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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Seizures associated with levofloxacin: case presentation and literature review.
T2 80-88 Sentence denotes PURPOSE:
T3 89-377 Sentence denotes We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.
T4 378-386 Sentence denotes METHODS:
T5 387-467 Sentence denotes Several biomedical databases were searched including MEDLINE, Cochrane and Ovid.
T6 468-533 Sentence denotes The main search terms utilized were case report and levofloxacin.
T7 534-589 Sentence denotes The search was limited to studies published in English.
T8 590-598 Sentence denotes RESULTS:
T9 599-679 Sentence denotes Six cases of levofloxacin-induced seizures have been reported in the literature.
T10 680-814 Sentence denotes Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.
T11 815-827 Sentence denotes CONCLUSIONS:
T12 828-1000 Sentence denotes Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates.
T1 0-79 Sentence denotes Seizures associated with levofloxacin: case presentation and literature review.
T2 80-88 Sentence denotes PURPOSE:
T3 89-377 Sentence denotes We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.
T4 378-386 Sentence denotes METHODS:
T5 387-467 Sentence denotes Several biomedical databases were searched including MEDLINE, Cochrane and Ovid.
T6 468-533 Sentence denotes The main search terms utilized were case report and levofloxacin.
T7 534-589 Sentence denotes The search was limited to studies published in English.
T8 590-598 Sentence denotes RESULTS:
T9 599-679 Sentence denotes Six cases of levofloxacin-induced seizures have been reported in the literature.
T10 680-814 Sentence denotes Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.
T11 815-827 Sentence denotes CONCLUSIONS:
T12 828-1000 Sentence denotes Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates.

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Seizures associated with levofloxacin: case presentation and literature review.
T2 80-88 Sentence denotes PURPOSE:
T3 89-377 Sentence denotes We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures.
T4 378-386 Sentence denotes METHODS:
T5 387-467 Sentence denotes Several biomedical databases were searched including MEDLINE, Cochrane and Ovid.
T6 468-533 Sentence denotes The main search terms utilized were case report and levofloxacin.
T7 534-589 Sentence denotes The search was limited to studies published in English.
T8 590-598 Sentence denotes RESULTS:
T9 599-679 Sentence denotes Six cases of levofloxacin-induced seizures have been reported in the literature.
T10 680-814 Sentence denotes Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases.
T11 815-827 Sentence denotes CONCLUSIONS:
T12 828-1000 Sentence denotes Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6398 0-8 DiseaseOrPhenotypicFeature denotes Seizures MESH:D012640
6399 25-37 ChemicalEntity denotes levofloxacin MESH:D064704
6400 112-119 OrganismTaxon denotes patient NCBITaxon:9606
6401 134-142 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6402 183-195 ChemicalEntity denotes levofloxacin MESH:D064704
6403 277-302 GeneOrGeneProduct denotes cytochrome P450 (CYP) 1A2 NCBIGene:1544
6404 347-359 ChemicalEntity denotes levofloxacin MESH:D064704
6405 368-376 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6406 520-532 ChemicalEntity denotes levofloxacin MESH:D064704
6407 612-624 ChemicalEntity denotes levofloxacin MESH:D064704
6408 633-641 DiseaseOrPhenotypicFeature denotes seizures MESH:D012640
6409 732-738 GeneOrGeneProduct denotes CYP1A2 NCBIGene:1544
6410 742-754 ChemicalEntity denotes levofloxacin MESH:D064704
6411 891-903 ChemicalEntity denotes levofloxacin MESH:D064704
6412 915-923 OrganismTaxon denotes patients NCBITaxon:9606
6413 982-988 GeneOrGeneProduct denotes CYP1A2 NCBIGene:1544

