PubMed:20401977 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20401977","sourcedb":"PubMed","sourceid":"20401977","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20401977","text":"The human AHR: identification of single nucleotide polymorphisms from six ethnic populations.\nBACKGROUND: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like chemicals are mediated through binding-dependent activation of the cytosolic aryl hydrocarbon receptor (AHR). The human AHR is a low-affinity receptor relative to most rodents, but some reports suggest that there may be individuals with polymorphic high-affinity receptors, thereby possibly increasing the sensitivity to dioxins in such people.\nMETHODS: Although no polymorphisms have been reported in the ligand binding region of the AHR in the over 100 reported sequences, we sequenced 108 additional human AHR genes in an effort to further identify single single nucleotide polymorphisms (SNPs) within the open reading frames of the AHR locus. The DNA was sequenced from six ethnic populations that included Japanese, Chinese, European/Caucasian, African-American, South East Asian, and Hispanic.\nRESULTS: Six exonic SNPs were identified; four had been described as previously reported and two seem to be novel. Four of the SNPs identified lead to amino acid changes in the AHR protein and two of the SNPs lead to synonymous substitutions. An additional four SNPs have been reported elsewhere that were not identified in the current analysis. With these new sequences, more than 200 human AHR gene sequences have been analyzed for SNPs.\nCONCLUSION: The results indicate a very limited presence of polymorphisms in the core ligand binding region of the human AHR. Other regions, such as the transactivation domain, seem to be slightly more polymorphic in the human population and the impact on functionality should be further examined.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_20401977_2_0","span":{"begin":258,"end":283},"obj":"expanded"},{"id":"SS2_20401977_2_0","span":{"begin":285,"end":288},"obj":"abbr"},{"id":"SS1_20401977_5_0","span":{"begin":740,"end":771},"obj":"expanded"},{"id":"SS2_20401977_5_0","span":{"begin":773,"end":777},"obj":"abbr"}],"relations":[{"id":"AE1_20401977_2_0","pred":"abbreviatedTo","subj":"SS1_20401977_2_0","obj":"SS2_20401977_2_0"},{"id":"AE1_20401977_5_0","pred":"abbreviatedTo","subj":"SS1_20401977_5_0","obj":"SS2_20401977_5_0"}],"attributes":[{"subj":"SS1_20401977_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_20401977_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_20401977_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_20401977_5_0","pred":"source","obj":"Allie"}]},{"project":"LitCoin-entities","denotations":[{"id":"7201","span":{"begin":4,"end":9},"obj":"OrganismTaxon"},{"id":"7202","span":{"begin":10,"end":13},"obj":"GeneOrGeneProduct"},{"id":"7203","span":{"begin":121,"end":156},"obj":"ChemicalEntity"},{"id":"7204","span":{"begin":169,"end":175},"obj":"ChemicalEntity"},{"id":"7205","span":{"begin":258,"end":283},"obj":"GeneOrGeneProduct"},{"id":"7206","span":{"begin":285,"end":288},"obj":"GeneOrGeneProduct"},{"id":"7207","span":{"begin":295,"end":300},"obj":"OrganismTaxon"},{"id":"7208","span":{"begin":301,"end":304},"obj":"GeneOrGeneProduct"},{"id":"7209","span":{"begin":502,"end":509},"obj":"ChemicalEntity"},{"id":"7210","span":{"begin":616,"end":619},"obj":"GeneOrGeneProduct"},{"id":"7211","span":{"begin":684,"end":689},"obj":"OrganismTaxon"},{"id":"7212","span":{"begin":690,"end":693},"obj":"GeneOrGeneProduct"},{"id":"7213","span":{"begin":817,"end":820},"obj":"GeneOrGeneProduct"},{"id":"7214","span":{"begin":1158,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"7215","span":{"begin":1367,"end":1372},"obj":"OrganismTaxon"},{"id":"7216","span":{"begin":1373,"end":1376},"obj":"GeneOrGeneProduct"},{"id":"7217","span":{"begin":1536,"end":1541},"obj":"OrganismTaxon"},{"id":"7218","span":{"begin":1542,"end":1545},"obj":"GeneOrGeneProduct"},{"id":"7219","span":{"begin":1642,"end":1647},"obj":"OrganismTaxon"}],"attributes":[{"id":"A13","pred":"db_id","subj":"7213","obj":"NCBIGene:196"},{"id":"A4","pred":"db_id","subj":"7204","obj":"MESH:D004147"},{"id":"A9","pred":"db_id","subj":"7209","obj":"MESH:D004147"},{"id":"A3","pred":"db_id","subj":"7203","obj":"MESH:D000072317"},{"id":"A12","pred":"db_id","subj":"7212","obj":"NCBIGene:196"},{"id":"A10","pred":"db_id","subj":"7210","obj":"NCBIGene:196"},{"id":"A19","pred":"db_id","subj":"7219","obj":"NCBITaxon:9606"},{"id":"A14","pred":"db_id","subj":"7214","obj":"NCBIGene:196"},{"id":"A1","pred":"db_id","subj":"7201","obj":"NCBITaxon:9606"},{"id":"A5","pred":"db_id","subj":"7205","obj":"NCBIGene:196"},{"id":"A8","pred":"db_id","subj":"7208","obj":"NCBIGene:196"},{"id":"A16","pred":"db_id","subj":"7216","obj":"NCBIGene:196"},{"id":"A2","pred":"db_id","subj":"7202","obj":"NCBIGene:196"},{"id":"A7","pred":"db_id","subj":"7207","obj":"NCBITaxon:9606"},{"id":"A17","pred":"db_id","subj":"7217","obj":"NCBITaxon:9606"},{"id":"A6","pred":"db_id","subj":"7206","obj":"NCBIGene:196"},{"id":"A15","pred":"db_id","subj":"7215","obj":"NCBITaxon:9606"},{"id":"A18","pred":"db_id","subj":"7218","obj":"NCBIGene:196"},{"id":"A11","pred":"db_id","subj":"7211","obj":"NCBITaxon:9606"},{"subj":"7201","pred":"source","obj":"LitCoin-entities"},{"subj":"7202","pred":"source","obj":"LitCoin-entities"},{"subj":"7203","pred":"source","obj":"LitCoin-entities"},{"subj":"7204","pred":"source","obj":"LitCoin-entities"},{"subj":"7205","pred":"source","obj":"LitCoin-entities"},{"subj":"7206","pred":"source","obj":"LitCoin-entities"},{"subj":"7207","pred":"source","obj":"LitCoin-entities"},{"subj":"7208","pred":"source","obj":"LitCoin-entities"},{"subj":"7209","pred":"source","obj":"LitCoin-entities"},{"subj":"7210","pred":"source","obj":"LitCoin-entities"},{"subj":"7211","pred":"source","obj":"LitCoin-entities"},{"subj":"7212","pred":"source","obj":"LitCoin-entities"},{"subj":"7213","pred":"source","obj":"LitCoin-entities"},{"subj":"7214","pred":"source","obj":"LitCoin-entities"},{"subj":"7215","pred":"source","obj":"LitCoin-entities"},{"subj":"7216","pred":"source","obj":"LitCoin-entities"},{"subj":"7217","pred":"source","obj":"LitCoin-entities"},{"subj":"7218","pred":"source","obj":"LitCoin-entities"},{"subj":"7219","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T2","span":{"begin":94,"end":105},"obj":"Sentence"},{"id":"T3","span":{"begin":106,"end":290},"obj":"Sentence"},{"id":"T4","span":{"begin":291,"end":525},"obj":"Sentence"},{"id":"T5","span":{"begin":526,"end":534