PubMed:19451547
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 39-49 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | hyaluronan |
| T2 | 82-92 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | Hyaluronan |
| T3 | 94-96 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T4 | 262-264 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T5 | 470-472 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T6 | 482-484 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T7 | 620-622 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T8 | 873-875 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T9 | 919-921 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T10 | 1068-1070 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
| T11 | 1203-1205 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | HA |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 39-49 | Glycan_Motif | denotes | hyaluronan | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T2 | 82-92 | Glycan_Motif | denotes | Hyaluronan | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T3 | 94-96 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T4 | 262-264 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T5 | 470-472 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T6 | 482-484 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T7 | 620-622 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T8 | 873-875 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T9 | 919-921 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T10 | 1068-1070 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T11 | 1203-1205 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 39-49 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | hyaluronan |
| T2 | 82-92 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | Hyaluronan |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-81 | Sentence | denotes | Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion. |
| TextSentencer_T2 | 82-209 | Sentence | denotes | Hyaluronan (HA) induces changes in cellular behavior that are crucial during both embryonic development and cancer progression. |
| TextSentencer_T3 | 210-352 | Sentence | denotes | However, the biological effects of varying sizes of HA and the signal transduction mechanisms that these polymers may activate remain unclear. |
| TextSentencer_T4 | 353-589 | Sentence | denotes | In this study, we demonstrate that pulse stimulation of mouse embryonic fibroblasts with high-molecular-weight (HMW) HA, but not HA of lower molecular sizes, leads to increases in Snail2 protein which are dependent on NFkappaB activity. |
| TextSentencer_T5 | 590-717 | Sentence | denotes | Involvement of CD44, the main HA receptor, in these responses was determined by use of a CD44 blocking antibody and CD44 siRNA. |
| TextSentencer_T6 | 718-888 | Sentence | denotes | Both the blockade and silencing of CD44 significantly abrogate the increases in nuclear factor kappaB (NFkappaB) activity and Snail2 protein following HMW-HA stimulation. |
| TextSentencer_T7 | 889-1035 | Sentence | denotes | Furthermore, we show that HMW-HA induces cellular invasion and that inhibition of CD44, Snail2, or NFkappaB significantly decreases this response. |
| TextSentencer_T8 | 1036-1211 | Sentence | denotes | These studies elucidate a novel HA/Snail2 functional connection through CD44 and NFkappaB that is important for the induction of cellular invasion and is dependent on HA size. |
| T1 | 0-81 | Sentence | denotes | Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion. |
| T2 | 82-209 | Sentence | denotes | Hyaluronan (HA) induces changes in cellular behavior that are crucial during both embryonic development and cancer progression. |
| T3 | 210-352 | Sentence | denotes | However, the biological effects of varying sizes of HA and the signal transduction mechanisms that these polymers may activate remain unclear. |
| T4 | 353-589 | Sentence | denotes | In this study, we demonstrate that pulse stimulation of mouse embryonic fibroblasts with high-molecular-weight (HMW) HA, but not HA of lower molecular sizes, leads to increases in Snail2 protein which are dependent on NFkappaB activity. |
| T5 | 590-717 | Sentence | denotes | Involvement of CD44, the main HA receptor, in these responses was determined by use of a CD44 blocking antibody and CD44 siRNA. |
| T6 | 718-888 | Sentence | denotes | Both the blockade and silencing of CD44 significantly abrogate the increases in nuclear factor kappaB (NFkappaB) activity and Snail2 protein following HMW-HA stimulation. |
| T7 | 889-1035 | Sentence | denotes | Furthermore, we show that HMW-HA induces cellular invasion and that inhibition of CD44, Snail2, or NFkappaB significantly decreases this response. |
| T8 | 1036-1211 | Sentence | denotes | These studies elucidate a novel HA/Snail2 functional connection through CD44 and NFkappaB that is important for the induction of cellular invasion and is dependent on HA size. |
| T1 | 0-81 | Sentence | denotes | Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion. |
| T2 | 82-209 | Sentence | denotes | Hyaluronan (HA) induces changes in cellular behavior that are crucial during both embryonic development and cancer progression. |
| T3 | 210-352 | Sentence | denotes | However, the biological effects of varying sizes of HA and the signal transduction mechanisms that these polymers may activate remain unclear. |
| T4 | 353-589 | Sentence | denotes | In this study, we demonstrate that pulse stimulation of mouse embryonic fibroblasts with high-molecular-weight (HMW) HA, but not HA of lower molecular sizes, leads to increases in Snail2 protein which are dependent on NFkappaB activity. |
| T5 | 590-717 | Sentence | denotes | Involvement of CD44, the main HA receptor, in these responses was determined by use of a CD44 blocking antibody and CD44 siRNA. |
| T6 | 718-888 | Sentence | denotes | Both the blockade and silencing of CD44 significantly abrogate the increases in nuclear factor kappaB (NFkappaB) activity and Snail2 protein following HMW-HA stimulation. |
| T7 | 889-1035 | Sentence | denotes | Furthermore, we show that HMW-HA induces cellular invasion and that inhibition of CD44, Snail2, or NFkappaB significantly decreases this response. |
| T8 | 1036-1211 | Sentence | denotes | These studies elucidate a novel HA/Snail2 functional connection through CD44 and NFkappaB that is important for the induction of cellular invasion and is dependent on HA size. |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 39-49 | FMAID:63014 | denotes | hyaluronan |
| _T2 | 39-49 | FMAID:167396 | denotes | hyaluronan |
| _T3 | 82-92 | FMAID:167396 | denotes | Hyaluronan |
| _T4 | 82-92 | FMAID:63014 | denotes | Hyaluronan |
| _T5 | 425-436 | FMAID:63877 | denotes | fibroblasts |
| _T6 | 425-436 | FMAID:162340 | denotes | fibroblasts |
| _T7 | 540-547 | FMAID:165447 | denotes | protein |
| _T8 | 540-547 | FMAID:67257 | denotes | protein |
| _T9 | 615-619 | FMAID:214734 | denotes | main |
| _T10 | 620-631 | FMAID:166248 | denotes | HA receptor |
| _T11 | 620-631 | FMAID:67669 | denotes | HA receptor |
| _T12 | 620-631 | FMAID:166251 | denotes | HA receptor |
| _T13 | 620-631 | FMAID:61983 | denotes | HA receptor |
| _T14 | 620-631 | FMAID:166254 | denotes | HA receptor |
| _T15 | 620-631 | FMAID:67670 | denotes | HA receptor |
| _T16 | 693-701 | FMAID:167180 | denotes | antibody |
| _T17 | 851-858 | FMAID:67257 | denotes | protein |
| _T18 | 851-858 | FMAID:165447 | denotes | protein |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 94-96 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T2 | 262-264 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T3 | 470-472 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T4 | 482-484 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T5 | 620-622 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T6 | 873-875 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T7 | 919-921 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T8 | 1068-1070 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T9 | 1203-1205 | http://www.uniprot.org/uniprot/P69208 | denotes | HA |
| T10 | 605-609 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
| T11 | 679-683 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
| T12 | 706-710 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
| T13 | 753-757 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
| T14 | 971-975 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
| T15 | 1108-1112 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | CD44 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 605-609 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
| T2 | 679-683 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
| T3 | 706-710 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
| T4 | 753-757 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
| T5 | 971-975 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
| T6 | 1108-1112 | http://www.uniprot.org/uniprot/Q62409 | denotes | CD44 |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 126-134 | http://purl.bioontology.org/ontology/STY/T053 | denotes | behavior |
| T2 | 159-173 | http://purl.bioontology.org/ontology/NCBITAXON/522292 | denotes | both embryonic |
| T3 | 190-196 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T4 | 293-303 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-25 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T2 | 63-71 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T3 | 117-125 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T4 | 930-938 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T5 | 1165-1173 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T6 | 126-134 | http://purl.obolibrary.org/obo/GO_0007610 | denotes | behavior |
| T7 | 164-185 | http://purl.obolibrary.org/obo/GO_0009790 | denotes | embryonic development |
| T8 | 174-185 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
| T9 | 273-279 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signal |
| T10 | 273-292 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signal transduction |
| T11 | 280-292 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 693-701 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 190-196 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 190-196 | Phenotype | denotes | cancer | HP:0002664 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 409-414 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 415-436 | Body_part | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL_2000042 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 415-436 | Cell | denotes | embryonic fibroblasts | http://purl.obolibrary.org/obo/CL:2000042 |