PubMed:18439317 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18439317","sourcedb":"PubMed","sourceid":"18439317","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/18439317","text":"Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese.\nBACKGROUND: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc. A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level. Hence it is a good candidate for genetic studies in DDD.\nMETHODS: Southern Chinese volunteers between 18 and 55 years were recruited from the population. DDD in the lumbar spine was defined by MRI using Schneiderman's classification. Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom platform. Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.\nRESULTS: Our results showed substantial evidence of association between -1607 promoter polymorphism of MMP1 and DDD in the Southern Chinese subjects. D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04-1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01-2.24). Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033-2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029-2.029). Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.\nCONCLUSION: We demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only. Further association was identified in individuals over 40 years of age. Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0044339"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0024534"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0024534"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0024534"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0024534"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0024534"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0024534"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T2","span":{"begin":101,"end":112},"obj":"Sentence"},{"id":"T3","span":{"begin":113,"end":233},"obj":"Sentence"},{"id":"T4","span":{"begin":234,"end":418},"obj":"Sentence"},{"id":"T5","span":{"begin":419,"end":475},"obj":"Sentence"},{"id":"T6","span":{"begin":476,"end":484},"obj":"Sentence"},{"id":"T7","span":{"begin":485,"end":572},"obj":"Sentence"},{"id":"T8","span":{"begin":573,"end":652},"obj":"Sentence"},{"id":"T9","span":{"begin":653,"end":755},"obj":"Sentence"},{"id":"T10","span":{"begin":756,"end":865},"obj":"Sentence"},{"id":"T11","span":{"begin":866,"end":874},"obj":"Sentence"},{"id":"T12","span":{"begin":875,"end":1015},"obj":"Sentence"},{"id":"T13","span":{"begin":1016,"end":1285},"obj":"Sentence"},{"id":"T14","span":{"begin":1286,"end":1550},"obj":"Sentence"},{"id":"T15","span":{"begin":1551,"end":1639},"obj":"Sentence"},{"id":"T18","span":{"begin":1858,"end":1929},"obj":"Sentence"},{"id":"T16","span":{"begin":1640,"end":1651},"obj":"Sentence"},{"id":"T17","span":{"begin":1652,"end":1857},"obj":"Sentence"},{"id":"T19","span":{"begin":1930,"end":2025},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"},{"subj":"T10","pred":"source","obj":"LitCoin-sentences"},{"subj":"T11","pred":"source","obj":"LitCoin-sentences"},{"subj":"T12","pred":"source","obj":"LitCoin-sentences"},{"subj":"T13","pred":"source","obj":"LitCoin-sentences"},{"subj":"T14","pred":"source","obj":"LitCoin-sentences"},{"subj":"T15","pred":"source","obj":"LitCoin-sentences"},{"subj":"T18","pred":"source","obj":"LitCoin-sentences"},{"subj":"T16","pred":"source","obj":"LitCoin-sentences"},{"subj":"T17","pred":"source","obj":"LitCoin-sentences"},{"subj":"T19","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"4949","span":{"begin":51,"end":55},"obj":"GeneOrGeneProduct"},{"id":"4950","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4951","span":{"begin":113,"end":138},"obj":"GeneOrGeneProduct"},{"id":"4952","span":{"begin":140,"end":144},"obj":"GeneOrGeneProduct"},{"id":"4953","span":{"begin":244,"end":309},"obj":"SequenceVariant"},{"id":"4954","span":{"begin":318,"end":322},"obj":"GeneOrGeneProduct"},{"id":"4955","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4956","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4957","span":{"begin":969,"end":973},"obj":"GeneOrGeneProduct"},{"id":"4958","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4959","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4960","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4961","span":{"begin":1706,"end":1728},"obj":"SequenceVariant"},{"id":"4962","span":{"begin":1754,"end":1758},"obj":"GeneOrGeneProduct"},{"id":"4963","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"db_id","subj":"4949","obj":"NCBIGene:4312"},{"id":"A2","pred":"db_id","subj":"4950","obj":"MESH:C535531"},{"id":"A3","pred":"db_id","subj":"4951","obj":"NCBIGene:4312"},{"id":"A4","pred":"db_id","subj":"4952","obj":"NCBIGene:4312"},{"id":"A5","pred":"db_id","subj":"4953","obj":"c|DEL|-1607|G"},{"id":"A6","pred":"db_id","subj":"4954","obj":"NCBIGene:4312"},{"id":"A7","pred":"db_id","subj":"4955","obj":"MESH:D055959"},{"id":"A8","pred":"db_id","subj":"4956","obj":"MESH:D055959"},{"id":"A9","pred":"db_id","subj":"4957","obj":"NCBIGene:4312"},{"id":"A10","pred":"db_id","subj":"4958","obj":"MESH:D055959"},{"id":"A11","pred":"db_id","subj":"4959","obj":"MESH:D055959"},{"id":"A12","pred":"db_id","subj":"4960","obj":"MESH:D055959"},{"id":"A13","pred":"db_id","subj":"4961","obj":"c|Allele|D|-1607"},{"id":"A14","pred":"db_id","subj":"4962","obj":"NCBIGene:4312"},{"id":"A15","pred":"db_id","subj":"4963","obj":"MESH:D055959"},{"subj":"4949","pred":"source","obj":"LitCoin-entities"},{"subj":"4950","pred":"source","obj":"LitCoin-entities"},{"subj":"4951","pred":"source","obj":"LitCoin-entities"},{"subj":"4952","pred":"source","obj":"LitCoin-entities"},{"subj":"