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PubMed:20401977 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes The human AHR: identification of single nucleotide polymorphisms from six ethnic populations.
T2 94-105 Sentence denotes BACKGROUND:
T3 106-290 Sentence denotes The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like chemicals are mediated through binding-dependent activation of the cytosolic aryl hydrocarbon receptor (AHR).
T4 291-525 Sentence denotes The human AHR is a low-affinity receptor relative to most rodents, but some reports suggest that there may be individuals with polymorphic high-affinity receptors, thereby possibly increasing the sensitivity to dioxins in such people.
T5 526-534 Sentence denotes METHODS:
T6 535-827 Sentence denotes Although no polymorphisms have been reported in the ligand binding region of the AHR in the over 100 reported sequences, we sequenced 108 additional human AHR genes in an effort to further identify single single nucleotide polymorphisms (SNPs) within the open reading frames of the AHR locus.
T7 828-980 Sentence denotes The DNA was sequenced from six ethnic populations that included Japanese, Chinese, European/Caucasian, African-American, South East Asian, and Hispanic.
T8 981-989 Sentence denotes RESULTS:
T9 990-1095 Sentence denotes Six exonic SNPs were identified; four had been described as previously reported and two seem to be novel.
T10 1096-1223 Sentence denotes Four of the SNPs identified lead to amino acid changes in the AHR protein and two of the SNPs lead to synonymous substitutions.
T11 1224-1326 Sentence denotes An additional four SNPs have been reported elsewhere that were not identified in the current analysis.
T12 1327-1420 Sentence denotes With these new sequences, more than 200 human AHR gene sequences have been analyzed for SNPs.
T13 1421-1432 Sentence denotes CONCLUSION:
T14 1433-1546 Sentence denotes The results indicate a very limited presence of polymorphisms in the core ligand binding region of the human AHR.
T15 1547-1718 Sentence denotes Other regions, such as the transactivation domain, seem to be slightly more polymorphic in the human population and the impact on functionality should be further examined.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 4-9 OrganismTaxon denotes human NCBItxid:9606
T2 295-300 OrganismTaxon denotes human NCBItxid:9606
T3 349-356 OrganismTaxon denotes rodents NCBItxid:9989
T4 684-689 OrganismTaxon denotes human NCBItxid:9606
T5 1367-1372 OrganismTaxon denotes human NCBItxid:9606
T6 1536-1541 OrganismTaxon denotes human NCBItxid:9606
T7 1642-1647 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7201 4-9 OrganismTaxon denotes human NCBITaxon:9606
7202 10-13 GeneOrGeneProduct denotes AHR NCBIGene:196
7203 121-156 ChemicalEntity denotes 2,3,7,8-tetrachlorodibenzo-p-dioxin MESH:D000072317
7204 169-175 ChemicalEntity denotes dioxin MESH:D004147
7205 258-283 GeneOrGeneProduct denotes aryl hydrocarbon receptor NCBIGene:196
7206 285-288 GeneOrGeneProduct denotes AHR NCBIGene:196
7207 295-300 OrganismTaxon denotes human NCBITaxon:9606
7208 301-304 GeneOrGeneProduct denotes AHR NCBIGene:196
7209 502-509 ChemicalEntity denotes dioxins MESH:D004147
7210 616-619 GeneOrGeneProduct denotes AHR NCBIGene:196
7211 684-689 OrganismTaxon denotes human NCBITaxon:9606
7212 690-693 GeneOrGeneProduct denotes AHR NCBIGene:196
7213 817-820 GeneOrGeneProduct denotes AHR NCBIGene:196
7214 1158-1161 GeneOrGeneProduct denotes AHR NCBIGene:196
7215 1367-1372 OrganismTaxon denotes human NCBITaxon:9606
7216 1373-1376 GeneOrGeneProduct denotes AHR NCBIGene:196
7217 1536-1541 OrganismTaxon denotes human NCBITaxon:9606
7218 1542-1545 GeneOrGeneProduct denotes AHR NCBIGene:196
7219 1642-1647 OrganismTaxon denotes human NCBITaxon:9606

