PubMed:18674790 / 1181-1744 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T8","span":{"begin":0,"end":563},"obj":"Sentence"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T10","span":{"begin":37,"end":41},"obj":"OrganismTaxon"}],"attributes":[{"id":"A10","pred":"db_id","subj":"T10","obj":"NCBItxid:10118"},{"id":"A11","pred":"db_id","subj":"T10","obj":"NCBItxid:10116"},{"id":"A12","pred":"db_id","subj":"T10","obj":"NCBItxid:10114"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-entities","denotations":[{"id":"5413","span":{"begin":34,"end":36},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5414","span":{"begin":37,"end":41},"obj":"OrganismTaxon"},{"id":"5415","span":{"begin":121,"end":148},"obj":"GeneOrGeneProduct"},{"id":"5416","span":{"begin":180,"end":229},"obj":"GeneOrGeneProduct"},{"id":"5417","span":{"begin":252,"end":263},"obj":"GeneOrGeneProduct"},{"id":"5418","span":{"begin":294,"end":304},"obj":"ChemicalEntity"},{"id":"5419","span":{"begin":392,"end":394},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5420","span":{"begin":425,"end":450},"obj":"GeneOrGeneProduct"},{"id":"5421","span":{"begin":480,"end":483},"obj":"ChemicalEntity"},{"id":"5422","span":{"begin":516,"end":519},"obj":"ChemicalEntity"},{"id":"5423","span":{"begin":520,"end":523},"obj":"ChemicalEntity"},{"id":"5424","span":{"begin":536,"end":547},"obj":"ChemicalEntity"}],"attributes":[{"id":"A34","pred":"db_id","subj":"5413","obj":"MESH:D009765"},{"id":"A35","pred":"db_id","subj":"5414","obj":"NCBITaxon:10116"},{"id":"A36","pred":"db_id","subj":"5415","obj":"NCBIGene:25708"},{"id":"A37","pred":"db_id","subj":"5415","obj":"NCBIGene:54315"},{"id":"A38","pred":"db_id","subj":"5416","obj":"NCBIGene:25747"},{"id":"A39","pred":"db_id","subj":"5417","obj":"NCBIGene:246253"},{"id":"A40","pred":"db_id","subj":"5418","obj":"MESH:D005227"},{"id":"A41","pred":"db_id","subj":"5419","obj":"MESH:D009765"},{"id":"A42","pred":"db_id","subj":"5420","obj":"NCBIGene:65248"},{"id":"A43","pred":"db_id","subj":"5421","obj":"MESH:D000255"},{"id":"A44","pred":"db_id","subj":"5422","obj":"MESH:D000255"},{"id":"A45","pred":"db_id","subj":"5423","obj":"MESH:D000244"},{"id":"A46","pred":"db_id","subj":"5424","obj":"MESH:D004317"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T11","span":{"begin":34,"end":36},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":121,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":215,"end":223},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":224,"end":229},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":252,"end":263},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":300,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":334,"end":339},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":340,"end":345},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":377,"end":382},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":383,"end":388},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":392,"end":394},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":411,"end":424},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":429,"end":435},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":436,"end":450},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":464,"end":468},"obj":"GeneOrGeneProduct"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T24","span":{"begin":34,"end":36},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":61,"end":68},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":121,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":215,"end":223},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":224,"end":229},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":252,"end":263},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":294,"end":299},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":300,"end":304},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":334,"end":339},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":340,"end":345},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":377,"end":382},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":383,"end":388},"obj":"GeneOrGeneProduct"},{"id":"T36","span":{"begin":392,"end":394},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":411,"end":424},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":425,"end":428},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":429,"end":435},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":436,"end":450},"obj":"GeneOrGeneProduct"},{"id":"T41","span":{"begin":464,"end":468},"obj":"GeneOrGeneProduct"},{"id":"T42","span":{"begin":480,"end":483},"obj":"GeneOrGeneProduct"},{"id":"T43","span":{"begin":516,"end":519},"obj":"GeneOrGeneProduct"},{"id":"T44","span":{"begin":520,"end":523},"obj":"GeneOrGeneProduct"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T13","span":{"begin":34,"end":36},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":392,"end":394},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"originalLabel","subj":"T13","obj":"DISEASE"},{"id":"A14","pred":"originalLabel","subj":"T14","obj":"DISEASE"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T3","span":{"begin":121,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":180,"end":223},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":224,"end":229},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":252,"end":263},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":429,"end":435},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":464,"end":468},"obj":"GeneOrGeneProduct"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T6","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0010691"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T13","span":{"begin":34,"end":36},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":392,"end":394},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"ID:","subj":"T13","obj":"DISEASE"},{"id":"A14","pred":"ID:","subj":"T14","obj":"DISEASE"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T13","span":{"begin":34,"end":36},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":392,"end":394},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"#label","subj":"T13","obj":"DISEASE"},{"id":"A14","pred":"#label","subj":"T14","obj":"DISEASE"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T27","span":{"begin":252,"end":263},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":425,"end":428},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":480,"end":483},"obj":"ChemicalEntity"},{"id":"T33","span":{"begin":516,"end":519},"obj":"ChemicalEntity"},{"id":"T35","span":{"begin":520,"end":523},"obj":"ChemicalEntity"},{"id":"T38","span":{"begin":536,"end":547},"obj":"ChemicalEntity"}],"attributes":[{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"id":"A28","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_456215"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_28971"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_16027"},{"id":"A31","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A32","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A33","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A34","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A35","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A36","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A37","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A38","pred":"ID:","subj":"T38","obj":"D004317"},{"id":"A39","pred":"ID:","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_64816"},{"id":"A40","pred":"ID:","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T5","span":{"begin":37,"end":41},"obj":"OrganismTaxon"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T38","span":{"begin":536,"end":547},"obj":"ChemicalEntity"},{"id":"T35","span":{"begin":520,"end":523},"obj":"ChemicalEntity"},{"id":"T33","span":{"begin":516,"end":519},"obj":"ChemicalEntity"},{"id":"T31","span":{"begin":480,"end":483},"obj":"ChemicalEntity"},{"id":"T28","span":{"begin":425,"end":428},"obj":"ChemicalEntity"},{"id":"T27","span":{"begin":252,"end":263},"obj":"ChemicalEntity"},{"id":"T70269","span":{"begin":464,"end":468},"obj":"GeneOrGeneProduct"},{"id":"T37019","span":{"begin":429,"end":435},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":252,"end":263},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":224,"end":229},"obj":"GeneOrGeneProduct"},{"id":"T35860","span":{"begin":180,"end":223},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":121,"end":142},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":392,"end":394},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T43014","span":{"begin":34,"end":36},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T41232","span":{"begin":37,"end":41},"obj":"OrganismTaxon"}],"attributes":[{"id":"A40","pred":"ID:","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_28748"},{"id":"A39","pred":"ID:","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_64816"},{"id":"A38","pred":"ID:","subj":"T38","obj":"D004317"},{"id":"A37","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_16761"},{"id":"A36","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_456216"},{"id":"A35","pred":"ID:","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_73342"},{"id":"A34","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A33","pred":"ID:","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A32","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A31","pred":"ID:","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A30","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_16027"},{"id":"A29","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_28971"},{"id":"A28","pred":"ID:","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_456215"},{"id":"A27","pred":"ID:","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_81572"},{"id":"A5600","pred":"#label","subj":"T14","obj":"DISEASE"},{"id":"A54019","pred":"#label","subj":"T43014","obj":"DISEASE"}],"text":"Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration."}