PubMed:19067809
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-144 | Sentence | denotes | Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of renin-angiotensin and serotonin system. |
| T2 | 145-153 | Sentence | denotes | PURPOSE: |
| T3 | 154-398 | Sentence | denotes | The aim of the study was to evaluate the renin-angiotensin system and serotonin transporter gene polymorphisms in relation to hemodynamic parameters and heart rate variability during a head-up tilt test (HUT) in patients with vasovagal syncope. |
| T4 | 399-488 | Sentence | denotes | METHODS: DNA was collected from 191 patients (mean age 44+/-18 years, 61 men, 130 women). |
| T5 | 489-998 | Sentence | denotes | The following gene polymorphisms were determined in genomic DNA: angiotensin-converting enzyme insertion/deletion polymorphism (I/D ACE), angiotensinogen gene polymorphism (M 235), angiotensin II receptor type 1 (ATR1) polymorphism (A 11666C), and polymorphism of serotonin transporter gene (5HTTLPR).Heart rate variability during HUT was assessed in 5-minute intervals by low frequency, high frequency, standard deviation of the normal-to-normal (SDNN), and root mean square successive difference parameters. |
| T6 | 999-1608 | Sentence | denotes | RESULTS: AA genotype of A 1166C polymorphism was associated with lower minimal systolic blood pressure (SBP) and diastolic blood pressure (DBP) during HUT compared with other genotypes (minimal SBP: AA 59.6+/-21,8, AC 79.9+/-22.7, CC 65.4+/-22.7 mmHg, P=0.007), (minimal DBP: AA 36.4+/-22.7, AC 52.3+/-22.9, CC 45.4+/-19.5 mmHg, P=0.007).AA genotype was also associated with higher SDNN compared to other genotypes in the early phase of HUT (SDNN in 5 minutes of tilt: AA 59.7+/-24.6, AC 50.6+/-20.6, CC 46.0+/-13.2, P=0.01) and at syncope occurrence (SDNN: AA 71.0+/-20.9, AC 58.2+/-17.9, CC 58+/-10, P=0.04) |
| T7 | 1609-1752 | Sentence | denotes | CONCLUSION: AA genotype of A 1166C polymorphism in the ATR1 gene may be associated with hypotension and decline in sympathetic tone during HUT. |
| T8 | 1753-1828 | Sentence | denotes | Its role in genetic predisposition to vasovagal syncope cannot be excluded. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 390-397 | OrganismTaxon | denotes | syncope | NCBItxid:1271638 |
| T2 | 948-952 | OrganismTaxon | denotes | root | NCBItxid:1 |
| T3 | 1531-1538 | OrganismTaxon | denotes | syncope | NCBItxid:1271638 |
| T4 | 1801-1808 | OrganismTaxon | denotes | syncope | NCBItxid:1271638 |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 5592 | 105-110 | GeneOrGeneProduct | denotes | renin | NCBIGene:5972 |
| 5593 | 111-122 | GeneOrGeneProduct | denotes | angiotensin | NCBIGene:183 |
| 5594 | 127-136 | ChemicalEntity | denotes | serotonin | MESH:D012701 |
| 5595 | 195-200 | GeneOrGeneProduct | denotes | renin | NCBIGene:5972 |
| 5596 | 201-212 | GeneOrGeneProduct | denotes | angiotensin | NCBIGene:183 |
| 5597 | 224-245 | GeneOrGeneProduct | denotes | serotonin transporter | NCBIGene:6532 |
| 5598 | 366-374 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 5599 | 380-397 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | MESH:D019462 |
| 5600 | 435-443 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 5601 | 472-475 | OrganismTaxon | denotes | men | NCBITaxon:9606 |
| 5602 | 481-486 | OrganismTaxon | denotes | women | NCBITaxon:9606 |
| 5603 | 554-583 | GeneOrGeneProduct | denotes | angiotensin-converting enzyme | NCBIGene:1636 |
| 5604 | 621-624 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 5605 | 627-642 | GeneOrGeneProduct | denotes | angiotensinogen | NCBIGene:183 |
| 5606 | 662-667 | SequenceVariant | denotes | M 235 | p|Allele|M|235 |
| 5607 | 670-700 | GeneOrGeneProduct | denotes | angiotensin II receptor type 1 | NCBIGene:185 |
