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PubMed:1907279 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-146 Sentence denotes Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.
T2 147-378 Sentence denotes We show here for the first time that actin, troponin C, Alzheimer amyloid precursor protein (AAP), and pro-interleukin 1 beta (pro-IL-1 beta), are substrates of the protease encoded by the human immunodeficiency virus (HIV) type-1.
T3 379-563 Sentence denotes As has been seen in other non-viral protein substrates of the HIV protease, the presence of Glu residues in the P2' position appears to play an important role in substrate recognition.
T4 564-718 Sentence denotes Three of the four bonds cleaved in actin, two of the three in troponin C, and all of the bonds hydrolyzed in AAP and pro-IL-1 beta have a P2' Glu residue.
T5 719-940 Sentence denotes In fact, Glu residues are accommodated in all positions from P4 to P4' surrounding the scissile bond in substrates of the HIV proteases, and as many as 4 adjacent Glu residues were seen in one of the bonds cleaved in AAP.
T6 941-1137 Sentence denotes This study of non-viral protein substrates has also revealed unexpected amino acids such as Gly, Arg, and Glu in the scissile bond itself rather than the more conventional hydrophobic amino acids.
T7 1138-1387 Sentence denotes The HIV-2 protease hydrolyzed actin in a manner similar to that of the HIV-1 enzyme, but its cleavage of troponin C was distinct in that it split a bond adjacent to a triplet of Glu residues in P2, P3, and P4 that was refractory to the HIV-1 enzyme.
T8 1388-1616 Sentence denotes Documentation of cleavage sites in the several important cellular proteins noted above has extended our understanding of the features in a substrate that are recognized by these multi sub-site proteases of retroviral maturation.
T9 1617-1856 Sentence denotes Moreover, the present work adds to an accumulating body of evidence which demonstrates that these enzymes can damage crucial structural and regulatory cellular proteins if ever their activity is expressed outside the viral particle itself.
T1 0-146 Sentence denotes Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.
T2 147-378 Sentence denotes We show here for the first time that actin, troponin C, Alzheimer amyloid precursor protein (AAP), and pro-interleukin 1 beta (pro-IL-1 beta), are substrates of the protease encoded by the human immunodeficiency virus (HIV) type-1.
T3 379-563 Sentence denotes As has been seen in other non-viral protein substrates of the HIV protease, the presence of Glu residues in the P2' position appears to play an important role in substrate recognition.
T4 564-718 Sentence denotes Three of the four bonds cleaved in actin, two of the three in troponin C, and all of the bonds hydrolyzed in AAP and pro-IL-1 beta have a P2' Glu residue.
T5 719-940 Sentence denotes In fact, Glu residues are accommodated in all positions from P4 to P4' surrounding the scissile bond in substrates of the HIV proteases, and as many as 4 adjacent Glu residues were seen in one of the bonds cleaved in AAP.
T6 941-1137 Sentence denotes This study of non-viral protein substrates has also revealed unexpected amino acids such as Gly, Arg, and Glu in the scissile bond itself rather than the more conventional hydrophobic amino acids.
T7 1138-1387 Sentence denotes The HIV-2 protease hydrolyzed actin in a manner similar to that of the HIV-1 enzyme, but its cleavage of troponin C was distinct in that it split a bond adjacent to a triplet of Glu residues in P2, P3, and P4 that was refractory to the HIV-1 enzyme.
T8 1388-1616 Sentence denotes Documentation of cleavage sites in the several important cellular proteins noted above has extended our understanding of the features in a substrate that are recognized by these multi sub-site proteases of retroviral maturation.
T9 1617-1856 Sentence denotes Moreover, the present work adds to an accumulating body of evidence which demonstrates that these enzymes can damage crucial structural and regulatory cellular proteins if ever their activity is expressed outside the viral particle itself.

Ab3P-abbreviations

Id Subject Object Predicate Lexical cue
SF0 240-243 ABBR denotes AAP
LF0 203-238 ABBR denotes Alzheimer amyloid precursor protein
SF1 274-287 ABBR denotes pro-IL-1 beta
LF1 250-272 ABBR denotes pro-interleukin 1 beta
SF2 366-369 ABBR denotes HIV
LF2 336-364 ABBR denotes human immunodeficiency virus
R0 LF0 SF0 ShortForm Alzheimer amyloid precursor protein,AAP
R1 LF1 SF1 ShortForm pro-interleukin 1 beta,pro-IL-1 beta
R2 LF2 SF2 ShortForm human immunodeficiency virus,HIV

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 29-36 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 123-139 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T3 213-220 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T4 342-358 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 123-139 Phenotype denotes immunodeficiency HP:0002721
T2 342-358 Phenotype denotes immunodeficiency HP:0002721

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 117-122 OrganismTaxon denotes human 9606
T2 336-341 OrganismTaxon denotes human 9606