PubMed:1899335 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1899335","sourcedb":"PubMed","sourceid":"1899335","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1899335","text":"Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.\nWe have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte 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