PubMed:18443194
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 93-101 | DiseaseOrPhenotypicFeature | denotes | diabetes | 0005015 |
| T2 | 216-231 | DiseaseOrPhenotypicFeature | denotes | type 1 diabetes | 0005147 |
| T3 | 268-276 | DiseaseOrPhenotypicFeature | denotes | diabetes | 0005015 |
| T4 | 640-648 | DiseaseOrPhenotypicFeature | denotes | diabetes | 0005015 |
| T5 | 756-771 | DiseaseOrPhenotypicFeature | denotes | type 1 diabetes | 0005147 |
| T6 | 915-930 | DiseaseOrPhenotypicFeature | denotes | type 1 diabetes | 0005147 |
| T7 | 1042-1057 | DiseaseOrPhenotypicFeature | denotes | type 1 diabetes | 0005147 |
| T8 | 1154-1169 | DiseaseOrPhenotypicFeature | denotes | type 1 diabetes | 0005147 |
| T9 | 1190-1198 | DiseaseOrPhenotypicFeature | denotes | diabetes | 0005015 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T4 | 278-306 | Sentence | denotes | RESEARCH DESIGN AND METHODS: |
| TextSentencer_T1 | 0-123 | Sentence | denotes | Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. |
| TextSentencer_T2 | 124-134 | Sentence | denotes | OBJECTIVE: |
| TextSentencer_T3 | 135-277 | Sentence | denotes | To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes. |
| TextSentencer_T5 | 307-501 | Sentence | denotes | We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). |
| TextSentencer_T6 | 502-570 | Sentence | denotes | We also assessed serum levels of the soluble form of CTLA4 (sCTLA4). |
| TextSentencer_T7 | 571-579 | Sentence | denotes | RESULTS: |
| TextSentencer_T8 | 580-661 | Sentence | denotes | The +49GG and CT60GG genotypes were associated with type 1A diabetes (P < 0.001). |
| TextSentencer_T9 | 662-835 | Sentence | denotes | In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01). |
| TextSentencer_T10 | 836-942 | Sentence | denotes | Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P < 0.05). |
| TextSentencer_T11 | 943-955 | Sentence | denotes | CONCLUSIONS: |
| TextSentencer_T12 | 956-1058 | Sentence | denotes | These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes. |
| TextSentencer_T13 | 1059-1199 | Sentence | denotes | Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes. |
| T1 | 0-123 | Sentence | denotes | Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. |
| T2 | 124-134 | Sentence | denotes | OBJECTIVE: |
| T3 | 135-277 | Sentence | denotes | To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes. |
| T4 | 278-306 | Sentence | denotes | RESEARCH DESIGN AND METHODS: |
| T5 | 307-501 | Sentence | denotes | We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). |
| T6 | 502-570 | Sentence | denotes | We also assessed serum levels of the soluble form of CTLA4 (sCTLA4). |
| T7 | 571-579 | Sentence | denotes | RESULTS: |
| T8 | 580-661 | Sentence | denotes | The +49GG and CT60GG genotypes were associated with type 1A diabetes (P < 0.001). |
| T9 | 662-835 | Sentence | denotes | In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01). |
| T10 | 836-942 | Sentence | denotes | Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P < 0.05). |
| T11 | 943-955 | Sentence | denotes | CONCLUSIONS: |
| T12 | 956-1058 | Sentence | denotes | These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes. |
| T13 | 1059-1199 | Sentence | denotes | Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 39-44 | gene:1493 | denotes | CTLA4 |
