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PubMed:18439317 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease 0044339
T2 471-474 DiseaseOrPhenotypicFeature denotes DDD 0024534
T3 573-576 DiseaseOrPhenotypicFeature denotes DDD 0024534
T4 978-981 DiseaseOrPhenotypicFeature denotes DDD 0024534
T5 1060-1063 DiseaseOrPhenotypicFeature denotes DDD 0024534
T6 1220-1223 DiseaseOrPhenotypicFeature denotes DDD 0024534
T7 1807-1810 DiseaseOrPhenotypicFeature denotes DDD 0024534

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese.
T2 101-112 Sentence denotes BACKGROUND:
T3 113-233 Sentence denotes Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc.
T4 234-418 Sentence denotes A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level.
T5 419-475 Sentence denotes Hence it is a good candidate for genetic studies in DDD.
T6 476-484 Sentence denotes METHODS:
T7 485-572 Sentence denotes Southern Chinese volunteers between 18 and 55 years were recruited from the population.
T8 573-652 Sentence denotes DDD in the lumbar spine was defined by MRI using Schneiderman's classification.
T9 653-755 Sentence denotes Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom platform.
T10 756-865 Sentence denotes Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.
T11 866-874 Sentence denotes RESULTS:
T12 875-1015 Sentence denotes Our results showed substantial evidence of association between -1607 promoter polymorphism of MMP1 and DDD in the Southern Chinese subjects.
T13 1016-1285 Sentence denotes D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04-1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01-2.24).
T14 1286-1550 Sentence denotes Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033-2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029-2.029).
T15 1551-1639 Sentence denotes Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.
T18 1858-1929 Sentence denotes Further association was identified in individuals over 40 years of age.
T16 1640-1651 Sentence denotes CONCLUSION:
T17 1652-1857 Sentence denotes We demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only.
T19 1930-2025 Sentence denotes Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
4949 51-55 GeneOrGeneProduct denotes MMP1 NCBIGene:4312
4950 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease MESH:C535531
4951 113-138 GeneOrGeneProduct denotes Matrix metalloproteinases NCBIGene:4312
4952 140-144 GeneOrGeneProduct denotes MMPs NCBIGene:4312
4953 244-309 SequenceVariant denotes guanine insertion/deletion (G/D), the -1607 promoter polymorphism c|DEL|-1607|G
4954 318-322 GeneOrGeneProduct denotes MMP1 NCBIGene:4312
4955 471-474 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959
4956 573-576 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959
4957 969-973 GeneOrGeneProduct denotes MMP1 NCBIGene:4312
4958 978-981 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959
4959 1060-1063 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959
4960 1220-1223 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959
4961 1706-1728 SequenceVariant denotes D allele for the -1607 c|Allele|D|-1607
4962 1754-1758 GeneOrGeneProduct denotes MMP1 NCBIGene:4312
4963 1807-1810 DiseaseOrPhenotypicFeature denotes DDD MESH:D055959

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 51-55 GeneOrGeneProduct denotes MMP1
T2 67-71 GeneOrGeneProduct denotes disc
T3 113-138 GeneOrGeneProduct denotes Matrix metalloproteinases
T4 140-144 GeneOrGeneProduct denotes MMPs
T5 185-198 GeneOrGeneProduct denotes extracellular
T6 199-205 GeneOrGeneProduct denotes matrix
T7 228-232 GeneOrGeneProduct denotes disc
T8 318-322 GeneOrGeneProduct denotes MMP1
T9 398-411 GeneOrGeneProduct denotes transcription
T10 591-596 GeneOrGeneProduct denotes spine
T11 829-835 GeneOrGeneProduct denotes square
T12 969-973 GeneOrGeneProduct denotes MMP1
T13 1556-1561 GeneOrGeneProduct denotes bulge
T14 1754-1758 GeneOrGeneProduct denotes MMP1
T15 1935-1940 GeneOrGeneProduct denotes bulge

