PubMed:19463742 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/19463742","sourcedb":"PubMed","sourceid":"19463742","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/19463742","text":"Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.\nThe melanocortin system is crucial to regulation of energy homeostasis. The melanocortin receptor type 4 (MC4R) modulates insulin signaling via effects on c-Jun N-terminal kinase (JNK). The melanocortin agonist NDP-MSH dose-dependently inhibited JNK activity in HEK293 cells stably expressing the human MC4R; effects were reversed by melanocortin receptor antagonist. NDP-MSH time- and dose-dependently inhibited IRS-1(ser307) phosphorylation, effects also reversed by a specific melanocortin receptor antagonist. NDP-MSH augmented insulin-stimulated AKT phosphorylation in vitro. The melanocortin agonist melanotan II increased insulin-stimulated AKT phosphorylation in the rat hypothalamus in vivo. NDP-MSH increased insulin-stimulated glucose uptake in hypothalamic GT1-1 cells. The current study shows that the melanocortinergic system interacts with insulin signaling via novel effects on JNK activity.","tracks":[{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T2","span":{"begin":109,"end":180},"obj":"Sentence"},{"id":"T3","span":{"begin":181,"end":294},"obj":"Sentence"},{"id":"T4","span":{"begin":295,"end":476},"obj":"Sentence"},{"id":"T5","span":{"begin":477,"end":622},"obj":"Sentence"},{"id":"T6","span":{"begin":623,"end":689},"obj":"Sentence"},{"id":"T7","span":{"begin":690,"end":809},"obj":"Sentence"},{"id":"T8","span":{"begin":810,"end":890},"obj":"Sentence"},{"id":"T9","span":{"begin":891,"end":1016},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":406,"end":411},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":784,"end":787},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:10116"},{"id":"A3","pred":"db_id","subj":"T2","obj":"NCBItxid:10114"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T2","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-entities","denotations":[{"id":"6073","span":{"begin":0,"end":23},"obj":"GeneOrGeneProduct"},{"id":"6074","span":{"begin":44,"end":67},"obj":"GeneOrGeneProduct"},{"id":"6075","span":{"begin":90,"end":97},"obj":"GeneOrGeneProduct"},{"id":"6076","span":{"begin":113,"end":125},"obj":"GeneOrGeneProduct"},{"id":"6077","span":{"begin":185,"end":213},"obj":"GeneOrGeneProduct"},{"id":"6078","span":{"begin":215,"end":219},"obj":"GeneOrGeneProduct"},{"id":"6079","span":{"begin":231,"end":238},"obj":"GeneOrGeneProduct"},{"id":"6080","span":{"begin":264,"end":287},"obj":"GeneOrGeneProduct"},{"id":"6081","span":{"begin":289,"end":292},"obj":"GeneOrGeneProduct"},{"id":"6082","span":{"begin":299,"end":311},"obj":"GeneOrGeneProduct"},{"id":"6083","span":{"begin":320,"end":327},"obj":"ChemicalEntity"},{"id":"6084","span":{"begin":355,"end":358},"obj":"GeneOrGeneProduct"},{"id":"6085","span":{"begin":371,"end":377},"obj":"CellLine"},{"id":"6086","span":{"begin":406,"end":411},"obj":"OrganismTaxon"},{"id":"6087","span":{"begin":412,"end":416},"obj":"GeneOrGeneProduct"},{"id":"6088","span":{"begin":443,"end":464},"obj":"GeneOrGeneProduct"},{"id":"6089","span":{"begin":477,"end":484},"obj":"ChemicalEntity"},{"id":"6090","span":{"begin":522,"end":527},"obj":"GeneOrGeneProduct"},{"id":"6091","span":{"begin":528,"end":534},"obj":"SequenceVariant"},{"id":"6092","span":{"begin":589,"end":610},"obj":"GeneOrGeneProduct"},{"id":"6093","span":{"begin":623,"end":630},"obj":"ChemicalEntity"},{"id":"6094","span":{"begin":641,"end":648},"obj":"GeneOrGeneProduct"},{"id":"6095","span":{"begin":660,"end":663},"obj":"GeneOrGeneProduct"},{"id":"6096","span":{"begin":694,"end":706},"obj":"GeneOrGeneProduct"},{"id":"6097","span":{"begin":715,"end":727},"obj":"ChemicalEntity"},{"id":"6098","span":{"begin":738,"end":745},"obj":"GeneOrGeneProduct"},{"id":"6099","span":{"begin":757,"end":760},"obj":"GeneOrGeneProduct"},{"id":"6100","span":{"begin":784,"end":787},"obj":"OrganismTaxon"},{"id":"6101","span":{"begin":810,"end":817},"obj":"ChemicalEntity"},{"id":"6102","span":{"begin":828,"end":835},"obj":"GeneOrGeneProduct"},{"id":"6103","span":{"begin":847,"end":854},"obj":"ChemicalEntity"},{"id":"6104","span":{"begin":878,"end":883},"obj":"CellLine"},{"id":"6105","span":{"begin":964,"end":971},"obj":"GeneOrGeneProduct"},{"id":"6106","span":{"begin":1003,"end":1006},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A19","pred":"db_id","subj":"6085","obj":"NCBITaxon:9606"},{"id":"A42","pred":"db_id","subj":"6106","obj":"NCBIGene:116554"},{"id":"A43","pred":"db_id","subj":"6106","obj":"NCBIGene:26419"},{"id":"A44","pred":"db_id","subj":"6106","obj":"NCBIGene:5599"},{"id":"A23","pred":"db_id","subj":"6089","obj":"MESH:C027756"},{"id":"A24","pred":"db_id","subj":"6090","obj":"NCBIGene:3667"},{"id":"A4","pred":"db_id","subj":"6074","obj":"NCBIGene:116554"},{"id":"A5","pred":"db_id","subj":"6074","obj":"NCBIGene:26419"},{"id":"A6","pred":"db_id","