PubMed:1851858
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1851858","sourcedb":"PubMed","sourceid":"1851858","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1851858","text":"Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.\nThe BZLF1 protein of Epstein-Barr virus (EBV) is a key immediate-early protein which has been shown to disrupt virus latency in EBV-infected B cells. We have generated a monoclonal antibody, BZ1, to BZLF1 which reacts in immunohistology, immunoblotting, and immunoprecipitation and which recognizes both the active, dimeric form and the inactive, monomeric form of the protein. Biopsies of oral hairy leukoplakia, an AIDS-associated lesion characterized by high-level EBV replication, were examined by immunohistochemistry using the BZ1 monoclonal antibody. A differentiation-associated pattern of BZLF1 expression was observed, BZ1 reacting with nuclei of the upper spinous layer of the lesion. This finding suggests that the BZLF1 promoter may be regulated by the degree of squamous differentiation. A comparison of in situ hybridization to EBV DNA and viral capsid antigen staining with BZ1 reactivity suggested that BZLF1 expression precedes rampant virus replication. The inability to detect EBV in the lower epithelial layers of oral hairy leukoplakia raises questions concerning the nature of EBV latency and persistence in stratified squamous epithelium.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":45,"end":63},"obj":"NP"},{"id":"C2","span":{"begin":64,"end":92},"obj":"NP"},{"id":"C3","span":{"begin":96,"end":118},"obj":"NP"},{"id":"C4","span":{"begin":120,"end":137},"obj":"NP"},{"id":"C5","span":{"begin":141,"end":165},"obj":"NP"},{"id":"C6","span":{"begin":169,"end":198},"obj":"NP"},{"id":"C7","span":{"begin":199,"end":204},"obj":"NP"},{"id":"C8","span":{"begin":288,"end":309},"obj":"NP"},{"id":"C9","span":{"begin":311,"end":314},"obj":"NP"},{"id":"C10","span":{"begin":319,"end":324},"obj":"NP"},{"id":"C11","span":{"begin":325,"end":330},"obj":"NP"},{"id":"C12","span":{"begin":402,"end":407},"obj":"NP"},{"id":"C13","span":{"begin":485,"end":496},"obj":"NP"},{"id":"C14","span":{"begin":510,"end":532},"obj":"NP"},{"id":"C16","span":{"begin":588,"end":591},"obj":"NP"},{"id":"C15","span":{"begin":534,"end":603},"obj":"NP"},{"id":"C18","span":{"begin":718,"end":723},"obj":"NP"},{"id":"C17","span":{"begin":718,"end":734},"obj":"NP"},{"id":"C19","span":{"begin":749,"end":752},"obj":"NP"},{"id":"C20","span":{"begin":963,"end":966},"obj":"NP"},{"id":"C21","span":{"begin":1010,"end":1013},"obj":"NP"},{"id":"C23","span":{"begin":1040,"end":1045},"obj":"NP"},{"id":"C22","span":{"begin":1040,"end":1056},"obj":"NP"},{"id":"C24","span":{"begin":1117,"end":1120},"obj":"NP"},{"id":"C25","span":{"begin":1155,"end":1177},"obj":"NP"},{"id":"C26","span":{"begin":1220,"end":1223},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-appos","subj":"C8","obj":"C9"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C4"},{"id":"R6","pred":"coref-relat","subj":"C11","obj":"C10"},{"id":"R7","pred":"coref-relat","subj":"C12","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C13","obj":"C10"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C3"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C5"},{"id":"R11","pred":"coref-appos","subj":"C15","obj":"C14"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C10"},{"id":"R13","pred":"coref-ident","subj":"C19","obj":"C9"},{"id":"R14","pred":"coref-ident","subj":"C20","obj":"C16"},{"id":"R15","pred":"coref-ident","subj":"C21","obj":"C19"},{"id":"R16","pred":"coref-ident","subj":"C23","obj":"C18"},{"id":"R17","pred":"coref-ident","subj":"C22","obj":"C17"},{"id":"R18","pred":"coref-ident","subj":"C24","obj":"C20"},{"id":"R19","pred":"coref-ident","subj":"C25","obj":"C14"},{"id":"R20","pred":"coref-ident","subj":"C26","obj":"C24"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C26","pred":"source","obj":"genia-medco-coref"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":70,"end":92},"obj":"gene:1385"},{"id":"T1","span":{"begin":96,"end":118},"obj":"disease:C0206186"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":45,"end":92},"obj":"protein"},{"id":"T2","span":{"begin":124,"end":137},"obj":"protein"},{"id":"T3","span":{"begin":175,"end":198},"obj":"protein"},{"id":"T4","span":{"begin":248,"end":268},"obj":"cell_type"},{"id":"T5","span":{"begin":290,"end":309},"obj":"protein"},{"id":"T6","span":{"begin":311,"end":314},"obj":"protein"},{"id":"T7","span":{"begin":319,"end":324},"obj":"protein"},{"id":"T8","span":{"begin":428,"end":448},"obj":"protein"},{"id":"T9","span":{"begin":457,"end":481},"obj":"protein"},{"id":"T10","span":{"begin":653,"end":656},"obj":"protein"},{"id":"T11","span":{"begin":657,"end":676},"obj":"protein