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PubMed:2010090 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 2-24 protein denotes thymus-specific member
T2 32-50 protein denotes HMG protein family
T3 65-103 DNA denotes human T cell receptor C alpha enhancer
T4 109-151 protein denotes human T cell-specific transcription factor
T5 152-163 protein denotes TCF-1 alpha
T6 222-237 protein denotes T cell receptor
T7 239-242 protein denotes TCR
T8 274-298 DNA denotes pyrimidine-rich elements
T9 345-376 DNA denotes T cell-specific control regions
T10 433-462 protein denotes DNA affinity-purified protein
T11 485-496 DNA denotes cDNA clones
T12 506-517 protein denotes TCF-1 alpha
T13 523-539 DNA denotes TCF-1 alpha cDNA
T14 558-578 protein denotes 68-amino-acid domain
T15 626-645 protein denotes high-mobility group
T16 647-650 protein denotes HMG
T17 656-687 protein denotes nonhistone chromosomal proteins
T18 703-714 DNA denotes full-length
T19 719-737 DNA denotes mutant cDNA clones
T20 766-782 protein denotes single HMG motif
T21 827-849 protein denotes alpha-helical segments
T22 908-919 protein denotes TCF-1 alpha
T23 979-995 RNA denotes TCF-1 alpha mRNA
T24 1046-1068 cell_line denotes thymus or T cell lines
T25 1074-1098 cell_line denotes immature CEM T cell line
T26 1134-1150 RNA denotes TCF-1 alpha mRNA
T27 1248-1267 protein denotes TCF-1 alpha protein
T28 1280-1305 protein denotes transcriptional activator
T29 1313-1337 DNA denotes human TCR alpha enhancer
T30 1341-1363 cell_line denotes nonlymphoid cell lines
T31 1393-1411 protein denotes endogenous protein
T32 1415-1427 cell_line denotes T cell lines
T33 1467-1490 cell_line denotes T cell-specific protein
T34 1530-1541 protein denotes TCF-1 alpha
T35 1597-1628 protein denotes DNA-binding regulatory proteins
T36 1644-1653 protein denotes HMG motif
T37 1670-1710 protein denotes highly tissue-specific RNA polymerase II
T38 1711-1731 protein denotes transcription factor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.
S2 105-377 Sentence denotes The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions.
S3 378-518 Sentence denotes Using amino acid sequence information derived from the DNA affinity-purified protein, we have now isolated cDNA clones encoding TCF-1 alpha.
S4 519-688 Sentence denotes The TCF-1 alpha cDNA contains a single 68-amino-acid domain that is homologous to a region conserved among high-mobility group (HMG) and nonhistone chromosomal proteins.
S5 689-927 Sentence denotes Expression of full-length and mutant cDNA clones in bacteria reveal that the single HMG motif, which is predicted to contain two extended alpha-helical segments, is sufficient to direct the sequence-specific binding of TCF-1 alpha to DNA.
S6 928-1069 Sentence denotes Northern blot experiments demonstrate further that TCF-1 alpha mRNA is highly tissue specific, found primarily in the thymus or T cell lines.
S7 1070-1221 Sentence denotes The immature CEM T cell line expresses relatively low levels of TCF-1 alpha mRNA, which are increased upon activation of these cells by phorbol esters.
S8 1222-1529 Sentence denotes Interestingly, the cloned TCF-1 alpha protein is a potent transcriptional activator of the human TCR alpha enhancer in nonlymphoid cell lines, whereas the activity of the endogenous protein in T cell lines is strongly dependent on an additional T cell-specific protein that interacts with the core enhancer.
