PubMed:18490429 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18490429","sourcedb":"PubMed","sourceid":"18490429","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/18490429","text":"POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo.\nO-Mannosylation represents an evolutionarily conserved, essential protein modification. In mammals the protein O-mannosyltransferases POMT1 and POMT2 act as a heteromeric complex to initiate O-mannosylation in the endoplasmic reticulum. Mutations in human POMT1 and POMT2 cause a group of congenital muscular dystrophies due to reduced O-glycosylation of alpha-dystroglycan. The most severe of these autosomal recessive conditions is Walker-Warburg syndrome (WWS) with severe brain and ocular involvement. We previously showed in the murine model that Pomt1 is expressed in WWS-related tissues both during embryogenesis and in adults. Whereas there is only a single Pomt1 transcript in adult mice, we demonstrated that there are two Pomt2 transcripts, somatic sPomt2 and testis-specific tPomt2. In this study we demonstrate that sPomt2, but not tPomt2, is prominently expressed in mouse embryos in the tissues that are most severely affected in WWS (developing muscle, eye, and brain). Correlation of POMT transcripts and protein isoforms with POMT mannosyltransferase enzyme activity demonstrates that sPOMT2-POMT1 complexes catalyze mannosyltransfer in adult somatic tissues and testis. It is suggested that the gonadal defects described in some WWS cases are associated with defects in O-mannosylation. Our data further show that whereas sPOMT2 is widely expressed, tPOMT2 is restricted to the acrosome of male germ cells and is not involved in the biosynthesis of O-mannosyl glycans in vivo. We prove that tPOMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from sPOMT2.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":149,"end":236},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":237,"end":385},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":386,"end":523},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":524,"end":654},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":655,"end":783},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":784,"end":943},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":944,"end":1134},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1135,"end":1337},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1338,"end":1454},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1455,"end":1644},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1645,"end":1778},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"T2","span":{"begin":149,"end":236},"obj":"Sentence"},{"id":"T3","span":{"begin":237,"end":385},"obj":"Sentence"},{"id":"T4","span":{"begin":386,"end":523},"obj":"Sentence"},{"id":"T5","span":{"begin":524,"end":654},"obj":"Sentence"},{"id":"T6","span":{"begin":655,"end":783},"obj":"Sentence"},{"id":"T7","span":{"begin":784,"end":943},"obj":"Sentence"},{"id":"T8","span":{"begin":944,"end":1134},"obj":"Sentence"},{"id":"T9","span":{"begin":1135,"end":1337},"obj":"Sentence"},{"id":"T10","span":{"begin":1338,"end":1454},"obj":"Sentence"},{"id":"T11","span":{"begin":1455,"end":1644},"obj":"Sentence"},{"id":"T12","span":{"begin":1645,"end":1778},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":148},"obj":"Sentence"},{"id":"T2","span":{"begin":149,"end":236},"obj":"Sentence"},{"id":"T3","span":{"begin":237,"end":385},"obj":"Sentence"},{"id":"T4","span":{"begin":386,"end":523},"obj":"Sentence"},{"id":"T5","span":{"begin":524,"end":654},"obj":"Sentence"},{"id":"T6","span":{"begin":655,"end":783},"obj":"Sentence"},{"id":"T7","span":{"begin":784,"end":943},"obj":"Sentence"},{"id":"T8","span":{"begin":944,"end":1134},"obj":"Sentence"},{"id":"T9","span":{"begin":1135,"end":1337},"obj":"Sentence"},{"id":"T10","span":{"begin":1338,"end":1454},"obj":"Sentence"},{"id":"T11","span":{"begin":1455,"end":1644},"obj":"Sentence"},{"id":"T12","span":{"begin":1645,"end":1778},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T2","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T3","span":{"begin":920,"end":926},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T4","span":{"begin":1036,"end":1043},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"T5","span":{"begin":1110,"end":1116},"obj":"http://purl.obolibrary.org/obo/MAT_0000025"},{"id":"T6","span":{"begin":1118,"end":1121},"obj":"http://purl.obolibrary.org/obo/MAT_0000140"},{"id":"T7","span":{"begin":1127,"end":1132},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T8","span":{"begin":1330,"end":1336},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T9","span":{"begin":1558,"end":1562},"obj":"http://purl.obolibrary.org/obo/MAT_0000029"},{"id":"T10","span":{"begin":1563,"end":1573},"obj":"http://purl.obolibrary.org/obo/MAT_0000334"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T3","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T4","