"},{"id":"T12","span":{"begin":718,"end":723},"obj":"protein"},{"id":"T13","span":{"begin":749,"end":752},"obj":"protein"},{"id":"T14","span":{"begin":847,"end":861},"obj":"DNA"},{"id":"T15","span":{"begin":963,"end":970},"obj":"DNA"},{"id":"T16","span":{"begin":975,"end":995},"obj":"protein"},{"id":"T17","span":{"begin":1010,"end":1013},"obj":"protein"},{"id":"T18","span":{"begin":1040,"end":1045},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"S2","span":{"begin":120,"end":269},"obj":"Sentence"},{"id":"S3","span":{"begin":270,"end":497},"obj":"Sentence"},{"id":"S4","span":{"begin":498,"end":677},"obj":"Sentence"},{"id":"S5","span":{"begin":678,"end":815},"obj":"Sentence"},{"id":"S6","span":{"begin":816,"end":921},"obj":"Sentence"},{"id":"S7","span":{"begin":922,"end":1092},"obj":"Sentence"},{"id":"S8","span":{"begin":1093,"end":1282},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":45,"end":63},"obj":"virus"},{"id":"T2","span":{"begin":96,"end":118},"obj":"other_name"},{"id":"T3","span":{"begin":124,"end":137},"obj":"protein_molecule"},{"id":"T4","span":{"begin":141,"end":159},"obj":"virus"},{"id":"T5","span":{"begin":161,"end":164},"obj":"virus"},{"id":"T6","span":{"begin":175,"end":198},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":248,"end":251},"obj":"virus"},{"id":"T8","span":{"begin":290,"end":309},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":311,"end":314},"obj":"protein_molecule"},{"id":"T10","span":{"begin":319,"end":324},"obj":"protein_molecule"},{"id":"T11","span":{"begin":341,"end":356},"obj":"other_name"},{"id":"T12","span":{"begin":358,"end":372},"obj":"other_name"},{"id":"T13","span":{"begin":378,"end":397},"obj":"other_name"},{"id":"T14","span":{"begin":428,"end":448},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":457,"end":481},"obj":"protein_family_or_group"},{"id":"T16","span":{"begin":510,"end":532},"obj":"other_name"},{"id":"T17","span":{"begin":537,"end":559},"obj":"other_name"},{"id":"T18","span":{"begin":577,"end":587},"obj":"other_name"},{"id":"T19","span":{"begin":588,"end":591},"obj":"virus"},{"id":"T20","span":{"begin":622,"end":642},"obj":"other_name"},{"id":"T21","span":{"begin":653,"end":656},"obj":"protein_molecule"},{"id":"T22","span":{"begin":657,"end":676},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":680,"end":714},"obj":"other_name"},{"id":"T24","span":{"begin":718,"end":723},"obj":"protein_molecule"},{"id":"T25","span":{"begin":749,"end":752},"obj":"protein_molecule"},{"id":"T26","span":{"begin":767,"end":773},"obj":"cell_component"},{"id":"T27","span":{"begin":781,"end":800},"obj":"tissue"},{"id":"T28","span":{"begin":808,"end":814},"obj":"other_name"},{"id":"T29","span":{"begin":847,"end":852},"obj":"protein_molecule"},{"id":"T30","span":{"begin":941,"end":959},"obj":"other_name"},{"id":"T31","span":{"begin":963,"end":966},"obj":"virus"},{"id":"T32","span":{"begin":975,"end":995},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1010,"end":1013},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1040,"end":1045},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1066,"end":1091},"obj":"other_name"},{"id":"T36","span":{"begin":1117,"end":1120},"obj":"virus"},{"id":"T37","span":{"begin":1155,"end":1177},"obj":"other_name"},{"id":"T38","span":{"begin":1220,"end":1223},"obj":"virus"},{"id":"T39","span":{"begin":1251,"end":1281},"obj":"tissue"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"1851858-0#70#92#gene1385","span":{"begin":70,"end":92},"obj":"gene1385"},{"id":"1851858-0#96#118#diseaseC0206186","span":{"begin":96,"end":118},"obj":"diseaseC0206186"}],"relations":[{"id":"70#92#gene138596#118#diseaseC0206186","pred":"associated_with","subj":"1851858-0#70#92#gene1385","obj":"1851858-0#96#118#diseaseC0206186"}],"attributes":[{"subj":"1851858-0#70#92#gene1385","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"1851858-0#96#118#diseaseC0206186","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":96,"end":118},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":510,"end":532},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":537,"end":541},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1155,"end":1177},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0000743"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0000743"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0012268"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0000743"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#e7ec93","default":true},{"id":"DisGeNET","color":"#d793ec"},{"id":"jnlpba-st-training","color":"#93ecbd"},{"id":"pubmed-sentences-benchmark","color":"#eca393"},{"id":"GENIAcorpus","color":"#939cec"},{"id":"DisGeNET5_gene_disease","color":"#b6ec93"},{"id":"PMID_GLOBAL","color":"#ec93d1"}]}]}}