| 5608 | 702-706 | GeneOrGeneProduct | denotes | ATR1 | NCBIGene:185 |
| 5609 | 722-730 | SequenceVariant | denotes | A 11666C | DBSNP:rs5186 |
| 5610 | 753-774 | GeneOrGeneProduct | denotes | serotonin transporter | NCBIGene:6532 |
| 5611 | 781-788 | GeneOrGeneProduct | denotes | 5HTTLPR | NCBIGene:6532 |
| 5612 | 1023-1030 | SequenceVariant | denotes | A 1166C | DBSNP:rs5186 |
| 5613 | 1531-1538 | DiseaseOrPhenotypicFeature | denotes | syncope | MESH:D013575 |
| 5614 | 1636-1643 | SequenceVariant | denotes | A 1166C | DBSNP:rs5186 |
| 5615 | 1664-1668 | GeneOrGeneProduct | denotes | ATR1 | NCBIGene:185 |
| 5616 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | MESH:D007022 |
| 5617 | 1791-1808 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | MESH:D019462 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 724-730 | SequenceVariant | denotes | 11666C |
| T2 | 1025-1030 | SequenceVariant | denotes | 1166C |
| T3 | 1638-1643 | SequenceVariant | denotes | 1166C |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-32 | GeneOrGeneProduct | denotes | heart |
| T2 | 59-63 | GeneOrGeneProduct | denotes | tilt |
| T3 | 64-68 | GeneOrGeneProduct | denotes | test |
| T4 | 105-110 | GeneOrGeneProduct | denotes | renin |
| T5 | 195-200 | GeneOrGeneProduct | denotes | renin |
| T6 | 224-245 | GeneOrGeneProduct | denotes | serotonin transporter |
| T7 | 307-312 | GeneOrGeneProduct | denotes | heart |
| T8 | 347-351 | GeneOrGeneProduct | denotes | tilt |
| T9 | 352-356 | GeneOrGeneProduct | denotes | test |
| T10 | 399-406 | GeneOrGeneProduct | denotes | METHODS |
| T11 | 462-467 | GeneOrGeneProduct | denotes | years |
| T12 | 527-537 | GeneOrGeneProduct | denotes | determined |
| T13 | 554-583 | GeneOrGeneProduct | denotes | angiotensin-converting enzyme |
| T14 | 621-624 | GeneOrGeneProduct | denotes | ACE |
| T15 | 627-642 | GeneOrGeneProduct | denotes | angiotensinogen |
| T16 | 670-700 | GeneOrGeneProduct | denotes | angiotensin II receptor type 1 |
| T17 | 702-706 | GeneOrGeneProduct | denotes | ATR1 |
| T18 | 753-774 | GeneOrGeneProduct | denotes | serotonin transporter |
| T19 | 781-788 | GeneOrGeneProduct | denotes | 5HTTLPR |
| T20 | 790-795 | GeneOrGeneProduct | denotes | Heart |
| T21 | 837-841 | GeneOrGeneProduct | denotes | in 5 |
| T22 | 842-848 | GeneOrGeneProduct | denotes | minute |
| T23 | 866-875 | GeneOrGeneProduct | denotes | frequency |
| T24 | 877-881 | GeneOrGeneProduct | denotes | high |
| T25 | 882-891 | GeneOrGeneProduct | denotes | frequency |
| T26 | 948-952 | GeneOrGeneProduct | denotes | root |
| T27 | 958-964 | GeneOrGeneProduct | denotes | square |
| T28 | 1168-1173 | GeneOrGeneProduct | denotes | other |
| T29 | 1398-1403 | GeneOrGeneProduct | denotes | other |
| T30 | 1421-1426 | GeneOrGeneProduct | denotes | early |
| T31 | 1446-1450 | GeneOrGeneProduct | denotes | in 5 |
| T32 | 1451-1458 | GeneOrGeneProduct | denotes | minutes |
| T33 | 1462-1466 | GeneOrGeneProduct | denotes | tilt |
| T34 | 1664-1668 | GeneOrGeneProduct | denotes | ATR1 |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-32 | GeneOrGeneProduct | denotes | heart |
| T2 | 59-63 | GeneOrGeneProduct | denotes | tilt |
| T3 | 105-110 | GeneOrGeneProduct | denotes | renin |
| T4 | 195-200 | GeneOrGeneProduct | denotes | renin |
| T5 | 224-245 | GeneOrGeneProduct | denotes | serotonin transporter |
| T6 | 307-312 | GeneOrGeneProduct | denotes | heart |
| T7 | 347-351 | GeneOrGeneProduct | denotes | tilt |
| T8 | 554-583 | GeneOrGeneProduct | denotes | angiotensin-converting enzyme |
| T9 | 627-642 | GeneOrGeneProduct | denotes | angiotensinogen |
| T10 | 670-700 | GeneOrGeneProduct | denotes | angiotensin II receptor type 1 |
| T11 | 702-706 | GeneOrGeneProduct | denotes | ATR1 |
| T12 | 753-774 | GeneOrGeneProduct | denotes | serotonin transporter |
