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PubMed:2050125 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 527-540 HP_0001427 denotes mitochondrial

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-42 protein denotes Human erythroid 5-aminolevulinate synthase
T2 44-52 DNA denotes promoter
T3 87-110 DNA denotes iron-responsive element
T4 118-122 RNA denotes mRNA
T5 124-150 protein denotes 5-Aminolevulinate synthase
T6 152-156 protein denotes ALAS
T7 190-194 protein denotes heme
T8 217-228 DNA denotes cDNA clones
T9 237-265 protein denotes human erythroid ALAS isozyme
T10 335-367 protein denotes erythroid ALAS precursor protein
T11 453-486 protein denotes human housekeeping ALAS precursor
T12 568-594 protein denotes housekeeping ALAS isozymes
T13 681-689 protein denotes isozymes
T14 731-758 protein denotes N-terminal signal sequences
T15 806-827 protein denotes C-terminal two-thirds
T16 866-884 DNA denotes immediate promoter
T17 892-917 DNA denotes human erythroid ALAS gene
T18 944-982 DNA denotes erythroid-specific cis-acting elements
T19 1000-1006 DNA denotes GATA-1
T20 1014-1032 DNA denotes NF-E2 binding site
T21 1037-1072 RNA denotes iron-responsive element (IRE) motif
T22 1130-1155 RNA denotes human erythroid ALAS mRNA
T23 1183-1205 RNA denotes housekeeping ALAS mRNA
T24 1257-1266 RNA denotes IRE motif
T25 1276-1297 protein denotes protein - RNA complex
T26 1327-1343 cell_line denotes human K562 cells
T27 1388-1403 RNA denotes IRE transcripts
T28 1409-1447 RNA denotes ferritin or transferrin receptor mRNAs
T29 1469-1477 DNA denotes ALAS IRE
T30 1516-1519 DNA denotes IRE
T31 1547-1568 protein denotes protein - RNA complex
T32 1601-1610 RNA denotes IRE motif
T33 1618-1627 RNA denotes ALAS mRNA
T34 1676-1680 RNA denotes mRNA

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-123 Sentence denotes Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.
S2 124-216 Sentence denotes 5-Aminolevulinate synthase (ALAS) catalyzes the first step of the heme biosynthetic pathway.
S3 217-307 Sentence denotes cDNA clones for the human erythroid ALAS isozyme were isolated from a fetal liver library.
S4 308-515 Sentence denotes It can be deduced that the erythroid ALAS precursor protein has a molecular weight of 64.6 kd, and is similar in size to the previously isolated human housekeeping ALAS precursor of molecular weight 70.6 kd.
S5 516-672 Sentence denotes The mature mitochondrial forms of the erythroid and housekeeping ALAS isozymes are predicted to have molecular weights of 59.5 kd and 64.6 kd, respectively.
S6 673-846 Sentence denotes The two isozymes show little amino acid identity in their N-terminal signal sequences but have considerable sequence identity in the C-terminal two-thirds of their proteins.
S7 847-1033 Sentence denotes An analysis of the immediate promoter of the human erythroid ALAS gene revealed several putative erythroid-specific cis-acting elements including both a GATA-1 and an NF-E2 binding site.
S8 1034-1206 Sentence denotes An iron-responsive element (IRE) motif has been identified in the 5'-untranslated region of the human erythroid ALAS mRNA, but is not present in the housekeeping ALAS mRNA.
S9 1207-1448 Sentence denotes Gel retardation experiments established that this IRE motif formed a protein - RNA complex with cytosolic extracts from human K562 cells and this binding was strongly competed with IRE transcripts from ferritin or transferrin receptor mRNAs.
S10 1449-1569 Sentence denotes A transcript of the ALAS IRE, mutated in the conserved loop of the IRE, did not readily form this protein - RNA complex.
S11 1570-1747 Sentence denotes These results suggest that the IRE motif in the ALAS mRNA is functional and imply that translation of the mRNA is controlled by cellular iron availability during erythropoiesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 16-42 NP denotes 5-aminolevulinate synthase
C1 0-42 NP denotes Human erythroid 5-aminolevulinate synthase
C3 124-157 NP denotes 5-Aminolevulinate synthase (ALAS)
C5 253-257 NP denotes ALAS
C4 233-265 NP denotes the human erythroid ALAS isozyme
C6 345-349 NP denotes ALAS
C8 472-476 NP denotes ALAS
C7 453-476 NP denotes human housekeeping ALAS
C10 581-585 NP denotes ALAS
C9 550-594 NP denotes the erythroid and housekeeping ALAS isozymes
C11 673-689 NP denotes The two isozymes
C12 831-836 NP denotes their
C14 908-912 NP denotes ALAS
C13 888-917 NP denotes the human erythroid ALAS gene
C15 1034-1072 NP denotes An iron-responsive element (IRE) motif
C17 1146-1150 NP denotes ALAS
C16 1126-1155 NP denotes the human erythroid ALAS mRNA
C19 1196-1200 NP denotes ALAS
C18 1179-1205 NP denotes the housekeeping ALAS mRNA
C20 1252-1266 NP denotes this IRE motif
C21 1388-1403 NP denotes IRE transcripts
C22 1469-1473 NP denotes ALAS
C23 1597-1610 NP denotes the IRE motif
C25 1618-1622 NP denotes ALAS
C24 1614-1627 NP denotes the ALAS mRNA
C26 1672-1680 NP denotes the mRNA
R1 C3 C2 coref-ident 5-Aminolevulinate synthase (ALAS),5-aminolevulinate synthase
R2 C5 C3 coref-ident ALAS,5-Aminolevulinate synthase (ALAS)
R3 C6 C5 coref-ident ALAS,ALAS
R4 C8 C6 coref-ident ALAS,ALAS
R5 C10 C8 coref-ident ALAS,ALAS
R6 C11 C9 coref-ident The two isozymes,the erythroid and housekeeping ALAS isozymes
R7 C12 C11 coref-pron their,The two isozymes
R8 C14 C10 coref-ident ALAS,ALAS
R9 C13 C4 coref-ident the human erythroid ALAS gene,the human erythroid ALAS isozyme
R10 C17 C14 coref-ident ALAS,ALAS
R11 C16 C13 coref-other the human erythroid ALAS mRNA,the human erythroid ALAS gene
R12 C19 C17 coref-ident ALAS,ALAS
R13 C18 C7 coref-other the housekeeping ALAS mRNA,human housekeeping ALAS
R14 C20 C15 coref-ident this IRE motif,An iron-responsive element (IRE) motif
R15 C21 C20 coref-other IRE transcripts,this IRE motif
R16 C22 C19 coref-ident ALAS,ALAS
R17 C23 C20 coref-ident the IRE motif,this IRE motif
R18 C25 C22 coref-ident ALAS,ALAS
R19 C24 C16 coref-other the ALAS mRNA,the human erythroid ALAS mRNA
R20 C26 C24 coref-ident the mRNA,the ALAS mRNA

