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PubMed:19207031 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Growth hormone dose in growth hormone-deficient adults is not associated with IGF-1 gene polymorphisms.
T2 104-109 Sentence denotes AIMS:
T3 110-288 Sentence denotes Several SNPs and a microsatellite cytosine-adenine repeat promoter polymorphism of the IGF-1 gene have been reported to be associated with circulating IGF-1 serum concentrations.
T4 289-491 Sentence denotes Variance in IGF-1 concentrations due to genetic variations may affect different response to growth hormone (GH) treatment, resulting in different individually required GH-doses in GH-deficient patients.
T5 492-613 Sentence denotes The aim of this study was to test if the IGF-1 gene polymorphisms are associated with the GH-dose of GH-deficient adults.
T6 614-634 Sentence denotes MATERIALS & METHODS:
T7 635-1015 Sentence denotes A total of nine tagging SNPs, five additionally selected SNPs and a cytosine-adenine repeat polymorphism were determined in 133 German adult patients (66 men, 67 women; mean age 45.4 years +/- 13.1 standard deviation; majority Caucasian) with GH-deficiency (GHD) of different origin, derived from the prospective Pfizer International Metabolic Study (KIMS) Pharmacogenetics Study.
T8 1016-1131 Sentence denotes Patients received GH-treatment for 12 months with finished dose-titration of GH and centralized IGF-1 measurements.
T9 1132-1296 Sentence denotes GH-dose after 1 year of treatment, IGF-1 concentrations, IGF-1-standard deviation score (SDS), the IGF-1:GH ratio and anthropometric data were analyzed by genotype.
T10 1297-1305 Sentence denotes RESULTS:
T11 1306-1581 Sentence denotes Except for rs1019731, which showed a significant difference of IGF-1-SDS by genotypes (p = 0.02), all polymorphisms showed no associations with the GH-doses, IGF-1 concentrations, IGF-1-SDS and IGF-1:GH ratio after adjusting for the confounding variables gender, age and BMI.
T12 1582-1686 Sentence denotes CONCLUSION: IGF-1 gene polymorphisms were not associated with the responsiveness to exogenous GH in GHD.
T13 1687-1847 Sentence denotes Therefore, genetic variations of the IGF-1 gene seem not to be major influencing factors of the GH-IGF-axis causing variable response to exogenous GH-treatment.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5734 0-14 GeneOrGeneProduct denotes Growth hormone NCBIGene:2688
5735 23-47 DiseaseOrPhenotypicFeature denotes growth hormone-deficient MESH:D004393
5736 78-83 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5737 197-202 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5738 261-266 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5739 301-306 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5740 381-395 GeneOrGeneProduct denotes growth hormone NCBIGene:2688
5741 397-399 GeneOrGeneProduct denotes GH NCBIGene:2688
5742 457-459 GeneOrGeneProduct denotes GH NCBIGene:2688
5743 469-481 DiseaseOrPhenotypicFeature denotes GH-deficient MESH:D004393
5744 482-490 OrganismTaxon denotes patients NCBITaxon:9606
5745 533-538 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5746 582-584 GeneOrGeneProduct denotes GH NCBIGene:2688
5747 593-605 DiseaseOrPhenotypicFeature denotes GH-deficient MESH:D004393
5748 776-784 OrganismTaxon denotes patients NCBITaxon:9606
5749 789-792 OrganismTaxon denotes men NCBITaxon:9606
5750 797-802 OrganismTaxon denotes women NCBITaxon:9606