4953","pred":"source","obj":"LitCoin-entities"},{"subj":"4954","pred":"source","obj":"LitCoin-entities"},{"subj":"4955","pred":"source","obj":"LitCoin-entities"},{"subj":"4956","pred":"source","obj":"LitCoin-entities"},{"subj":"4957","pred":"source","obj":"LitCoin-entities"},{"subj":"4958","pred":"source","obj":"LitCoin-entities"},{"subj":"4959","pred":"source","obj":"LitCoin-entities"},{"subj":"4960","pred":"source","obj":"LitCoin-entities"},{"subj":"4961","pred":"source","obj":"LitCoin-entities"},{"subj":"4962","pred":"source","obj":"LitCoin-entities"},{"subj":"4963","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":51,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":67,"end":71},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":113,"end":138},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":140,"end":144},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":185,"end":198},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":199,"end":205},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":228,"end":232},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":318,"end":322},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":398,"end":411},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":591,"end":596},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":829,"end":835},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":969,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1556,"end":1561},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1754,"end":1758},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1935,"end":1940},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":51,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":67,"end":71},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":113,"end":138},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":140,"end":144},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":185,"end":198},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":199,"end":205},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":228,"end":232},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":318,"end":322},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":371,"end":379},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":398,"end":411},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":476,"end":483},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":531,"end":536},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":591,"end":596},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":772,"end":777},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":829,"end":835},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":836,"end":840},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":860,"end":864},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":969,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1067,"end":1072},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1227,"end":1232},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1397,"end":1402},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1417,"end":1422},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1489,"end":1494},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1551,"end":1555},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1556,"end":1561},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1595,"end":1600},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1754,"end":1758},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1773,"end":1778},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1916,"end":1921},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1930,"end":1934},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1935,"end":1940},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1976,"end":1981},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"C535531"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":51,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":113,"end":138},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":140,"end":144},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":318,"end":322},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":969,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":1754,"end":1758},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0044339"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0024534"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0024534"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0024534"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0024534"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0024534"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0024534"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"C535531"},{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"},{"id":"A5","pred":"ID:","subj":"T5","obj":"DISEASE"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"DISEASE"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"C535531"},{"id":"A2","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"DISEASE"},{"id":"A5","pred":"#label","subj":"T5","obj":"DISEASE"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"#label","subj":"T7","obj":"DISEASE"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":113,"end":138},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":140,"end":144},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":244,"end":251},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":471,"end":474},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":573,"end":576},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":978,"end":981},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