source","obj":"Test-merged-2"},{"subj":"T22494","pred":"source","obj":"Test-merged-2"},{"subj":"T54654","pred":"source","obj":"Test-merged-2"},{"subj":"T54841","pred":"source","obj":"Test-merged-2"},{"subj":"T36773","pred":"source","obj":"Test-merged-2"},{"subj":"T51554","pred":"source","obj":"Test-merged-2"},{"subj":"T30923","pred":"source","obj":"Test-merged-2"},{"subj":"T78797","pred":"source","obj":"Test-merged-2"},{"subj":"T21807","pred":"source","obj":"Test-merged-2"},{"subj":"T20","pred":"source","obj":"Test-merged-2"},{"subj":"T23","pred":"source","obj":"Test-merged-2"},{"subj":"T24","pred":"source","obj":"Test-merged-2"},{"subj":"T27","pred":"source","obj":"Test-merged-2"},{"subj":"T28","pred":"source","obj":"Test-merged-2"},{"subj":"T31","pred":"source","obj":"Test-merged-2"},{"subj":"T32","pred":"source","obj":"Test-merged-2"},{"subj":"T33","pred":"source","obj":"Test-merged-2"},{"subj":"T77588","pred":"source","obj":"Test-merged-2"},{"subj":"T84556","pred":"source","obj":"Test-merged-2"},{"subj":"T94231","pred":"source","obj":"Test-merged-2"},{"subj":"T96270","pred":"source","obj":"Test-merged-2"},{"subj":"T4926","pred":"source","obj":"Test-merged-2"},{"subj":"T5","pred":"source","obj":"Test-merged-2"},{"subj":"T6","pred":"source","obj":"Test-merged-2"},{"subj":"T7","pred":"source","obj":"Test-merged-2"},{"subj":"T8","pred":"source","obj":"Test-merged-2"},{"subj":"T9","pred":"source","obj":"Test-merged-2"},{"subj":"T10","pred":"source","obj":"Test-merged-2"},{"subj":"T11","pred":"source","obj":"Test-merged-2"},{"subj":"T12","pred":"source","obj":"Test-merged-2"},{"subj":"T13","pred":"source","obj":"Test-merged-2"},{"subj":"T14","pred":"source","obj":"Test-merged-2"},{"subj":"T15","pred":"source","obj":"Test-merged-2"},{"subj":"T16","pred":"source","obj":"Test-merged-2"},{"subj":"T17","pred":"source","obj":"Test-merged-2"},{"subj":"T18","pred":"source","obj":"Test-merged-2"},{"subj":"T19","pred":"source","obj":"Test-merged-2"},{"subj":"T1","pred":"source","obj":"Test-merged-2"},{"subj":"T2","pred":"source","obj":"Test-merged-2"},{"subj":"T3","pred":"source","obj":"Test-merged-2"},{"subj":"T4","pred":"source","obj":"Test-merged-2"}]},{"project":"Allie","denotations":[{"id":"SS1_20648600_1_0","span":{"begin":173,"end":183},"obj":"expanded"},{"id":"SS2_20648600_1_0","span":{"begin":185,"end":188},"obj":"abbr"},{"id":"SS1_20648600_1_1","span":{"begin":279,"end":296},"obj":"expanded"},{"id":"SS2_20648600_1_1","span":{"begin":298,"end":301},"obj":"abbr"},{"id":"SS1_20648600_5_0","span":{"begin":559,"end":578},"obj":"expanded"},{"id":"SS2_20648600_5_0","span":{"begin":580,"end":583},"obj":"abbr"}],"relations":[{"id":"AE1_20648600_1_0","pred":"abbreviatedTo","subj":"SS1_20648600_1_0","obj":"SS2_20648600_1_0"},{"id":"AE1_20648600_1_1","pred":"abbreviatedTo","subj":"SS1_20648600_1_1","obj":"SS2_20648600_1_1"},{"id":"AE1_20648600_5_0","pred":"abbreviatedTo","subj":"SS1_20648600_5_0","obj":"SS2_20648600_5_0"}],"attributes":[{"subj":"SS1_20648600_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_20648600_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_20648600_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_20648600_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_20648600_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_20648600_5_0","pred":"source","obj":"Allie"}]},{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":1019,"end":1024},"obj":"ProteinMutation:p|SUB|L|180|M"},{"id":"T2","span":{"begin":1029,"end":1034},"obj":"ProteinMutation:p|SUB|M|204|V"},{"id":"T3","span":{"begin":1130,"end":1135},"obj":"ProteinMutation:p|SUB|V|173|L"},{"id":"T4","span":{"begin":1239,"end":1244},"obj":"ProteinMutation:p|SUB|V|173|L"},{"id":"T5","span":{"begin":1249,"end":1254},"obj":"ProteinMutation:p|SUB|L|180|M"},{"id":"T6","span":{"begin":1259,"end":1264},"obj":"ProteinMutation:p|SUB|M|204|V"},{"id":"T7","span":{"begin":1312,"end":1317},"obj":"ProteinMutation:p|SUB|E|164|D"},{"id":"T8","span":{"begin":1321,"end":1326},"obj":"ProteinMutation:p|SUB|I|195|M"},{"id":"T9","span":{"begin":1358,"end":1364},"obj":"DNAMutation:g|SUB|A|1762|T"},{"id":"T10","span":{"begin":1366,"end":1372},"obj":"DNAMutation:g|SUB|G|1764|A"},{"id":"T11","span":{"begin":1401,"end":1407},"obj":"DNAMutation:g|SUB|G|1896|A"},{"id":"T12","span":{"begin":1409,"end":1415},"obj":"DNAMutation:g|SUB|G|1899|A"}],"attributes":[{"subj":"T1","pred":"source","obj":"tmVarCorpus"},{"subj":"T2","pred":"source","obj":"tmVarCorpus"},{"subj":"T3","pred":"source","obj":"tmVarCorpus"},{"subj":"T4","pred":"source","obj":"tmVarCorpus"},{"subj":"T5","pred":"source","obj":"tmVarCorpus"},{"subj":"T6","pred":"source","obj":"tmVarCorpus"},{"subj":"T7","pred":"source","obj":"tmVarCorpus"},{"subj":"T8","pred":"source","obj":"tmVarCorpus"},{"subj":"T9","pred":"source","obj":"tmVarCorpus"},{"subj":"T10","pred":"source","obj":"tmVarCorpus"},{"subj":"T11","pred":"source","obj":"tmVarCorpus"},{"subj":"T12","pred":"source","obj":"tmVarCorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST-DiseaseOrPhenotypicFeature","color":"#93ecbb","default":true},{"id":"TEST-ChemicalEntity","color":"#eca193"},{"id":"TEST-OrganismTaxon","color":"#939fec"},{"id":"Test-SequenceVariant","color":"#b9ec93"},{"id":"Test-GeneOrGeneProduct","color":"#ec93d3"},{"id":"Test-merged","color":"#93eceb"},{"id":"Test-merged-2","color":"#ecd193"},{"id":"Allie","color":"#b793ec"},{"id":"tmVarCorpus","color":"#93ec9d"}]}]}}