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PubMed:20005218 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-165 Sentence denotes A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population.
T2 166-177 Sentence denotes BACKGROUND:
T3 178-276 Sentence denotes Mice with defects in the Klotho gene exhibit multiple aging phenotypes including arteriosclerosis.
T4 277-434 Sentence denotes We hypothesised that the G-395A polymorphism in the promoter region of the human Klotho gene may contribute to the prevalence of Essential Hypertension (EH).
T5 435-443 Sentence denotes METHODS:
T6 444-608 Sentence denotes We investigate whether the G-395A polymorphism of Klotho is associated with EH in a population consisting of 215 patients with EH and 220 non-hypertensive subjects.
T7 609-755 Sentence denotes We also tested whether a G/A substitution at the G-395A site affected the transcription level in vitro through the dual-luciferase reporter assay.
T8 756-764 Sentence denotes RESULTS:
T9 765-917 Sentence denotes Differences in the genotype distributions of the G-395A polymorphism between the EH and non-hypertension groups are statistically significant (P=0.032).
T10 918-1157 Sentence denotes There are differential effects of age, gender and smoking status on the association of the G-395A polymorphism with EH; the G-395A polymorphism is significantly associated with EH in subjects over 60years old, in females and in nonsmokers.
T11 1158-1372 Sentence denotes A multiple logistic regression analysis indicated that the odds ratio for EH in the -395A allele carriers as compared with the control group was 0.593 (P=0.024) after adjusting for current traditional risk factors.
T12 1373-1585 Sentence denotes The dual-luciferase reporter assay revealed that the -395A carrier of a 498-bp DNA fragment (containing the G-395A site) upstream of the Klotho gene has higher relative luciferase activity than the -395G carrier.
T13 1586-1598 Sentence denotes CONCLUSIONS:
T14 1599-1709 Sentence denotes The G-395A polymorphism of the human Klotho gene is associated with EH and may be a potential regulatory site.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 178-182 OrganismTaxon denotes Mice NCBItxid:10095|NCBItxid:10088
T3 352-357 OrganismTaxon denotes human NCBItxid:9606
T4 1630-1635 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6859 77-83 GeneOrGeneProduct denotes Klotho NCBIGene:9365
6860 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension MESH:D000075222
6861 178-182 OrganismTaxon denotes Mice NCBITaxon:10090
6862 203-209 GeneOrGeneProduct denotes Klotho NCBIGene:16591
6863 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis MESH:D001161
6864 302-308 SequenceVariant denotes G-395A DBSNP:rs1207568
6865 352-357 OrganismTaxon denotes human NCBITaxon:9606
6866 358-364 GeneOrGeneProduct denotes Klotho NCBIGene:9365
6867 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension MESH:D000075222
6868 430-432 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6869 471-477 SequenceVariant denotes G-395A DBSNP:rs1207568
6870 494-500 GeneOrGeneProduct denotes Klotho NCBIGene:9365
6871 520-522 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6872 557-565 OrganismTaxon denotes patients NCBITaxon:9606
6873 571-573 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6874 586-598 DiseaseOrPhenotypicFeature denotes hypertensive MESH:D006973
6875 634-637 SequenceVariant denotes G/A DBSNP:rs1207568
6876 658-664 SequenceVariant denotes G-395A DBSNP:rs1207568
6877 814-820 SequenceVariant denotes G-395A DBSNP:rs1207568
6878 846-848 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6879 857-869 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
6880 1009-1015 SequenceVariant denotes G-395A DBSNP:rs1207568
6881 1034-1036 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6882 1042-1048 SequenceVariant denotes G-395A DBSNP:rs1207568
6883 1095-1097 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6884 1232-1234 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222
6885 1242-1247 SequenceVariant denotes -395A DBSNP:rs1207568
6886 1426-1431 SequenceVariant denotes -395A DBSNP:rs1207568
6887 1481-1487 SequenceVariant denotes G-395A DBSNP:rs1207568
6888 1510-1516 GeneOrGeneProduct denotes Klotho NCBIGene:9365
6889 1571-1576 SequenceVariant denotes -395G DBSNP:rs1207568
6890 1603-1609 SequenceVariant denotes G-395A DBSNP:rs1207568
6891 1630-1635 OrganismTaxon denotes human NCBITaxon:9606
6892 1636-1642 GeneOrGeneProduct denotes Klotho NCBIGene:9365
6893 1667-1669 DiseaseOrPhenotypicFeature denotes EH MESH:D000075222