| T13 | 781-788 | GeneOrGeneProduct | denotes | 5HTTLPR |
| T14 | 790-795 | GeneOrGeneProduct | denotes | Heart |
| T15 | 842-848 | GeneOrGeneProduct | denotes | minute |
| T16 | 866-875 | GeneOrGeneProduct | denotes | frequency |
| T17 | 877-881 | GeneOrGeneProduct | denotes | high |
| T18 | 882-891 | GeneOrGeneProduct | denotes | frequency |
| T19 | 958-964 | GeneOrGeneProduct | denotes | square |
| T20 | 1168-1173 | GeneOrGeneProduct | denotes | other |
| T21 | 1398-1403 | GeneOrGeneProduct | denotes | other |
| T22 | 1421-1426 | GeneOrGeneProduct | denotes | early |
| T23 | 1462-1466 | GeneOrGeneProduct | denotes | tilt |
| T24 | 1664-1668 | GeneOrGeneProduct | denotes | ATR1 |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 380-397 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
| T2 | 1531-1538 | DiseaseOrPhenotypicFeature | denotes | syncope | D013575 |
| T3 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | D007022 |
| T4 | 1765-1787 | DiseaseOrPhenotypicFeature | denotes | genetic predisposition | D020022 |
| T5 | 1791-1808 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 105-110 | GeneOrGeneProduct | denotes | renin |
| T2 | 195-200 | GeneOrGeneProduct | denotes | renin |
| T3 | 224-245 | GeneOrGeneProduct | denotes | serotonin transporter |
| T4 | 627-642 | GeneOrGeneProduct | denotes | angiotensinogen |
| T5 | 670-700 | GeneOrGeneProduct | denotes | angiotensin II receptor type 1 |
| T6 | 702-706 | GeneOrGeneProduct | denotes | ATR1 |
| T7 | 753-774 | GeneOrGeneProduct | denotes | serotonin transporter |
| T8 | 781-788 | GeneOrGeneProduct | denotes | 5HTTLPR |
| T9 | 1664-1668 | GeneOrGeneProduct | denotes | ATR1 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 472-475 | DiseaseOrPhenotypicFeature | denotes | men | 0017169 |
| T2 | 1230-1232 | DiseaseOrPhenotypicFeature | denotes | CC | 0019087 |
| T3 | 1307-1309 | DiseaseOrPhenotypicFeature | denotes | CC | 0019087 |
| T4 | 1500-1502 | DiseaseOrPhenotypicFeature | denotes | CC | 0019087 |
| T5 | 1589-1591 | DiseaseOrPhenotypicFeature | denotes | CC | 0019087 |
| T6 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | 0005468 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 380-397 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
| T2 | 1531-1538 | DiseaseOrPhenotypicFeature | denotes | syncope | D013575 |
| T3 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | D007022 |
| T4 | 1765-1787 | DiseaseOrPhenotypicFeature | denotes | genetic predisposition | D020022 |
| T5 | 1791-1808 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 380-397 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
| T2 | 1531-1538 | DiseaseOrPhenotypicFeature | denotes | syncope | D013575 |
| T3 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | D007022 |
| T4 | 1791-1808 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 366-374 | OrganismTaxon | denotes | patients |
| T2 | 435-443 | OrganismTaxon | denotes | patients |
| T3 | 472-475 | OrganismTaxon | denotes | men |
| T4 | 481-486 | OrganismTaxon | denotes | women |
| T5 | 619-624 | OrganismTaxon | denotes | D ACE |
| T6 | 948-952 | OrganismTaxon | denotes | root |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 105-110 | ChemicalEntity | denotes | renin | D012083 |
| T2 | 111-122 | ChemicalEntity | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T3 | 127-136 | ChemicalEntity | denotes | serotonin | D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T6 | 195-200 | ChemicalEntity | denotes | renin | D012083 |
| T7 | 201-212 | ChemicalEntity | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T8 | 224-233 | ChemicalEntity | denotes | serotonin | D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T11 | 554-583 | ChemicalEntity | denotes | angiotensin-converting enzyme | D007703 |
