PubMed:18634852 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18634852","sourcedb":"PubMed","sourceid":"18634852","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/18634852","text":"Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra.\nA hallmark of Parkinson's disease (PD) is the progressive loss of the A9 midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta. Recently, multiple causative mutations have been identified in the leucine-rich repeat kinase 2 (LRRK2) gene for both familial and sporadic PD cases. Therefore, to investigate functional roles of LRRK2 in normal and/or diseased brain, it is critical to define LRRK2 expression in mDA neurons. To address whether LRRK2 mRNA and protein are expressed in mDA neurons, we purified DA neurons from the tyrosine hydroxylase (TH)-GFP transgenic mouse using FACS-sorting and analyzed the expression of LRRK2 and other mDA markers. We observed that all mDA markers tested in this study (TH, Pitx3, DAT, Nurr1 and Lmx1a) are robustly expressed only in GFP(+) cells, but not in GFP(-) cells. Notably, LRRK2 was expressed in both GFP(+) and GFP(-) cells. Consistent with this, our immunohistochemical analyses showed that LRRK2 is expressed in TH-positive mDA neurons as well as in surrounding TH-negative cells in the rat brain. Importantly, in the midbrain region, LRRK2 protein was preferentially expressed in A9 DA neurons of the substantia nigra, compared to A10 DA neurons of the ventral tegmental area. However, LRRK2 was also highly expressed in the cortical and hippocampal regions. Taken together, our results suggest that LRRK2 may have direct functional role(s) in the neurophysiology of A9 DA neurons and that dysfunction of these neurons by mutant LRRK2 may directly cause their selective degeneration.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":18,"end":23},"obj":"PR:Q5S006"},{"id":"T2","span":{"begin":18,"end":23},"obj":"PR:000003033"},{"id":"T3","span":{"begin":18,"end":23},"obj":"PR:Q5S007"},{"id":"T4","span":{"begin":24,"end":28},"obj":"SO:0000704"},{"id":"T5","span":{"begin":36,"end":44},"obj":"UBERON:0001891"},{"id":"T6","span":{"begin":73,"end":89},"obj":"UBERON:0002038"},{"id":"T11","span":{"begin":105,"end":124},"obj":"D010300"},{"id":"T12","span":{"begin":105,"end":124},"obj":"D010300"},{"id":"T15","span":{"begin":164,"end":172},"obj":"UBERON:0001891"},{"id":"T16","span":{"begin":187,"end":190},"obj":"CHEBI:566274"},{"id":"T18","span":{"begin":207,"end":237},"obj":"UBERON:0001966"},{"id":"T19","span":{"begin":207,"end":237},"obj":"UBERON:0001965"},{"id":"T20","span":{"begin":224,"end":228},"obj":"PR:P07814"},{"id":"T21","span":{"begin":224,"end":228},"obj":"PR:000007144"},{"id":"T24","span":{"begin":306,"end":313},"obj":"6308"},{"id":"T25","span":{"begin":306,"end":313},"obj":"SO:0001437"},{"id":"T23","span":{"begin":306,"end":313},"obj":"CHEBI:15603"},{"id":"T26","span":{"begin":306,"end":313},"obj":"D007930"},{"id":"T27","span":{"begin":306,"end":313},"obj":"CHEBI:25017"},{"id":"T28","span":{"begin":306,"end":313},"obj":"D007930"},{"id":"T29","span":{"begin":319,"end":325},"obj":"SO:0001068"},{"id":"T30","span":{"begin":336,"end":341},"obj":"PR:Q5S006"},{"id":"T31","span":{"begin":336,"end":341},"obj":"PR:000003033"},{"id":"T32","span":{"begin":336,"end":341},"obj":"PR:Q5S007"},{"id":"T33","span":{"begin":343,"end":347},"obj":"SO:0000704"},{"id":"T34","span":{"begin":435,"end":440},"obj":"PR:Q5S006"},{"id":"T35","span":{"begin":435,"end":440},"obj":"PR:000003033"},{"id":"T36","span":{"begin":435,"end":440},"obj":"PR:Q5S007"},{"id":"T37","span":{"begin":467,"end":472},"obj":"UBERON:6110636"},{"id":"T38","span":{"begin":467,"end":472},"obj":"UBERON:0000955"},{"id":"T39","span":{"begin":499,"end":504},"obj":"PR:Q5S006"},{"id":"T40","span":{"begin":499,"end":504},"obj":"PR:000003033"},{"id":"T41","span":{"begin":499,"end":504},"obj":"PR:Q5S007"},{"id":"T42","span":{"begin":519,"end":522},"obj":"CHEBI:566274"},{"id":"T43","span":{"begin":551,"end":556},"obj":"PR:Q5S006"},{"id":"T44","span":{"begin":551,"end":556},"obj":"PR:000