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension 0001134
T2 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension 0001134

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 302-308 SequenceVariant denotes G-395A
T2 471-477 SequenceVariant denotes G-395A
T3 658-664 SequenceVariant denotes G-395A
T4 814-820 SequenceVariant denotes G-395A
T5 1009-1015 SequenceVariant denotes G-395A
T6 1042-1048 SequenceVariant denotes G-395A
T7 1243-1247 SequenceVariant denotes 395A
T8 1427-1431 SequenceVariant denotes 395A
T9 1481-1487 SequenceVariant denotes G-395A
T10 1572-1576 SequenceVariant denotes 395G
T11 1603-1609 SequenceVariant denotes G-395A

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 77-83 GeneOrGeneProduct denotes Klotho
T2 122-134 GeneOrGeneProduct denotes hypertension
T3 178-182 GeneOrGeneProduct denotes Mice
T4 188-195 GeneOrGeneProduct denotes defects
T5 203-209 GeneOrGeneProduct denotes Klotho
T6 223-231 GeneOrGeneProduct denotes multiple
T7 358-364 GeneOrGeneProduct denotes Klotho
T8 416-428 GeneOrGeneProduct denotes Hypertension
T9 430-432 GeneOrGeneProduct denotes EH
T10 435-442 GeneOrGeneProduct denotes METHODS
T11 494-500 GeneOrGeneProduct denotes Klotho
T12 520-522 GeneOrGeneProduct denotes EH
T13 523-527 GeneOrGeneProduct denotes in a
T14 571-573 GeneOrGeneProduct denotes EH
T15 586-598 GeneOrGeneProduct denotes hypertensive
T16 617-623 GeneOrGeneProduct denotes tested
T17 683-696 GeneOrGeneProduct denotes transcription
T18 729-739 GeneOrGeneProduct denotes luciferase
T19 846-848 GeneOrGeneProduct denotes EH
T20 857-869 GeneOrGeneProduct denotes hypertension
T21 1034-1036 GeneOrGeneProduct denotes EH
T22 1095-1097 GeneOrGeneProduct denotes EH
T23 1160-1168 GeneOrGeneProduct denotes multiple
T24 1232-1234 GeneOrGeneProduct denotes EH
T25 1255-1263 GeneOrGeneProduct denotes carriers
T26 1364-1371 GeneOrGeneProduct denotes factors
T27 1382-1392 GeneOrGeneProduct denotes luciferase
T28 1432-1439 GeneOrGeneProduct denotes carrier
T29 1510-1516 GeneOrGeneProduct denotes Klotho
T30 1542-1552 GeneOrGeneProduct denotes luciferase
T31 1553-1561 GeneOrGeneProduct denotes activity
T32 1577-1584 GeneOrGeneProduct denotes carrier
T33 1636-1642 GeneOrGeneProduct denotes Klotho
T34 1667-1669 GeneOrGeneProduct denotes EH
T35 1674-1682 GeneOrGeneProduct denotes may be a

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 77-83 GeneOrGeneProduct denotes Klotho
T2 122-134 GeneOrGeneProduct denotes hypertension
T3 203-209 GeneOrGeneProduct denotes Klotho
T4 223-231 GeneOrGeneProduct denotes multiple
T5 358-364 GeneOrGeneProduct denotes Klotho
T6 416-428 GeneOrGeneProduct denotes Hypertension
T7 494-500 GeneOrGeneProduct denotes Klotho
T8 683-696 GeneOrGeneProduct denotes transcription
T9 729-739 GeneOrGeneProduct denotes luciferase
T10 857-869 GeneOrGeneProduct denotes hypertension
T11 1160-1168 GeneOrGeneProduct denotes multiple
T12 1382-1392 GeneOrGeneProduct denotes luciferase
T13 1432-1439 GeneOrGeneProduct denotes carrier
T14 1510-1516 GeneOrGeneProduct denotes Klotho
T15 1542-1552 GeneOrGeneProduct denotes luciferase
T16 1577-1584 GeneOrGeneProduct denotes carrier
T17 1636-1642 GeneOrGeneProduct denotes Klotho