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T5","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T6","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T7","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T8","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T9","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T10","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":0,"end":5},"obj":"gene:29954"},{"id":"T1","span":{"begin":23,"end":46},"obj":"disease:C0265221"},{"id":"T2","span":{"begin":504,"end":522},"obj":"gene:1605"},{"id":"T3","span":{"begin":449,"end":469},"obj":"disease:C0026850"},{"id":"T4","span":{"begin":415,"end":420},"obj":"gene:29954"},{"id":"T5","span":{"begin":449,"end":469},"obj":"disease:C0026850"},{"id":"T6","span":{"begin":405,"end":410},"obj":"gene:10585"},{"id":"T7","span":{"begin":449,"end":469},"obj":"disease:C0026850"},{"id":"T8","span":{"begin":701,"end":706},"obj":"gene:10585"},{"id":"T9","span":{"begin":723,"end":726},"obj":"disease:C0265221"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"}]},{"project":"GlycoBiology-GDGDB","denotations":[{"id":"_T1","span":{"begin":0,"end":5},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T2","span":{"begin":283,"end":288},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T3","span":{"begin":293,"end":298},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T4","span":{"begin":405,"end":410},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T5","span":{"begin":415,"end":420},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T6","span":{"begin":701,"end":706},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T7","span":{"begin":815,"end":820},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T8","span":{"begin":882,"end":887},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T9","span":{"begin":1259,"end":1264},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00376"},{"id":"_T10","span":{"begin":438,"end":469},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00381"},{"id":"_T11","span":{"begin":438,"end":469},"obj":"http://acgg.asia/db/diseases/gdgdb?con_ui=CON00383"}],"attributes":[{"subj":"_T1","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T2","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T3","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T4","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T5","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T6","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T7","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T8","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T9","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T10","pred":"source","obj":"GlycoBiology-GDGDB"},{"subj":"_T11","pred":"source","obj":"GlycoBiology-GDGDB"}]},{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":449,"end":469},"obj":"http://purl.bioontology.org/ontology/ICD10/G71.0"}],"attributes":[{"subj":"T1","pred":"source","obj":"ICD10"}]},{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"http://www.uniprot.org/uniprot/Q9UKY4"},{"id":"T2","span":{"begin":293,"end":298},"obj":"http://www.uniprot.org/uniprot/Q9UKY4"},{"id":"T3","span":{"begin":415,"end":420},"obj":"http://www.uniprot.org/uniprot/Q9UKY4"},{"id":"T4","span":{"begin":283,"end":288},"obj":"http://www.uniprot.org/uniprot/Q9NX32"},{"id":"T5","span":{"begin":405,"end":410},"obj":"http://www.uniprot.org/uniprot/Q9NX32"},{"id":"T6","span":{"begin":1259,"end":1264},"obj":"http://www.uniprot.org/uniprot/Q9NX32"},{"id":"T7","span":{"begin":510,"end":522},"obj":"http://www.uniprot.org/uniprot/Q14118"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-human"},{"subj":"T2","pred":"source","obj":"uniprot-human"},{"subj":"T3","pred":"source","obj":"uniprot-human"},{"subj":"T4","pred":"source","obj":"uniprot-human"},{"subj":"T5","pred":"source","obj":"uniprot-human"},{"subj":"T6","pred":"source","obj":"uniprot-human"},{"subj":"T7","pred":"source","obj":"uniprot-human"}]},{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":510,"end":522},"obj":"http://www.uniprot.org/uniprot/Q62165"},{"id":"T2","span":{"begin":701,"end":706},"obj":"http://www.uniprot.org/uniprot/Q8R2R1"},{"id":"T3","span":{"begin":815,"end":820},"obj":"http://www.uniprot.org/uniprot/Q8R2R1"},{"id":"T4","span":{"begin":882,"end":887},"obj":"http://www.uniprot.org/uniprot/Q8BGQ4"}],"attributes":[{"subj":"T1","pred":"source","obj":"uniprot-mouse"},{"subj":"T2","pred":"source","obj":"uniprot-mouse"},{"subj":"T3","pred":"source","obj":"uniprot-mouse"},{"subj":"T4","pred":"source","obj":"uniprot-mouse"}]},{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":240,"end":247},"obj":"http://purl.bioontology.org/ontology/STY/T015"},{"id":"T2","span":{"begin":308,"end":319},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/133265"},{"id":"T3","span":{"begin":429,"end":434},"obj":"http://purl.bioontology.org/ontology/STY/T096"},{"id":"T4","span":{"begin":549,"end":558},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