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PubMed:18376396 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-104 Sentence denotes The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
TextSentencer_T2 105-270 Sentence denotes Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis.
TextSentencer_T3 271-571 Sentence denotes We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or to ectopic expression of the protein tyrosine phosphatase Pez.
TextSentencer_T4 572-667 Sentence denotes Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT.
TextSentencer_T5 668-893 Sentence denotes Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis.
TextSentencer_T6 894-1007 Sentence denotes Inhibition of the microRNAs was sufficient to induce EMT in a process requiring upregulation of ZEB1 and/or SIP1.
TextSentencer_T7 1008-1132 Sentence denotes Conversely, ectopic expression of these microRNAs in mesenchymal cells initiated mesenchymal to epithelial transition (MET).
TextSentencer_T8 1133-1294 Sentence denotes Consistent with their role in regulating EMT, expression of these microRNAs was found to be lost in invasive breast cancer cell lines with mesenchymal phenotype.
TextSentencer_T9 1295-1411 Sentence denotes Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin.
TextSentencer_T10 1412-1515 Sentence denotes These data suggest that downregulation of the microRNAs may be an important step in tumour progression.
T1 0-104 Sentence denotes The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
T2 105-270 Sentence denotes Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis.
T3 271-571 Sentence denotes We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or to ectopic expression of the protein tyrosine phosphatase Pez.
T4 572-667 Sentence denotes Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT.
T5 668-893 Sentence denotes Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and SIP1 (also known as ZEB2), factors previously implicated in EMT and tumour metastasis.
T6 894-1007 Sentence denotes Inhibition of the microRNAs was sufficient to induce EMT in a process requiring upregulation of ZEB1 and/or SIP1.
T7 1008-1132 Sentence denotes Conversely, ectopic expression of these microRNAs in mesenchymal cells initiated mesenchymal to epithelial transition (MET).
T8 1133-1294 Sentence denotes Consistent with their role in regulating EMT, expression of these microRNAs was found to be lost in invasive breast cancer cell lines with mesenchymal phenotype.
T9 1295-1411 Sentence denotes Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin.
T10 1412-1515 Sentence denotes These data suggest that downregulation of the microRNAs may be an important step in tumour progression.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 773-777 gene:6935 denotes ZEB1
T1 875-892 disease:C0027627 denotes tumour metastasis
T2 773-777 gene:6935 denotes ZEB1
T3 875-892 disease:C2939419 denotes tumour metastasis
T4 793-801 gene:6935 denotes deltaEF1
T5 875-892 disease:C0027627 denotes tumour metastasis
T6 793-801 gene:6935 denotes deltaEF1
T7 875-892 disease:C2939419 denotes tumour metastasis
T8 807-811 gene:9351 denotes SIP1
T9 875-892 disease:C0027627 denotes tumour metastasis
T10 807-811 gene:9351 denotes SIP1
T11 875-892 disease:C2939419 denotes tumour metastasis
T12 807-811 gene:9839 denotes SIP1
T13 875-892 disease:C0027627 denotes tumour metastasis
T14 807-811 gene:9839 denotes SIP1
T15 875-892 disease:C2939419 denotes tumour metastasis
T16 807-811 gene:9169 denotes SIP1
T17 875-892 disease:C0027627 denotes tumour metastasis
T18 807-811 gene:9169 denotes SIP1
T19 875-892 disease:C2939419 denotes tumour metastasis
T20 807-811 gene:8487 denotes SIP1
T21 875-892 disease:C0027627 denotes tumour metastasis
T22 807-811 gene:8487 denotes SIP1
T23 875-892 disease:C2939419 denotes tumour metastasis
T24 827-831 gene:9839 denotes ZEB2
T25 875-892 disease:C0027627 denotes tumour metastasis
T26 827-831 gene:9839 denotes ZEB2
