PubMed:1980125 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":105,"end":132},"obj":"gene:3562"},{"id":"T1","span":{"begin":78,"end":92},"obj":"disease:C0006142"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":105,"end":132},"obj":"protein"},{"id":"T2","span":{"begin":144,"end":155},"obj":"cell_type"},{"id":"T3","span":{"begin":418,"end":440},"obj":"DNA"},{"id":"T4","span":{"begin":479,"end":484},"obj":"DNA"},{"id":"T5","span":{"begin":512,"end":517},"obj":"DNA"},{"id":"T6","span":{"begin":647,"end":654},"obj":"DNA"},{"id":"T7","span":{"begin":722,"end":743},"obj":"protein"},{"id":"T8","span":{"begin":745,"end":747},"obj":"protein"},{"id":"T9","span":{"begin":1031,"end":1038},"obj":"DNA"},{"id":"T10","span":{"begin":1182,"end":1190},"obj":"DNA"},{"id":"T11","span":{"begin":1462,"end":1470},"obj":"protein"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"1980125-0#105#132#gene3562","span":{"begin":105,"end":132},"obj":"gene3562"},{"id":"1980125-0#78#92#diseaseC0006142","span":{"begin":78,"end":92},"obj":"diseaseC0006142"}],"relations":[{"id":"105#132#gene356278#92#diseaseC0006142","pred":"associated_with","subj":"1980125-0#105#132#gene3562","obj":"1980125-0#78#92#diseaseC0006142"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":156},"obj":"Sentence"},{"id":"S2","span":{"begin":157,"end":266},"obj":"Sentence"},{"id":"S3","span":{"begin":267,"end":326},"obj":"Sentence"},{"id":"S4","span":{"begin":327,"end":407},"obj":"Sentence"},{"id":"S5","span":{"begin":408,"end":478},"obj":"Sentence"},{"id":"S6","span":{"begin":479,"end":541},"obj":"Sentence"},{"id":"S7","span":{"begin":542,"end":771},"obj":"Sentence"},{"id":"S8","span":{"begin":772,"end":957},"obj":"Sentence"},{"id":"S9","span":{"begin":958,"end":1105},"obj":"Sentence"},{"id":"S10","span":{"begin":1106,"end":1262},"obj":"Sentence"},{"id":"S11","span":{"begin":1263,"end":1430},"obj":"Sentence"},{"id":"S12","span":{"begin":1431,"end":1516},"obj":"Sentence"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":22},"obj":"NP"},{"id":"C2","span":{"begin":157,"end":202},"obj":"NP"},{"id":"C3","span":{"begin":230,"end":235},"obj":"NP"},{"id":"C4","span":{"begin":336,"end":354},"obj":"NP"},{"id":"C5","span":{"begin":466,"end":477},"obj":"NP"},{"id":"C6","span":{"begin":479,"end":484},"obj":"NP"},{"id":"C7","span":{"begin":647,"end":668},"obj":"NP"},{"id":"C8","span":{"begin":1031,"end":1053},"obj":"NP"},{"id":"C10","span":{"begin":1182,"end":1204},"obj":"NP"},{"id":"C9","span":{"begin":1148,"end":1261},"obj":"NP"},{"id":"C11","span":{"begin":1263,"end":1279},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C4"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C9"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":22},"obj":"other_name"},{"id":"T2","span":{"begin":45,"end":68},"obj":"other_name"},{"id":"T3","span":{"begin":72,"end":92},"obj":"other_name"},{"id":"T4","span":{"begin":105,"end":132},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":144,"end":155},"obj":"cell_type"},{"id":"T6","span":{"begin":173,"end":202},"obj":"other_name"},{"id":"T7","span":{"begin":288,"end":305},"obj":"other_name"},{"id":"T8","span":{"begin":336,"end":354},"obj":"other_name"},{"id":"T9","span":{"begin":370,"end":378},"obj":"other_name"},{"id":"T10","span":{"begin":386,"end":406},"obj":"other_name"},{"id":"T11","span":{"begin":418,"end":440},"obj":"DNA_molecule"},{"id":"T12","span":{"begin":479,"end":484},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":512,"end":517},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":547,"end":566},"obj":"other_name"},{"id":"T15","span":{"begin":647,"end":654},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":722,"end":743},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":745,"end":747},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":901,"end":923},"obj":"other_name"},{"id":"T19","span":{"begin":928,"end":948},"obj":"other_name"},{"id":"T20","span":{"begin":1017,"end":1025},"obj":"multi_cell"},{"id":"T21","span":{"begin":1031,"end":1038},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":1062,"end":1070},"obj":"tissue"},{"id":"T23","span":{"begin":1071,"end":1082},"obj":"tissue"},{"id":"T24","span":{"begin":1182,"end":1190},"obj":"DNA_family_or_group"},{"id":"T25","span":{"begin":1215,"end":1238},"obj":"other_name"},{"id":"T26","span":{"begin":1246,"end":1251},"obj":"tissue"},{"id":"T27","span":{"begin":1447,"end":1461},"obj":"other_name"},{"id":"T28","span":{"begin":1462,"end":1470},"obj":"protein_family_or_group"}],"text":"Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: a role for hematopoietic growth factor release by tumor cells?\nOne hundred six primary breast cancer samples were analysed for c-erbB2, int-2, and c-myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of gene amplification was studied by Southern and/or slot blot techniques. Amplified c-erbB2 gene sequences were present in 21.5% of all samples. Int-2 was amplified in 13.1% and c-myc was amplified in 10.3%. In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor (PR) (P = .011) expression. No correlations were found between all or high levels of amplification of each oncogene separately or combined with T, N, grade, multifocality of tumor, or associated carcinoma in situ. There was a trend approaching statistical significance for patients with c-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). We propose that malignant cell cytokine production may help explain this observation."}