/150701"},{"id":"T5","span":{"begin":727,"end":734},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/353209"},{"id":"T6","span":{"begin":735,"end":742},"obj":"http://purl.bioontology.org/ontology/STY/T024"},{"id":"T7","span":{"begin":1051,"end":1058},"obj":"http://purl.bioontology.org/ontology/STY/T024"},{"id":"T8","span":{"begin":1318,"end":1325},"obj":"http://purl.bioontology.org/ontology/STY/T024"},{"id":"T9","span":{"begin":1568,"end":1573},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T10","span":{"begin":1692,"end":1699},"obj":"http://purl.bioontology.org/ontology/STY/T015"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T2","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T3","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T4","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T5","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T6","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T7","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T8","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T9","pred":"source","obj":"GlycoBiology-NCBITAXON"},{"subj":"T10","pred":"source","obj":"GlycoBiology-NCBITAXON"}]},{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":111,"end":139},"obj":"http://purl.obolibrary.org/obo/GO_0000030"},{"id":"T2","span":{"begin":151,"end":164},"obj":"http://purl.obolibrary.org/obo/GO_0097502"},{"id":"T3","span":{"begin":342,"end":355},"obj":"http://purl.obolibrary.org/obo/GO_0097502"},{"id":"T4","span":{"begin":1440,"end":1453},"obj":"http://purl.obolibrary.org/obo/GO_0097502"},{"id":"T5","span":{"begin":1619,"end":1627},"obj":"http://purl.obolibrary.org/obo/GO_0097502"},{"id":"T6","span":{"begin":215,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0036211"},{"id":"T7","span":{"begin":252,"end":282},"obj":"http://purl.obolibrary.org/obo/GO_0004169"},{"id":"T8","span":{"begin":487,"end":500},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T9","span":{"begin":755,"end":768},"obj":"http://purl.obolibrary.org/obo/GO_0009790"},{"id":"T10","span":{"begin":755,"end":768},"obj":"http://purl.obolibrary.org/obo/GO_0009792"},{"id":"T11","span":{"begin":755,"end":768},"obj":"http://purl.obolibrary.org/obo/GO_0009793"},{"id":"T12","span":{"begin":821,"end":831},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T13","span":{"begin":888,"end":899},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T14","span":{"begin":1155,"end":1166},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T15","span":{"begin":1099,"end":1109},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T16","span":{"begin":1218,"end":1233},"obj":"http://purl.obolibrary.org/obo/GO_0003824"},{"id":"T17","span":{"begin":1601,"end":1613},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-BP"},{"subj":"T2","pred":"source","obj":"GO-BP"},{"subj":"T3","pred":"source","obj":"GO-BP"},{"subj":"T4","pred":"source","obj":"GO-BP"},{"subj":"T5","pred":"source","obj":"GO-BP"},{"subj":"T6","pred":"source","obj":"GO-BP"},{"subj":"T7","pred":"source","obj":"GO-BP"},{"subj":"T8","pred":"source","obj":"GO-BP"},{"subj":"T9","pred":"source","obj":"GO-BP"},{"subj":"T10","pred":"source","obj":"GO-BP"},{"subj":"T11","pred":"source","obj":"GO-BP"},{"subj":"T12","pred":"source","obj":"GO-BP"},{"subj":"T13","pred":"source","obj":"GO-BP"},{"subj":"T14","pred":"source","obj":"GO-BP"},{"subj":"T15","pred":"source","obj":"GO-BP"},{"subj":"T16","pred":"source","obj":"GO-BP"},{"subj":"T17","pred":"source","obj":"GO-BP"}]},{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":363,"end":384},"obj":"http://purl.obolibrary.org/obo/GO_0005783"},{"id":"T2","span":{"begin":549,"end":558},"obj":"http://purl.obolibrary.org/obo/GO_0030849"},{"id":"T3","span":{"begin":1546,"end":1554},"obj":"http://purl.obolibrary.org/obo/GO_0001669"},{"id":"T4","span":{"begin":1568,"end":1573},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T1","pred":"source","obj":"GO-CC"},{"subj":"T2","pred":"source","obj":"GO-CC"},{"subj":"T3","pred":"source","obj":"GO-CC"},{"subj":"T4","pred":"source","obj":"GO-CC"}]},{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T2","span":{"begin":920,"end":926},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T3","span":{"begin":1330,"end":1336},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T4","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T5","span":{"begin":1127,"end":1132},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T6","span":{"begin":735,"end":742},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T7","span":{"begin":1051,"end":1058},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T8","span":{"begin":1318,"end":1325},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"T9","span":{"begin":1036,"end":1043},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"},{"id":"T10","span":{"begin":1118,"end":1121},"obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"T11","span":{"begin":1363,"end":1370},"obj":"http://purl.obolibrary.org/obo/UBERON_0000991