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-42 protein_molecule denotes Human erythroid 5-aminolevulinate synthase
T2 44-52 DNA_domain_or_region denotes promoter
T3 87-110 DNA_domain_or_region denotes iron-responsive element
T4 118-122 RNA_domain_or_region denotes mRNA
T5 124-150 protein_molecule denotes 5-Aminolevulinate synthase
T6 152-156 protein_molecule denotes ALAS
T7 190-194 protein_molecule denotes heme
T8 217-228 DNA_domain_or_region denotes cDNA clones
T9 237-265 protein_family_or_group denotes human erythroid ALAS isozyme
T10 287-298 tissue denotes fetal liver
T11 335-367 protein_molecule denotes erythroid ALAS precursor protein
T12 453-486 protein_molecule denotes human housekeeping ALAS precursor
T13 520-546 other_name denotes mature mitochondrial forms
T14 568-594 protein_family_or_group denotes housekeeping ALAS isozymes
T15 617-634 other_name denotes molecular weights
T16 681-689 protein_family_or_group denotes isozymes
T17 702-721 other_name denotes amino acid identity
T18 731-758 protein_domain_or_region denotes N-terminal signal sequences
T19 806-827 protein_domain_or_region denotes C-terminal two-thirds
T20 866-884 DNA_domain_or_region denotes immediate promoter
T21 892-917 DNA_domain_or_region denotes human erythroid ALAS gene
T22 944-982 DNA_domain_or_region denotes erythroid-specific cis-acting elements
T23 1000-1006 DNA_domain_or_region denotes GATA-1
T24 1014-1032 DNA_domain_or_region denotes NF-E2 binding site
T25 1037-1060 DNA_domain_or_region denotes iron-responsive element
T26 1100-1122 other_name denotes 5'-untranslated region
T27 1130-1155 RNA_molecule denotes human erythroid ALAS mRNA
T28 1183-1205 RNA_family_or_group denotes housekeeping ALAS mRNA
T29 1257-1266 RNA_domain_or_region denotes IRE motif
T30 1276-1297 protein_subunit denotes protein - RNA complex
T31 1303-1321 cell_component denotes cytosolic extracts
T32 1327-1343 cell_line denotes human K562 cells
T33 1388-1403 RNA_family_or_group denotes IRE transcripts
T34 1469-1477 DNA_domain_or_region denotes ALAS IRE
T35 1516-1519 DNA_domain_or_region denotes IRE
T36 1547-1568 protein_complex denotes protein - RNA complex
T37 1601-1610 RNA_domain_or_region denotes IRE motif
T38 1618-1627 RNA_domain_or_region denotes ALAS mRNA
T39 1676-1680 RNA_domain_or_region denotes mRNA
T40 1698-1724 other_name denotes cellular iron availability
T41 1732-1746 other_name denotes erythropoiesis