PubMed:20385360
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20385360","sourcedb":"PubMed","sourceid":"20385360","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20385360","text":"A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.\nTranscriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly, lipid metabolism genes are important for transformation and are upregulated in cancer tissues. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation. OLR1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth, suggesting a molecular connection between cancer and atherosclerosis. We suggest that the interplay between this common transcriptional program and cell-type-specific factors gives rise to phenotypically disparate human diseases.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":218,"end":224},"obj":"HP_0002664"},{"id":"T2","span":{"begin":416,"end":421},"obj":"HP_0002664"},{"id":"T3","span":{"begin":523,"end":529},"obj":"HP_0002664"},{"id":"T4","span":{"begin":545,"end":560},"obj":"HP_0002621"},{"id":"T5","span":{"begin":760,"end":766},"obj":"HP_0002664"},{"id":"T6","span":{"begin":786,"end":791},"obj":"HP_0002664"},{"id":"T7","span":{"begin":842,"end":848},"obj":"HP_0002664"},{"id":"T8","span":{"begin":853,"end":868},"obj":"HP_0002621"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":592,"end":596},"obj":"gene:4973"},{"id":"T1","span":{"begin":545,"end":560},"obj":"disease:C0003850"},{"id":"T2","span":{"begin":592,"end":596},"obj":"gene:4973"},{"id":"T3","span":{"begin":545,"end":560},"obj":"disease:C0004153"},{"id":"T4","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T5","span":{"begin":842,"end":848},"obj":"disease:C0006826"},{"id":"T6","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T7","span":{"begin":760,"end":766},"obj":"disease:C1306459"},{"id":"T8","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T9","span":{"begin":760,"end":766},"obj":"disease:C0006826"},{"id":"T10","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T11","span":{"begin":842,"end":848},"obj":"disease:C1306459"},{"id":"T12","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T13","span":{"begin":853,"end":868},"obj":"disease:C0003850"},{"id":"T14","span":{"begin":677,"end":681},"obj":"gene:4973"},{"id":"T15","span":{"begin":853,"end":868},"obj":"disease:C0004153"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"20385360-5#0#4#gene4973","span":{"begin":677,"end":681},"obj":"gene4973"},{"id":"20385360-5#176#191#diseaseC0003850","span":{"begin":853,"end":868},"obj":"diseaseC0003850"},{"id":"20385360-5#176#191#diseaseC0004153","span":{"begin":853,"end":868},"obj":"diseaseC0004153"}],"relations":[{"id":"0#4#gene4973176#191#diseaseC0003850","pred":"associated_with","subj":"20385360-5#0#4#gene4973","obj":"20385360-5#176#191#diseaseC0003850"},{"id":"0#4#gene4973176#191#diseaseC0004153","pred":"associated_with","subj":"20385360-5#0#4#gene4973","obj":"20385360-5#176#191#diseaseC0004153"}],"attributes":[{"subj":"20385360-5#0#4#gene4973","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20385360-5#176#191#diseaseC0003850","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20385360-5#176#191#diseaseC0004153","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"3","span":{"begin":58,"end":64},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4","span":{"begin":70,"end":75},"obj":"ChemicalEntity"},{"id":"5","span":{"begin":99,"end":104},"obj":"OrganismTaxon"},{"id":"21","span":{"begin":218,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"22","span":{"begin":247,"end":265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"23","span":{"begin":352,"end":360},"obj":"DiseaseOrPhenotypicFeature"},{"id":"24","span":{"begin":365,"end":388},"obj":"DiseaseOrPhenotypicFeature"},{"id":"25","span":{"begin":416,"end":421},"obj":"DiseaseOrPhenotypicFeature"},{"id":"26","span":{"begin":444,"end":449},"obj":"ChemicalEntity"},{"id":"27","span":{"begin":523,"end":529},"obj":"DiseaseOrPhenotypicFeature"},{"id":"28","span":{"begin":545,"end":560},"obj":"DiseaseOrPhenotypicFeature"},{"id":"29","span":{"begin":592,"end":596},"obj":"GeneOrGeneProduct"},{"id":"30","span":{"begin":677,"end":681},"obj":"GeneOrGeneProduct"},{"id":"31","span":{"begin":760,"end":766},"obj":"DiseaseOrPhenotypicFeature"},{"id":"32","span":{"begin":786,"end":791},"obj":"DiseaseOrPhenotypicFeature"},{"id":"33","span":{"begin":842,"end":848},"obj":"DiseaseOrPhenotypicFeature"},{"id":"34","span":{"begin":853,"end":868},"obj":"DiseaseOrPhenotypicFeature"},{"id":"35","span":{"begin":1014,"end":1019},"obj":"OrganismTaxon"}],"attributes":[{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"Tax:9606"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D009369"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:4973"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D050197"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D009369"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D009369"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D009369"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D008055"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:9606"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D050197"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D009369"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D008055"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D009369"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D009369"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:D008659"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"MESH:D003920"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Gene:4973"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:D002318"},{"subj":"3","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"4","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"5","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"21","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"22","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"23","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