PubMed:19561030 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1006,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":1176,"end":1191},"obj":"http://purl.bioontology.org/ontology/ICD10/I70"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":22,"end":30},"obj":"FMAID:167164"},{"id":"_T2","span":{"begin":22,"end":30},"obj":"FMAID:62864"},{"id":"_T3","span":{"begin":57,"end":60},"obj":"FMAID:90078"},{"id":"_T4","span":{"begin":183,"end":191},"obj":"FMAID:165447"},{"id":"_T5","span":{"begin":183,"end":191},"obj":"FMAID:67257"},{"id":"_T6","span":{"begin":310,"end":318},"obj":"FMAID:167164"},{"id":"_T7","span":{"begin":310,"end":318},"obj":"FMAID:62864"},{"id":"_T8","span":{"begin":383,"end":394},"obj":"FMAID:63261"},{"id":"_T9","span":{"begin":383,"end":394},"obj":"FMAID:167685"},{"id":"_T10","span":{"begin":415,"end":423},"obj":"FMAID:167164"},{"id":"_T11","span":{"begin":415,"end":423},"obj":"FMAID:62864"},{"id":"_T12","span":{"begin":493,"end":501},"obj":"FMAID:167180"},{"id":"_T13","span":{"begin":525,"end":535},"obj":"FMAID:167180"},{"id":"_T14","span":{"begin":570,"end":578},"obj":"FMAID:167164"},{"id":"_T15","span":{"begin":570,"end":578},"obj":"FMAID:62864"},{"id":"_T16","span":{"begin":685,"end":688},"obj":"FMAID:90078"},{"id":"_T17","span":{"begin":806,"end":815},"obj":"FMAID:166112"},{"id":"_T18","span":{"begin":808,"end":815},"obj":"FMAID:67257"},{"id":"_T19","span":{"begin":808,"end":815},"obj":"FMAID:165447"},{"id":"_T20","span":{"begin":917,"end":925},"obj":"FMAID:62864"},{"id":"_T21","span":{"begin":917,"end":925},"obj":"FMAID:167164"},{"id":"_T22","span":{"begin":975,"end":986},"obj":"FMAID:167685"},{"id":"_T23","span":{"begin":975,"end":986},"obj":"FMAID:63261"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T2","span":{"begin":117,"end":127},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T3","span":{"begin":396,"end":406},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T4","span":{"begin":482,"end":492},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T5","span":{"begin":550,"end":560},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T6","span":{"begin":721,"end":731},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T7","span":{"begin":835,"end":845},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T8","span":{"begin":903,"end":913},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T9","span":{"begin":1049,"end":1059},"obj":"http://www.uniprot.org/uniprot/P09382"},{"id":"T10","span":{"begin":50,"end":53},"obj":"http://www.uniprot.org/uniprot/Q8TCB0"},{"id":"T11","span":{"begin":57,"end":60},"obj":"http://www.uniprot.org/uniprot/P12872"},{"id":"T12","span":{"begin":685,"end":688},"obj":"http://www.uniprot.org/uniprot/P12872"},{"id":"T13","span":{"begin":57,"end":60},"obj":"http://www.uniprot.org/uniprot/Q96HU1"},{"id":"T14","span":{"begin":685,"end":688},"obj":"http://www.uniprot.org/uniprot/Q96HU1"},{"id":"T15","span":{"begin":163,"end":191},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T16","span":{"begin":956,"end":966},"obj":"http://www.uniprot.org/uniprot/P17931"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T2","span":{"begin":117,"end":127},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T3","span":{"begin":396,"end":406},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T4","span":{"begin":482,"end":492},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T5","span":{"begin":550,"end":560},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T6","span":{"begin":721,"end":731},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T7","span":{"begin":835,"end":845},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T8","span":{"begin":903,"end":913},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T9","span":{"begin":1049,"end":1059},"obj":"http://www.uniprot.org/uniprot/P16045"},{"id":"T10","span":{"begin":956,"end":966},"obj":"http://www.uniprot.org/uniprot/P16110"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":158,"end":162},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T2","span":{"begin":158,"end":162},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":31,"end":41},"obj":"http://purl.obolibrary.org/obo/GO_0006935"},{"id":"T2","span":{"begin":424,"end":434},"obj":"http://purl.obolibrary.org/obo/GO_0006935"},{"id":"T3","span":{"begin":854,"end":864},"obj":"http://purl.obolibrary.org/obo/GO_0006935"},{"id":"T4","span":{"begin":926,"end":936},"obj":"http://purl.obolibrary.org/obo/GO_0006935"},{"id":"T5","span":{"begin":98,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0046960"},{"id":"T6","span":{"begin":1079,"end":1094},"obj":"http://purl.obolibrary.org/obo/GO_0050918"},{"id":"T7","span":{"begin":1107,"end":1119},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GO-MF","denotations":[{"id":"T1","span":{"begin":163,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0016936"},{"id":"T2","span":{"begin":175,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0070026"},{"id":"T3","span":{"begin":175,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0003680"},{"id":"T4","span":{"begin":175,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0017091"},{"id":"T5","span":{"begin":175,"end":182},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T6","span":{"begin":175,"end":191},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T7","span":{"begin":493,"end":501},"obj":"http://purl.obolibrary.org/obo/GO_0003823"},{"id":"T8","span":{"begin":525,"end":535},"obj":"http://purl.obolibrary.org/obo/GO_0003823"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"Lectin","denotations":[{"id":"Lectin_T1","span":{"begin":0,"end":10},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T2","span":{"begin":117,"end":127},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T3","span":{"begin":288,"end":298},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T4","span":{"begin":396,"end":406},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T5","span":{"begin":482,"end":492},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T6","span":{"begin":550,"end":560},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T7","span":{"begin":721,"end":731},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T8","span":{"begin":835,"end":845},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T9","span":{"begin":903,"end":913},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T10","span":{"begin":1049,"end":1059},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T11","span":{"begin":0,"end":10},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T12","span":{"begin":117,"end":127},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