5751 878-891 DiseaseOrPhenotypicFeature denotes GH-deficiency MESH:D004393
5752 893-896 DiseaseOrPhenotypicFeature denotes GHD MESH:D004393
5753 1016-1024 OrganismTaxon denotes Patients NCBITaxon:9606
5754 1034-1036 GeneOrGeneProduct denotes GH NCBIGene:2688
5755 1093-1095 GeneOrGeneProduct denotes GH NCBIGene:2688
5756 1112-1117 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5757 1132-1134 GeneOrGeneProduct denotes GH NCBIGene:2688
5758 1167-1172 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5759 1189-1194 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5760 1231-1236 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5761 1237-1239 GeneOrGeneProduct denotes GH NCBIGene:2688
5762 1317-1326 SequenceVariant denotes rs1019731 DBSNP:rs1019731
5763 1369-1374 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5764 1454-1456 GeneOrGeneProduct denotes GH NCBIGene:2688
5765 1464-1469 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5766 1486-1491 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5767 1500-1505 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5768 1506-1508 GeneOrGeneProduct denotes GH NCBIGene:2688
5769 1594-1599 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5770 1676-1678 GeneOrGeneProduct denotes GH NCBIGene:2688
5771 1682-1685 DiseaseOrPhenotypicFeature denotes GHD MESH:D004393
5772 1724-1729 GeneOrGeneProduct denotes IGF-1 NCBIGene:3479
5773 1783-1785 GeneOrGeneProduct denotes GH NCBIGene:2688
5774 1786-1789 GeneOrGeneProduct denotes IGF NCBIGene:3479
5775 1834-1836 GeneOrGeneProduct denotes GH NCBIGene:2688

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 1317-1326 SequenceVariant denotes rs1019731

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-14 GeneOrGeneProduct denotes Growth hormone
T2 23-37 GeneOrGeneProduct denotes growth hormone
T3 78-83 GeneOrGeneProduct denotes IGF-1
T4 197-202 GeneOrGeneProduct denotes IGF-1
T5 261-266 GeneOrGeneProduct denotes IGF-1
T6 301-306 GeneOrGeneProduct denotes IGF-1
T7 381-395 GeneOrGeneProduct denotes growth hormone
T8 397-399 GeneOrGeneProduct denotes GH
T9 457-459 GeneOrGeneProduct denotes GH
T10 469-471 GeneOrGeneProduct denotes GH
T11 533-538 GeneOrGeneProduct denotes IGF-1
T12 582-584 GeneOrGeneProduct denotes GH
T13 593-595 GeneOrGeneProduct denotes GH
T14 878-880 GeneOrGeneProduct denotes GH
T15 1034-1036 GeneOrGeneProduct denotes GH
T16 1093-1095 GeneOrGeneProduct denotes GH
T17 1112-1117 GeneOrGeneProduct denotes IGF-1
T18 1132-1134 GeneOrGeneProduct denotes GH
T19 1167-1172 GeneOrGeneProduct denotes IGF-1
T20 1189-1194 GeneOrGeneProduct denotes IGF-1
T21 1231-1236 GeneOrGeneProduct denotes IGF-1
T22 1237-1239 GeneOrGeneProduct denotes GH
T23 1369-1374 GeneOrGeneProduct denotes IGF-1
T24 1454-1456 GeneOrGeneProduct denotes GH
T25 1464-1469 GeneOrGeneProduct denotes IGF-1
T26 1486-1491 GeneOrGeneProduct denotes IGF-1
T27 1500-1505 GeneOrGeneProduct denotes IGF-1
T28 1506-1508 GeneOrGeneProduct denotes GH
T29 1594-1599 GeneOrGeneProduct denotes IGF-1
T30 1676-1678 GeneOrGeneProduct denotes GH
T31 1724-1729 GeneOrGeneProduct denotes IGF-1
T32 1750-1755 GeneOrGeneProduct denotes major
T33 1783-1785 GeneOrGeneProduct denotes GH
T34 1790-1794 GeneOrGeneProduct denotes axis
T35 1834-1836 GeneOrGeneProduct denotes GH

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-14 GeneOrGeneProduct denotes Growth hormone
T2 23-37 GeneOrGeneProduct denotes growth hormone
T3 78-83 GeneOrGeneProduct denotes IGF-1
T4 197-202 GeneOrGeneProduct denotes IGF-1
