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PubMed:18577513 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 122-125 DiseaseOrPhenotypicFeature denotes ion 0044688
T2 186-189 DiseaseOrPhenotypicFeature denotes ion 0044688

sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.
T2 136-291 Sentence denotes The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species.
T3 292-431 Sentence denotes In humans, increased TTYH2 expression is associated with cancer progression, whereas fly Tweety is associated with developmental processes.
T4 432-715 Sentence denotes Structurally, Tweety proteins are characterized by five membrane-spanning domains and N-glycan modifications important for trafficking to the plasma membrane, where these proteins are oriented with the amino terminus located extracellularly and the carboxyl terminus cytoplasmically.
T5 716-894 Sentence denotes In addition to N-glycosylation, ubiquitination mediated by the HECT type E3 ubiquitin ligase Nedd4-2 is a post-translation modification important in regulating membrane proteins.
T6 895-1067 Sentence denotes In the present study, we performed a comprehensive analysis of the ability of each of TTYH1-3 to interact with Nedd4-2 and to be ubiquitinated and regulated by this ligase.
T7 1068-1274 Sentence denotes Our data indicate that Nedd4-2 binds to two family members, TTYH2 and TTYH3, which contain consensus PY ((L/P)PXY) binding sites for HECT type E3 ubiquitin ligases, but not to TTYH1, which lacks this motif.
T8 1275-1332 Sentence denotes Consistently, Nedd4-2 ubiquitinates both TTYH2 and TTYH3.
T9 1333-1492 Sentence denotes Importantly, we have shown that endogenous TTYH2 and Nedd4-2 are binding partners and demonstrated that the TTYH2 PY motif is essential for these interactions.
T10 1493-1640 Sentence denotes We have also shown that Nedd4-2-mediated ubiquitination of TTYH2 is a critical regulator of cell surface and total cellular levels of this protein.
T11 1641-1831 Sentence denotes These data, indicating that Nedd4-2 differentially interacts with and regulates TTYH1-3, will be important for understanding mechanisms controlling Tweety proteins in physiology and disease.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 4-13 Protein denotes ubiquitin
T2 29-36 Protein denotes Nedd4-2
T3 140-146 Protein denotes Tweety
T4 240-245 Protein denotes TTYH1
T5 246-247 Protein denotes 3
T6 313-318 Protein denotes TTYH2
T7 381-387 Protein denotes Tweety
T8 446-452 Protein denotes Tweety
T9 792-801 Protein denotes ubiquitin
T10 809-816 Protein denotes Nedd4-2
T11 981-986 Protein denotes TTYH1
T12 987-988 Protein denotes 3
T13 1006-1013 Protein denotes Nedd4-2
T14 1091-1098 Protein denotes Nedd4-2
T15 1128-1133 Protein denotes TTYH2
T16 1138-1143 Protein denotes TTYH3
T17 1214-1223 Protein denotes ubiquitin
T18 1244-1249 Protein denotes TTYH1
T19 1289-1296 Protein denotes Nedd4-2
T20 1316-1321 Protein denotes TTYH2
T21 1326-1331 Protein denotes TTYH3
T22 1376-1381 Protein denotes TTYH2
T23 1386-1393 Protein denotes Nedd4-2
T24 1441-1446 Protein denotes TTYH2
T25 1517-1524 Protein denotes Nedd4-2
T26 1552-1557 Protein denotes TTYH2
T27 1669-1676 Protein denotes Nedd4-2
T28 1721-1726 Protein denotes TTYH1
T29 1727-1728 Protein denotes 3
T30 1789-1795 Protein denotes Tweety

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 349-355 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 349-355 Phenotype denotes cancer HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 488-496 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 574-589 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T5 657-672 Body_part denotes extracellularly http://purl.obolibrary.org/obo/GO_0005576
T6 876-884 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158