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PubMed:19463742 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.
T2 109-180 Sentence denotes The melanocortin system is crucial to regulation of energy homeostasis.
T3 181-294 Sentence denotes The melanocortin receptor type 4 (MC4R) modulates insulin signaling via effects on c-Jun N-terminal kinase (JNK).
T4 295-476 Sentence denotes The melanocortin agonist NDP-MSH dose-dependently inhibited JNK activity in HEK293 cells stably expressing the human MC4R; effects were reversed by melanocortin receptor antagonist.
T5 477-622 Sentence denotes NDP-MSH time- and dose-dependently inhibited IRS-1(ser307) phosphorylation, effects also reversed by a specific melanocortin receptor antagonist.
T6 623-689 Sentence denotes NDP-MSH augmented insulin-stimulated AKT phosphorylation in vitro.
T7 690-809 Sentence denotes The melanocortin agonist melanotan II increased insulin-stimulated AKT phosphorylation in the rat hypothalamus in vivo.
T8 810-890 Sentence denotes NDP-MSH increased insulin-stimulated glucose uptake in hypothalamic GT1-1 cells.
T9 891-1016 Sentence denotes The current study shows that the melanocortinergic system interacts with insulin signaling via novel effects on JNK activity.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 406-411 OrganismTaxon denotes human NCBItxid:9606
T2 784-787 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6073 0-23 GeneOrGeneProduct denotes Melanocortin-4 receptor NCBIGene:17202|NCBIGene:25635|NCBIGene:4160
6074 44-67 GeneOrGeneProduct denotes c-Jun N-terminal kinase NCBIGene:116554|NCBIGene:26419|NCBIGene:5599
6075 90-97 GeneOrGeneProduct denotes insulin NCBIGene:16333|NCBIGene:24505|NCBIGene:3630
6076 113-125 GeneOrGeneProduct denotes melanocortin NCBIGene:5443
6077 185-213 GeneOrGeneProduct denotes melanocortin receptor type 4 NCBIGene:4160
6078 215-219 GeneOrGeneProduct denotes MC4R NCBIGene:4160
6079 231-238 GeneOrGeneProduct denotes insulin NCBIGene:3630
6080 264-287 GeneOrGeneProduct denotes c-Jun N-terminal kinase NCBIGene:5599
6081 289-292 GeneOrGeneProduct denotes JNK NCBIGene:5599
6082 299-311 GeneOrGeneProduct denotes melanocortin NCBIGene:5443
6083 320-327 ChemicalEntity denotes NDP-MSH MESH:C027756
6084 355-358 GeneOrGeneProduct denotes JNK NCBIGene:5599
6085 371-377 CellLine denotes HEK293 NCBITaxon:9606
6086 406-411 OrganismTaxon denotes human NCBITaxon:9606
6087 412-416 GeneOrGeneProduct denotes MC4R NCBIGene:4160
6088 443-464 GeneOrGeneProduct denotes melanocortin receptor NCBIGene:4160
6089 477-484 ChemicalEntity denotes NDP-MSH MESH:C027756
6090 522-527 GeneOrGeneProduct denotes IRS-1 NCBIGene:3667
6091 528-534 SequenceVariant denotes ser307 p|Allele|S|307
6092 589-610 GeneOrGeneProduct denotes melanocortin receptor NCBIGene:4160
6093 623-630 ChemicalEntity denotes NDP-MSH MESH:C027756
6094 641-648 GeneOrGeneProduct denotes insulin NCBIGene:3630
6095 660-663 GeneOrGeneProduct denotes AKT NCBIGene:207
6096 694-706 GeneOrGeneProduct denotes melanocortin NCBIGene:5443
6097 715-727 ChemicalEntity denotes melanotan II MESH:C079282
6098 738-745 GeneOrGeneProduct denotes insulin NCBIGene:24505
6099 757-760 GeneOrGeneProduct denotes AKT NCBIGene:24185
6100 784-787 OrganismTaxon denotes rat NCBITaxon:10116
6101 810-817 ChemicalEntity denotes NDP-MSH MESH:C027756
6102 828-835 GeneOrGeneProduct denotes insulin NCBIGene:16333
6103 847-854 ChemicalEntity denotes glucose MESH:D005947
6104 878-883 CellLine denotes GT1-1 NCBITaxon:10090
6105 964-971 GeneOrGeneProduct denotes insulin NCBIGene:16333|NCBIGene:24505|NCBIGene:3630
6106 1003-1006 GeneOrGeneProduct denotes JNK NCBIGene:116554|NCBIGene:26419|NCBIGene:5599