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension D000075222
T2 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis D001161
T3 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension D000075222
T4 430-432 DiseaseOrPhenotypicFeature denotes EH D000075222
T5 520-522 DiseaseOrPhenotypicFeature denotes EH D000075222
T6 571-573 DiseaseOrPhenotypicFeature denotes EH D000075222
T7 586-598 DiseaseOrPhenotypicFeature denotes hypertensive D006973
T8 846-848 DiseaseOrPhenotypicFeature denotes EH D000075222
T9 857-869 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 1034-1036 DiseaseOrPhenotypicFeature denotes EH D000075222
T11 1095-1097 DiseaseOrPhenotypicFeature denotes EH D000075222
T12 1232-1234 DiseaseOrPhenotypicFeature denotes EH D000075222
T13 1667-1669 DiseaseOrPhenotypicFeature denotes EH D000075222

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 77-83 GeneOrGeneProduct denotes Klotho
T2 203-209 GeneOrGeneProduct denotes Klotho
T3 358-364 GeneOrGeneProduct denotes Klotho
T4 494-500 GeneOrGeneProduct denotes Klotho
T5 1510-1516 GeneOrGeneProduct denotes Klotho
T6 1636-1642 GeneOrGeneProduct denotes Klotho

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension 0001134
T2 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis 0002277
T3 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension 0001134
T4 430-432 DiseaseOrPhenotypicFeature denotes EH 0001134
T5 520-522 DiseaseOrPhenotypicFeature denotes EH 0001134
T6 571-573 DiseaseOrPhenotypicFeature denotes EH 0001134
T7 846-848 DiseaseOrPhenotypicFeature denotes EH 0001134
T8 857-869 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T9 1034-1036 DiseaseOrPhenotypicFeature denotes EH 0001134
T10 1095-1097 DiseaseOrPhenotypicFeature denotes EH 0001134
T11 1232-1234 DiseaseOrPhenotypicFeature denotes EH 0001134
T12 1667-1669 DiseaseOrPhenotypicFeature denotes EH 0001134

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension D000075222
T2 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis D001161
T3 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension D000075222
T4 430-432 DiseaseOrPhenotypicFeature denotes EH D000075222
T5 520-522 DiseaseOrPhenotypicFeature denotes EH D000075222
T6 571-573 DiseaseOrPhenotypicFeature denotes EH D000075222
T7 846-848 DiseaseOrPhenotypicFeature denotes EH D000075222
T8 857-869 DiseaseOrPhenotypicFeature denotes hypertension D006973
T9 1034-1036 DiseaseOrPhenotypicFeature denotes EH D000075222
T10 1095-1097 DiseaseOrPhenotypicFeature denotes EH D000075222
T11 1232-1234 DiseaseOrPhenotypicFeature denotes EH D000075222
T12 1667-1669 DiseaseOrPhenotypicFeature denotes EH D000075222

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension D000075222
T2 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis D001161
T3 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension D000075222
T4 430-432 DiseaseOrPhenotypicFeature denotes EH D000075222
T5 520-522 DiseaseOrPhenotypicFeature denotes EH D000075222
T6 571-573 DiseaseOrPhenotypicFeature denotes EH D000075222
T7 846-848 DiseaseOrPhenotypicFeature denotes EH D000075222
T8 857-869 DiseaseOrPhenotypicFeature denotes hypertension D006973
T9 1034-1036 DiseaseOrPhenotypicFeature denotes EH D000075222
T10 1095-1097 DiseaseOrPhenotypicFeature denotes EH D000075222
T11 1232-1234 DiseaseOrPhenotypicFeature denotes EH D000075222
T12 1667-1669 DiseaseOrPhenotypicFeature denotes EH D000075222