| T1 | 93-101 | disease:C0011849 | denotes | diabetes |
| T2 | 39-44 | gene:1493 | denotes | CTLA4 |
| T3 | 93-101 | disease:C0011847 | denotes | diabetes |
| T4 | 170-175 | gene:1493 | denotes | CTLA4 |
| T5 | 268-276 | disease:C0011849 | denotes | diabetes |
| T6 | 170-175 | gene:1493 | denotes | CTLA4 |
| T7 | 268-276 | disease:C0011847 | denotes | diabetes |
| T8 | 170-175 | gene:1493 | denotes | CTLA4 |
| T9 | 216-231 | disease:C0011854 | denotes | type 1 diabetes |
| T10 | 989-993 | gene:348120 | denotes | CT60 |
| T11 | 1042-1057 | disease:C0011854 | denotes | type 1 diabetes |
| T12 | 943-988 | gene:1493 | denotes | CONCLUSIONS: These results suggest that CTLA4 |
| T13 | 1042-1057 | disease:C0011854 | denotes | type 1 diabetes |
| T14 | 1092-1097 | gene:1493 | denotes | CTLA4 |
| T15 | 1190-1198 | disease:C0011849 | denotes | diabetes |
| T16 | 1092-1097 | gene:1493 | denotes | CTLA4 |
| T17 | 1190-1198 | disease:C0011847 | denotes | diabetes |
| T18 | 1092-1097 | gene:1493 | denotes | CTLA4 |
| T19 | 1154-1169 | disease:C0011854 | denotes | type 1 diabetes |
| R1 | T0 | T1 | associated_with | CTLA4,diabetes |
| R2 | T2 | T3 | associated_with | CTLA4,diabetes |
| R3 | T4 | T5 | associated_with | CTLA4,diabetes |
| R4 | T6 | T7 | associated_with | CTLA4,diabetes |
| R5 | T8 | T9 | associated_with | CTLA4,type 1 diabetes |
| R6 | T10 | T11 | associated_with | CT60,type 1 diabetes |
| R7 | T12 | T13 | associated_with | CONCLUSIONS: These results suggest that CTLA4,type 1 diabetes |
| R8 | T14 | T15 | associated_with | CTLA4,diabetes |
| R9 | T16 | T17 | associated_with | CTLA4,diabetes |
| R10 | T18 | T19 | associated_with | CTLA4,type 1 diabetes |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 18443194-0#39#44#gene1493 | 39-44 | gene1493 | denotes | CTLA4 |
| 18443194-0#93#101#diseaseC0011847 | 93-101 | diseaseC0011847 | denotes | diabetes |
| 18443194-0#93#101#diseaseC0011849 | 93-101 | diseaseC0011849 | denotes | diabetes |
| 18443194-7#33#37#gene348120 | 989-993 | gene348120 | denotes | CT60 |
| 18443194-7#86#101#diseaseC0011854 | 1042-1057 | diseaseC0011854 | denotes | type 1 diabetes |
| 18443194-8#33#38#gene1493 | 1092-1097 | gene1493 | denotes | CTLA4 |
| 18443194-8#95#110#diseaseC0011854 | 1154-1169 | diseaseC0011854 | denotes | type 1 diabetes |
| 39#44#gene149393#101#diseaseC0011847 | 18443194-0#39#44#gene1493 | 18443194-0#93#101#diseaseC0011847 | associated_with | CTLA4,diabetes |
| 39#44#gene149393#101#diseaseC0011849 | 18443194-0#39#44#gene1493 | 18443194-0#93#101#diseaseC0011849 | associated_with | CTLA4,diabetes |
| 33#37#gene34812086#101#diseaseC0011854 | 18443194-7#33#37#gene348120 | 18443194-7#86#101#diseaseC0011854 | associated_with | CT60,type 1 diabetes |
| 33#38#gene149395#110#diseaseC0011854 | 18443194-8#33#38#gene1493 | 18443194-8#95#110#diseaseC0011854 | associated_with | CTLA4,type 1 diabetes |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T838 | 39-44 | gene:1493 | denotes | CTLA4 |
| T839 | 93-101 | disease:C0011847 | denotes | diabetes |
| R1 | T838 | T839 | associated_with | CTLA4,diabetes |
| R2 | T838 | T839 | associated_with | CTLA4,diabetes |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 519-524 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 519-524 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T2 | 836-841 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | Serum |