"}],"attributes":[{"subj":"T1","pred":"source","obj":"UBERON-AE"},{"subj":"T2","pred":"source","obj":"UBERON-AE"},{"subj":"T3","pred":"source","obj":"UBERON-AE"},{"subj":"T4","pred":"source","obj":"UBERON-AE"},{"subj":"T5","pred":"source","obj":"UBERON-AE"},{"subj":"T6","pred":"source","obj":"UBERON-AE"},{"subj":"T7","pred":"source","obj":"UBERON-AE"},{"subj":"T8","pred":"source","obj":"UBERON-AE"},{"subj":"T9","pred":"source","obj":"UBERON-AE"},{"subj":"T10","pred":"source","obj":"UBERON-AE"},{"subj":"T11","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"18490429-0#0#5#gene29954","span":{"begin":0,"end":5},"obj":"gene29954"},{"id":"18490429-0#23#46#diseaseC0265221","span":{"begin":23,"end":46},"obj":"diseaseC0265221"},{"id":"18490429-3#29#34#gene29954","span":{"begin":415,"end":420},"obj":"gene29954"},{"id":"18490429-3#118#136#gene1605","span":{"begin":504,"end":522},"obj":"gene1605"},{"id":"18490429-3#63#83#diseaseC0026850","span":{"begin":449,"end":469},"obj":"diseaseC0026850"},{"id":"18490429-5#46#51#gene10585","span":{"begin":701,"end":706},"obj":"gene10585"},{"id":"18490429-5#68#71#diseaseC0265221","span":{"begin":723,"end":726},"obj":"diseaseC0265221"}],"relations":[{"id":"0#5#gene2995423#46#diseaseC0265221","pred":"associated_with","subj":"18490429-0#0#5#gene29954","obj":"18490429-0#23#46#diseaseC0265221"},{"id":"29#34#gene2995463#83#diseaseC0026850","pred":"associated_with","subj":"18490429-3#29#34#gene29954","obj":"18490429-3#63#83#diseaseC0026850"},{"id":"118#136#gene160563#83#diseaseC0026850","pred":"associated_with","subj":"18490429-3#118#136#gene1605","obj":"18490429-3#63#83#diseaseC0026850"},{"id":"46#51#gene1058568#71#diseaseC0265221","pred":"associated_with","subj":"18490429-5#46#51#gene10585","obj":"18490429-5#68#71#diseaseC0265221"}],"attributes":[{"subj":"18490429-0#0#5#gene29954","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-0#23#46#diseaseC0265221","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-3#29#34#gene29954","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-3#118#136#gene1605","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-3#63#83#diseaseC0026850","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-5#46#51#gene10585","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18490429-5#68#71#diseaseC0265221","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"GlycoBiology-MAT","denotations":[{"id":"T1","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T2","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T3","span":{"begin":920,"end":926},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T4","span":{"begin":1036,"end":1043},"obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"T5","span":{"begin":1110,"end":1116},"obj":"http://purl.obolibrary.org/obo/MAT_0000025"},{"id":"T6","span":{"begin":1118,"end":1121},"obj":"http://purl.obolibrary.org/obo/MAT_0000140"},{"id":"T7","span":{"begin":1127,"end":1132},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T8","span":{"begin":1330,"end":1336},"obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"T9","span":{"begin":1558,"end":1562},"obj":"http://purl.obolibrary.org/obo/MAT_0000029"},{"id":"T10","span":{"begin":1563,"end":1573},"obj":"http://purl.obolibrary.org/obo/MAT_0000334"}],"attributes":[{"subj":"T1","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T2","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T3","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T4","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T5","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T6","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T7","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T8","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T9","pred":"source","obj":"GlycoBiology-MAT"},{"subj":"T10","pred":"source","obj":"GlycoBiology-MAT"}]},{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":1127,"end":1132},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":735,"end":742},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1051,"end":1058},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1318,"end":1325},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":920,"end":926},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":1330,"end":1336},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":1036,"end":1043},"obj":"http://purl.obolibrary.org/obo/UBERON_0000922"},{"id":"PD-UBERON-AE-B_T10","span":{"begin":1118,"end":1121},"obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"PD-UBERON-AE-B_T11","span":{"begin":1363,"end":1370},"obj":"http://purl.obolibrary.org/obo/UBERON_0000991"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T8","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T9","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T10","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T11","pred":"source","obj":"performance-test"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":72,"end":78},"obj":"Body_part"},{"id":"T2","span":