"24","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"25","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"26","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"27","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"28","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"29","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"30","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"31","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"32","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"33","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"34","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"35","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":58,"end":64},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":105,"end":113},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":218,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":230,"end":242},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":247,"end":265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":352,"end":360},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":365,"end":388},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":416,"end":421},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":523,"end":529},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":545,"end":560},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":610,"end":622},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":760,"end":766},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":786,"end":791},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":842,"end":848},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":853,"end":868},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1020,"end":1028},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"ID:","subj":"T13","obj":"D009369"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D002318"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D050197"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D008659"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D009369"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D004194"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D050197"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D009369"},{"id":"A11","pred":"ID:","subj":"T11","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D009369"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D009369"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D009369"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D009369"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D004194"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T13","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T15","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T16","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":58,"end":64},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":218,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":247,"end":265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":352,"end":360},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":365,"end":388},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":416,"end":421},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":523,"end":529},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":545,"end":560},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":760,"end":766},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":786,"end":791},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":842,"end":848},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":853,"end":868},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"#label","subj":"T6","obj":"D009369"},{"id":"A4","pred":"#label","subj":"T4","obj":"DISEASE"},{"id":"A1","pred":"#label","subj":"T1","obj":"D009369"},{"id":"A5","pred":"#label","subj":"T5","obj":"D002318"},{"id":"A9","pred":"#label","subj":"T9","obj":"D009369"},{"id":"A11","pred":"#label","subj":"T11","obj":"D009369"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"},{"id":"A10","pred":"#label","subj":"T10","obj":"D009369"},{"id":"A3","pred":"#label","subj":"T3","obj":"D008659"},{"id":"A2","pred":"#label","subj":"T2","obj":"D009369"},{"id":"A8","pred":"#label","subj":"T8","obj":"D050197"},{"id":"A12","pred":"#label","subj":"T12","obj":"D050197"},{"subj":"T1","pred":"source","obj":"LitEisuke"},{"subj":"T2","pred":"source","obj":"LitEisuke"},{"subj":"T3","pred":"source","obj":"LitEisuke"},{"subj":"T4","pred":"source","obj":"LitEisuke"},{"subj":"T5","pred":"source","obj":"LitEisuke"},{"subj":"T6","pred":"source","obj":"LitEisuke"},{"subj":"T7","pred":"source","obj":"LitEisuke"},{"subj":"T8","pred":"source","obj":"LitEisuke"},{"subj":"T9","pred":"source","obj":"LitEisuke"},{"subj":"T10","pred":"source","obj":"LitEisuke"},{"subj":"T11","pred":"source","obj":"LitEisuke"},{"subj":"T12","pred":"source","obj":"LitEisuke"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T2","span":{"begin":115,"end":266},"obj":"Sentence"},{"id":"T3","span":{"begin":267,"end":429},"obj":"Sentence"},{"id":"T4","span":{"begin":430,"end":538},"obj":"Sentence"},{"id":"T5","span":{"begin":539,"end":676},"obj":"Sentence"},{"id":"T6","span":{"begin":677,"end":869},"obj":"Sentence"},{"id":"T7","span":{"begin":870,"end":1029},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T2","span":{"begin":115,"end":266},"obj":"Sentence"},{"id":"T3","span":{"begin":267,"end":429},"obj":"Sentence"},{"id":"T4","span":{"begin":430,"end":538},"obj":"Sentence"},{"id":"T5","span":{"begin":539,"end":676},"obj":"Sentence"},{"id":"T6","span":{"begin":677,"end":869},"obj":"Sentence"},{"id":"T7","span":{"begin":870,"end":1029},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#939cec","default":true},{"id":"DisGeNET","color":"#b6ec93"},{"id":"DisGeNET5_gene_disease","color":"#ec93d0"},{"id":"LitCoin-PubTator-for-Tuning","color":"#93ebec"},{"id":"LitCoin-Disease-Tuning-1","color":"#ecd393"},{"id":"LitEisuke","color":"#b993ec"},{"id":"Inflammaging","color":"#93ec9f"}]}]}}