PubMed:19707748 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":88},"obj":"Sentence"},{"id":"T3","span":{"begin":89,"end":377},"obj":"Sentence"},{"id":"T4","span":{"begin":378,"end":386},"obj":"Sentence"},{"id":"T5","span":{"begin":387,"end":467},"obj":"Sentence"},{"id":"T6","span":{"begin":468,"end":533},"obj":"Sentence"},{"id":"T7","span":{"begin":534,"end":589},"obj":"Sentence"},{"id":"T8","span":{"begin":590,"end":598},"obj":"Sentence"},{"id":"T9","span":{"begin":599,"end":679},"obj":"Sentence"},{"id":"T10","span":{"begin":680,"end":814},"obj":"Sentence"},{"id":"T11","span":{"begin":815,"end":827},"obj":"Sentence"},{"id":"T12","span":{"begin":828,"end":1000},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":88},"obj":"Sentence"},{"id":"T3","span":{"begin":89,"end":377},"obj":"Sentence"},{"id":"T4","span":{"begin":378,"end":386},"obj":"Sentence"},{"id":"T5","span":{"begin":387,"end":467},"obj":"Sentence"},{"id":"T6","span":{"begin":468,"end":533},"obj":"Sentence"},{"id":"T7","span":{"begin":534,"end":589},"obj":"Sentence"},{"id":"T8","span":{"begin":590,"end":598},"obj":"Sentence"},{"id":"T9","span":{"begin":599,"end":679},"obj":"Sentence"},{"id":"T10","span":{"begin":680,"end":814},"obj":"Sentence"},{"id":"T11","span":{"begin":815,"end":827},"obj":"Sentence"},{"id":"T12","span":{"begin":828,"end":1000},"obj":"Sentence"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":79},"obj":"Sentence"},{"id":"T2","span":{"begin":80,"end":88},"obj":"Sentence"},{"id":"T3","span":{"begin":89,"end":377},"obj":"Sentence"},{"id":"T4","span":{"begin":378,"end":386},"obj":"Sentence"},{"id":"T5","span":{"begin":387,"end":467},"obj":"Sentence"},{"id":"T6","span":{"begin":468,"end":533},"obj":"Sentence"},{"id":"T7","span":{"begin":534,"end":589},"obj":"Sentence"},{"id":"T8","span":{"begin":590,"end":598},"obj":"Sentence"},{"id":"T9","span":{"begin":599,"end":679},"obj":"Sentence"},{"id":"T10","span":{"begin":680,"end":814},"obj":"Sentence"},{"id":"T11","span":{"begin":815,"end":827},"obj":"Sentence"},{"id":"T12","span":{"begin":828,"end":1000},"obj":"Sentence"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-entities","denotations":[{"id":"6398","span":{"begin":0,"end":8},"obj":"DiseaseOrPhenotypicFeature"},{"id":"6399","span":{"begin":25,"end":37},"obj":"ChemicalEntity"},{"id":"6400","span":{"begin":112,"end":119},"obj":"OrganismTaxon"},{"id":"6401","span":{"begin":134,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"6402","span":{"begin":183,"end":195},"obj":"ChemicalEntity"},{"id":"6403","span":{"begin":277,"end":302},"obj":"GeneOrGeneProduct"},{"id":"6404","span":{"begin":347,"end":359},"obj":"ChemicalEntity"},{"id":"6405","span":{"begin":368,"end":376},"obj":"DiseaseOrPhenotypicFeature"},{"id":"6406","span":{"begin":520,"end":532},"obj":"ChemicalEntity"},{"id":"6407","span":{"begin":612,"end":624},"obj":"ChemicalEntity"},{"id":"6408","span":{"begin":633,"end":641},"obj":"DiseaseOrPhenotypicFeature"},{"id":"6409","span":{"begin":732,"end":738},"obj":"GeneOrGeneProduct"},{"id":"6410","span":{"begin":742,"end":754},"obj":"ChemicalEntity"},{"id":"6411","span":{"begin":891,"end":903},"obj":"ChemicalEntity"},{"id":"6412","span":{"begin":915,"end":923},"obj":"OrganismTaxon"},{"id":"6413","span":{"begin":982,"end":988},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A1","pred":"db_id","subj":"6398","obj":"MESH:D012640"},{"id":"A2","pred":"db_id","subj":"6399","obj":"MESH:D064704"},{"id":"A3","pred":"db_id","subj":"6400","obj":"NCBITaxon:9606"},{"id":"A4","pred":"db_id","subj":"6401","obj":"MESH:D012640"},{"id":"A5","pred":"db_id","subj":"6402","obj":"MESH:D064704"},{"id":"A6","pred":"db_id","subj":"6403","obj":"NCBIGene:1544"},{"id":"A7","pred":"db_id","subj":"6404","obj":"MESH:D064704"},{"id":"A8","pred":"db_id","subj":"6405","obj":"MESH:D012640"},{"id":"A9","pred":"db_id","subj":"6406","obj":"MESH:D064704"},{"id":"A10","pred":"db_id","subj":"6407","obj":"MESH:D064704"},{"id":"A11","pred":"db_id","subj":"6408","obj":"MESH:D012640"},{"id":"A12","pred":"db_id","subj":"6409","obj":"NCBIGene:1544"},{"id":"A13","pred":"db_id","subj":"6410","obj":"MESH:D064704"},{"id":"A14","pred":"db_id","subj":"6411","obj":"MESH:D064704"},{"id":"A15","pred":"db_id","subj":"6412","obj":"NCBITaxon:9606"},{"id":"A16","pred":"db_id","subj":"6413","obj":"NCBIGene:1544"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":39,"end":43},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":102,"end":106},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":134,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":157,"end":167},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":277,"end":292},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":293,"end":302},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":294,"end":297},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":311,"end":315},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":331,"end":336},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":337,"end":342},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":360,"end":367},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":368,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":378,"end":385},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":472,"end":476},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":484,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":504,"end":508},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":549,"end":556},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":603,"end":608},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":625,"end":632},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":633,"end":641},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":732,"end":738},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":759,"end":765},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":808,"end":813},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":880,"end":890},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":982,"end":988},"obj":"GeneOrGeneProduct"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":134,