003033"},{"id":"T45","span":{"begin":551,"end":556},"obj":"PR:Q5S007"},{"id":"T48","span":{"begin":557,"end":561},"obj":"SO:0000234"},{"id":"T46","span":{"begin":557,"end":561},"obj":"D012333"},{"id":"T47","span":{"begin":557,"end":561},"obj":"CHEBI:33699"},{"id":"T53","span":{"begin":566,"end":573},"obj":"SO:0000104"},{"id":"T52","span":{"begin":566,"end":573},"obj":"PR:000000001"},{"id":"T50","span":{"begin":566,"end":573},"obj":"CHEBI:36080"},{"id":"T51","span":{"begin":566,"end":573},"obj":"CHEBI:11122"},{"id":"T49","span":{"begin":566,"end":573},"obj":"GO:0003675"},{"id":"T54","span":{"begin":591,"end":594},"obj":"CHEBI:566274"},{"id":"T56","span":{"begin":636,"end":644},"obj":"10962"},{"id":"T60","span":{"begin":636,"end":644},"obj":"SO:0001446"},{"id":"T63","span":{"begin":636,"end":656},"obj":"A0A060X6Z0"},{"id":"T62","span":{"begin":636,"end":656},"obj":"D014446"},{"id":"T64","span":{"begin":658,"end":665},"obj":"CVCL_JJ81"},{"id":"T65","span":{"begin":666,"end":676},"obj":"SO:0000781"},{"id":"T66","span":{"begin":666,"end":682},"obj":"D008822"},{"id":"T69","span":{"begin":689,"end":693},"obj":"P9WQ36"},{"id":"T70","span":{"begin":689,"end":693},"obj":"P9WQ37"},{"id":"T71","span":{"begin":733,"end":738},"obj":"PR:Q5S006"},{"id":"T72","span":{"begin":733,"end":738},"obj":"PR:000003033"},{"id":"T73","span":{"begin":733,"end":738},"obj":"PR:Q5S007"},{"id":"T74","span":{"begin":749,"end":752},"obj":"CHEBI:566274"},{"id":"T75","span":{"begin":783,"end":786},"obj":"CHEBI:566274"},{"id":"T76","span":{"begin":821,"end":826},"obj":"PR:000012761"},{"id":"T77","span":{"begin":821,"end":826},"obj":"PR:P81062"},{"id":"T78","span":{"begin":821,"end":826},"obj":"PR:Q6QU75"},{"id":"T79","span":{"begin":821,"end":826},"obj":"PR:O75364"},{"id":"T80","span":{"begin":821,"end":826},"obj":"PR:O35160"},{"id":"T81","span":{"begin":828,"end":831},"obj":"PR:Q61327"},{"id":"T82","span":{"begin":828,"end":831},"obj":"Q03614"},{"id":"T84","span":{"begin":828,"end":831},"obj":"PR:P13483"},{"id":"T85","span":{"begin":828,"end":831},"obj":"P27922"},{"id":"T86","span":{"begin":828,"end":831},"obj":"Q61327"},{"id":"T87","span":{"begin":828,"end":831},"obj":"P23977"},{"id":"T88","span":{"begin":828,"end":831},"obj":"Q9GJT6"},{"id":"T89","span":{"begin":828,"end":831},"obj":"PR:000015188"},{"id":"T90","span":{"begin":828,"end":831},"obj":"PR:Q94521"},{"id":"T91","span":{"begin":828,"end":831},"obj":"Q01959"},{"id":"T92","span":{"begin":828,"end":831},"obj":"PR:Q7K4Y6"},{"id":"T83","span":{"begin":828,"end":831},"obj":"CHEBI:137433"},{"id":"T93","span":{"begin":833,"end":838},"obj":"PR:Q07917"},{"id":"T94","span":{"begin":833,"end":838},"obj":"PR:P43354"},{"id":"T95","span":{"begin":833,"end":838},"obj":"PR:000011409"},{"id":"T96","span":{"begin":833,"end":838},"obj":"PR:Q06219"},{"id":"T99","span":{"begin":843,"end":846},"obj":"1011859"},{"id":"T102","span":{"begin":843,"end":848},"obj":"PR:000009870"},{"id":"T103","span":{"begin":843,"end":848},"obj":"PR:Q9JKU8"},{"id":"T104","span":{"begin":843,"end":848},"obj":"PR:Q8TE12"},{"id":"T105","span":{"begin":929,"end":934},"obj":"PR:Q5S006"},{"id":"T106","span":{"begin":929,"end":934},"obj":"PR:000003033"},{"id":"T107","span":{"begin":929,"end":934},"obj":"PR:Q5S007"},{"id":"T108","span":{"begin":1049,"end":1054},"obj":"PR:Q5S006"},{"id":"T109","span":{"begin":1049,"end":1054},"obj":"PR:000003033"},{"id":"T110","span":{"begin":1049,"end":1054},"obj":"PR:Q5S007"},{"id":"T111","span":{"begin":1083,"end":1086},"obj":"CHEBI:566274"},{"id":"T113","span":{"begin":1146,"end":1149},"obj":"PR:P63003-1"},{"id":"T114","span":{"begin":1146,"end":1149},"obj":"PR:Q2G0B1"},{"id":"T115","span":{"begin":1146,"end":1149},"obj":"PR:Q8VHJ4"},{"id":"T112","span":{"begin":1146,"end":1149},"obj":"10116"},{"id":"T116","span":{"begin":1146,"end":1149},"obj":"D051381"},{"id":"T117","span":{"begin":1150,"end":1155},"obj":"UBERON:6110636"},{"id":"T118","span":{"begin":1150,"end":1155},"obj":"UBERON:0000955"},{"id":"T119","span":{"begin":1177,"end":1185},"obj":"UBERON:0001891"},{"id":"T120","span":{"begin":