{"begin":625,"end":630},"obj":"Body_part"},{"id":"T3","span":{"begin":920,"end":926},"obj":"Body_part"},{"id":"T4","span":{"begin":1036,"end":1043},"obj":"Body_part"},{"id":"T5","span":{"begin":1110,"end":1116},"obj":"Body_part"},{"id":"T6","span":{"begin":1118,"end":1121},"obj":"Body_part"},{"id":"T7","span":{"begin":1127,"end":1132},"obj":"Body_part"},{"id":"T8","span":{"begin":1330,"end":1336},"obj":"Body_part"},{"id":"T9","span":{"begin":1558,"end":1562},"obj":"Body_part"},{"id":"T10","span":{"begin":1563,"end":1573},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000226"},{"id":"A5","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000025"},{"id":"A6","pred":"mat_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MAT_0000140"},{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000132"},{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000029"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000334"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"},{"subj":"T3","pred":"source","obj":"Anatomy-MAT"},{"subj":"T4","pred":"source","obj":"Anatomy-MAT"},{"subj":"T5","pred":"source","obj":"Anatomy-MAT"},{"subj":"T6","pred":"source","obj":"Anatomy-MAT"},{"subj":"T7","pred":"source","obj":"Anatomy-MAT"},{"subj":"T8","pred":"source","obj":"Anatomy-MAT"},{"subj":"T9","pred":"source","obj":"Anatomy-MAT"},{"subj":"T10","pred":"source","obj":"Anatomy-MAT"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":438,"end":469},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0003560"},{"subj":"T1","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":23,"end":46},"obj":"Disease"},{"id":"T2","span":{"begin":438,"end":469},"obj":"Disease"},{"id":"T3","span":{"begin":583,"end":606},"obj":"Disease"},{"id":"T4","span":{"begin":608,"end":611},"obj":"Disease"},{"id":"T5","span":{"begin":723,"end":726},"obj":"Disease"},{"id":"T6","span":{"begin":1094,"end":1097},"obj":"Disease"},{"id":"T7","span":{"begin":1397,"end":1400},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0019950"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0019523"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"},{"subj":"T6","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":399,"end":404},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":841,"end":845},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1030,"end":1035},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"10088"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"id":"A4","pred":"db_id","subj":"T3","obj":"10090"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":72,"end":78},"obj":"Body_part"},{"id":"T2","span":{"begin":375,"end":384},"obj":"Body_part"},{"id":"T3","span":{"begin":625,"end":630},"obj":"Body_part"},{"id":"T5","span":{"begin":920,"end":926},"obj":"Body_part"},{"id":"T6","span":{"begin":1110,"end":1116},"obj":"Body_part"},{"id":"T8","span":{"begin":1118,"end":1121},"obj":"Body_part"},{"id":"T11","span":{"begin":1127,"end":1132},"obj":"Body_part"},{"id":"T13","span":{"begin":1330,"end":1336},"obj":"Body_part"},{"id":"T14","span":{"begin":1546,"end":1554},"obj":"Body_part"},{"id":"T15","span":{"begin":1558,"end":1573},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0007361"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A4","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"A7","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000019"},{"id":"A9","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"A10","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0010230"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A12","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/GO_0001669"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL_0000015"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T8","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T11","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T13","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T14","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T15","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":1558,"end":1573},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000015"},{"subj":"T1","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ecbd93","default":true},{"id":"Glycosmos6-MAT","color":"#a393ec"},{"id":"DisGeNET","color":"#9dec93"},{"id":"GlycoBiology-GDGDB","color":"#ec93b7"},{"id":"ICD10","color":"#93d1ec"},{"id":"uniprot-human","color":"#ebec93"},{"id":"uniprot-mouse","color":"#d393ec"},{"id":"GlycoBiology-NCBITAXON","color":"#93ecb9"},{"id":"GO-BP","color":"#ec9f93"},{"id":"GO-CC","color":"#93a1ec"},{"id":"UBERON-AE","color":"#bbec93"},{"id":"DisGeNET5_gene_disease","color":"#ec93d5"},{"id":"GlycoBiology-MAT","color":"#93ece9"},{"id":"performance-test","color":"#eccf93"},{"id":"Anatomy-MAT","color":"#b593ec"},{"id":"HP-phenotype","color":"#93ec9b"},{"id":"mondo_disease","color":"#ec93a4"},{"id":"NCBITAXON","color":"#93beec"},{"id":"Anatomy-UBERON","color":"#d8ec93"},{"id":"CL-cell","color":"#e593ec"}]}]}}