PubMed:19099590 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/19099590","sourcedb":"PubMed","sourceid":"19099590","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/19099590","text":"Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer.\nBACKGROUND: Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.\nMETHODS: A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.\nRESULTS: Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.\nCONCLUSION: Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":79,"end":94},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":202,"end":217},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":333,"end":348},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":557,"end":572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":657,"end":672},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":847,"end":862},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":933,"end":948},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1136,"end":1151},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1360,"end":1375},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1601,"end":1616},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008315"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008315"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0008315"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0008315"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0008315"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0008315"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0008315"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0008315"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0008315"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0008315"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T8","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T10","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":96,"end":107},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":108,"end":218},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":219,"end":354},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":355,"end":578},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":579,"end":587},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":588,"end":910},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":911,"end":919},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":920,"end":1094},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1095,"end":1223},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1224,"end":1309},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1310,"end":1414},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1415,"end":1426},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1427,"end":1629},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T2","span":{"begin":96,"end":107},"obj":"Sentence"},{"id":"T3","span":{"begin":108,"end":218},"obj":"Sentence"},{"id":"T4","span":{"begin":219,"end":354},"obj":"Sentence"},{"id":"T5","span":{"begin":355,"end":578},"obj":"Sentence"},{"id":"T6","span":{"begin":579,"end":587},"obj":"Sentence"},{"id":"T7","span":{"begin":588,"end":910},"obj":"Sentence"},{"id":"T8","span":{"begin":911,"end":919},"obj":"Sentence"},{"id":"T9","span":{"begin":920,"end":1094},"obj":"Sentence"},{"id":"T10","span":{"begin":1095,"end":1223},"obj":"Sentence"},{"id":"T11","span":{"begin":1224,"end":1309},"obj":"Sentence"},{"id":"T12","span":{"begin":1310,"end":1414},"obj":"Sentence"},{"id":"T13","span":{"begin":1415,"end":1426},"obj":"Sentence"},{"id":"T14","span":{"begin":1427,"end":1629},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T14","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T2","span":{"begin":96,"end":107},"obj":"Sentence"},{"id":"T3","span":{"begin":108,"end":218},"obj":"Sentence"},{"id":"T4","span":{"begin":219,"end":354},"obj":"Sentence"},{"id":"T5","span":{"begin":355,"end":578},"obj":"Sentence"},{"id":"T6","span":{"begin":579,"end":587},"obj":"Sentence"},{"id":"T7","span":{"begin":588,"end":910},"obj":"Sentence"},{"id":"T8","span":{"begin":911,"end":919},"obj":"Sentence"},{"id":"T9","span":{"begin":920,"end":1094},"obj":"Sentence"},{"id":"T10","span":{"begin":1095,"end":1223},"obj":"Sentence"},{"id":"T11","span":{"begin":1224,"end":1309},"obj":"Sentence"},{"id":"T12","