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PubMed:19025767 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T2 0-7 6308 denotes Leucine
T3 0-7 SO:0001437 denotes Leucine
T1 0-7 CHEBI:15603 denotes Leucine
T4 0-7 D007930 denotes Leucine
T5 0-7 CHEBI:25017 denotes Leucine
T6 0-7 D007930 denotes Leucine
T7 13-19 SO:0001068 denotes repeat
T8 30-35 PR:Q5S006 denotes LRRK2
T9 30-35 PR:000003033 denotes LRRK2
T10 30-35 PR:Q5S007 denotes LRRK2
T11 58-70 GO:0009405 denotes pathogenesis
T16 74-93 D010300 denotes Parkinson's disease
T17 74-93 D010300 denotes Parkinson's disease
T20 107-114 D004194 denotes disease
T21 107-114 D004194 denotes disease
T22 139-156 D019636 denotes neurodegenerative
T23 139-156 D019636 denotes neurodegenerative
T24 157-174 D009069 denotes movement disorder
T25 157-174 D009069 denotes movement disorder
T26 254-258 SO:0000704 denotes gene
T28 268-275 6308 denotes leucine
T27 268-275 CHEBI:15603 denotes leucine
T30 268-275 D007930 denotes leucine
T31 268-275 CHEBI:25017 denotes leucine
T32 268-275 D007930 denotes leucine
T29 268-275 SO:0001437 denotes leucine
T33 281-287 SO:0001068 denotes repeat
T34 298-303 PR:Q5S006 denotes LRRK2
T35 298-303 PR:000003033 denotes LRRK2
T36 298-303 PR:Q5S007 denotes LRRK2
T37 334-352 C566739 denotes autosomal dominant
T38 354-364 D000067562 denotes late-onset
T39 354-364 D000067562 denotes late-onset
T40 430-437 D004194 denotes disease
T41 430-437 D004194 denotes disease
T42 439-444 PR:Q5S006 denotes LRRK2
T43 439-444 PR:000003033 denotes LRRK2
T44 439-444 PR:Q5S007 denotes LRRK2
T48 462-469 PR:000000001 denotes protein
T46 462-469 CHEBI:36080 denotes protein
T47 462-469 CHEBI:11122 denotes protein
T49 462-469 SO:0000104 denotes protein
T45 462-469 GO:0003675 denotes protein
T53 489-496 PR:000000001 denotes protein
T51 489-496 CHEBI:36080 denotes protein
T52 489-496 CHEBI:11122 denotes protein
T54 489-496 SO:0000104 denotes protein
T50 489-496 GO:0003675 denotes protein
T55 532-541 SO:0001185 denotes enzymatic
T56 553-559 D020558 denotes GTPase
T60 564-571 PR:000000001 denotes protein
T61 564-571 SO:0000104 denotes protein
T57 564-571 GO:0003675 denotes protein
T62 564-578 D011494 denotes protein kinase
T63 591-598 D004194 denotes Disease
T64 591-598 D004194 denotes Disease
T68 674-681 PR:000000001 denotes protein
T66 674-681 CHEBI:36080 denotes protein
T67 674-681 CHEBI:11122 denotes protein
T69 674-681 SO:0000104 denotes protein
T65 674-681 GO:0003675 denotes protein
T70 683-688 PR:Q5S006 denotes LRRK2
T71 683-688 PR:000003033 denotes LRRK2
T72 683-688 PR:Q5S007 denotes LRRK2
T73 747-755 SO:0001583 denotes missense
T74 756-764 SO:0000109 denotes mutation
T75 849-854 PR:Q5S006 denotes LRRK2
T76 849-854 PR:000003033 denotes LRRK2
T77 849-854 PR:Q5S007 denotes LRRK2
T78 996-1002 SO:0000417 denotes domain
T80 1014-1024 CHEBI:33704 denotes amino acid
T82 1014-1024 CHEBI:33709 denotes amino acid
T81 1014-1024 SO:0001237 denotes amino acid
T84 1074-1079 PR:Q5S006 denotes LRRK2
T85 1074-1079 PR:000003033 denotes LRRK2
T86 1074-1079 PR:Q5S007 denotes LRRK2

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 8-12 DiseaseOrPhenotypicFeature denotes rich 0015404
T2 74-93 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T3 95-114 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T4 116-118 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T7 157-174 DiseaseOrPhenotypicFeature denotes movement disorder 0005395
T8 276-280 DiseaseOrPhenotypicFeature denotes rich 0015404
T9 365-367 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T12 419-437 DiseaseOrPhenotypicFeature denotes idiopathic disease 0700007
T13 719-721 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T16 839-841 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T19 915-917 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180

DisGeNET

Id Subject Object Predicate Lexical cue
T0 298-303 gene:120892 denotes LRRK2
T1 419-437 disease:C0277553 denotes idiopathic disease
R1 T0 T1 associated_with LRRK2,idiopathic disease

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 95-236 DRI_Background denotes Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with a prevalence of more than 1% after the age of 65 years.
T2 237-438 DRI_Background denotes Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have recently been linked to autosomal dominant, late-onset PD that is clinically indistinguishable from typical, idiopathic disease.
T3 439-590 DRI_Background denotes LRRK2 is a multidomain protein containing several protein interaction motifs as well as dual enzymatic domains of GTPase and protein kinase activities.
T4 591-682 DRI_Background denotes Disease-associated mutations are found throughout the multidomain structure of the protein.
T5 683-842 DRI_Background denotes LRRK2, however, is unique among the PD-causing genes, because a missense mutation, G2019S, is a frequent determinant of not only familial but also sporadic PD.
T6 843-918 DRI_Challenge denotes Thus, LRRK2 has emerged as a promising therapeutic target for combating PD.
T7 919-1080 DRI_Challenge denotes In this Mini-Review, we look at the current state of knowledge regarding the domain structure, amino acid substitutions, and potential functional roles of LRRK2.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
19025767-5#83#89#geners34637584 766-772 geners34637584 denotes G2019S
19025767-5#36#38#diseaseC0030567 719-721 diseaseC0030567 denotes PD
19025767-5#156#158#diseaseC0030567 839-841 diseaseC0030567 denotes PD
83#89#geners3463758436#38#diseaseC0030567 19025767-5#83#89#geners34637584 19025767-5#36#38#diseaseC0030567 associated_with G2019S,PD
83#89#geners34637584156#158#diseaseC0030567 19025767-5#83#89#geners34637584 19025767-5#156#158#diseaseC0030567 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19025767-0#0#28#gene120892 0-28 gene120892 denotes Leucine-rich repeat kinase 2
19025767-0#30#35#gene120892 30-35 gene120892 denotes LRRK2
19025767-0#74#93#diseaseC0030567 74-93 diseaseC0030567 denotes Parkinson's disease
0#28#gene12089274#93#diseaseC0030567 19025767-0#0#28#gene120892 19025767-0#74#93#diseaseC0030567 associated_with Leucine-rich repeat kinase 2,Parkinson's disease
30#35#gene12089274#93#diseaseC0030567 19025767-0#30#35#gene120892 19025767-0#74#93#diseaseC0030567 associated_with LRRK2,Parkinson's disease