subj":"6074","obj":"NCBIGene:5599"},{"id":"A39","pred":"db_id","subj":"6105","obj":"NCBIGene:16333"},{"id":"A40","pred":"db_id","subj":"6105","obj":"NCBIGene:24505"},{"id":"A41","pred":"db_id","subj":"6105","obj":"NCBIGene:3630"},{"id":"A27","pred":"db_id","subj":"6093","obj":"MESH:C027756"},{"id":"A1","pred":"db_id","subj":"6073","obj":"NCBIGene:17202"},{"id":"A2","pred":"db_id","subj":"6073","obj":"NCBIGene:25635"},{"id":"A3","pred":"db_id","subj":"6073","obj":"NCBIGene:4160"},{"id":"A11","pred":"db_id","subj":"6077","obj":"NCBIGene:4160"},{"id":"A28","pred":"db_id","subj":"6094","obj":"NCBIGene:3630"},{"id":"A33","pred":"db_id","subj":"6099","obj":"NCBIGene:24185"},{"id":"A16","pred":"db_id","subj":"6082","obj":"NCBIGene:5443"},{"id":"A29","pred":"db_id","subj":"6095","obj":"NCBIGene:207"},{"id":"A21","pred":"db_id","subj":"6087","obj":"NCBIGene:4160"},{"id":"A25","pred":"db_id","subj":"6091","obj":"p|Allele|S|307"},{"id":"A34","pred":"db_id","subj":"6100","obj":"NCBITaxon:10116"},{"id":"A18","pred":"db_id","subj":"6084","obj":"NCBIGene:5599"},{"id":"A20","pred":"db_id","subj":"6086","obj":"NCBITaxon:9606"},{"id":"A10","pred":"db_id","subj":"6076","obj":"NCBIGene:5443"},{"id":"A36","pred":"db_id","subj":"6102","obj":"NCBIGene:16333"},{"id":"A32","pred":"db_id","subj":"6098","obj":"NCBIGene:24505"},{"id":"A7","pred":"db_id","subj":"6075","obj":"NCBIGene:16333"},{"id":"A8","pred":"db_id","subj":"6075","obj":"NCBIGene:24505"},{"id":"A9","pred":"db_id","subj":"6075","obj":"NCBIGene:3630"},{"id":"A13","pred":"db_id","subj":"6079","obj":"NCBIGene:3630"},{"id":"A12","pred":"db_id","subj":"6078","obj":"NCBIGene:4160"},{"id":"A31","pred":"db_id","subj":"6097","obj":"MESH:C079282"},{"id":"A26","pred":"db_id","subj":"6092","obj":"NCBIGene:4160"},{"id":"A14","pred":"db_id","subj":"6080","obj":"NCBIGene:5599"},{"id":"A22","pred":"db_id","subj":"6088","obj":"NCBIGene:4160"},{"id":"A15","pred":"db_id","subj":"6081","obj":"NCBIGene:5599"},{"id":"A30","pred":"db_id","subj":"6096","obj":"NCBIGene:5443"},{"id":"A17","pred":"db_id","subj":"6083","obj":"MESH:C027756"},{"id":"A35","pred":"db_id","subj":"6101","obj":"MESH:C027756"},{"id":"A37","pred":"db_id","subj":"6103","obj":"MESH:D005947"},{"id":"A38","pred":"db_id","subj":"6104","obj":"NCBITaxon:10090"},{"subj":"6073","pred":"source","obj":"LitCoin-entities"},{"subj":"6074","pred":"source","obj":"LitCoin-entities"},{"subj":"6075","pred":"source","obj":"LitCoin-entities"},{"subj":"6076","pred":"source","obj":"LitCoin-entities"},{"subj":"6077","pred":"source","obj":"LitCoin-entities"},{"subj":"6078","pred":"source","obj":"LitCoin-entities"},{"subj":"6079","pred":"source","obj":"LitCoin-entities"},{"subj":"6080","pred":"source","obj":"LitCoin-entities"},{"subj":"6081","pred":"source","obj":"LitCoin-entities"},{"subj":"6082","pred":"source","obj":"LitCoin-entities"},{"subj":"6083","pred":"source","obj":"LitCoin-entities"},{"subj":"6084","pred":"source","obj":"LitCoin-entities"},{"subj":"6085","pred":"source","obj":"LitCoin-entities"},{"subj":"6086","pred":"source","obj":"LitCoin-entities"},{"subj":"6087","pred":"source","obj":"LitCoin-entities"},{"subj":"6088","pred":"source","obj":"LitCoin-entities"},{"subj":"6089","pred":"source","obj":"LitCoin-entities"},{"subj":"6090","pred":"source","obj":"LitCoin-entities"},{"subj":"6091","pred":"source","obj":"LitCoin-entities"},{"subj":"6092","pred":"source","obj":"LitCoin-entities"},{"subj":"6093","pred":"source","obj":"LitCoin-entities"},{"subj":"6094","pred":"source","obj":"LitCoin-entities"},{"subj":"6095","pred":"source","obj":"LitCoin-entities"},{"subj":"6096","pred":"source","obj":"LitCoin-entities"},{"subj":"6097","pred":"source","obj":"LitCoin-entities"},{"subj":"6098","pred":"source","obj":"LitCoin-entities"},{"subj":"6099","pred":"source","obj":"LitCoin-entities"},{"subj":"6100","pred":"source","obj":"LitCoin-entities"},{"subj":"6101","pred":"source","obj":"LitCoin-entities"},{"subj":"6102","pred":"source","obj":"LitCoin-entities"},{"subj":"6103","pred":"source","obj":"LitCoin-entities"},{"subj":"6104","pred":"source","obj":"LitCoin-entities"},{"subj":"6105","pred":"source","obj":"LitCoin-entities"},{"subj":"6106","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":15,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":24,"end":34},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":44,"end":67},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":68,"end":76},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":90,"end":97},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":147,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":185,"end":213},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":215,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":231,"end":238},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":264,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":324,"end":327},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":359,"end":367},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