T5 261-266 GeneOrGeneProduct denotes IGF-1
T6 301-306 GeneOrGeneProduct denotes IGF-1
T7 381-395 GeneOrGeneProduct denotes growth hormone
T8 397-399 GeneOrGeneProduct denotes GH
T9 457-459 GeneOrGeneProduct denotes GH
T10 469-471 GeneOrGeneProduct denotes GH
T11 521-525 GeneOrGeneProduct denotes test
T12 533-538 GeneOrGeneProduct denotes IGF-1
T13 582-584 GeneOrGeneProduct denotes GH
T14 593-595 GeneOrGeneProduct denotes GH
T15 626-633 GeneOrGeneProduct denotes METHODS
T16 637-642 GeneOrGeneProduct denotes total
T17 646-650 GeneOrGeneProduct denotes nine
T18 745-755 GeneOrGeneProduct denotes determined
T19 818-823 GeneOrGeneProduct denotes years
T20 828-832 GeneOrGeneProduct denotes 13.1
T21 853-861 GeneOrGeneProduct denotes majority
T22 878-880 GeneOrGeneProduct denotes GH
T23 1034-1036 GeneOrGeneProduct denotes GH
T24 1047-1053 GeneOrGeneProduct denotes for 12
T25 1093-1095 GeneOrGeneProduct denotes GH
T26 1112-1117 GeneOrGeneProduct denotes IGF-1
T27 1132-1134 GeneOrGeneProduct denotes GH
T28 1148-1152 GeneOrGeneProduct denotes year
T29 1167-1172 GeneOrGeneProduct denotes IGF-1
T30 1189-1194 GeneOrGeneProduct denotes IGF-1
T31 1231-1236 GeneOrGeneProduct denotes IGF-1
T32 1237-1239 GeneOrGeneProduct denotes GH
T33 1369-1374 GeneOrGeneProduct denotes IGF-1
T34 1404-1407 GeneOrGeneProduct denotes all
T35 1454-1456 GeneOrGeneProduct denotes GH
T36 1464-1469 GeneOrGeneProduct denotes IGF-1
T37 1486-1491 GeneOrGeneProduct denotes IGF-1
T38 1500-1505 GeneOrGeneProduct denotes IGF-1
T39 1506-1508 GeneOrGeneProduct denotes GH
T40 1594-1599 GeneOrGeneProduct denotes IGF-1
T41 1676-1678 GeneOrGeneProduct denotes GH
T42 1724-1729 GeneOrGeneProduct denotes IGF-1
T43 1750-1755 GeneOrGeneProduct denotes major
T44 1768-1775 GeneOrGeneProduct denotes factors
T45 1783-1785 GeneOrGeneProduct denotes GH
T46 1790-1794 GeneOrGeneProduct denotes axis
T47 1834-1836 GeneOrGeneProduct denotes GH

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 78-83 GeneOrGeneProduct denotes IGF-1
T2 197-202 GeneOrGeneProduct denotes IGF-1
T3 261-266 GeneOrGeneProduct denotes IGF-1
T4 301-306 GeneOrGeneProduct denotes IGF-1
T5 533-538 GeneOrGeneProduct denotes IGF-1
T6 1112-1117 GeneOrGeneProduct denotes IGF-1
T7 1167-1172 GeneOrGeneProduct denotes IGF-1
T8 1189-1194 GeneOrGeneProduct denotes IGF-1
T9 1231-1236 GeneOrGeneProduct denotes IGF-1
T10 1369-1374 GeneOrGeneProduct denotes IGF-1
T11 1464-1469 GeneOrGeneProduct denotes IGF-1
T12 1486-1491 GeneOrGeneProduct denotes IGF-1
T13 1500-1505 GeneOrGeneProduct denotes IGF-1
T14 1594-1599 GeneOrGeneProduct denotes IGF-1
T15 1724-1729 GeneOrGeneProduct denotes IGF-1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 789-792 DiseaseOrPhenotypicFeature denotes men 0017169
T2 1221-1224 DiseaseOrPhenotypicFeature denotes SDS 0009833
T3 1375-1378 DiseaseOrPhenotypicFeature denotes SDS 0009833
T4 1492-1495 DiseaseOrPhenotypicFeature denotes SDS 0009833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 23-47 DiseaseOrPhenotypicFeature denotes growth hormone-deficient DISEASE
T2 469-481 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T3 593-605 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T4 878-891 DiseaseOrPhenotypicFeature denotes GH-deficiency DISEASE
T5 893-896 DiseaseOrPhenotypicFeature denotes GHD DISEASE
T6 1682-1685 DiseaseOrPhenotypicFeature denotes GHD DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 482-490 OrganismTaxon denotes patients
T2 776-784 OrganismTaxon denotes patients
T3 789-792 OrganismTaxon denotes men