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 10-13 GeneOrGeneProduct denotes AHR
T2 176-180 GeneOrGeneProduct denotes like
T3 195-203 GeneOrGeneProduct denotes mediated
T4 212-219 GeneOrGeneProduct denotes binding
T5 230-240 GeneOrGeneProduct denotes activation
T6 248-257 GeneOrGeneProduct denotes cytosolic
T7 258-283 GeneOrGeneProduct denotes aryl hydrocarbon receptor
T8 285-288 GeneOrGeneProduct denotes AHR
T9 301-309 GeneOrGeneProduct denotes AHR is a
T10 301-304 GeneOrGeneProduct denotes AHR
T11 323-331 GeneOrGeneProduct denotes receptor
T12 430-434 GeneOrGeneProduct denotes high
T13 444-453 GeneOrGeneProduct denotes receptors
T14 526-533 GeneOrGeneProduct denotes METHODS
T15 594-601 GeneOrGeneProduct denotes binding
T16 612-619 GeneOrGeneProduct denotes the AHR
T17 616-619 GeneOrGeneProduct denotes AHR
T18 690-693 GeneOrGeneProduct denotes AHR
T19 790-809 GeneOrGeneProduct denotes open reading frames
T20 817-820 GeneOrGeneProduct denotes AHR
T21 955-959 GeneOrGeneProduct denotes East
T22 1089-1094 GeneOrGeneProduct denotes novel
T23 1132-1142 GeneOrGeneProduct denotes amino acid
T24 1154-1161 GeneOrGeneProduct denotes the AHR
T25 1158-1161 GeneOrGeneProduct denotes AHR
T26 1162-1169 GeneOrGeneProduct denotes protein
T27 1373-1376 GeneOrGeneProduct denotes AHR
T28 1461-1468 GeneOrGeneProduct denotes limited
T29 1502-1506 GeneOrGeneProduct denotes core
T30 1514-1521 GeneOrGeneProduct denotes binding
T31 1542-1545 GeneOrGeneProduct denotes AHR
T32 1547-1552 GeneOrGeneProduct denotes Other
T33 1574-1589 GeneOrGeneProduct denotes transactivation
T34 1609-1617 GeneOrGeneProduct denotes slightly
T35 1667-1673 GeneOrGeneProduct denotes impact

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 10-13 GeneOrGeneProduct denotes AHR
T2 176-180 GeneOrGeneProduct denotes like
T3 212-219 GeneOrGeneProduct denotes binding
T4 248-257 GeneOrGeneProduct denotes cytosolic
T5 258-283 GeneOrGeneProduct denotes aryl hydrocarbon receptor
T6 285-288 GeneOrGeneProduct denotes AHR
T7 301-304 GeneOrGeneProduct denotes AHR
T8 323-331 GeneOrGeneProduct denotes receptor
T9 430-434 GeneOrGeneProduct denotes high
T10 594-601 GeneOrGeneProduct denotes binding
T11 616-619 GeneOrGeneProduct denotes AHR
T12 690-693 GeneOrGeneProduct denotes AHR
T13 790-809 GeneOrGeneProduct denotes open reading frames
T14 817-820 GeneOrGeneProduct denotes AHR
T15 955-959 GeneOrGeneProduct denotes East
T16 1089-1094 GeneOrGeneProduct denotes novel
T17 1132-1142 GeneOrGeneProduct denotes amino acid
T18 1158-1161 GeneOrGeneProduct denotes AHR
T19 1162-1169 GeneOrGeneProduct denotes protein
T20 1373-1376 GeneOrGeneProduct denotes AHR
T21 1461-1468 GeneOrGeneProduct denotes limited
T22 1502-1506 GeneOrGeneProduct denotes core
T23 1514-1521 GeneOrGeneProduct denotes binding
T24 1542-1545 GeneOrGeneProduct denotes AHR
T25 1547-1552 GeneOrGeneProduct denotes Other
T26 1667-1673 GeneOrGeneProduct denotes impact

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 10-13 GeneOrGeneProduct denotes AHR
T2 258-283 GeneOrGeneProduct denotes aryl hydrocarbon receptor
T3 285-288 GeneOrGeneProduct denotes AHR
T4 301-304 GeneOrGeneProduct denotes AHR
T5 616-619 GeneOrGeneProduct denotes AHR
T6 690-693 GeneOrGeneProduct denotes AHR
T7 817-820 GeneOrGeneProduct denotes AHR
T8 955-959 GeneOrGeneProduct denotes East
T9 1158-1161 GeneOrGeneProduct denotes AHR
T10 1373-1376 GeneOrGeneProduct denotes AHR
T11 1542-1545 GeneOrGeneProduct denotes AHR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 487-498 DiseaseOrPhenotypicFeature denotes sensitivity 0000605