},"obj":"Sentence"},{"id":"T6","span":{"begin":535,"end":827},"obj":"Sentence"},{"id":"T7","span":{"begin":828,"end":980},"obj":"Sentence"},{"id":"T8","span":{"begin":981,"end":989},"obj":"Sentence"},{"id":"T9","span":{"begin":990,"end":1095},"obj":"Sentence"},{"id":"T10","span":{"begin":1096,"end":1223},"obj":"Sentence"},{"id":"T11","span":{"begin":1224,"end":1326},"obj":"Sentence"},{"id":"T12","span":{"begin":1327,"end":1420},"obj":"Sentence"},{"id":"T13","span":{"begin":1421,"end":1432},"obj":"Sentence"},{"id":"T14","span":{"begin":1433,"end":1546},"obj":"Sentence"},{"id":"T15","span":{"begin":1547,"end":1718},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"},{"subj":"T10","pred":"source","obj":"LitCoin-sentences"},{"subj":"T11","pred":"source","obj":"LitCoin-sentences"},{"subj":"T12","pred":"source","obj":"LitCoin-sentences"},{"subj":"T13","pred":"source","obj":"LitCoin-sentences"},{"subj":"T14","pred":"source","obj":"LitCoin-sentences"},{"subj":"T15","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":4,"end":9},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":295,"end":300},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":349,"end":356},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":684,"end":689},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1367,"end":1372},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1536,"end":1541},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1642,"end":1647},"obj":"OrganismTaxon"}],"attributes":[{"id":"A6","pred":"db_id","subj":"T6","obj":"NCBItxid:9606"},{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"NCBItxid:9989"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:9606"},{"id":"A7","pred":"db_id","subj":"T7","obj":"NCBItxid:9606"},{"id":"A4","pred":"db_id","subj":"T4","obj":"NCBItxid:9606"},{"id":"A5","pred":"db_id","subj":"T5","obj":"NCBItxid:9606"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T2","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T3","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T4","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T5","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T6","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T7","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":10,"end":13},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":176,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":195,"end":203},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":212,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":230,"end":240},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":248,"end":257},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":258,"end":283},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":285,"end":288},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":301,"end":309},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":301,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":323,"end":331},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":430,"end":434},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":444,"end":453},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":526,"end":533},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":594,"end":601},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":612,"end":619},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":616,"end":619},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":690,"end":693},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":790,"end":809},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":817,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":955,"end":959},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1089,"end":1094},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1132,"end":1142},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1154,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1158,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1162,"end":1169},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1373,"end":1376},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1461,"end":1468},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1502,"end":1506},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1514,"end":1521},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1542,"end":1545},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1547,"end":1552},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1574,"end":1589},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1609,"end":1617},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":1667,"end":1673},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T33","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T34","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T35","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":4,"end":9},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":295,"end":300},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":349,"end":356},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":684,"end":689},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1367,"end":1372},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1536,"end":1541},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1642,"end":1647},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T3","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T4","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T5","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T6","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T7","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":121,"end":156},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":169,"end":175},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":263,"end":274},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":502,"end":509},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1124,"end":1128},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":1190,"end":1194},"obj":"ChemicalEntity"}],"attributes":[{"id":"A6","pred":"ID:","subj":"T6","obj":"D006838"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_24632"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D000072317"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_28119"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D004147"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_36682"},{"id":"A5","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_134044"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D004147"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36682"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