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":277,"end":292},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":294,"end":297},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":331,"end":336},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":368,"end":376},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":549,"end":556},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":633,"end":641},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":732,"end":738},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":982,"end":988},"obj":"GeneOrGeneProduct"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":134,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":368,"end":376},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":633,"end":641},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D012640"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D012640"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D012640"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D012640"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":277,"end":302},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":732,"end":738},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":982,"end":988},"obj":"GeneOrGeneProduct"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":134,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":368,"end":376},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":633,"end":641},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D012640"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D012640"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012640"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D012640"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":134,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":368,"end":376},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":633,"end":641},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D012640"},{"id":"A2","pred":"#label","subj":"T2","obj":"D012640"},{"id":"A3","pred":"#label","subj":"T3","obj":"D012640"},{"id":"A4","pred":"#label","subj":"T4","obj":"D012640"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":25,"end":37},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":183,"end":195},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":277,"end":292},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":294,"end":297},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":347,"end":359},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":520,"end":532},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":612,"end":624},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":742,"end":754},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":891,"end":903},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D064704"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D064704"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D064704"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D064704"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D064704"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D064704"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D064704"},{"id":"A16","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":112,"end":119},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":915,"end":923},"obj":"OrganismTaxon"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T15","span":{"begin":891,"end":903},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":742,"end":754},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":612,"end":624},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":520,"end":532},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":347,"end":359},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":294,"end":297},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":277,"end":292},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":183,"end":195},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":25,"end":37},"obj":"ChemicalEntity"},{"id":"T98723","span":{"begin":982,"end":988},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":732,"end":738},"obj":"GeneOrGeneProduct"},{"id":"T8548","span":{"begin":277,"end":302},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":633,"end":641},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T67745","span":{"begin":368,"end":376},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10619","span":{"begin":134,"end":142},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14782","span":{"begin":0,"end":8},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T84749","span":{"begin":915,"end":923},"obj":"OrganismTaxon"},{"id":"T94412","span":{"begin":112,"end":119},"obj":"OrganismTaxon"}],"attributes":[{"id":"A16","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D064704"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D064704"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D064704"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D064704"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D064704"},{"id":"A6","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D064704"},{"id":"A2","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63598"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D064704"},{"id":"A4050","pred":"#label","subj":"T4","obj":"D012640"},{"id":"A28141","pred":"#label","subj":"T67745","obj":"D012640"},{"id":"A90304","pred":"#label","subj":"T10619","obj":"D012640"},{"id":"A51470","pred":"#label","subj":"T14782","obj":"D012640"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":0,"end":8},"obj":"HP:0001250"},{"id":"AB1","span":{"begin":134,"end":142},"obj":"HP:0001250"},{"id":"AB2","span":{"begin":368,"end":376},"obj":"HP:0001250"},{"id":"AB3","span":{"begin":633,"end":641},"obj":"HP:0001250"}],"text":"Seizures associated with levofloxacin: case presentation and literature review.\nPURPOSE: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.\nMETHODS: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English.\nRESULTS: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.\nCONCLUSIONS: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates."}