PubMed:19067809 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T2","span":{"begin":145,"end":153},"obj":"Sentence"},{"id":"T3","span":{"begin":154,"end":398},"obj":"Sentence"},{"id":"T4","span":{"begin":399,"end":488},"obj":"Sentence"},{"id":"T5","span":{"begin":489,"end":998},"obj":"Sentence"},{"id":"T6","span":{"begin":999,"end":1608},"obj":"Sentence"},{"id":"T7","span":{"begin":1609,"end":1752},"obj":"Sentence"},{"id":"T8","span":{"begin":1753,"end":1828},"obj":"Sentence"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":390,"end":397},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":948,"end":952},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1531,"end":1538},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1801,"end":1808},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:1271638"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:1"},{"id":"A3","pred":"db_id","subj":"T3","obj":"NCBItxid:1271638"},{"id":"A4","pred":"db_id","subj":"T4","obj":"NCBItxid:1271638"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-entities","denotations":[{"id":"5592","span":{"begin":105,"end":110},"obj":"GeneOrGeneProduct"},{"id":"5593","span":{"begin":111,"end":122},"obj":"GeneOrGeneProduct"},{"id":"5594","span":{"begin":127,"end":136},"obj":"ChemicalEntity"},{"id":"5595","span":{"begin":195,"end":200},"obj":"GeneOrGeneProduct"},{"id":"5596","span":{"begin":201,"end":212},"obj":"GeneOrGeneProduct"},{"id":"5597","span":{"begin":224,"end":245},"obj":"GeneOrGeneProduct"},{"id":"5598","span":{"begin":366,"end":374},"obj":"OrganismTaxon"},{"id":"5599","span":{"begin":380,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5600","span":{"begin":435,"end":443},"obj":"OrganismTaxon"},{"id":"5601","span":{"begin":472,"end":475},"obj":"OrganismTaxon"},{"id":"5602","span":{"begin":481,"end":486},"obj":"OrganismTaxon"},{"id":"5603","span":{"begin":554,"end":583},"obj":"GeneOrGeneProduct"},{"id":"5604","span":{"begin":621,"end":624},"obj":"GeneOrGeneProduct"},{"id":"5605","span":{"begin":627,"end":642},"obj":"GeneOrGeneProduct"},{"id":"5606","span":{"begin":662,"end":667},"obj":"SequenceVariant"},{"id":"5607","span":{"begin":670,"end":700},"obj":"GeneOrGeneProduct"},{"id":"5608","span":{"begin":702,"end":706},"obj":"GeneOrGeneProduct"},{"id":"5609","span":{"begin":722,"end":730},"obj":"SequenceVariant"},{"id":"5610","span":{"begin":753,"end":774},"obj":"GeneOrGeneProduct"},{"id":"5611","span":{"begin":781,"end":788},"obj":"GeneOrGeneProduct"},{"id":"5612","span":{"begin":1023,"end":1030},"obj":"SequenceVariant"},{"id":"5613","span":{"begin":1531,"end":1538},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5614","span":{"begin":1636,"end":1643},"obj":"SequenceVariant"},{"id":"5615","span":{"begin":1664,"end":1668},"obj":"GeneOrGeneProduct"},{"id":"5616","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5617","span":{"begin":1791,"end":1808},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A23","pred":"db_id","subj":"5614","obj":"DBSNP:rs5186"},{"id":"A26","pred":"db_id","subj":"5617","obj":"MESH:D019462"},{"id":"A10","pred":"db_id","subj":"5601","obj":"NCBITaxon:9606"},{"id":"A15","pred":"db_id","subj":"5606","obj":"p|Allele|M|235"},{"id":"A18","pred":"db_id","subj":"5609","obj":"DBSNP:rs5186"},{"id":"A7","pred":"db_id","subj":"5598","obj":"NCBITaxon:9606"},{"id":"A8","pred":"db_id","subj":"5599","obj":"MESH:D019462"},{"id":"A11","pred":"db_id","subj":"5602","obj":"NCBITaxon:9606"},{"id":"A14","pred":"db_id","subj":"5605","obj":"NCBIGene:183"},{"id":"A21","pred":"db_id","subj":"5612","obj":"DBSNP:rs5186"},{"id":"A9","pred":"db_id","subj":"5600","obj":"NCBITaxon:9606"},{"id":"A6","pred":"db_id","subj":"5597","obj":"NCBIGene:6532"},{"id":"A12","pred":"db_id","subj":"5603","obj":"NCBIGene:1636"},{"id":"A20","pred":"db_id","subj":"5611","obj":"NCBIGene:6532"},{"id":"A24","pred":"db_id","subj":"5615","obj":"NCBIGene:185"},{"id":"A3","pred":"db_id","subj":"5594","obj":"MESH:D012701"},{"id":"A16","pred":"db_id","subj":"5607","obj":"NCBIGene:185"},{"id":"A22","pred":"db_id","subj":"5613","obj":"MESH:D013575"},{"id":"A25","pred":"db_id","subj":"5616","obj":"MESH:D007022"},{"id":"A4","pred":"db_id","subj":"5595","obj":"NCBIGene:5972"},{"id":"A13","pred":"db_id","subj":"5604","obj":"NCBIGene:1636"},{"id":"A17","pred":"db_id","subj":"5608","obj":"NCBIGene:185"},{"id":"A19","pred":"db_id","subj":"5610","obj":"NCBIGene:6532"},{"id":"A1","pred":"db_id","subj":"5592","obj":"NCBIGene:5972"},{"id":"A5","pred":"db_id","subj":"5596","obj":"NCBIGene:183"},{"id":"A2","pred":"db_id","subj":"5593","obj":"NCBIGene:183"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":724,"end":730},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":1025,"end":1030},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":1638,"end":1643},"obj":"SequenceVariant"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":27,"end":32},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":59,"end":63},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":64,"end":68},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":105,"end":110},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":195,"end":200},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":224,"end":245},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":307,"end":312},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":347,"end":351},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":352,"end":356},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":399,"end":406},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":462,"end":467},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":527,"end":537},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":554,"end":583},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":621,"end":624},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":627,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":670,"end":700},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":702,"end":706},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":753,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":781,"end":788},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":790,"end":795},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":837,"end":841},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