PubMed:19735549 / 1470-2051 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/19735549","sourcedb":"PubMed","sourceid":"19735549","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/19735549","text":"uman DCIS cells initially grew within the mammary ducts, followed by progression to invasion in some cases into the stroma. The lesions were histologically almost identical to those of clinical human DCIS. This method was successful for growing DCIS cell lines (MCF10DCIS.COM and SUM-225) as well as a primary human DCIS (FSK-H7). MCF10DCIS.COM represented a basal-like DCIS model, whereas SUM-225 and FSK-H7 cells were models for HER-2+ DCIS. With this approach, we showed that various subtypes of human DCIS appeared to contain distinct subpopulations of tumor-initiating 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