span":{"begin":1310,"end":1414},"obj":"Sentence"},{"id":"T13","span":{"begin":1415,"end":1426},"obj":"Sentence"},{"id":"T14","span":{"begin":1427,"end":1629},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T2","span":{"begin":96,"end":107},"obj":"Sentence"},{"id":"T3","span":{"begin":108,"end":218},"obj":"Sentence"},{"id":"T4","span":{"begin":219,"end":354},"obj":"Sentence"},{"id":"T5","span":{"begin":355,"end":578},"obj":"Sentence"},{"id":"T6","span":{"begin":579,"end":587},"obj":"Sentence"},{"id":"T7","span":{"begin":588,"end":910},"obj":"Sentence"},{"id":"T8","span":{"begin":911,"end":919},"obj":"Sentence"},{"id":"T9","span":{"begin":920,"end":1094},"obj":"Sentence"},{"id":"T10","span":{"begin":1095,"end":1223},"obj":"Sentence"},{"id":"T11","span":{"begin":1224,"end":1309},"obj":"Sentence"},{"id":"T12","span":{"begin":1310,"end":1414},"obj":"Sentence"},{"id":"T13","span":{"begin":1415,"end":1426},"obj":"Sentence"},{"id":"T14","span":{"begin":1427,"end":1629},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":25,"end":31},"obj":"gene:6352"},{"id":"T1","span":{"begin":79,"end":94},"obj":"disease:C0376358"},{"id":"T2","span":{"begin":50,"end":55},"obj":"gene:7124"},{"id":"T3","span":{"begin":79,"end":94},"obj":"disease:C0600139"},{"id":"T4","span":{"begin":50,"end":55},"obj":"gene:7124"},{"id":"T5","span":{"begin":79,"end":94},"obj":"disease:C0376358"},{"id":"T6","span":{"begin":40,"end":45},"obj":"gene:6347"},{"id":"T7","span":{"begin":79,"end":94},"obj":"disease:C0600139"},{"id":"T8","span":{"begin":40,"end":45},"obj":"gene:6347"},{"id":"T9","span":{"begin":79,"end":94},"obj":"disease:C0376358"},{"id":"T10","span":{"begin":25,"end":31},"obj":"gene:6352"},{"id":"T11","span":{"begin":79,"end":94},"obj":"disease:C0600139"},{"id":"T12","span":{"begin":757,"end":760},"obj":"gene:3552"},{"id":"T13","span":{"begin":847,"end":862},"obj":"disease:C0600139"},{"id":"T14","span":{"begin":788,"end":793},"obj":"gene:6347"},{"id":"T15","span":{"begin":657,"end":672},"obj":"disease:C0376358"},{"id":"T16","span":{"begin":788,"end":793},"obj":"gene:6347"},{"id":"T17","span":{"begin":657,"end":672},"obj":"disease:C0600139"},{"id":"T18","span":{"begin":788,"end":793},"obj":"gene:6347"},{"id":"T19","span":{"begin":847,"end":862},"obj":"disease:C0376358"},{"id":"T20","span":{"begin":788,"end":793},"obj":"gene:6347"},{"id":"T21","span":{"begin":847,"end":862},"obj":"disease:C0600139"},{"id":"T22","span":{"begin":757,"end":760},"obj":"gene:3552"},{"id":"T23","span":{"begin":847,"end":862},"obj":"disease:C0376358"},{"id":"T24","span":{"begin":757,"end":760},"obj":"gene:3552"},{"id":"T25","span":{"begin":657,"end":672},"obj":"disease:C0600139"},{"id":"T26","span":{"begin":757,"end":760},"obj":"gene:3552"},{"id":"T27","span":{"begin":657,"end":672},"obj":"disease:C0376358"},{"id":"T28","span":{"begin":700,"end":705},"obj":"gene:7124"},{"id":"T29","span":{"begin":657,"end":672},"obj":"disease:C0376358"},{"id":"T30","span":{"begin":728,"end":734},"obj":"gene:6352"},{"id":"T31","span":{"begin":657,"end":672},"obj":"disease:C0600139"},{"id":"T32","span":{"begin":700,"end":705},"obj":"gene:7124"},{"id":"T33","span":{"begin":657,"end":672},"obj":"disease:C0600139"},{"id":"T34","span":{"begin":728,"end":734},"obj":"gene:6352"},{"id":"T35","span":{"begin":657,"end":672},"obj":"disease:C0376358"},{"id":"T36","span":{"begin":1040,"end":1046},"obj":"gene:6352"},{"id":"T37","span":{"begin":933,"end":948},"obj":"disease:C0600139"},{"id":"T38","span":{"begin":1040,"end":1046},"obj":"gene:6352"},{"id":"T39","span":{"begin":933,"end":948},"obj":"disease:C0376358"},{"id":"T40","span":{"begin":983,"end":988},"obj":"gene:7124"},{"id":"T41","span":{"begin":933,"end":948},"obj":"disease:C0376358"},{"id":"T42","span":{"begin":983,"end":988},"obj":"gene:7124"},{"id":"T43","span":{"begin":933,"end":948},"obj":"disease:C0600139"},{"id":"T44","span":{"begin":1118,"end":1124},"obj":"gene:6352"},{"id":"T45","span":{"begin":1136,"end":1151},"obj":"disease:C0600139"},{"id":"T46","span":{"begin":1118,"end":1124},"obj":"gene:6352"},{"id":"T47","span":{"begin":1136,"end":1151},"obj":"disease:C0376358"},{"id":"T48","span":{"begin":1108,"end":1113},"obj":"gene:7124"},{"id":"T49","span":{"begin":1136,"end":1151},"obj":"disease:C0600139"},{"id":"T50","span":{"begin":1108,"end":1113},"obj":"gene:7124"},{"id":