T27 875-892 disease:C2939419 denotes tumour metastasis
R1 T0 T1 associated_with ZEB1,tumour metastasis
R2 T2 T3 associated_with ZEB1,tumour metastasis
R3 T4 T5 associated_with deltaEF1,tumour metastasis
R4 T6 T7 associated_with deltaEF1,tumour metastasis
R5 T8 T9 associated_with SIP1,tumour metastasis
R6 T10 T11 associated_with SIP1,tumour metastasis
R7 T12 T13 associated_with SIP1,tumour metastasis
R8 T14 T15 associated_with SIP1,tumour metastasis
R9 T16 T17 associated_with SIP1,tumour metastasis
R10 T18 T19 associated_with SIP1,tumour metastasis
R11 T20 T21 associated_with SIP1,tumour metastasis
R12 T22 T23 associated_with SIP1,tumour metastasis
R13 T24 T25 associated_with ZEB2,tumour metastasis
R14 T26 T27 associated_with ZEB2,tumour metastasis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18376396-4#105#109#gene6935 773-777 gene6935 denotes ZEB1
18376396-4#125#133#gene6935 793-801 gene6935 denotes deltaEF1
18376396-4#139#143#gene8487 807-811 gene8487 denotes SIP1
18376396-4#139#143#gene9169 807-811 gene9169 denotes SIP1
18376396-4#139#143#gene9351 807-811 gene9351 denotes SIP1
18376396-4#139#143#gene9839 807-811 gene9839 denotes SIP1
18376396-4#159#163#gene9839 827-831 gene9839 denotes ZEB2
18376396-4#207#224#diseaseC0027627 875-892 diseaseC0027627 denotes tumour metastasis
105#109#gene6935207#224#diseaseC0027627 18376396-4#105#109#gene6935 18376396-4#207#224#diseaseC0027627 associated_with ZEB1,tumour metastasis
125#133#gene6935207#224#diseaseC0027627 18376396-4#125#133#gene6935 18376396-4#207#224#diseaseC0027627 associated_with deltaEF1,tumour metastasis
139#143#gene8487207#224#diseaseC0027627 18376396-4#139#143#gene8487 18376396-4#207#224#diseaseC0027627 associated_with SIP1,tumour metastasis
139#143#gene9169207#224#diseaseC0027627 18376396-4#139#143#gene9169 18376396-4#207#224#diseaseC0027627 associated_with SIP1,tumour metastasis
139#143#gene9351207#224#diseaseC0027627 18376396-4#139#143#gene9351 18376396-4#207#224#diseaseC0027627 associated_with SIP1,tumour metastasis
139#143#gene9839207#224#diseaseC0027627 18376396-4#139#143#gene9839 18376396-4#207#224#diseaseC0027627 associated_with SIP1,tumour metastasis
159#163#gene9839207#224#diseaseC0027627 18376396-4#159#163#gene9839 18376396-4#207#224#diseaseC0027627 associated_with ZEB2,tumour metastasis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1526 773-777 gene:6935 denotes ZEB1
T1527 875-892 disease:C0027627 denotes tumour metastasis
T1528 793-801 gene:6935 denotes deltaEF1
T1529 807-811 gene:8487 denotes SIP1
T1530 827-831 gene:9839 denotes ZEB2
R1 T1526 T1527 associated_with ZEB1,tumour metastasis
R2 T1528 T1527 associated_with deltaEF1,tumour metastasis
R3 T1529 T1527 associated_with SIP1,tumour metastasis
R4 T1529 T1527 associated_with SIP1,tumour metastasis
R5 T1529 T1527 associated_with SIP1,tumour metastasis
R6 T1529 T1527 associated_with SIP1,tumour metastasis
R7 T1530 T1527 associated_with ZEB2,tumour metastasis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 54-65 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T2 119-130 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T3 1061-1072 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T4 1089-1100 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T5 1272-1283 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T6 160-166 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T7 1242-1248 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1368-1374 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1242-1248 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 1368-1374 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 160-166 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 54-65 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T5 119-130 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T6 1061-1072 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T7 1089-1100 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T8 1272-1283 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal