PubMed:18443194 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18443194","sourcedb":"PubMed","sourceid":"18443194","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/18443194","text":"Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients.\nOBJECTIVE: To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes.\nRESEARCH DESIGN AND METHODS: We genotyped the +49G\u003eA and CT60G\u003eA variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). We also assessed serum levels of the soluble form of CTLA4 (sCTLA4).\nRESULTS: The +49GG and CT60GG genotypes were associated with type 1A diabetes (P \u003c 0.001). In contrast, the CT60AA genotype, but not the +49G\u003eA variation, was associated with fulminant type 1 diabetes (P \u003c 0.05), especially in patients carrying HLA-DR4 (P \u003c 0.01). Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P \u003c 0.05).\nCONCLUSIONS: These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes. Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":519,"end":524},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":836,"end":841},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":39,"end":44},"obj":"gene:1493"},{"id":"T1","span":{"begin":93,"end":101},"obj":"disease:C0011849"},{"id":"T2","span":{"begin":39,"end":44},"obj":"gene:1493"},{"id":"T3","span":{"begin":93,"end":101},"obj":"disease:C0011847"},{"id":"T4","span":{"begin":170,"end":175},"obj":"gene:1493"},{"id":"T5","span":{"begin":268,"end":276},"obj":"disease:C0011849"},{"id":"T6","span":{"begin":170,"end":175},"obj":"gene:1493"},{"id":"T7","span":{"begin":268,"end":276},"obj":"disease:C0011847"},{"id":"T8","span":{"begin":170,"end":175},"obj":"gene:1493"},{"id":"T9","span":{"begin":216,"end":231},"obj":"disease:C0011854"},{"id":"T10","span":{"begin":989,"end":993},"obj":"gene:348120"},{"id":"T11","span":{"begin":1042,"end":1057},"obj":"disease:C0011854"},{"id":"T12","span":{"begin":943,"end":988},"obj":"gene:1493"},{"id":"T13","span":{"begin":1042,"end":1057},"obj":"disease:C0011854"},{"id":"T14","span":{"begin":1092,"end":1097},"obj":"gene:1493"},{"id":"T15","span":{"begin":1190,"end":1198},"obj":"disease:C0011849"},{"id":"T16","span":{"begin":1092,"end":1097},"obj":"gene:1493"},{"id":"T17","span":{"begin":1190,"end":1198},"obj":"disease:C0011847"},{"id":"T18","span":{"begin":1092,"end":1097},"obj":"gene:1493"},{"id":"T19","span":{"begin":1154,"end":1169},"obj":"disease:C0011854"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T4","span":{"begin":278,"end":306},"obj":"Sentence"},{"id":"TextSentencer_T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":124,"end":134},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":135,"end":277},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":307,"end":501},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":502,"end":570},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":571,"end":579},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":580,"end":661},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":662,"end":835},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":836,"end":942},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":943,"end":955},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":956,"end":1058},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1059,"end":1199},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":134},"obj":"Sentence"},{"id":"T3","span":{"begin":135,"end":277},"obj":"Sentence"},{"id":"T4","span":{"begin":278,"end":306},"obj":"Sentence"},{"id":"T5","span":{"begin":307,"end":501},"obj":"Sentence"},{"id":"T6","span":{"begin":502,"end":570},"obj":"Sentence"},{"id":"T7","span":{"begin":571,"end":579},"obj":"Sentence"},{"id":"T8","span":{"begin":580,"end":661},"obj":"Sentence"},{"id":"T9","span":{"begin":662,"end":835},"obj":"Sentence"},{"id":"T10","span":{"begin":836,"end":942},"obj":"Sentence"},{"id":"T11","span":{"begin":943,"end":955},"obj":"Sentence"},{"id":"T12","span":{"begin":956,"end":1058},"obj":"Sentence"},{"id":"T13","span":{"begin":1059,"end":1199},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":519,"end":524},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T838","span":{"begin":39,"end":44},"obj":"gene:1493"},{"id":"T839","span":{"begin":93,"end":101},"obj":"disease:C0011847"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T838","obj":"T839"},{"id":"R2","pred":"associated_with","subj":"T838","obj":"T839"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T838","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T839","pred":"source","obj":"DisGeNet-2017-sample"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"18443194-0#39#44#gene1493","span":{"begin":39,"end":44},"obj":"gene1493"},{"id":"18443194-0#93#101#diseaseC0011847","span":{"begin":93,"end":101},"obj":"diseaseC0011847"},{"id":"18443194-0#93#101#diseaseC0011849","span":{"begin":93,"end":101},"obj":"diseaseC0011849"},{"id":"18443194-7#33#37#gene348120","span":{"begin":989,"end":993},"obj":"gene348120"},{"id":"18443194-7#86#101#diseaseC0011854","span":{"begin":1042,"end":1057},"obj":"diseaseC0011854"},{"id":"18443194-8#33#38#gene1493","span":{"begin":1092,"end":1097},"obj":"gene1493"},{"id":"18443194-8#95#110#diseaseC0011854","span":{"begin":1154,"end":1169},"obj":"diseaseC0011854"}],"relations":[{"id":"39#44#gene149393#101#diseaseC0011847","pred":"associated_with","subj":"18443194-0#39#44#gene1493","obj":"18443194-0#93#101#diseaseC0011847"},{"id":"39#44#gene149393#101#diseaseC0011849","pred":"associated_with","subj":"18443194-0#39#44#gene1493","obj":"18443194-0#93#101#diseaseC0011849"},{"id":"33#37#gene34812086#101#diseaseC0011854","pred":"associated_with","subj":"18443194-7#33#37#gene348120","obj":"18443194-7#86#101#diseaseC0011854"},{"id":"33#38#gene149395#110#diseaseC0011854","pred":"associated_with","subj":"18443194-8#33#38#gene1493","obj":"18443194-8#95#110#diseaseC0011854"}],"attributes":[{"subj":"18443194-0#39#44#gene1493","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-0#93#101#diseaseC0011847","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-0#93#101#diseaseC0011849","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-7#33#37#gene348120","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-7#86#101#diseaseC0011854","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-8#33#38#gene1493","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18443194-8#95#110#diseaseC0011854","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":93,"end":101},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":216,"end":231},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":268,"end":276},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":640,"end":648},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":756,"end":771},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":915,"end":930},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1042,"end":1057},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1154,"end":1169},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1190,"end":1198},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005015"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005147"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005015"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005015"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005147"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005147"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005147"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005147"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005015"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T8","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#93eca4","default":true},{"id":"DisGeNET","color":"#ec939b"},{"id":"sentences","color":"#93b5ec"},{"id":"UBERON-AE","color":"#d0ec93"},{"id":"DisGeNet-2017-sample","color":"#ec93ea"},{"id":"DisGeNET5_gene_disease","color":"#93ecd4"},{"id":"PMID_GLOBAL","color":"#ecba93"}]}]}}