> top > docs > PubMed:18687046 > annotations

PubMed:18687046 JSONTXT

Annnotations TAB JSON ListView MergeView

bionlp-st-bb3-2016-training

Id Subject Object Predicate Lexical cue
T1 0-125 Title denotes Impact of intracranial pressure monitor prophylaxis on central nervous system infections and bacterial multi-drug resistance.
T2 138-598 Paragraph denotes Routine intracranial pressure monitor (ICP) prophylaxis is not practiced at our institution. Nevertheless, some patients receive de facto prophylaxis as a result of the use of antibiotics for injuries such as open or facial fractures. We tested the hypothesis that prophylactic antibiotics do not reduce the incidence of central nervous system (CNS) infections but instead are associated with the acquisition of multi-drug resistant (MDR) bacterial infections.
T3 608-1655 Paragraph denotes Patients admitted to the trauma intensive care unit (TICU) from January, 2001 through December, 2004 with blunt, non-operative traumatic brain injury who were managed solely with an ICP monitor were identified from our trauma registry and divided into two groups: (1) Those receiving no antibiotics prior to or during ICP monitoring (NONE; n = 71); and (2) those already receiving antibiotics at the time of ICP monitor insertion (PRO; n = 84). Groups were stratified on the basis of age, Injury Severity Score (ISS), Glasgow Coma Scale (GCS) Score, base excess (BE), ICP days, transfusions in 24 h, ICU days, ventilator days, head Abbreviated Injury Score (AIS), and chest AIS. The study groups did not differ with respect to age, ISS, GCS, BE, ICP days, 24-h transfusions, ICU days, ventilator days, head AIS, or length of stay. In all, 183 patients were identified, of whom 28 died within seven days and were excluded from the analysis. All patients were followed until discharge for both CNS infections and subsequent infectious complications.
T4 1665-2149 Paragraph denotes Only two patients, both in the PRO group, developed CNS infection. Both infectious complications (0.7 vs 1.4 per patient; p < 0.05) and infections secondary to MDR pathogens (0.03 vs. 0.33 per patient; p < 0.01) were significantly more common in the PRO group. Twenty-nine percent of the ventilator-associated pneumonias and 33% of the blood stream infections in the PRO group were MDR, whereas only two blood stream infections in the NONE group (4% of the total infections) were MDR.
T5 2163-2389 Paragraph denotes The routine use of prophylactic antibiotics for ICP monitor insertion is not warranted. This practice does not reduce the CNS infection rate and is associated with more MDR pathogens in any subsequent infectious complications.
T6 55-77 Habitat denotes central nervous system
T7 250-258 Habitat denotes patients
T8 355-361 Habitat denotes facial
T9 459-481 Habitat denotes central nervous system
T10 483-486 Habitat denotes CNS
T11 608-616 Habitat denotes Patients
T12 633-659 Habitat denotes trauma intensive care unit
T13 661-665 Habitat denotes TICU
T14 745-757 Habitat denotes brain injury
T15 745-750 Habitat denotes brain
T16 1208-1211 Habitat denotes ICU
T17 1383-1386 Habitat denotes ICU
T18 1451-1459 Habitat denotes patients
T19 1552-1560 Habitat denotes patients
T20 1600-1603 Habitat denotes CNS
T21 1674-1682 Habitat denotes patients
T22 1717-1720 Habitat denotes CNS
T23 1778-1785 Habitat denotes patient
T24 1858-1865 Habitat denotes patient
T25 2001-2013 Habitat denotes blood stream
T26 2069-2081 Habitat denotes blood stream
T27 2285-2288 Habitat denotes CNS