PubMed:19561030
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
TextSentencer_T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
TextSentencer_T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
TextSentencer_T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
TextSentencer_T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
TextSentencer_T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
TextSentencer_T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
TextSentencer_T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1176-1191 | http://purl.bioontology.org/ontology/ICD10/I70 | denotes | atherosclerosis |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 22-30 | FMAID:167164 | denotes | monocyte |
_T2 | 22-30 | FMAID:62864 | denotes | monocyte |
_T3 | 57-60 | FMAID:90078 | denotes | MAP |
_T4 | 183-191 | FMAID:165447 | denotes | proteins |
_T5 | 183-191 | FMAID:67257 | denotes | proteins |
_T6 | 310-318 | FMAID:167164 | denotes | monocyte |
_T7 | 310-318 | FMAID:62864 | denotes | monocyte |
_T8 | 383-394 | FMAID:63261 | denotes | macrophages |
_T9 | 383-394 | FMAID:167685 | denotes | macrophages |
_T10 | 415-423 | FMAID:167164 | denotes | monocyte |
_T11 | 415-423 | FMAID:62864 | denotes | monocyte |
_T12 | 493-501 | FMAID:167180 | denotes | antibody |
_T13 | 525-535 | FMAID:167180 | denotes | antibodies |
_T14 | 570-578 | FMAID:167164 | denotes | monocyte |
_T15 | 570-578 | FMAID:62864 | denotes | monocyte |
_T16 | 685-688 | FMAID:90078 | denotes | MAP |
_T17 | 806-815 | FMAID:166112 | denotes | G-protein |
_T18 | 808-815 | FMAID:67257 | denotes | protein |
_T19 | 808-815 | FMAID:165447 | denotes | protein |
_T20 | 917-925 | FMAID:62864 | denotes | monocyte |
_T21 | 917-925 | FMAID:167164 | denotes | monocyte |
_T22 | 975-986 | FMAID:167685 | denotes | macrophages |
_T23 | 975-986 | FMAID:63261 | denotes | macrophages |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-10 | http://www.uniprot.org/uniprot/P09382 | denotes | Galectin-1 |
T2 | 117-127 | http://www.uniprot.org/uniprot/P09382 | denotes | Galectin-1 |
T3 | 396-406 | http://www.uniprot.org/uniprot/P09382 | denotes | Galectin-1 |
T4 | 482-492 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T5 | 550-560 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T6 | 721-731 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T7 | 835-845 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T8 | 903-913 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T9 | 1049-1059 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
T10 | 50-53 | http://www.uniprot.org/uniprot/Q8TCB0 | denotes | p44 |
T11 | 57-60 | http://www.uniprot.org/uniprot/P12872 | denotes | MAP |
T12 | 685-688 | http://www.uniprot.org/uniprot/P12872 | denotes | MAP |
T13 | 57-60 | http://www.uniprot.org/uniprot/Q96HU1 | denotes | MAP |
T14 | 685-688 | http://www.uniprot.org/uniprot/Q96HU1 | denotes | MAP |
T15 | 163-191 | http://www.uniprot.org/uniprot/P17931 | denotes | galactoside-binding proteins |
T16 | 956-966 | http://www.uniprot.org/uniprot/P17931 | denotes | galectin-3 |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-10 | http://www.uniprot.org/uniprot/P16045 | denotes | Galectin-1 |
T2 | 117-127 | http://www.uniprot.org/uniprot/P16045 | denotes | Galectin-1 |
T3 | 396-406 | http://www.uniprot.org/uniprot/P16045 | denotes | Galectin-1 |
T4 | 482-492 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T5 | 550-560 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T6 | 721-731 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T7 | 835-845 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T8 | 903-913 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T9 | 1049-1059 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
T10 | 956-966 | http://www.uniprot.org/uniprot/P16110 | denotes | galectin-3 |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 158-162 | http://purl.bioontology.org/ontology/NCBITAXON/3554 | denotes | beta |
T2 | 158-162 | http://purl.bioontology.org/ontology/NCBITAXON/158455 | denotes | beta |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 31-41 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
T2 | 424-434 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
T3 | 854-864 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
T4 | 926-936 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
T5 | 98-107 | http://purl.obolibrary.org/obo/GO_0046960 | denotes | sensitive |
T6 | 1079-1094 | http://purl.obolibrary.org/obo/GO_0050918 | denotes | chemoattraction |
T7 | 1107-1119 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 163-182 | http://purl.obolibrary.org/obo/GO_0016936 | denotes | galactoside-binding |
T2 | 175-182 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T3 | 175-182 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T4 | 175-182 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T5 | 175-182 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T6 | 175-191 | http://purl.obolibrary.org/obo/GO_0005515 | denotes | binding proteins |
T7 | 493-501 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T8 | 525-535 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
Lectin
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
Lectin_T1 | 0-10 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | Galectin-1 |
Lectin_T2 | 117-127 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | Galectin-1 |
Lectin_T3 | 288-298 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T4 | 396-406 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | Galectin-1 |
Lectin_T5 | 482-492 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T6 | 550-560 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T7 | 721-731 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T8 | 835-845 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T9 | 903-913 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T10 | 1049-1059 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
