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PubMed:1945879 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 431-439 DiseaseOrPhenotypicFeature denotes lymphoma 0003659|0003660|0005062

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 67-97 DNA denotes kB-like proto-enhancer element
T2 107-129 DNA denotes interleukin 2 promoter
T3 146-171 DNA denotes T cell-specific enhancers
T4 175-218 DNA denotes murine and human Interleukin 2 (Il-2) genes
T5 231-247 DNA denotes kB-like sequence
T6 266-301 DNA denotes essential cis-acting enhancer motif
T7 349-353 DNA denotes TCEd
T8 355-376 DNA denotes distal T cell element
T9 399-421 DNA denotes proto-enhancer element
T10 425-445 cell_line denotes E14 T lymphoma cells
T11 458-468 cell_line denotes HeLa cells
T12 494-518 cell_line denotes Il-2 secreting El4 cells
T13 536-551 protein denotes protein factors
T14 560-568 DNA denotes TCEd DNA
T15 618-623 protein denotes TCF-1
T16 625-640 protein denotes T cell factor 1
T17 699-704 protein denotes TCF-1
T18 799-816 protein denotes 50 kD polypeptide
T19 820-825 protein denotes NF-kB
T20 827-841 protein denotes Purified NF-kB
T21 870-874 DNA denotes TCEd
T22 880-885 protein denotes TCF-1
T23 906-911 protein denotes NF-kB
T24 915-919 DNA denotes TCEd
T25 947-951 DNA denotes TCEd
T26 957-985 DNA denotes 'perfect' NF-kB binding site
T27 1016-1021 protein denotes NF-kB
T28 1025-1033 DNA denotes TCEd DNA
T29 1091-1114 DNA denotes 'converted' TCEd motifs
T30 1118-1128 cell_line denotes HeLa cells
T31 1199-1216 DNA denotes GGGATTTCACC motif
T32 1295-1304 cell_line denotes El4 cells
T33 1309-1319 cell_line denotes HeLa cells
T34 1392-1396 DNA denotes TCEd
T35 1465-1474 DNA denotes Il-2 gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-130 Sentence denotes One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.
S2 131-302 Sentence denotes The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif.
S3 303-469 Sentence denotes When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14 T lymphoma cells, but not in HeLa cells.
S4 470-569 Sentence denotes In extracts of induced, Il-2 secreting El4 cells three individual protein factors bind to TCEd DNA.
S5 570-698 Sentence denotes The binding of the most prominent factor, named TCF-1 (T cell factor 1), is correlated with the proto-enhancer activity of TCEd.
S6 699-826 Sentence denotes TCF-1 consists of two polypeptides of about 50 kD and 105 kD; the former seems to be related to the 50 kD polypeptide of NF-kB.
S7 827-924 Sentence denotes Purified NF-kB is also able to bind to the TCEd, but TCF-1 binds stronger than NF-kB to TCEd DNA.
S8 925-1129 Sentence denotes The conversion of the TCEd to a 'perfect' NF-kB binding site leads to a tighter binding of NF-kB to TCEd DNA and, as a functional consequence, to the activity of the 'converted' TCEd motifs in HeLa cells.
S9 1130-1320 Sentence denotes Thus, the substitution of the underlined A residue to a C within the GGGATTTCACC motif abolishes its T cell-restricted activity and leads to its functioning in both El4 cells and HeLa cells.
S10 1321-1475 Sentence denotes These results indicate that lymphocyte-specific factors binding to the TCEd are involved in the control of T cell specific-transcription of the Il-2 gene.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 31-61 NP denotes the T cell-restricted activity
C2 175-218 NP denotes murine and human Interleukin 2 (Il-2) genes
C3 227-259 NP denotes the kB-like sequence GGGATTTCACC
C4 349-377 NP denotes TCEd (distal T cell element)
C5 425-445 NP denotes E14 T lymphoma cells
C6 458-468 NP denotes HeLa cells
C7 494-498 NP denotes Il-2
C8 509-518 NP denotes El4 cells
C10 560-564 NP denotes TCEd
C9 560-568 NP denotes TCEd DNA
C11 585-610 NP denotes the most prominent factor
C12 618-641 NP denotes TCF-1 (T cell factor 1)
C13 693-697 NP denotes TCEd
C14 699-704 NP denotes TCF-1
C15 717-759 NP denotes two polypeptides of about 50 kD and 105 kD
C16 761-771 NP denotes the former
C17 820-825 NP denotes NF-kB
C18 827-841 NP denotes Purified NF-kB
C19 866-874 NP denotes the TCEd
C20 880-885 NP denotes TCF-1
C21 906-911 NP denotes NF-kB
C23 915-919 NP denotes TCEd
C22 915-923 NP denotes TCEd DNA
