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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes Human dectin-1 deficiency and mucocutaneous fungal infections.
T2 63-160 Sentence denotes Mucocutaneous fungal infections are typically found in patients who have no known immune defects.
T3 161-361 Sentence denotes We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
T4 362-609 Sentence denotes The mutated form of dectin-1 was poorly expressed, did not mediate beta-glucan binding, and led to defective production of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with beta-glucan or Candida albicans.
T5 610-860 Sentence denotes In contrast, fungal phagocytosis and fungal killing were normal in the patients, explaining why dectin-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dectin-1 in human mucosal antifungal defense.
T1 0-62 Sentence denotes Human dectin-1 deficiency and mucocutaneous fungal infections.
T2 63-160 Sentence denotes Mucocutaneous fungal infections are typically found in patients who have no known immune defects.
T3 161-361 Sentence denotes We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
T4 362-609 Sentence denotes The mutated form of dectin-1 was poorly expressed, did not mediate beta-glucan binding, and led to defective production of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with beta-glucan or Candida albicans.
T5 610-860 Sentence denotes In contrast, fungal phagocytosis and fungal killing were normal in the patients, explaining why dectin-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dectin-1 in human mucosal antifungal defense.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 6-14 gene:64581 denotes dectin-1
T1 44-61 disease:C0026946 denotes fungal infections
T2 815-823 gene:64581 denotes dectin-1
T3 647-653 disease:C0026946 denotes fungal
T4 706-714 gene:64581 denotes dectin-1
T5 759-776 disease:C0026946 denotes fungal infections
T6 815-823 gene:64581 denotes dectin-1
T7 759-776 disease:C0026946 denotes fungal infections
T8 706-714 gene:64581 denotes dectin-1
T9 647-653 disease:C0026946 denotes fungal
R1 T0 T1 associated_with dectin-1,fungal infections
R2 T2 T3 associated_with dectin-1,fungal
R3 T4 T5 associated_with dectin-1,fungal infections
R4 T6 T7 associated_with dectin-1,fungal infections
R5 T8 T9 associated_with dectin-1,fungal

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
19864674-2#155#162#geners16910526 316-323 geners16910526 denotes Tyr238X
19864674-2#79#103#diseaseC0700345 240-264 diseaseC0700345 denotes vulvovaginal candidiasis
19864674-2#107#120#diseaseC0040261 268-281 diseaseC0040261 denotes onychomycosis
155#162#geners1691052679#103#diseaseC0700345 19864674-2#155#162#geners16910526 19864674-2#79#103#diseaseC0700345 associated_with Tyr238X,vulvovaginal candidiasis
155#162#geners16910526107#120#diseaseC0040261 19864674-2#155#162#geners16910526 19864674-2#107#120#diseaseC0040261 associated_with Tyr238X,onychomycosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19864674-0#6#14#gene64581 6-14 gene64581 denotes dectin-1
19864674-0#44#61#diseaseC0026946 44-61 diseaseC0026946 denotes fungal infections
19864674-2#191#199#gene64581 352-360 gene64581 denotes dectin-1
19864674-2#79#103#diseaseC0700345 240-264 diseaseC0700345 denotes vulvovaginal candidiasis
19864674-2#107#120#diseaseC0040261 268-281 diseaseC0040261 denotes onychomycosis
19864674-4#96#104#gene64581 706-714 gene64581 denotes dectin-1
19864674-4#205#213#gene64581 815-823 gene64581 denotes dectin-1
19864674-4#140#166#diseaseC1262313 750-776 diseaseC1262313 denotes invasive fungal infections
6#14#gene6458144#61#diseaseC0026946 19864674-0#6#14#gene64581 19864674-0#44#61#diseaseC0026946 associated_with dectin-1,fungal infections
191#199#gene6458179#103#diseaseC0700345 19864674-2#191#199#gene64581 19864674-2#79#103#diseaseC0700345 associated_with dectin-1,vulvovaginal candidiasis
191#199#gene64581107#120#diseaseC0040261 19864674-2#191#199#gene64581 19864674-2#107#120#diseaseC0040261 associated_with dectin-1,onychomycosis
96#104#gene64581140#166#diseaseC1262313 19864674-4#96#104#gene64581 19864674-4#140#166#diseaseC1262313 associated_with dectin-1,invasive fungal infections
205#213#gene64581140#166#diseaseC1262313 19864674-4#205#213#gene64581 19864674-4#140#166#diseaseC1262313 associated_with dectin-1,invasive fungal infections