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PubMed:18408466 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
TextSentencer_T2 99-117 Sentence denotes PURPOSE OF REVIEW:
TextSentencer_T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
TextSentencer_T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
TextSentencer_T5 407-423 Sentence denotes RECENT FINDINGS:
TextSentencer_T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
TextSentencer_T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
TextSentencer_T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
TextSentencer_T9 957-965 Sentence denotes SUMMARY:
TextSentencer_T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
TextSentencer_T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
TextSentencer_T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.
T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
T2 99-117 Sentence denotes PURPOSE OF REVIEW:
T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
T5 407-423 Sentence denotes RECENT FINDINGS:
T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
T9 957-965 Sentence denotes SUMMARY:
T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
T2 99-117 Sentence denotes PURPOSE OF REVIEW:
T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
T5 407-423 Sentence denotes RECENT FINDINGS:
T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
T9 957-965 Sentence denotes SUMMARY:
T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.
T1 0-98 Sentence denotes Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers.
T2 99-117 Sentence denotes PURPOSE OF REVIEW:
T3 118-217 Sentence denotes Chronic biliary diseases are due to complex interactions between environmental and genetic factors.
T4 218-406 Sentence denotes Here we summarize the current knowledge of genetic factors that contribute to common biliary diseases, focusing on gallstones and carcinogenesis, and review the recent association studies.
T5 407-423 Sentence denotes RECENT FINDINGS:
T6 424-518 Sentence denotes Since most studies were based on small sample sizes, replication of the findings is mandatory.
T7 519-752 Sentence denotes Recently a large twin study confirmed a genetic predisposition to gallstones and a genome-wide association scan identified the hepatocanalicular cholesterol transporter ABCG8 as the common susceptibility factor for gallstone disease.
T8 753-956 Sentence denotes Genetic studies in patients with cholangiocarcinoma indicate that genes controlling the metabolism and transport of xenobiotics or modulating chronic inflammation may determine individual susceptibility.
T9 957-965 Sentence denotes SUMMARY:
T10 966-1116 Sentence denotes Genetic studies have identified the first susceptibility factors for gallstones and biliary tract cancers, but most results have yet to be replicated.
T11 1117-1265 Sentence denotes In the future, genome-wide studies in different populations are likely to identify the entire set of genes contributing to chronic biliary diseases.
T12 1266-1565 Sentence denotes Since the disease phenotypes result from the manifestation of susceptibility factors under the influence of environmental triggers, the discovery of these genes will open avenues to control environmental challenges and lead to novel strategies for risk assessment ('gene signatures') and prevention.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 688-693 gene:64241 denotes ABCG8
T1 585-595 disease:C0008350 denotes gallstones
T2 688-693 gene:64241 denotes ABCG8
T3 585-595 disease:C0947622 denotes gallstones
T4 688-693 gene:64241 denotes ABCG8
T5 734-751 disease:C0008350 denotes gallstone disease
R1 T0 T1 associated_with ABCG8,gallstones
R2 T2 T3 associated_with ABCG8,gallstones
R3 T4 T5 associated_with ABCG8,gallstone disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18408466-4#169#174#gene64241 688-693 gene64241 denotes ABCG8
18408466-4#66#76#diseaseC0008350 585-595 diseaseC0008350 denotes gallstones
18408466-4#66#76#diseaseC0947622 585-595 diseaseC0947622 denotes gallstones
18408466-4#215#232#diseaseC0008350 734-751 diseaseC0008350 denotes gallstone disease
169#174#gene6424166#76#diseaseC0008350 18408466-4#169#174#gene64241 18408466-4#66#76#diseaseC0008350 associated_with ABCG8,gallstones
169#174#gene6424166#76#diseaseC0947622 18408466-4#169#174#gene64241 18408466-4#66#76#diseaseC0947622 associated_with ABCG8,gallstones
169#174#gene64241215#232#diseaseC0008350 18408466-4#169#174#gene64241 18408466-4#215#232#diseaseC0008350 associated_with ABCG8,gallstone disease

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1104 688-693 gene:64241 denotes ABCG8
T1105 585-595 disease:C0008350 denotes gallstones
R1 T1104 T1105 associated_with ABCG8,gallstones
R2 T1104 T1105 associated_with ABCG8,gallstones