":842,"end":848},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":866,"end":875},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":877,"end":881},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":882,"end":891},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":948,"end":952},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":958,"end":964},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1168,"end":1173},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1398,"end":1403},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1421,"end":1426},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1446,"end":1450},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1451,"end":1458},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1462,"end":1466},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1664,"end":1668},"obj":"GeneOrGeneProduct"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":27,"end":32},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":59,"end":63},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":105,"end":110},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":195,"end":200},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":224,"end":245},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":307,"end":312},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":347,"end":351},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":554,"end":583},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":627,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":670,"end":700},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":702,"end":706},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":753,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":781,"end":788},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":790,"end":795},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":842,"end":848},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":866,"end":875},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":877,"end":881},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":882,"end":891},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":958,"end":964},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1168,"end":1173},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1398,"end":1403},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1421,"end":1426},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1462,"end":1466},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1664,"end":1668},"obj":"GeneOrGeneProduct"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":380,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":1531,"end":1538},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1765,"end":1787},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1791,"end":1808},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D020022"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D007022"},{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D019462"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D013575"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D019462"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":105,"end":110},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":195,"end":200},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":224,"end":245},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":627,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":670,"end":700},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":702,"end":706},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":753,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":781,"end":788},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1664,"end":1668},"obj":"GeneOrGeneProduct"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":472,"end":475},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":1230,"end":1232},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1307,"end":1309},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1500,"end":1502},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1589,"end":1591},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0017169"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005468"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0019087"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0019087"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0019087"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0019087"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":380,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":1531,"end":1538},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1765,"end":1787},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1791,"end":1808},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"ID:","subj":"T5","obj":"D019462"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D019462"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D013575"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D007022"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D020022"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":380,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":1531,"end":1538},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1791,"end":1808},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D019462"},{"id":"A2","pred":"#label","subj":"T2","obj":"D013575"},{"id":"A3","pred":"#label","subj":"T3","obj":"D007022"},{"id":"A4","pred":"#label","subj":"T4","obj":"D019462"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":366,"end":374},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":435,"end":443},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":472,"end":475},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":481,"end":486},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":619,"end":624},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":948,"end":952},"obj":"OrganismTaxon"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":105,"end":110},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":111,"end":122},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":127,"end":136},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":195,"end":200},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