C24 943-951 NP denotes the TCEd
C25 1016-1021 NP denotes NF-kB
C27 1025-1029 NP denotes TCEd
C26 1025-1033 NP denotes TCEd DNA
C28 1118-1128 NP denotes HeLa cells
C29 1195-1216 NP denotes the GGGATTTCACC motif
C30 1227-1230 NP denotes its
C31 1231-1257 NP denotes T cell-restricted activity
C32 1271-1274 NP denotes its
C33 1295-1304 NP denotes El4 cells
C34 1309-1319 NP denotes HeLa cells
C35 1388-1396 NP denotes the TCEd
C36 1461-1474 NP denotes the Il-2 gene
R1 C7 C2 coref-ident Il-2,murine and human Interleukin 2 (Il-2) genes
R2 C8 C5 coref-ident El4 cells,E14 T lymphoma cells
R3 C10 C4 coref-ident TCEd,TCEd (distal T cell element)
R4 C11 C12 coref-appos the most prominent factor,TCF-1 (T cell factor 1)
R5 C13 C10 coref-ident TCEd,TCEd
R6 C14 C12 coref-ident TCF-1,TCF-1 (T cell factor 1)
R7 C16 C15 coref-other the former,two polypeptides of about 50 kD and 105 kD
R8 C18 C17 coref-other Purified NF-kB,NF-kB
R9 C19 C13 coref-ident the TCEd,TCEd
R10 C20 C14 coref-ident TCF-1,TCF-1
R11 C21 C17 coref-ident NF-kB,NF-kB
R12 C23 C19 coref-ident TCEd,the TCEd
R13 C22 C9 coref-ident TCEd DNA,TCEd DNA
R14 C24 C23 coref-ident the TCEd,TCEd
R15 C25 C21 coref-ident NF-kB,NF-kB
R16 C27 C24 coref-ident TCEd,the TCEd
R17 C26 C22 coref-ident TCEd DNA,TCEd DNA
R18 C28 C6 coref-ident HeLa cells,HeLa cells
R19 C29 C3 coref-ident the GGGATTTCACC motif,the kB-like sequence GGGATTTCACC
R20 C30 C29 coref-pron its,the GGGATTTCACC motif
R21 C31 C1 coref-ident T cell-restricted activity,the T cell-restricted activity
R22 C32 C29 coref-pron its,the GGGATTTCACC motif
R23 C33 C8 coref-ident El4 cells,El4 cells
R24 C34 C28 coref-ident HeLa cells,HeLa cells
R25 C35 C27 coref-ident the TCEd,TCEd
R26 C36 C7 coref-ident the Il-2 gene,Il-2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 35-61 other_name denotes T cell-restricted activity
T2 67-97 DNA_domain_or_region denotes kB-like proto-enhancer element
T3 107-129 DNA_domain_or_region denotes interleukin 2 promoter
T4 146-171 DNA_domain_or_region denotes T cell-specific enhancers
T5 175-207 DNA_domain_or_region denotes murine and human Interleukin 2 (
T6 207-211 protein_molecule denotes Il-2
T7 231-247 DNA_domain_or_region denotes kB-like sequence
T8 248-259 polynucleotide denotes GGGATTTCACC
T9 266-301 DNA_domain_or_region denotes essential cis-acting enhancer motif
T10 349-353 DNA_domain_or_region denotes TCEd
T11 355-376 DNA_domain_or_region denotes distal T cell element
T12 399-421 DNA_domain_or_region denotes proto-enhancer element
T13 425-445 cell_line denotes E14 T lymphoma cells
T14 458-468 cell_line denotes HeLa cells
T15 494-498 protein_molecule denotes Il-2
T16 536-551 protein_family_or_group denotes protein factors
T17 560-568 DNA_domain_or_region denotes TCEd DNA
T18 618-623 protein_molecule denotes TCF-1
T19 625-640 protein_molecule denotes T cell factor 1
T20 666-689 other_name denotes proto-enhancer activity
T21 693-697 DNA_substructure denotes TCEd
T22 699-704 protein_molecule denotes TCF-1
T23 721-733 peptide denotes polypeptides
T24 743-748 peptide denotes 50 kD
T25 753-759 peptide denotes 105 kD
T26 799-816 protein_subunit denotes 50 kD polypeptide
T27 820-825 protein_subunit denotes NF-kB
T28 827-841 protein_molecule denotes Purified NF-kB
T29 870-874 DNA_domain_or_region denotes TCEd
T30 880-885 protein_molecule denotes TCF-1
T31 906-911 protein_molecule denotes NF-kB
T32 915-919 DNA_domain_or_region denotes TCEd
T33 947-951 DNA_domain_or_region denotes TCEd
T34 957-966 DNA_domain_or_region denotes 'perfect'
T35 967-972 protein_molecule denotes NF-kB
T36 1016-1021 protein_molecule denotes NF-kB
T37 1025-1029 DNA_domain_or_region denotes TCEd
T38 1091-1102 DNA_domain_or_region denotes 'converted'
T39 1103-1107 DNA_domain_or_region denotes TCEd
T40 1118-1128 cell_line denotes HeLa cells
T41 1140-1152 other_name denotes substitution
T42 1199-1216 DNA_domain_or_region denotes GGGATTTCACC motif
T43 1231-1257 other_name denotes T cell-restricted activity
T44 1295-1304 cell_line denotes El4 cells
T45 1309-1319 cell_line denotes HeLa cells
T46 1392-1396 DNA_domain_or_region denotes TCEd
T47 1428-1457 other_name denotes T cell specific-transcription
T48 1465-1469 protein_molecule denotes Il-2