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 15-23 GeneOrGeneProduct denotes receptor
T2 24-34 GeneOrGeneProduct denotes activation
T3 44-67 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T4 68-76 GeneOrGeneProduct denotes activity
T5 90-97 GeneOrGeneProduct denotes insulin
T6 147-157 GeneOrGeneProduct denotes regulation
T7 185-213 GeneOrGeneProduct denotes melanocortin receptor type 4
T8 215-219 GeneOrGeneProduct denotes MC4R
T9 231-238 GeneOrGeneProduct denotes insulin
T10 264-287 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T11 324-327 GeneOrGeneProduct denotes MSH
T12 359-367 GeneOrGeneProduct denotes activity
T13 378-383 GeneOrGeneProduct denotes cells
T14 412-416 GeneOrGeneProduct denotes MC4R
T15 443-464 GeneOrGeneProduct denotes melanocortin receptor
T16 465-475 GeneOrGeneProduct denotes antagonist
T17 481-484 GeneOrGeneProduct denotes MSH
T18 485-489 GeneOrGeneProduct denotes time
T19 522-527 GeneOrGeneProduct denotes IRS-1
T20 589-610 GeneOrGeneProduct denotes melanocortin receptor
T21 611-621 GeneOrGeneProduct denotes antagonist
T22 627-630 GeneOrGeneProduct denotes MSH
T23 641-648 GeneOrGeneProduct denotes insulin
T24 725-727 GeneOrGeneProduct denotes II
T25 738-745 GeneOrGeneProduct denotes insulin
T26 814-817 GeneOrGeneProduct denotes MSH
T27 828-835 GeneOrGeneProduct denotes insulin
T28 878-881 GeneOrGeneProduct denotes GT1
T29 884-889 GeneOrGeneProduct denotes cells
T30 964-971 GeneOrGeneProduct denotes insulin
T31 986-991 GeneOrGeneProduct denotes novel
T32 1007-1015 GeneOrGeneProduct denotes activity

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 15-23 GeneOrGeneProduct denotes receptor
T2 44-67 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T3 90-97 GeneOrGeneProduct denotes insulin
T4 185-213 GeneOrGeneProduct denotes melanocortin receptor type 4
T5 215-219 GeneOrGeneProduct denotes MC4R
T6 231-238 GeneOrGeneProduct denotes insulin
T7 264-287 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T8 324-327 GeneOrGeneProduct denotes MSH
T9 412-416 GeneOrGeneProduct denotes MC4R
T10 443-464 GeneOrGeneProduct denotes melanocortin receptor
T11 481-484 GeneOrGeneProduct denotes MSH
T12 522-527 GeneOrGeneProduct denotes IRS-1
T13 589-610 GeneOrGeneProduct denotes melanocortin receptor
T14 627-630 GeneOrGeneProduct denotes MSH
T15 641-648 GeneOrGeneProduct denotes insulin
T16 738-745 GeneOrGeneProduct denotes insulin
T17 814-817 GeneOrGeneProduct denotes MSH
T18 828-835 GeneOrGeneProduct denotes insulin
T19 878-881 GeneOrGeneProduct denotes GT1
T20 964-971 GeneOrGeneProduct denotes insulin
T21 986-991 GeneOrGeneProduct denotes novel