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Seizures
T2 39-43 GeneOrGeneProduct denotes case
T3 102-106 GeneOrGeneProduct denotes case
T4 134-142 GeneOrGeneProduct denotes seizures
T5 157-167 GeneOrGeneProduct denotes initiating
T6 277-292 GeneOrGeneProduct denotes cytochrome P450
T7 293-302 GeneOrGeneProduct denotes (CYP) 1A2
T8 294-297 GeneOrGeneProduct denotes CYP
T9 311-315 GeneOrGeneProduct denotes case
T10 331-336 GeneOrGeneProduct denotes other
T11 337-342 GeneOrGeneProduct denotes cases
T12 360-367 GeneOrGeneProduct denotes induced
T13 368-376 GeneOrGeneProduct denotes seizures
T14 378-385 GeneOrGeneProduct denotes METHODS
T15 472-476 GeneOrGeneProduct denotes main
T16 484-489 GeneOrGeneProduct denotes terms
T17 504-508 GeneOrGeneProduct denotes case
T18 549-556 GeneOrGeneProduct denotes limited
T19 603-608 GeneOrGeneProduct denotes cases
T20 625-632 GeneOrGeneProduct denotes induced
T21 633-641 GeneOrGeneProduct denotes seizures
T22 732-738 GeneOrGeneProduct denotes CYP1A2
T23 759-765 GeneOrGeneProduct denotes likely
T24 808-813 GeneOrGeneProduct denotes cases
T25 880-890 GeneOrGeneProduct denotes initiating
T26 982-988 GeneOrGeneProduct denotes CYP1A2

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Seizures
T2 134-142 GeneOrGeneProduct denotes seizures
T3 277-292 GeneOrGeneProduct denotes cytochrome P450
T4 294-297 GeneOrGeneProduct denotes CYP
T5 331-336 GeneOrGeneProduct denotes other
T6 368-376 GeneOrGeneProduct denotes seizures
T7 549-556 GeneOrGeneProduct denotes limited
T8 633-641 GeneOrGeneProduct denotes seizures
T9 732-738 GeneOrGeneProduct denotes CYP1A2
T10 982-988 GeneOrGeneProduct denotes CYP1A2

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-8 DiseaseOrPhenotypicFeature denotes Seizures D012640
T2 134-142 DiseaseOrPhenotypicFeature denotes seizures D012640
T3 368-376 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 633-641 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 277-302 GeneOrGeneProduct denotes cytochrome P450 (CYP) 1A2
T2 732-738 GeneOrGeneProduct denotes CYP1A2
T3 982-988 GeneOrGeneProduct denotes CYP1A2

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-8 DiseaseOrPhenotypicFeature denotes Seizures D012640
T2 134-142 DiseaseOrPhenotypicFeature denotes seizures D012640
T3 368-376 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 633-641 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 0-8 DiseaseOrPhenotypicFeature denotes Seizures D012640
T2 134-142 DiseaseOrPhenotypicFeature denotes seizures D012640
T3 368-376 DiseaseOrPhenotypicFeature denotes seizures D012640
T4 633-641 DiseaseOrPhenotypicFeature denotes seizures D012640

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 25-37 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T3 183-195 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T5 277-292 ChemicalEntity denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T6 294-297 ChemicalEntity denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T7 347-359 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T9 520-532 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T11 612-624 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T13 742-754 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598
T15 891-903 ChemicalEntity denotes levofloxacin D064704|http://purl.obolibrary.org/obo/CHEBI_63598

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 112-119 OrganismTaxon denotes patient
T2 915-923 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 891-903 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T13 742-754 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T11 612-624 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T9 520-532 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T7 347-359 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T6 294-297 ChemicalEntity denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T5 277-292 ChemicalEntity denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T3 183-195 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T1 25-37 ChemicalEntity denotes levofloxacin http://purl.obolibrary.org/obo/CHEBI_63598|D064704
T98723 982-988 GeneOrGeneProduct denotes CYP1A2
T2 732-738 GeneOrGeneProduct denotes CYP1A2
T8548 277-302 GeneOrGeneProduct denotes cytochrome P450 (CYP) 1A2
T4 633-641 DiseaseOrPhenotypicFeature denotes seizures D012640
T67745 368-376 DiseaseOrPhenotypicFeature denotes seizures D012640
T10619 134-142 DiseaseOrPhenotypicFeature denotes seizures D012640
T14782 0-8 DiseaseOrPhenotypicFeature denotes Seizures D012640
T84749 915-923 OrganismTaxon denotes patients
T94412 112-119 OrganismTaxon denotes patient

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 0-8 HP:0001250 denotes Seizures
AB1 134-142 HP:0001250 denotes seizures
AB2 368-376 HP:0001250 denotes seizures
AB3 633-641 HP:0001250 denotes seizures