"T51","span":{"begin":1136,"end":1151},"obj":"disease:C0376358"},{"id":"T52","span":{"begin":1394,"end":1399},"obj":"gene:6347"},{"id":"T53","span":{"begin":1360,"end":1375},"obj":"disease:C0600139"},{"id":"T54","span":{"begin":1394,"end":1399},"obj":"gene:6347"},{"id":"T55","span":{"begin":1360,"end":1375},"obj":"disease:C0376358"},{"id":"T56","span":{"begin":1385,"end":1388},"obj":"gene:3552"},{"id":"T57","span":{"begin":1360,"end":1375},"obj":"disease:C0600139"},{"id":"T58","span":{"begin":1385,"end":1388},"obj":"gene:3552"},{"id":"T59","span":{"begin":1360,"end":1375},"obj":"disease:C0376358"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"},{"id":"R11","pred":"associated_with","subj":"T20","obj":"T21"},{"id":"R12","pred":"associated_with","subj":"T22","obj":"T23"},{"id":"R13","pred":"associated_with","subj":"T24","obj":"T25"},{"id":"R14","pred":"associated_with","subj":"T26","obj":"T27"},{"id":"R15","pred":"associated_with","subj":"T28","obj":"T29"},{"id":"R16","pred":"associated_with","subj":"T30","obj":"T31"},{"id":"R17","pred":"associated_with","subj":"T32","obj":"T33"},{"id":"R18","pred":"associated_with","subj":"T34","obj":"T35"},{"id":"R19","pred":"associated_with","subj":"T36","obj":"T37"},{"id":"R20","pred":"associated_with","subj":"T38","obj":"T39"},{"id":"R21","pred":"associated_with","subj":"T40","obj":"T41"},{"id":"R22","pred":"associated_with","subj":"T42","obj":"T43"},{"id":"R23","pred":"associated_with","subj":"T44","obj":"T45"},{"id":"R24","pred":"associated_with","subj":"T46","obj":"T47"},{"id":"R25","pred":"associated_with","subj":"T48","obj":"T49"},{"id":"R26","pred":"associated_with","subj":"T50","obj":"T51"},{"id":"R27","pred":"associated_with","subj":"T52","obj":"T53"},{"id":"R28","pred":"associated_with","subj":"T54","obj":"T55"},{"id":"R29","pred":"associated_with","subj":"T56","obj":"T57"},{"id":"R30","pred":"associated_with","subj":"T58","obj":"T59"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"},{"subj":"T20","pred":"source","obj":"DisGeNET"},{"subj":"T21","pred":"source","obj":"DisGeNET"},{"subj":"T22","pred":"source","obj":"DisGeNET"},{"subj":"T23","pred":"source","obj":"DisGeNET"},{"subj":"T24","pred":"source","obj":"DisGeNET"},{"subj":"T25","pred":"source","obj":"DisGeNET"},{"subj":"T26","pred":"source","obj":"DisGeNET"},{"subj":"T27","pred":"source","obj":"DisGeNET"},{"subj":"T28","pred":"source","obj":"DisGeNET"},{"subj":"T29","pred":"source","obj":"DisGeNET"},{"subj":"T30","pred":"source","obj":"DisGeNET"},{"subj":"T31","pred":"source","obj":"DisGeNET"},{"subj":"T32","pred":"source","obj":"DisGeNET"},{"subj":"T33","pred":"source","obj":"DisGeNET"},{"subj":"T34","pred":"source","obj":"DisGeNET"},{"subj":"T35","pred":"source","obj":"DisGeNET"},{"subj":"T36","pred":"source","obj":"DisGeNET"},{"subj":"T37","pred":"source","obj":"DisGeNET"},{"subj":"T38","pred":"source","obj":"DisGeNET"},{"subj":"T39","pred":"source","obj":"DisGeNET"},{"subj":"T40","pred":"source","obj":"DisGeNET"},{"subj":"T41","pred":"source","obj":"DisGeNET"},{"subj":"T42","pred":"source","obj":"DisGeNET"},{"subj":"T43","pred":"source","obj":"DisGeNET"},{"subj":"T44","pred":"source","obj":"DisGeNET"},{"subj":"T45","pred":"source","obj":"DisGeNET"},{"subj":"T46","pred":"source","obj":"DisGeNET"},{"subj":"T47","pred":"source","obj":"DisGeNET"},{"subj":"T48","pred":"source","obj":"DisGeNET"},{"subj":"T49","pred":"source","obj":"DisGeNET"},{"subj":"T50","pred":"source","obj":"DisGeNET"},{"subj":"T51","pred":"source","obj":"DisGeNET"},{"subj":"T52","pred":"source","obj":"DisGeNET"},{"subj":"T53","pred":"source","obj":"DisGeNET"},{"subj":"T54","pred":"source","obj":"DisGeNET"},{"subj":"T55","pred":"source","obj":"DisGeNET"},{"subj":"T56","pred":"source","obj":"DisGeNET"},{"subj":"T57","pred":"source","obj":"DisGeNET"},{"subj":"T58","pred":"source","obj":"DisGeNET"},{"subj":"T59","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"19099590-0#50#55#gene7124","span":{"begin":50,"end":55},"obj":"gene7124"},{"id":"19099590-0#79#94#diseaseC0376358","span":{"begin":79,"end":94},"obj":"diseaseC0376358"},{"id":"19099590-0#79#94#diseaseC0600139","span":{"begin":79,"end":94},"obj":"diseaseC0600139"},{"id":"19099590-4#200#205#gene6347","span":{"begin":788,"end":793},"obj":"gene6347"},{"id":"19099590-4#69#84#diseaseC0376358","span":{"begin":657,"end":672},"obj":"diseaseC0376358"},{"id":"19099590-4#69#84#diseaseC0600139","span":{"begin":657,"end":672},"obj":"diseaseC0600139"},{"id":"19099590-4#259#274#diseaseC0376358","span":{"begin":847,"end":862},"obj":"diseaseC0376358"},{"id":"19099590-4#259#274#diseaseC0600139","span":{"begin":847,"end":862},"obj":"diseaseC0600139"},{"id":"19099590-6#23#29#gene6352","span":{"begin":1118,"end":1124},"obj":"gene6352"},{"id":"19099590-6#41#56#diseaseC0376358","span":{"begin":1136,"end":1151},"obj":"diseaseC0376358"},{"id":"19099590-6#41#56#diseaseC0600139","span":{"begin":1136,"end":1151},"obj":"diseaseC0600139"},{"id":"19099590-8#75#78#gene3552","span":{"begin":1385,"end":1388},"obj":"gene3552"},{"id":"19099590-8#50#65#diseaseC0376358","span":{"begin":1360,"end":1375},"obj":"diseaseC0376358"},{"id":"19099590-8#50#65#diseaseC0600139","span":{"begin":1360,"end":1375},"obj":"diseaseC0600139"}],"relations":[{"id":"50#55#gene712479#94#diseaseC0376358","pred":"associated_with","subj":"19099590-0#50#55#gene7124","obj":"19099590-0#79#94#diseaseC0376358"},{"id":"50#55#gene712479#94#diseaseC0600139","pred":"associated_with","subj":"19099590-0#50#55#gene7124","obj":"19099590-0#79#94#diseaseC0600139"},{"id":"200#205#gene634769#84#diseaseC0376358","pred":"associated_with","subj":"19099590-4#200#205#gene6347","obj":"19099590-4#69#84#diseaseC0376358"},{"id":"200#205#gene634769#84#diseaseC0600139","pred":"associated_with","subj":"19099590-4#200#205#gene6347","obj":"19099590-4#69#84#diseaseC0600139"},{"id":"200#205#gene6347259#274#diseaseC0376358","pred":"associated_with","subj":"19099590-4#200#205#gene6347","obj":"19099590-4#259#274#diseaseC0376358"},{"id":"200#205#gene6347259#274#diseaseC0600139","pred":"associated_with","subj":"19099590-4#200#205#gene6347","obj":"19099590-4#259#274#diseaseC0600139"},{"id":"23#29#gene635241#56#diseaseC0376358","pred":"associated_with","subj":"19099590-6#23#29#gene6352","obj":"19099590-6#41#56#diseaseC0376358"},{"id":"23#29#gene635241#56#diseaseC0600139","pred":"associated_with","subj":"19099590-6#23#29#gene6352","obj":"19099590-6#41#56#diseaseC0600139"},{"id":"75#78#gene355250#65#diseaseC0376358","pred":"associated_with","subj":"19099590-8#75#78#gene3552","obj":"19099590-8#50#65#diseaseC0376358"},{"id":"75#78#gene355250#65#diseaseC0600139","pred":"associated_with","subj":"19099590-8#75#78#gene3552","obj":"19099590-8#50#65#diseaseC0600139"}],"attributes":[{"subj":"19099590-0#50#55#gene7124","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-0#79#94#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-0#79#94#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-4#200#205#gene6347","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-4#69#84#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-4#69#84#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-4#259#274#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-4#259#274#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-6#23#29#gene6352","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-6#41#56#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-6#41#56#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-8#75#78#gene3552","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-8#50#65#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"19099590-8#50#65#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T554","span":{"begin":788,"end":793},"obj":"gene:6347"},{"id":"T555","span":{"begin":657,"end":672},"obj":"disease:C0376358"},{"id":"T556","span":{"begin":847,"end":862},"obj":"disease:C0376358"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T554","obj":"T555"},{"id":"R2","pred":"associated_with","subj":"T554","obj":"T555"},{"id":"R3","pred":"associated_with","subj":"T554","obj":"T556"},{"id":"R4","pred":"associated_with","subj":"T554","obj":"T556"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T554","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T555","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T556","pred":"source","obj":"DisGeNet-2017-sample"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PMID_GLOBAL","color":"#ecc893","default":true},{"id":"sentences","color":"#ae93ec"},{"id":"Inflammaging","color":"#93ec94"},{"id":"DisGeNET","color":"#ec93ac"},{"id":"DisGeNET5_gene_disease","color":"#93c6ec"},{"id":"DisGeNet-2017-sample","color":"#e0ec93"}]}]}}