":378,"end":383},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":412,"end":416},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":443,"end":464},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":465,"end":475},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":481,"end":484},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":485,"end":489},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":522,"end":527},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":589,"end":610},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":611,"end":621},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":627,"end":630},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":641,"end":648},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":725,"end":727},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":738,"end":745},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":814,"end":817},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":828,"end":835},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":878,"end":881},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":884,"end":889},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":964,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":986,"end":991},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1007,"end":1015},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":15,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":44,"end":67},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":90,"end":97},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":185,"end":213},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":215,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":231,"end":238},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":264,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":324,"end":327},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":412,"end":416},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":443,"end":464},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":481,"end":484},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":522,"end":527},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":589,"end":610},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":627,"end":630},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":641,"end":648},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":738,"end":745},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":814,"end":817},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":828,"end":835},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":878,"end":881},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":964,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":986,"end":991},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":44,"end":67},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":185,"end":213},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":215,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":264,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":324,"end":327},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":412,"end":416},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":443,"end":464},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":481,"end":484},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":522,"end":527},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":589,"end":610},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":627,"end":630},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":814,"end":817},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":878,"end":881},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":320,"end":323},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":477,"end":480},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":522,"end":525},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":623,"end":626},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":810,"end":813},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0010691"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0010691"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0100185"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0010691"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0010691"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin_CellLine","denotations":[{"id":"T1","span":{"begin":371,"end":377},"obj":"CellLine"},{"id":"T2","span":{"begin":878,"end":883},"obj":"CellLine"}],"attributes":[{"id":"A1","pred":"cellosaurus_accession_id","subj":"T1","obj":"CVCL_0045"},{"id":"A2","pred":"cellosaurus_accession_id","subj":"T2","obj":"CVCL_6236"},{"subj":"T1","pred":"source","obj":"LitCoin_CellLine"},{"subj":"T2","pred":"source","obj":"LitCoin_CellLine"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":406,"end":411},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":784,"end":787},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":320,"end":327},