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PubMed:18509110 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes Temperature-dependent cooperativity in donor-acceptor substrate binding to the human blood group glycosyltransferases.
TextSentencer_T2 119-526 Sentence denotes Affinities of the human blood group glycosyltransferases, alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) for their common acceptor substrate alpha-l-Fucp-(1-->2)-beta-d-Galp-O(CH2)(7)CH3 (1), in the absence and presence of bound uridine 5'-diphosphate (UDP) and Mn2+ were determined using temperature-controlled electrospray ionization mass spectrometry.
TextSentencer_T3 527-687 Sentence denotes The presence of bound UDP and Mn(2+) in the donor binding site has a marked influence on the thermodynamic parameters for the association of 1 with GTA and GTB.
TextSentencer_T4 688-779 Sentence denotes Both the enthalpy and entropy of association (DeltaH(a), DeltaS(a)) decrease significantly.
TextSentencer_T5 780-874 Sentence denotes However, the free energy of association (DeltaG(a)) is unchanged at physiological temperature.
TextSentencer_T6 875-1095 Sentence denotes The differences in the DeltaH(a) and DeltaS(a) values determined in the presence and absence of bound UDP are attributed to structural changes in the glycosyltransferases induced by the simultaneous binding of 1 and UDP.
T1 0-118 Sentence denotes Temperature-dependent cooperativity in donor-acceptor substrate binding to the human blood group glycosyltransferases.
T2 119-526 Sentence denotes Affinities of the human blood group glycosyltransferases, alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) for their common acceptor substrate alpha-l-Fucp-(1-->2)-beta-d-Galp-O(CH2)(7)CH3 (1), in the absence and presence of bound uridine 5'-diphosphate (UDP) and Mn2+ were determined using temperature-controlled electrospray ionization mass spectrometry.
T3 527-687 Sentence denotes The presence of bound UDP and Mn(2+) in the donor binding site has a marked influence on the thermodynamic parameters for the association of 1 with GTA and GTB.
T4 688-779 Sentence denotes Both the enthalpy and entropy of association (DeltaH(a), DeltaS(a)) decrease significantly.
T5 780-874 Sentence denotes However, the free energy of association (DeltaG(a)) is unchanged at physiological temperature.
T6 875-1095 Sentence denotes The differences in the DeltaH(a) and DeltaS(a) values determined in the presence and absence of bound UDP are attributed to structural changes in the glycosyltransferases induced by the simultaneous binding of 1 and UDP.
T1 0-118 Sentence denotes Temperature-dependent cooperativity in donor-acceptor substrate binding to the human blood group glycosyltransferases.
T2 119-526 Sentence denotes Affinities of the human blood group glycosyltransferases, alpha-(1-->3)-N-acetylgalactosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) for their common acceptor substrate alpha-l-Fucp-(1-->2)-beta-d-Galp-O(CH2)(7)CH3 (1), in the absence and presence of bound uridine 5'-diphosphate (UDP) and Mn2+ were determined using temperature-controlled electrospray ionization mass spectrometry.
T3 527-687 Sentence denotes The presence of bound UDP and Mn(2+) in the donor binding site has a marked influence on the thermodynamic parameters for the association of 1 with GTA and GTB.
T4 688-779 Sentence denotes Both the enthalpy and entropy of association (DeltaH(a), DeltaS(a)) decrease significantly.
T5 780-874 Sentence denotes However, the free energy of association (DeltaG(a)) is unchanged at physiological temperature.
T6 875-1095 Sentence denotes The differences in the DeltaH(a) and DeltaS(a) values determined in the presence and absence of bound UDP are attributed to structural changes in the glycosyltransferases induced by the simultaneous binding of 1 and UDP.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 85-90 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 85-90 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 143-148 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 143-148 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

uniprot-human

Id Subject Object Predicate Lexical cue
T1 188-224 http://www.uniprot.org/uniprot/Q70JA7 denotes 3)-N-acetylgalactosaminyltransferase
T2 188-224 http://www.uniprot.org/uniprot/Q14435 denotes 3)-N-acetylgalactosaminyltransferase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 188-224 http://www.uniprot.org/uniprot/Q5DTK1 denotes 3)-N-acetylgalactosaminyltransferase
T2 249-270 http://www.uniprot.org/uniprot/P23336 denotes galactosyltransferase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 91-96 http://purl.bioontology.org/ontology/STY/T096 denotes group
T2 149-154 http://purl.bioontology.org/ontology/STY/T096 denotes group
T3 334-338 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T4 334-338 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta

GO-MF

Id Subject Object Predicate Lexical cue
T1 64-71 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 577-584 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1074-1081 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 64-71 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 577-584 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1074-1081 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 64-71 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T8 577-584 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1074-1081 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 64-71 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 577-584 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1074-1081 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 85-90 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2 143-148 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 85-90 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T2 85-90 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 143-148 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 143-148 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 85-96 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group
T2 143-154 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 85-90 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 143-148 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 85-90 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 143-148 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 79-84 OrganismTaxon denotes human 9606
T2 137-142 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 85-90 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 143-148 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178