T13","span":{"begin":288,"end":298},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T14","span":{"begin":396,"end":406},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T15","span":{"begin":482,"end":492},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T16","span":{"begin":550,"end":560},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T17","span":{"begin":721,"end":731},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T18","span":{"begin":835,"end":845},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T19","span":{"begin":903,"end":913},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T20","span":{"begin":1049,"end":1059},"obj":"https://acgg.asia/db/lfdb/LfDB0057"},{"id":"Lectin_T21","span":{"begin":0,"end":8},"obj":"https://acgg.asia/db/lfdb/LfDB0272"},{"id":"Lectin_T22","span":{"begin":117,"end":125},"obj":"https://acgg.asia/db/lfdb/LfDB0272"},{"id":"Lectin_T23","span":{"begin":396,"end":404},"obj":"https://acgg.asia/db/lfdb/LfDB0272"},{"id":"Lectin_T24","span":{"begin":0,"end":8},"obj":"https://acgg.asia/db/lfdb/LfDB0274"},{"id":"Lectin_T25","span":{"begin":117,"end":125},"obj":"https://acgg.asia/db/lfdb/LfDB0274"},{"id":"Lectin_T26","span":{"begin":396,"end":404},"obj":"https://acgg.asia/db/lfdb/LfDB0274"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":1176,"end":1191},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002621"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":82,"end":91},"obj":"Disease"},{"id":"T2","span":{"begin":781,"end":790},"obj":"Disease"},{"id":"T3","span":{"begin":1107,"end":1119},"obj":"Disease"},{"id":"T4","span":{"begin":1176,"end":1191},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005077"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005077"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005311"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":449,"end":456},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G15541SE"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":1176,"end":1191},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002621"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T1","span":{"begin":82,"end":91},"obj":"Disease"},{"id":"T2","span":{"begin":781,"end":790},"obj":"Disease"},{"id":"T3","span":{"begin":1107,"end":1119},"obj":"Disease"},{"id":"T4","span":{"begin":1176,"end":1191},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005077"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005077"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005311"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-CL","denotations":[{"id":"T1","span":{"begin":22,"end":30},"obj":"Cell"},{"id":"T3","span":{"begin":310,"end":318},"obj":"Cell"},{"id":"T5","span":{"begin":383,"end":394},"obj":"Cell"},{"id":"T7","span":{"begin":415,"end":423},"obj":"Cell"},{"id":"T9","span":{"begin":570,"end":578},"obj":"Cell"},{"id":"T11","span":{"begin":917,"end":925},"obj":"Cell"},{"id":"T13","span":{"begin":975,"end":986},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A8","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A10","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A12","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A14","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000394"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T1","span":{"begin":22,"end":30},"obj":"Body_part"},{"id":"T3","span":{"begin":310,"end":318},"obj":"Body_part"},{"id":"T5","span":{"begin":383,"end":394},"obj":"Body_part"},{"id":"T6","span":{"begin":415,"end":423},"obj":"Body_part"},{"id":"T8","span":{"begin":570,"end":578},"obj":"Body_part"},{"id":"T10","span":{"begin":917,"end":925},"obj":"Body_part"},{"id":"T12","span":{"begin":975,"end":986},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A4","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A7","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A9","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL_0000235"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1006,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T2","span":{"begin":117,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":536},"obj":"Sentence"},{"id":"T5","span":{"begin":537,"end":732},"obj":"Sentence"},{"id":"T6","span":{"begin":733,"end":865},"obj":"Sentence"},{"id":"T7","span":{"begin":866,"end":1005},"obj":"Sentence"},{"id":"T8","span":{"begin":1006,"end":1192},"obj":"Sentence"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":449,"end":456},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G15541SE"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"GlyCosmos15-Lectin-Jamboree","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"Lectin"},{"id":"T2","span":{"begin":117,"end":127},"obj":"Lectin"},{"id":"T3","span":{"begin":396,"end":406},"obj":"Lectin"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"GL_001885"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"GL_001885"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"GL_001885"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":22,"end":30},"obj":"Body_part"},{"id":"T3","span":{"begin":310,"end":318},"obj":"Body_part"},{"id":"T5","span":{"begin":383,"end":394},"obj":"Body_part"},{"id":"T6","span":{"begin":415,"end":423},"obj":"Body_part"},{"id":"T8","span":{"begin":570,"end":578},"obj":"Body_part"},{"id":"T10","span":{"begin":917,"end":925},"obj":"Body_part"},{"id":"T12","span":{"begin":975,"end":986},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A4","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A7","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A9","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A11","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL_0000235"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":22,"end":30},"obj":"Cell"},{"id":"T3","span":{"begin":310,"end":318},"obj":"Cell"},{"id":"T5","span":{"begin":383,"end":394},"obj":"Cell"},{"id":"T7","span":{"begin":415,"end":423},"obj":"Cell"},{"id":"T9","span":{"begin":570,"end":578},"obj":"Cell"},{"id":"T11","span":{"begin":917,"end":925},"obj":"Cell"},{"id":"T13","span":{"begin":975,"end":986},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A7","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A8","pred":"cl_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A10","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A12","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A14","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000394"}],"text":"Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.\nGalectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis."}