_23825"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D007854"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D007854"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":10,"end":13},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":176,"end":180},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":212,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":248,"end":257},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":258,"end":283},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":285,"end":288},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":301,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":323,"end":331},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":430,"end":434},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":594,"end":601},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":616,"end":619},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":690,"end":693},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":790,"end":809},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":817,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":955,"end":959},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1089,"end":1094},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1132,"end":1142},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1158,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1162,"end":1169},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1373,"end":1376},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1461,"end":1468},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1502,"end":1506},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1514,"end":1521},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1542,"end":1545},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1547,"end":1552},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1667,"end":1673},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":487,"end":498},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0000605"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":10,"end":13},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":258,"end":283},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":285,"end":288},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":301,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":616,"end":619},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":690,"end":693},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":817,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":955,"end":959},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1158,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1373,"end":1376},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1542,"end":1545},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T12","span":{"begin":1190,"end":1194},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1124,"end":1128},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":502,"end":509},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":263,"end":274},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":169,"end":175},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":121,"end":156},"obj":"ChemicalEntity"},{"id":"T66092","span":{"begin":1542,"end":1545},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1373,"end":1376},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1158,"end":1161},"obj":"GeneOrGeneProduct"},{"id":"T87584","span":{"begin":955,"end":959},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":817,"end":820},"obj":"GeneOrGeneProduct"},{"id":"T89937","span":{"begin":690,"end":693},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":616,"end":619},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":301,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T61696","span":{"begin":285,"end":288},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":258,"end":283},"obj":"GeneOrGeneProduct"},{"id":"T62968","span":{"begin":10,"end":13},"obj":"GeneOrGeneProduct"},{"id":"T41376","span":{"begin":1642,"end":1647},"obj":"OrganismTaxon"},{"id":"T91454","span":{"begin":1536,"end":1541},"obj":"OrganismTaxon"},{"id":"T82066","span":{"begin":1367,"end":1372},"obj":"OrganismTaxon"},{"id":"T6786","span":{"begin":684,"end":689},"obj":"OrganismTaxon"},{"id":"T63785","span":{"begin":349,"end":356},"obj":"OrganismTaxon"},{"id":"T88284","span":{"begin":295,"end":300},"obj":"OrganismTaxon"},{"id":"T88053","span":{"begin":4,"end":9},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D000072317"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_23825"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36682"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D004147"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D007854"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D007854"},{"id":"A5","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_134044"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_36682"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D004147"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_24632"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D006838"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_28119"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T66092","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T87584","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T89937","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T61696","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T62968","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T41376","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T91454","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T82066","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6786","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T63785","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T88284","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T88053","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#9d93ec","default":true},{"id":"LitCoin-entities","color":"#a3ec93"},{"id":"LitCoin-sentences","color":"#ec93bd"},{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#93d7ec"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ece793"},{"id":"LitCoin-NCBITaxon-2","color":"#cd93ec"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#93ecb3"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#ec9993"},{"id":"LitCoin_Mondo_095","color":"#93a7ec"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#c1ec93"},{"id":"LitCoin-training-merged","color":"#ec93db"}]}]}}