1194,"end":1199},"obj":"PR:Q5S006"},{"id":"T121","span":{"begin":1194,"end":1199},"obj":"PR:000003033"},{"id":"T122","span":{"begin":1194,"end":1199},"obj":"PR:Q5S007"},{"id":"T123","span":{"begin":1194,"end":1207},"obj":"D000071158"},{"id":"T128","span":{"begin":1200,"end":1207},"obj":"SO:0000104"},{"id":"T127","span":{"begin":1200,"end":1207},"obj":"PR:000000001"},{"id":"T124","span":{"begin":1200,"end":1207},"obj":"GO:0003675"},{"id":"T129","span":{"begin":1261,"end":1277},"obj":"UBERON:0002038"},{"id":"T134","span":{"begin":1291,"end":1294},"obj":"CVCL_0130"},{"id":"T132","span":{"begin":1291,"end":1294},"obj":"PR:000012656"},{"id":"T135","span":{"begin":1291,"end":1294},"obj":"PR:Q27377"},{"id":"T136","span":{"begin":1291,"end":1294},"obj":"Q61753"},{"id":"T131","span":{"begin":1291,"end":1294},"obj":"C052091"},{"id":"T133","span":{"begin":1291,"end":1294},"obj":"C052091"},{"id":"T137","span":{"begin":1313,"end":1335},"obj":"UBERON:0002691"},{"id":"T138","span":{"begin":1346,"end":1351},"obj":"PR:Q5S006"},{"id":"T139","span":{"begin":1346,"end":1351},"obj":"PR:000003033"},{"id":"T140","span":{"begin":1346,"end":1351},"obj":"PR:Q5S007"},{"id":"T141","span":{"begin":1460,"end":1465},"obj":"PR:Q5S006"},{"id":"T142","span":{"begin":1460,"end":1465},"obj":"PR:000003033"},{"id":"T143","span":{"begin":1460,"end":1465},"obj":"PR:Q5S007"},{"id":"T144","span":{"begin":1589,"end":1594},"obj":"PR:Q5S006"},{"id":"T145","span":{"begin":1589,"end":1594},"obj":"PR:000003033"},{"id":"T146","span":{"begin":1589,"end":1594},"obj":"PR:Q5S007"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":105,"end":124},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":126,"end":128},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":314,"end":318},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":379,"end":381},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":689,"end":693},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005180"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008199"},{"id":"A3","pred":"mondo_id","subj":"T2","obj":"0015873"},{"id":"A4","pred":"mondo_id","subj":"T2","obj":"0005180"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0015404"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0008199"},{"id":"A7","pred":"mondo_id","subj":"T6","obj":"0015873"},{"id":"A8","pred":"mondo_id","subj":"T6","obj":"0005180"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0018262"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":90},"obj":"DRI_Outcome"},{"id":"T2","span":{"begin":91,"end":238},"obj":"DRI_Background"},{"id":"T3","span":{"begin":239,"end":388},"obj":"DRI_Background"},{"id":"T4","span":{"begin":389,"end":531},"obj":"DRI_Background"},{"id":"T5","span":{"begin":532,"end":761},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":762,"end":919},"obj":"DRI_Approach"},{"id":"T7","span":{"begin":920,"end":981},"obj":"DRI_Background"},{"id":"T8","span":{"begin":982,"end":1156},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1157,"end":1336},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1337,"end":1418},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1419,"end":1643},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":91,"end":238},"obj":"DRI_Background"},{"id":"T2","span":{"begin":239,"end":388},"obj":"DRI_Background"},{"id":"T3","span":{"begin":389,"end":531},"obj":"DRI_Background"},{"id":"T4","span":{"begin":532,"end":761},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":762,"end":919},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":920,"end":981},"obj":"DRI_Background"},{"id":"T7","span":{"begin":982,"end":1156},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1157,"end":1336},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1337,"end":1418},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1419,"end":1643},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#96ec93","default":true},{"id":"PMID_GLOBAL","color":"#ec93b0"},{"id":"UseCases_ArguminSci_Discourse","color":"#93caec"},{"id":"PubMed_ArguminSci","color":"#e4ec93"}]}]}}