T4 797-802 OrganismTaxon denotes women

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 23-47 DiseaseOrPhenotypicFeature denotes growth hormone-deficient DISEASE
T2 469-481 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T3 593-605 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T4 878-891 DiseaseOrPhenotypicFeature denotes GH-deficiency DISEASE
T5 893-896 DiseaseOrPhenotypicFeature denotes GHD DISEASE
T6 1682-1685 DiseaseOrPhenotypicFeature denotes GHD DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 144-152 ChemicalEntity denotes cytosine D003596|http://purl.obolibrary.org/obo/CHEBI_16040
T3 153-160 ChemicalEntity denotes adenine D000225|http://purl.obolibrary.org/obo/CHEBI_16708
T5 703-711 ChemicalEntity denotes cytosine D003596|http://purl.obolibrary.org/obo/CHEBI_16040
T7 712-719 ChemicalEntity denotes adenine D000225|http://purl.obolibrary.org/obo/CHEBI_16708
T9 1221-1224 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T10 1375-1378 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T11 1492-1495 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T11 1492-1495 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T10 1375-1378 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T9 1221-1224 ChemicalEntity denotes SDS http://purl.obolibrary.org/obo/CHEBI_8984
T7 712-719 ChemicalEntity denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708|D000225
T5 703-711 ChemicalEntity denotes cytosine http://purl.obolibrary.org/obo/CHEBI_16040|D003596
T3 153-160 ChemicalEntity denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708|D000225
T1 144-152 ChemicalEntity denotes cytosine http://purl.obolibrary.org/obo/CHEBI_16040|D003596
T15 1724-1729 GeneOrGeneProduct denotes IGF-1
T14 1594-1599 GeneOrGeneProduct denotes IGF-1
T13 1500-1505 GeneOrGeneProduct denotes IGF-1
T12 1486-1491 GeneOrGeneProduct denotes IGF-1
T62024 1464-1469 GeneOrGeneProduct denotes IGF-1
T49993 1369-1374 GeneOrGeneProduct denotes IGF-1
T796 1231-1236 GeneOrGeneProduct denotes IGF-1
T8 1189-1194 GeneOrGeneProduct denotes IGF-1
T20439 1167-1172 GeneOrGeneProduct denotes IGF-1
T6 1112-1117 GeneOrGeneProduct denotes IGF-1
T62612 533-538 GeneOrGeneProduct denotes IGF-1
T4 301-306 GeneOrGeneProduct denotes IGF-1
T53517 261-266 GeneOrGeneProduct denotes IGF-1
T2 197-202 GeneOrGeneProduct denotes IGF-1
T31995 78-83 GeneOrGeneProduct denotes IGF-1
T50089 1682-1685 DiseaseOrPhenotypicFeature denotes GHD DISEASE
T69159 893-896 DiseaseOrPhenotypicFeature denotes GHD DISEASE
T29685 878-891 DiseaseOrPhenotypicFeature denotes GH-deficiency DISEASE
T60676 593-605 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T50377 469-481 DiseaseOrPhenotypicFeature denotes GH-deficient DISEASE
T70442 23-47 DiseaseOrPhenotypicFeature denotes growth hormone-deficient DISEASE
T28334 797-802 OrganismTaxon denotes women
T29546 789-792 OrganismTaxon denotes men
T38304 776-784 OrganismTaxon denotes patients
T21701 482-490 OrganismTaxon denotes patients
T48658 1317-1326 SequenceVariant denotes rs1019731

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
69 1317-1326 SNP denotes rs1019731 tmVar:rs1019731;VariantGroup:0;CorrespondingGene:3479;RS#:1019731;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
69 1317-1326 SNP denotes rs1019731 tmVar:rs1019731;VariantGroup:0;CorrespondingGene:3479;RS#:1019731;CorrespondingSpecies:9606
T1 1317-1326 SNP denotes rs1019731 tmVar:rs1019731;VariantGroup:0;CorrespondingGene:3479;RS#:1019731;CorrespondingSpecies:9606