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 178-182 OrganismTaxon denotes Mice
T2 352-357 OrganismTaxon denotes human
T3 557-565 OrganismTaxon denotes patients
T4 1630-1635 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T6 1636-1642 GeneOrGeneProduct denotes Klotho
T5 1510-1516 GeneOrGeneProduct denotes Klotho
T4 494-500 GeneOrGeneProduct denotes Klotho
T3 358-364 GeneOrGeneProduct denotes Klotho
T2 203-209 GeneOrGeneProduct denotes Klotho
T1 77-83 GeneOrGeneProduct denotes Klotho
T12 1667-1669 DiseaseOrPhenotypicFeature denotes EH D000075222
T11 1232-1234 DiseaseOrPhenotypicFeature denotes EH D000075222
T10 1095-1097 DiseaseOrPhenotypicFeature denotes EH D000075222
T9 1034-1036 DiseaseOrPhenotypicFeature denotes EH D000075222
T8 857-869 DiseaseOrPhenotypicFeature denotes hypertension D006973
T7 846-848 DiseaseOrPhenotypicFeature denotes EH D000075222
T88188 571-573 DiseaseOrPhenotypicFeature denotes EH D000075222
T11793 520-522 DiseaseOrPhenotypicFeature denotes EH D000075222
T32541 430-432 DiseaseOrPhenotypicFeature denotes EH D000075222
T36593 406-428 DiseaseOrPhenotypicFeature denotes Essential Hypertension D000075222
T51792 259-275 DiseaseOrPhenotypicFeature denotes arteriosclerosis D001161
T4158 112-134 DiseaseOrPhenotypicFeature denotes essential hypertension D000075222
T24394 1630-1635 OrganismTaxon denotes human
T87251 557-565 OrganismTaxon denotes patients
T93486 352-357 OrganismTaxon denotes human
T74375 178-182 OrganismTaxon denotes Mice
T21071 1603-1609 SequenceVariant denotes G-395A
T71508 1572-1576 SequenceVariant denotes 395G
T8254 1481-1487 SequenceVariant denotes G-395A
T69851 1427-1431 SequenceVariant denotes 395A
T64331 1243-1247 SequenceVariant denotes 395A
T407 1042-1048 SequenceVariant denotes G-395A
T92142 1009-1015 SequenceVariant denotes G-395A
T61940 814-820 SequenceVariant denotes G-395A
T21169 658-664 SequenceVariant denotes G-395A
T15828 471-477 SequenceVariant denotes G-395A
T47737 302-308 SequenceVariant denotes G-395A

DisGeNET

Id Subject Object Predicate Lexical cue
T0 203-209 gene:9365 denotes Klotho
T1 259-275 disease:C0003850 denotes arteriosclerosis
T2 358-364 gene:9365 denotes Klotho
T3 406-428 disease:C0085580 denotes Essential Hypertension
T4 358-364 gene:9365 denotes Klotho
T5 430-432 disease:C0085580 denotes EH
T6 494-500 gene:9365 denotes Klotho
T7 520-522 disease:C0085580 denotes EH
T8 494-500 gene:9365 denotes Klotho
T9 571-573 disease:C0085580 denotes EH
R1 T0 T1 associated_with Klotho,arteriosclerosis
R2 T2 T3 associated_with Klotho,Essential Hypertension
R3 T4 T5 associated_with Klotho,EH
R4 T6 T7 associated_with Klotho,EH
R5 T8 T9 associated_with Klotho,EH

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 259-275 HP_0002634 denotes arteriosclerosis
T2 416-428 HP_0000822 denotes Hypertension

Allie

Id Subject Object Predicate Lexical cue
SS1_20005218_3_0 406-428 expanded denotes Essential Hypertension
SS2_20005218_3_0 430-432 abbr denotes EH
AE1_20005218_3_0 SS1_20005218_3_0 SS2_20005218_3_0 abbreviatedTo Essential Hypertension,EH

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20005218-0#77#83#gene9365 77-83 gene9365 denotes Klotho
20005218-0#112#134#diseaseC0085580 112-134 diseaseC0085580 denotes essential hypertension
20005218-1#25#31#gene9365 203-209 gene9365 denotes Klotho
20005218-1#81#97#diseaseC0003850 259-275 diseaseC0003850 denotes arteriosclerosis
77#83#gene9365112#134#diseaseC0085580 20005218-0#77#83#gene9365 20005218-0#112#134#diseaseC0085580 associated_with Klotho,essential hypertension
25#31#gene936581#97#diseaseC0003850 20005218-1#25#31#gene9365 20005218-1#81#97#diseaseC0003850 associated_with Klotho,arteriosclerosis

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 302-308 DNAMutation:c|SUB|G|-395|A denotes G-395A
T2 471-477 DNAMutation:c|SUB|G|-395|A denotes G-395A
T3 634-637 DNAMutation:|SUB|G||A denotes G/A
T4 658-664 DNAMutation:c|SUB|G|-395|A denotes G-395A
T5 814-820 DNAMutation:c|SUB|G|-395|A denotes G-395A
T6 1009-1015 DNAMutation:c|SUB|G|-395|A denotes G-395A
T7 1042-1048 DNAMutation:c|SUB|G|-395|A denotes G-395A
T8 1481-1487 DNAMutation:c|SUB|G|-395|A denotes G-395A
T9 1603-1609 DNAMutation:c|SUB|G|-395|A denotes G-395A