Lectin_T11 | 0-10 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | Galectin-1 |
Lectin_T12 | 117-127 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | Galectin-1 |
Lectin_T13 | 288-298 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T14 | 396-406 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | Galectin-1 |
Lectin_T15 | 482-492 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T16 | 550-560 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T17 | 721-731 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T18 | 835-845 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T19 | 903-913 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T20 | 1049-1059 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
Lectin_T21 | 0-8 | https://acgg.asia/db/lfdb/LfDB0272 | denotes | Galectin |
Lectin_T22 | 117-125 | https://acgg.asia/db/lfdb/LfDB0272 | denotes | Galectin |
Lectin_T23 | 396-404 | https://acgg.asia/db/lfdb/LfDB0272 | denotes | Galectin |
Lectin_T24 | 0-8 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | Galectin |
Lectin_T25 | 117-125 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | Galectin |
Lectin_T26 | 396-404 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | Galectin |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 1176-1191 | Phenotype | denotes | atherosclerosis | HP:0002621 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 82-91 | Disease | denotes | pertussis | http://purl.obolibrary.org/obo/MONDO_0005077 |
T2 | 781-790 | Disease | denotes | pertussis | http://purl.obolibrary.org/obo/MONDO_0005077 |
T3 | 1107-1119 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T4 | 1176-1191 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 449-456 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 1176-1191 | Phenotype | denotes | atherosclerosis | HP:0002621 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 82-91 | Disease | denotes | pertussis | http://purl.obolibrary.org/obo/MONDO_0005077 |
T2 | 781-790 | Disease | denotes | pertussis | http://purl.obolibrary.org/obo/MONDO_0005077 |
T3 | 1107-1119 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T4 | 1176-1191 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 22-30 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T3 | 310-318 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T5 | 383-394 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T7 | 415-423 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T9 | 570-578 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T11 | 917-925 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T13 | 975-986 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 22-30 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T3 | 310-318 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T5 | 383-394 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T6 | 415-423 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T8 | 570-578 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T10 | 917-925 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T12 | 975-986 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
TextSentencer_T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
TextSentencer_T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
TextSentencer_T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
TextSentencer_T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
TextSentencer_T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
TextSentencer_T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
TextSentencer_T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-116 | Sentence | denotes | Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. |
T2 | 117-255 | Sentence | denotes | Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. |
T3 | 256-395 | Sentence | denotes | Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages. |
T4 | 396-536 | Sentence | denotes | Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. |
T5 | 537-732 | Sentence | denotes | Furthermore, galectin-1-mediated monocyte migration was significantly inhibited by MEK inhibitors in a rapid, time-dependent manner suggesting that MAP kinase pathways are involved in galectin-1. |
T6 | 733-865 | Sentence | denotes | Migration was also almost completely blocked by pertussis toxin implying G-protein involvement in the galectin-1-induced chemotaxis. |
T7 | 866-1005 | Sentence | denotes | These results demonstrate a role for galectin-1 in monocyte chemotaxis which differs from galectin-3 in that macrophages are nonresponsive. |
T8 | 1006-1192 | Sentence | denotes | Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 449-456 | Glycan | denotes | lactose | https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE |
GlyCosmos15-Lectin-Jamboree
Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
---|---|---|---|---|---|
T1 | 0-10 | Lectin | denotes | Galectin-1 | GL_001885 |
T2 | 117-127 | Lectin | denotes | Galectin-1 | GL_001885 |
T3 | 396-406 | Lectin | denotes | Galectin-1 | GL_001885 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 22-30 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T3 | 310-318 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T5 | 383-394 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T6 | 415-423 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T8 | 570-578 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T10 | 917-925 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
T12 | 975-986 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 22-30 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T3 | 310-318 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T5 | 383-394 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T7 | 415-423 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T9 | 570-578 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T11 | 917-925 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
T13 | 975-986 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |