PubMed:1930693
Annnotations
jnlpba-st-training
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pubmed-sentences-benchmark
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genia-medco-coref
{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":28,"end":40},"obj":"NP"},{"id":"C1","span":{"begin":0,"end":45},"obj":"NP"},{"id":"C3","span":{"begin":57,"end":74},"obj":"NP"},{"id":"C4","span":{"begin":83,"end":104},"obj":"NP"},{"id":"C6","span":{"begin":173,"end":189},"obj":"NP"},{"id":"C5","span":{"begin":146,"end":201},"obj":"NP"},{"id":"C7","span":{"begin":361,"end":365},"obj":"NP"},{"id":"C9","span":{"begin":388,"end":406},"obj":"NP"},{"id":"C8","span":{"begin":367,"end":406},"obj":"NP"},{"id":"C10","span":{"begin":408,"end":417},"obj":"NP"},{"id":"C11","span":{"begin":784,"end":824},"obj":"NP"},{"id":"C12","span":{"begin":1005,"end":1021},"obj":"NP"},{"id":"C15","span":{"begin":1023,"end":1034},"obj":"NP"},{"id":"C13","span":{"begin":1122,"end":1130},"obj":"NP"},{"id":"C14","span":{"begin":1140,"end":1157},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C9","obj":"C5"},{"id":"R4","pred":"coref-appos","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-relat","subj":"C10","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C4"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C6"},{"id":"R8","pred":"coref-ident","subj":"C15","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C1"},{"id":"R10","pred":"coref-ident","subj":"C14","obj":"C3"}],"text":"A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated.\nGenes actively involved in the G0/G1 switch (G0S genes) may be differentially expressed during the lectin-induced switch of lymphocytes from the G0 to the G1 phases of the cell cycle. This paper presents studies of G0S2, a member of a set of putative G0S genes, for which cDNAs were cloned and selected on the basis of differential cDNA hybridization. G0S2 mRNA increases transiently within 1-2 hr of the addition of lectin or cycloheximide to cultured blood mononuclear cells. Comparison of a nearly full-length cDNA sequence with the corresponding genomic sequence reveals one small intron and an open reading frame in the second exon. The derived 103-amino-acid basic protein has two potential alpha-helical domains separated by a hydrophobic region with the potential to generate turns and assume a beta-sheet conformation. Consistent with involvement in the G0/G1 switch, the protein contains potential sites for phosphorylation by protein kinase C and casein kinase II. The gene contains a CpG-rich island suggesting expression in the germ line. An upstream segment contains tandem dinucleotide repeats (CT)19/(CA)16. There is a suitably located TATA box, but potential sites for CCAAT-box binding factors are far upstream, embedded in a 42-nucleotide repeat element. Potential sites for transcription factors AP1, AP2, and AP3 are consistent with rapid transcriptional activation in response to inducing agents."}
GENIAcorpus
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