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 51-55 GeneOrGeneProduct denotes MMP1
T2 67-71 GeneOrGeneProduct denotes disc
T3 113-138 GeneOrGeneProduct denotes Matrix metalloproteinases
T4 140-144 GeneOrGeneProduct denotes MMPs
T5 185-198 GeneOrGeneProduct denotes extracellular
T6 199-205 GeneOrGeneProduct denotes matrix
T7 228-232 GeneOrGeneProduct denotes disc
T8 318-322 GeneOrGeneProduct denotes MMP1
T9 371-379 GeneOrGeneProduct denotes activity
T10 398-411 GeneOrGeneProduct denotes transcription
T11 476-483 GeneOrGeneProduct denotes METHODS
T12 531-536 GeneOrGeneProduct denotes years
T13 591-596 GeneOrGeneProduct denotes spine
T14 772-777 GeneOrGeneProduct denotes Hardy
T15 829-835 GeneOrGeneProduct denotes square
T16 836-840 GeneOrGeneProduct denotes test
T17 860-864 GeneOrGeneProduct denotes test
T18 969-973 GeneOrGeneProduct denotes MMP1
T19 1067-1072 GeneOrGeneProduct denotes value
T20 1227-1232 GeneOrGeneProduct denotes value
T21 1397-1402 GeneOrGeneProduct denotes years
T22 1417-1422 GeneOrGeneProduct denotes value
T23 1489-1494 GeneOrGeneProduct denotes value
T24 1551-1555 GeneOrGeneProduct denotes Disc
T25 1556-1561 GeneOrGeneProduct denotes bulge
T26 1595-1600 GeneOrGeneProduct denotes nodes
T27 1754-1758 GeneOrGeneProduct denotes MMP1
T28 1773-1778 GeneOrGeneProduct denotes times
T29 1916-1921 GeneOrGeneProduct denotes years
T30 1930-1934 GeneOrGeneProduct denotes Disc
T31 1935-1940 GeneOrGeneProduct denotes bulge
T32 1976-1981 GeneOrGeneProduct denotes nodes

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease C535531

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 51-55 GeneOrGeneProduct denotes MMP1
T2 113-138 GeneOrGeneProduct denotes Matrix metalloproteinases
T3 140-144 GeneOrGeneProduct denotes MMPs
T4 318-322 GeneOrGeneProduct denotes MMP1
T5 969-973 GeneOrGeneProduct denotes MMP1
T6 1754-1758 GeneOrGeneProduct denotes MMP1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease 0044339
T2 471-474 DiseaseOrPhenotypicFeature denotes DDD 0024534
T3 573-576 DiseaseOrPhenotypicFeature denotes DDD 0024534
T4 978-981 DiseaseOrPhenotypicFeature denotes DDD 0024534
T5 1060-1063 DiseaseOrPhenotypicFeature denotes DDD 0024534
T6 1220-1223 DiseaseOrPhenotypicFeature denotes DDD 0024534
T7 1807-1810 DiseaseOrPhenotypicFeature denotes DDD 0024534

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease C535531
T2 471-474 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T3 573-576 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T4 978-981 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T5 1060-1063 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T6 1220-1223 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T7 1807-1810 DiseaseOrPhenotypicFeature denotes DDD DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease C535531
T2 471-474 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T3 573-576 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T4 978-981 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T5 1060-1063 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T6 1220-1223 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T7 1807-1810 DiseaseOrPhenotypicFeature denotes DDD DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 113-138 ChemicalEntity denotes Matrix metalloproteinases D020782
T2 140-144 ChemicalEntity denotes MMPs D020782
T3 244-251 ChemicalEntity denotes guanine D006147|http://purl.obolibrary.org/obo/CHEBI_16235
T5 471-474 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841
T7 573-576 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841
T9 978-981 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841
T11 1060-1063 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841
T13 1220-1223 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841
T15 1807-1810 ChemicalEntity denotes DDD D003632|http://purl.obolibrary.org/obo/CHEBI_27841

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 1807-1810 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T13 1220-1223 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T11 1060-1063 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T9 978-981 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T7 573-576 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T5 471-474 ChemicalEntity denotes DDD http://purl.obolibrary.org/obo/CHEBI_27841|D003632
T3 244-251 ChemicalEntity denotes guanine http://purl.obolibrary.org/obo/CHEBI_16235|D006147
T2 140-144 ChemicalEntity denotes MMPs D020782
T1 113-138 ChemicalEntity denotes Matrix metalloproteinases D020782
T6 1754-1758 GeneOrGeneProduct denotes MMP1
T12651 969-973 GeneOrGeneProduct denotes MMP1
T4 318-322 GeneOrGeneProduct denotes MMP1
T7642 140-144 GeneOrGeneProduct denotes MMPs
T25474 113-138 GeneOrGeneProduct denotes Matrix metalloproteinases
T54771 51-55 GeneOrGeneProduct denotes MMP1
T27172 1807-1810 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T96325 1220-1223 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T22317 1060-1063 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T33109 978-981 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T73128 573-576 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T22405 471-474 DiseaseOrPhenotypicFeature denotes DDD DISEASE
T99508 60-79 DiseaseOrPhenotypicFeature denotes lumbar disc disease C535531

DisGeNET

Id Subject Object Predicate Lexical cue
T0 51-55 gene:4312 denotes MMP1
T1 60-79 disease:C0221775 denotes lumbar disc disease
R1 T0 T1 associated_with MMP1,lumbar disc disease

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 272-275 DNAMutation:|DEL||G denotes G/D