":201,"end":212},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":224,"end":233},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":554,"end":583},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":627,"end":642},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":670,"end":684},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":753,"end":762},"obj":"ChemicalEntity"},{"id":"T19","span":{"begin":1138,"end":1141},"obj":"ChemicalEntity"},{"id":"T21","span":{"begin":1270,"end":1273},"obj":"ChemicalEntity"}],"attributes":[{"id":"A6","pred":"ID:","subj":"T6","obj":"D012083"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012701"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012701"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A5","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A21","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_35861"},{"id":"A22","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_34687"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A15","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D012083"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D007703"},{"id":"A12","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_2720"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D012701"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A18","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A19","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_35861"},{"id":"A20","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_34687"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T19","span":{"begin":1138,"end":1141},"obj":"ChemicalEntity"},{"id":"T21","span":{"begin":1270,"end":1273},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":753,"end":762},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":670,"end":684},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":627,"end":642},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":554,"end":583},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":224,"end":233},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":201,"end":212},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":195,"end":200},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":127,"end":136},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":111,"end":122},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":105,"end":110},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":1664,"end":1668},"obj":"GeneOrGeneProduct"},{"id":"T92146","span":{"begin":781,"end":788},"obj":"GeneOrGeneProduct"},{"id":"T18174","span":{"begin":753,"end":774},"obj":"GeneOrGeneProduct"},{"id":"T53764","span":{"begin":702,"end":706},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":670,"end":700},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":627,"end":642},"obj":"GeneOrGeneProduct"},{"id":"T87521","span":{"begin":224,"end":245},"obj":"GeneOrGeneProduct"},{"id":"T29204","span":{"begin":195,"end":200},"obj":"GeneOrGeneProduct"},{"id":"T4596","span":{"begin":105,"end":110},"obj":"GeneOrGeneProduct"},{"id":"T34339","span":{"begin":1791,"end":1808},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T18876","span":{"begin":1697,"end":1708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23086","span":{"begin":1531,"end":1538},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T57932","span":{"begin":380,"end":397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17176","span":{"begin":948,"end":952},"obj":"OrganismTaxon"},{"id":"T86758","span":{"begin":619,"end":624},"obj":"OrganismTaxon"},{"id":"T26298","span":{"begin":481,"end":486},"obj":"OrganismTaxon"},{"id":"T41515","span":{"begin":472,"end":475},"obj":"OrganismTaxon"},{"id":"T50138","span":{"begin":435,"end":443},"obj":"OrganismTaxon"},{"id":"T26161","span":{"begin":366,"end":374},"obj":"OrganismTaxon"},{"id":"T11643","span":{"begin":1638,"end":1643},"obj":"SequenceVariant"},{"id":"T61231","span":{"begin":1025,"end":1030},"obj":"SequenceVariant"},{"id":"T86748","span":{"begin":724,"end":730},"obj":"SequenceVariant"}],"attributes":[{"id":"A17530","pred":"#label","subj":"T23086","obj":"D013575"},{"id":"A92215","pred":"#label","subj":"T57932","obj":"D019462"},{"id":"A20","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_34687"},{"id":"A19","pred":"ID:","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_35861"},{"id":"A10","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A9","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D012701"},{"id":"A5","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D012701"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D012083"},{"id":"A67537","pred":"#label","subj":"T34339","obj":"D019462"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A12","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_2720"},{"id":"A99789","pred":"#label","subj":"T18876","obj":"D007022"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D007703"},{"id":"A18","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_28790"},{"id":"A17","pred":"ID:","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_350546"},{"id":"A16","pred":"ID:","subj":"T16","obj":"D012701"},{"id":"A22","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_34687"},{"id":"A21","pred":"ID:","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_35861"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D012083"},{"id":"A15","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":195,"end":200},"obj":"gene:5972"},{"id":"T1","span":{"begin":380,"end":397},"obj":"disease:C0042420"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}

{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":722,"end":730},"obj":"DNAMutation:|SUB|A|11666|C"},{"id":"T2","span":{"begin":1023,"end":1030},"obj":"DNAMutation:|SUB|A|1166|C"},{"id":"T3","span":{"begin":1636,"end":1643},"obj":"DNAMutation:|SUB|A|1166|C"}],"text":"Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system.\nPURPOSE: The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope.\nMETHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters.\nRESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04)\nCONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. Its role in genetic predisposition to vasovagal syncope cannot be excluded."}