| T12 | 627-642 | ChemicalEntity | denotes | angiotensinogen | http://purl.obolibrary.org/obo/CHEBI_2720 |
| T13 | 670-684 | ChemicalEntity | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_58506|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_2719 |
| T16 | 753-762 | ChemicalEntity | denotes | serotonin | D012701|http://purl.obolibrary.org/obo/CHEBI_350546|http://purl.obolibrary.org/obo/CHEBI_28790 |
| T19 | 1138-1141 | ChemicalEntity | denotes | DBP | http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687 |
| T21 | 1270-1273 | ChemicalEntity | denotes | DBP | http://purl.obolibrary.org/obo/CHEBI_35861|http://purl.obolibrary.org/obo/CHEBI_34687 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T19 | 1138-1141 | ChemicalEntity | denotes | DBP | http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861 | |
| T21 | 1270-1273 | ChemicalEntity | denotes | DBP | http://purl.obolibrary.org/obo/CHEBI_34687|http://purl.obolibrary.org/obo/CHEBI_35861 | |
| T16 | 753-762 | ChemicalEntity | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701 | |
| T13 | 670-684 | ChemicalEntity | denotes | angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506 | |
| T12 | 627-642 | ChemicalEntity | denotes | angiotensinogen | http://purl.obolibrary.org/obo/CHEBI_2720 | |
| T11 | 554-583 | ChemicalEntity | denotes | angiotensin-converting enzyme | D007703 | |
| T8 | 224-233 | ChemicalEntity | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701 | |
| T7 | 201-212 | ChemicalEntity | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 | |
| T6 | 195-200 | ChemicalEntity | denotes | renin | D012083 | |
| T3 | 127-136 | ChemicalEntity | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546|D012701 | |
| T2 | 111-122 | ChemicalEntity | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 | |
| T1 | 105-110 | ChemicalEntity | denotes | renin | D012083 | |
| T9 | 1664-1668 | GeneOrGeneProduct | denotes | ATR1 | ||
| T92146 | 781-788 | GeneOrGeneProduct | denotes | 5HTTLPR | ||
| T18174 | 753-774 | GeneOrGeneProduct | denotes | serotonin transporter | ||
| T53764 | 702-706 | GeneOrGeneProduct | denotes | ATR1 | ||
| T5 | 670-700 | GeneOrGeneProduct | denotes | angiotensin II receptor type 1 | ||
| T4 | 627-642 | GeneOrGeneProduct | denotes | angiotensinogen | ||
| T87521 | 224-245 | GeneOrGeneProduct | denotes | serotonin transporter | ||
| T29204 | 195-200 | GeneOrGeneProduct | denotes | renin | ||
| T4596 | 105-110 | GeneOrGeneProduct | denotes | renin | ||
| T34339 | 1791-1808 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 | |
| T18876 | 1697-1708 | DiseaseOrPhenotypicFeature | denotes | hypotension | D007022 | |
| T23086 | 1531-1538 | DiseaseOrPhenotypicFeature | denotes | syncope | D013575 | |
| T57932 | 380-397 | DiseaseOrPhenotypicFeature | denotes | vasovagal syncope | D019462 | |
| T17176 | 948-952 | OrganismTaxon | denotes | root | ||
| T86758 | 619-624 | OrganismTaxon | denotes | D ACE | ||
| T26298 | 481-486 | OrganismTaxon | denotes | women | ||
| T41515 | 472-475 | OrganismTaxon | denotes | men | ||
| T50138 | 435-443 | OrganismTaxon | denotes | patients | ||
| T26161 | 366-374 | OrganismTaxon | denotes | patients | ||
| T11643 | 1638-1643 | SequenceVariant | denotes | 1166C | ||
| T61231 | 1025-1030 | SequenceVariant | denotes | 1166C | ||
| T86748 | 724-730 | SequenceVariant | denotes | 11666C |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 195-200 | gene:5972 | denotes | renin |
| T1 | 380-397 | disease:C0042420 | denotes | vasovagal syncope |
| R1 | T0 | T1 | associated_with | renin,vasovagal syncope |
tmVarCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 722-730 | DNAMutation:|SUB|A|11666|C | denotes | A 11666C |
| T2 | 1023-1030 | DNAMutation:|SUB|A|1166|C | denotes | A 1166C |
| T3 | 1636-1643 | DNAMutation:|SUB|A|1166|C | denotes | A 1166C |