1060,"end":1063},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1220,"end":1223},"obj":"ChemicalEntity"},{"id":"T15","span":{"begin":1807,"end":1810},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D020782"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D020782"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D006147"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_16235"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D003632"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D003632"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D003632"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D003632"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D003632"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D003632"},{"id":"A16","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T15","span":{"begin":1807,"end":1810},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1220,"end":1223},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1060,"end":1063},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":978,"end":981},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":573,"end":576},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":471,"end":474},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":244,"end":251},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":140,"end":144},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":113,"end":138},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":1754,"end":1758},"obj":"GeneOrGeneProduct"},{"id":"T12651","span":{"begin":969,"end":973},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":318,"end":322},"obj":"GeneOrGeneProduct"},{"id":"T7642","span":{"begin":140,"end":144},"obj":"GeneOrGeneProduct"},{"id":"T25474","span":{"begin":113,"end":138},"obj":"GeneOrGeneProduct"},{"id":"T54771","span":{"begin":51,"end":55},"obj":"GeneOrGeneProduct"},{"id":"T27172","span":{"begin":1807,"end":1810},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T96325","span":{"begin":1220,"end":1223},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22317","span":{"begin":1060,"end":1063},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T33109","span":{"begin":978,"end":981},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T73128","span":{"begin":573,"end":576},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22405","span":{"begin":471,"end":474},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T99508","span":{"begin":60,"end":79},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A16","pred":"ID:","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D003632"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D003632"},{"id":"A12","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A11","pred":"ID:","subj":"T11","obj":"D003632"},{"id":"A10","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D003632"},{"id":"A8","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D003632"},{"id":"A6","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_27841"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D003632"},{"id":"A4","pred":"ID:","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_16235"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D006147"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D020782"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D020782"},{"id":"A30957","pred":"#label","subj":"T27172","obj":"DISEASE"},{"id":"A34734","pred":"#label","subj":"T96325","obj":"DISEASE"},{"id":"A33474","pred":"#label","subj":"T22317","obj":"DISEASE"},{"id":"A81154","pred":"#label","subj":"T33109","obj":"DISEASE"},{"id":"A30195","pred":"#label","subj":"T73128","obj":"DISEASE"},{"id":"A44618","pred":"#label","subj":"T22405","obj":"DISEASE"},{"id":"A22757","pred":"#label","subj":"T99508","obj":"C535531"},{"subj":"T15","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12651","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7642","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T25474","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T54771","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T27172","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T96325","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T22317","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T33109","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T73128","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T22405","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T99508","pred":"source","obj":"LitCoin-training-merged"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":51,"end":55},"obj":"gene:4312"},{"id":"T1","span":{"begin":60,"end":79},"obj":"disease:C0221775"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"}]},{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":272,"end":275},"obj":"DNAMutation:|DEL||G"}],"attributes":[{"subj":"T1","pred":"source","obj":"tmVarCorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PMID_GLOBAL","color":"#eca293","default":true},{"id":"LitCoin-sentences","color":"#939eec"},{"id":"LitCoin-entities","color":"#b8ec93"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#ec93d2"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#93ecec"},{"id":"LitCoin-Disease-MeSH","color":"#ecd293"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#b893ec"},{"id":"LitCoin_Mondo_095","color":"#93ec9e"},{"id":"LitCoin-MeSH-Disease-2","color":"#ec93a2"},{"id":"LitCoin-MONDO_bioort2019","color":"#93bcec"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#d6ec93"},{"id":"LitCoin-training-merged","color":"#e893ec"},{"id":"DisGeNET","color":"#93ecce"},{"id":"tmVarCorpus","color":"#ecb493"}]}]}}