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 121-156 ChemicalEntity denotes 2,3,7,8-tetrachlorodibenzo-p-dioxin D000072317|http://purl.obolibrary.org/obo/CHEBI_28119
T3 169-175 ChemicalEntity denotes dioxin D004147|http://purl.obolibrary.org/obo/CHEBI_36682|http://purl.obolibrary.org/obo/CHEBI_134044
T6 263-274 ChemicalEntity denotes hydrocarbon D006838|http://purl.obolibrary.org/obo/CHEBI_24632
T8 502-509 ChemicalEntity denotes dioxins D004147|http://purl.obolibrary.org/obo/CHEBI_36682|http://purl.obolibrary.org/obo/CHEBI_23825
T11 1124-1128 ChemicalEntity denotes lead D007854
T12 1190-1194 ChemicalEntity denotes lead D007854

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 4-9 OrganismTaxon denotes human
T2 295-300 OrganismTaxon denotes human
T3 349-356 OrganismTaxon denotes rodents
T4 684-689 OrganismTaxon denotes human
T5 1367-1372 OrganismTaxon denotes human
T6 1536-1541 OrganismTaxon denotes human
T7 1642-1647 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue ID:
T12 1190-1194 ChemicalEntity denotes lead D007854
T11 1124-1128 ChemicalEntity denotes lead D007854
T8 502-509 ChemicalEntity denotes dioxins http://purl.obolibrary.org/obo/CHEBI_23825|http://purl.obolibrary.org/obo/CHEBI_36682|D004147
T6 263-274 ChemicalEntity denotes hydrocarbon http://purl.obolibrary.org/obo/CHEBI_24632|D006838
T3 169-175 ChemicalEntity denotes dioxin http://purl.obolibrary.org/obo/CHEBI_134044|http://purl.obolibrary.org/obo/CHEBI_36682|D004147
T1 121-156 ChemicalEntity denotes 2,3,7,8-tetrachlorodibenzo-p-dioxin D000072317|http://purl.obolibrary.org/obo/CHEBI_28119
T66092 1542-1545 GeneOrGeneProduct denotes AHR
T10 1373-1376 GeneOrGeneProduct denotes AHR
T9 1158-1161 GeneOrGeneProduct denotes AHR
T87584 955-959 GeneOrGeneProduct denotes East
T7 817-820 GeneOrGeneProduct denotes AHR
T89937 690-693 GeneOrGeneProduct denotes AHR
T5 616-619 GeneOrGeneProduct denotes AHR
T4 301-304 GeneOrGeneProduct denotes AHR
T61696 285-288 GeneOrGeneProduct denotes AHR
T2 258-283 GeneOrGeneProduct denotes aryl hydrocarbon receptor
T62968 10-13 GeneOrGeneProduct denotes AHR
T41376 1642-1647 OrganismTaxon denotes human
T91454 1536-1541 OrganismTaxon denotes human
T82066 1367-1372 OrganismTaxon denotes human
T6786 684-689 OrganismTaxon denotes human
T63785 349-356 OrganismTaxon denotes rodents
T88284 295-300 OrganismTaxon denotes human
T88053 4-9 OrganismTaxon denotes human

Allie

Id Subject Object Predicate Lexical cue
SS1_20401977_2_0 258-283 expanded denotes aryl hydrocarbon receptor
SS2_20401977_2_0 285-288 abbr denotes AHR
SS1_20401977_5_0 740-771 expanded denotes single nucleotide polymorphisms
SS2_20401977_5_0 773-777 abbr denotes SNPs
AE1_20401977_2_0 SS1_20401977_2_0 SS2_20401977_2_0 abbreviatedTo aryl hydrocarbon receptor,AHR
AE1_20401977_5_0 SS1_20401977_5_0 SS2_20401977_5_0 abbreviatedTo single nucleotide polymorphisms,SNPs