S9 1530-1732 Sentence denotes TCF-1 alpha is currently unique among the newly emerging family of DNA-binding regulatory proteins that share the HMG motif in that it is a highly tissue-specific RNA polymerase II transcription factor.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 32-35 NP denotes HMG
C3 61-86 NP denotes the human T cell receptor
C2 61-103 NP denotes the human T cell receptor C alpha enhancer
C4 105-151 NP denotes The human T cell-specific transcription factor
C5 152-163 NP denotes TCF-1 alpha
C7 218-243 NP denotes the T cell receptor (TCR)
C6 218-260 NP denotes the T cell receptor (TCR) C alpha enhancer
C9 506-517 NP denotes TCF-1 alpha
C8 485-517 NP denotes cDNA clones encoding TCF-1 alpha
C10 519-539 NP denotes The TCF-1 alpha cDNA
C11 626-651 NP denotes high-mobility group (HMG)
C13 773-776 NP denotes HMG
C12 762-782 NP denotes the single HMG motif
C14 784-789 NP denotes which
C15 908-919 NP denotes TCF-1 alpha
C17 979-990 NP denotes TCF-1 alpha
C16 979-995 NP denotes TCF-1 alpha mRNA
C18 1070-1098 NP denotes The immature CEM T cell line
C20 1134-1145 NP denotes TCF-1 alpha
C19 1134-1150 NP denotes TCF-1 alpha mRNA
C21 1152-1157 NP denotes which
C22 1191-1202 NP denotes these cells
C23 1248-1259 NP denotes TCF-1 alpha
C24 1309-1337 NP denotes the human TCR alpha enhancer
C25 1530-1541 NP denotes TCF-1 alpha
C26 1644-1647 NP denotes HMG
C28 1640-1653 NP denotes the HMG motif
C27 1662-1664 NP denotes it
R1 C5 C4 coref-appos TCF-1 alpha,The human T cell-specific transcription factor
R2 C7 C3 coref-ident the T cell receptor (TCR),the human T cell receptor
R3 C6 C2 coref-ident the T cell receptor (TCR) C alpha enhancer,the human T cell receptor C alpha enhancer
R4 C9 C5 coref-ident TCF-1 alpha,TCF-1 alpha
R5 C10 C8 coref-other The TCF-1 alpha cDNA,cDNA clones encoding TCF-1 alpha
R6 C11 C1 coref-ident high-mobility group (HMG),HMG
R7 C13 C11 coref-ident HMG,high-mobility group (HMG)
R8 C14 C12 coref-relat which,the single HMG motif
R9 C15 C9 coref-ident TCF-1 alpha,TCF-1 alpha
R10 C17 C15 coref-ident TCF-1 alpha,TCF-1 alpha
R11 C20 C17 coref-ident TCF-1 alpha,TCF-1 alpha
R12 C19 C16 coref-ident TCF-1 alpha mRNA,TCF-1 alpha mRNA
R13 C21 C19 coref-relat which,TCF-1 alpha mRNA
R14 C22 C18 coref-ident these cells,The immature CEM T cell line
R15 C23 C20 coref-ident TCF-1 alpha,TCF-1 alpha
R16 C24 C6 coref-ident the human TCR alpha enhancer,the T cell receptor (TCR) C alpha enhancer
R17 C25 C23 coref-ident TCF-1 alpha,TCF-1 alpha
R18 C26 C13 coref-ident HMG,HMG
R19 C28 C12 coref-other the HMG motif,the single HMG motif
R20 C27 C25 coref-pron it,TCF-1 alpha

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-24 protein_family_or_group denotes thymus-specific member
T2 32-50 protein_family_or_group denotes HMG protein family
T3 65-94 protein_subunit denotes human T cell receptor C alpha
T4 109-130 protein_family_or_group denotes human T cell-specific
T5 131-151 protein_family_or_group denotes transcription factor
T6 152-163 protein_molecule denotes TCF-1 alpha
T7 222-237 protein_family_or_group denotes T cell receptor
T8 239-242 protein_family_or_group denotes TCR
T9 274-284 nucleotide denotes pyrimidine
T10 300-313 polynucleotide denotes 5'-PyCTTTG-3'
T11 345-376 DNA_domain_or_region denotes T cell-specific control regions
T12 384-403 protein_N/A denotes amino acid sequence
T13 433-462 protein_molecule denotes DNA affinity-purified protein
T14 485-496 DNA_family_or_group denotes cDNA clones
T15 506-517 protein_molecule denotes TCF-1 alpha
T16 523-539 DNA_family_or_group denotes TCF-1 alpha cDNA
T17 558-578 protein_domain_or_region denotes 68-amino-acid domain
T18 626-645 protein_family_or_group denotes high-mobility group
T19 647-650 protein_family_or_group denotes HMG
T20 656-687 protein_family_or_group denotes nonhistone chromosomal proteins
T21 703-714 DNA_family_or_group denotes full-length
T22 719-737 DNA_family_or_group denotes mutant cDNA clones
T23 827-849 protein_domain_or_region denotes alpha-helical segments
T24 908-919 protein_molecule denotes TCF-1 alpha
T25 928-953 other_name denotes Northern blot experiments
T26 979-990 protein_molecule denotes TCF-1 alpha
T27 1074-1098 cell_line denotes immature CEM T cell line
T28 1134-1145 protein_molecule denotes TCF-1 alpha
T29 1206-1220 other_organic_compound denotes phorbol esters
T30 1248-1259 protein_molecule denotes TCF-1 alpha
T31 1280-1305 protein_family_or_group denotes transcriptional activator
T32 1313-1337 DNA_domain_or_region denotes human TCR alpha enhancer
T33 1341-1363 cell_line denotes nonlymphoid cell lines
T34 1393-1411 protein_family_or_group denotes endogenous protein
T35 1415-1427 cell_line denotes T cell lines
T36 1467-1490 cell_line denotes T cell-specific protein
T37 1530-1541 protein_molecule denotes TCF-1 alpha
T38 1597-1628 protein_family_or_group denotes DNA-binding regulatory proteins
T39 1670-1710 protein_molecule denotes highly tissue-specific RNA polymerase II
T40 1711-1731 protein_family_or_group denotes transcription factor