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":477,"end":484},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":623,"end":630},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":715,"end":727},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":810,"end":817},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":847,"end":854},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A3","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A4","pred":"ID:","subj":"T4","obj":"ChemicalEntity"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D005947"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A8","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T2","span":{"begin":878,"end":883},"obj":"CellLine"},{"id":"T1","span":{"begin":371,"end":377},"obj":"CellLine"},{"id":"T6","span":{"begin":847,"end":854},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":810,"end":817},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":715,"end":727},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":623,"end":630},"obj":"ChemicalEntity"},{"id":"T96262","span":{"begin":477,"end":484},"obj":"ChemicalEntity"},{"id":"T74640","span":{"begin":320,"end":327},"obj":"ChemicalEntity"},{"id":"T14","span":{"begin":878,"end":881},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":814,"end":817},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":627,"end":630},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":589,"end":610},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":522,"end":527},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":481,"end":484},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":443,"end":464},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":412,"end":416},"obj":"GeneOrGeneProduct"},{"id":"T29245","span":{"begin":324,"end":327},"obj":"GeneOrGeneProduct"},{"id":"T4465","span":{"begin":264,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T28790","span":{"begin":215,"end":219},"obj":"GeneOrGeneProduct"},{"id":"T73467","span":{"begin":185,"end":213},"obj":"GeneOrGeneProduct"},{"id":"T99498","span":{"begin":44,"end":67},"obj":"GeneOrGeneProduct"},{"id":"T7398","span":{"begin":0,"end":23},"obj":"GeneOrGeneProduct"},{"id":"T8216","span":{"begin":784,"end":787},"obj":"OrganismTaxon"},{"id":"T29152","span":{"begin":406,"end":411},"obj":"OrganismTaxon"}],"attributes":[{"id":"A2","pred":"cellosaurus_accession_id","subj":"T2","obj":"CVCL_6236"},{"id":"A1","pred":"cellosaurus_accession_id","subj":"T1","obj":"CVCL_0045"},{"id":"A8","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A7","pred":"ID:","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D005947"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A4","pred":"ID:","subj":"T4","obj":"ChemicalEntity"},{"id":"A3","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A81782","pred":"ID:","subj":"T96262","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"id":"A98520","pred":"ID:","subj":"T74640","obj":"http://purl.obolibrary.org/obo/CHEBI_136034"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T96262","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74640","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T29245","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4465","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T28790","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T73467","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T99498","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7398","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8216","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T29152","pred":"source","obj":"LitCoin-training-merged"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":320,"end":323},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":477,"end":480},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":522,"end":525},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":623,"end":626},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":810,"end":813},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0010691"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0010691"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0100185"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0010691"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0010691"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-sentences","color":"#93eccc","default":true},{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#ecb293"},{"id":"LitCoin-entities","color":"#9893ec"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#a8ec93"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#ec93c2"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#93dcec"},{"id":"LitCoin_Mondo_095","color":"#ece293"},{"id":"LitCoin_CellLine","color":"#c893ec"},{"id":"LitCoin-NCBITaxon-2","color":"#93ecae"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#ec9493"},{"id":"LitCoin-training-merged","color":"#93abec"},{"id":"PMID_GLOBAL","color":"#c5ec93"}]}]}}