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-23 GeneOrGeneProduct denotes Melanocortin-4 receptor
T2 44-67 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T3 185-213 GeneOrGeneProduct denotes melanocortin receptor type 4
T4 215-219 GeneOrGeneProduct denotes MC4R
T5 264-287 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T6 324-327 GeneOrGeneProduct denotes MSH
T7 412-416 GeneOrGeneProduct denotes MC4R
T8 443-464 GeneOrGeneProduct denotes melanocortin receptor
T9 481-484 GeneOrGeneProduct denotes MSH
T10 522-527 GeneOrGeneProduct denotes IRS-1
T11 589-610 GeneOrGeneProduct denotes melanocortin receptor
T12 627-630 GeneOrGeneProduct denotes MSH
T13 814-817 GeneOrGeneProduct denotes MSH
T14 878-881 GeneOrGeneProduct denotes GT1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 320-323 DiseaseOrPhenotypicFeature denotes NDP 0010691
T2 477-480 DiseaseOrPhenotypicFeature denotes NDP 0010691
T3 522-525 DiseaseOrPhenotypicFeature denotes IRS 0100185
T4 623-626 DiseaseOrPhenotypicFeature denotes NDP 0010691
T5 810-813 DiseaseOrPhenotypicFeature denotes NDP 0010691

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 371-377 CellLine denotes HEK293 CVCL_0045
T2 878-883 CellLine denotes GT1-1 CVCL_6236

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 406-411 OrganismTaxon denotes human
T2 784-787 OrganismTaxon denotes rat

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 320-327 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T2 477-484 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T3 623-630 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T4 715-727 ChemicalEntity denotes melanotan II ChemicalEntity
T5 810-817 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T6 847-854 ChemicalEntity denotes glucose D005947|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234

LitCoin-training-merged

Id Subject Object Predicate Lexical cue ID: cellosaurus_accession_id
T2 878-883 CellLine denotes GT1-1 CVCL_6236
T1 371-377 CellLine denotes HEK293 CVCL_0045
T6 847-854 ChemicalEntity denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167|D005947
T5 810-817 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T4 715-727 ChemicalEntity denotes melanotan II ChemicalEntity
T3 623-630 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T96262 477-484 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T74640 320-327 ChemicalEntity denotes NDP-MSH http://purl.obolibrary.org/obo/CHEBI_136034
T14 878-881 GeneOrGeneProduct denotes GT1
T13 814-817 GeneOrGeneProduct denotes MSH
T12 627-630 GeneOrGeneProduct denotes MSH
T11 589-610 GeneOrGeneProduct denotes melanocortin receptor
T10 522-527 GeneOrGeneProduct denotes IRS-1
T9 481-484 GeneOrGeneProduct denotes MSH
T8 443-464 GeneOrGeneProduct denotes melanocortin receptor
T7 412-416 GeneOrGeneProduct denotes MC4R
T29245 324-327 GeneOrGeneProduct denotes MSH
T4465 264-287 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T28790 215-219 GeneOrGeneProduct denotes MC4R
T73467 185-213 GeneOrGeneProduct denotes melanocortin receptor type 4
T99498 44-67 GeneOrGeneProduct denotes c-Jun N-terminal kinase
T7398 0-23 GeneOrGeneProduct denotes Melanocortin-4 receptor
T8216 784-787 OrganismTaxon denotes rat
T29152 406-411 OrganismTaxon denotes human

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 320-323 DiseaseOrPhenotypicFeature denotes NDP 0010691
T2 477-480 DiseaseOrPhenotypicFeature denotes NDP 0010691
T3 522-525 DiseaseOrPhenotypicFeature denotes IRS 0100185
T4 623-626 DiseaseOrPhenotypicFeature denotes NDP 0010691
T5 810-813 DiseaseOrPhenotypicFeature denotes NDP 0010691