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PubMed:18356633 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes An evaluation of amikacin nephrotoxicity in the hematology/oncology population.
T2 80-231 Sentence denotes Amikacin is an aminoglycoside commonly used to provide empirical double gram-negative treatment for febrile neutropenia and other suspected infections.
T3 232-447 Sentence denotes Strategies of extended-interval and conventional dosing have been utilized extensively in the general medical population; however, data are lacking to support a dosing strategy in the hematology/oncology population.
T4 448-639 Sentence denotes To evaluate amikacin-associated nephrotoxicity in an adult hematology/oncology population, a prospective, randomized, open-label trial was conducted at a university-affiliated medical center.
T5 640-837 Sentence denotes Forty patients with a diagnosis consistent with a hematologic/oncologic disorder that required treatment with an aminoglycoside were randomized to either conventional or extended-interval amikacin.
T6 838-1016 Sentence denotes The occurrence of nephrotoxicity by means of an increase in serum creatinine and evaluation of efficacy via amikacin serum concentrations with respective pathogens were assessed.
T7 1017-1156 Sentence denotes The occurrence of nephrotoxicity was similar between the conventional and extended-interval groups, at 10% and 5%, respectively (P = 1.00).
T8 1157-1282 Sentence denotes Six patients in the conventional group had a positive culture, compared with none in the extended-interval group (P = 0.002).
T9 1283-1434 Sentence denotes The occurrence of nephrotoxicity was similar between the two dosing regimens, but the distribution of risk factors was variable between the two groups.
T10 1435-1466 Sentence denotes Efficacy could not be assessed.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
4815 17-25 ChemicalEntity denotes amikacin MESH:D000583
4816 26-40 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
4817 80-88 ChemicalEntity denotes Amikacin MESH:D000583
4818 95-109 ChemicalEntity denotes aminoglycoside MESH:D000617
4819 180-199 DiseaseOrPhenotypicFeature denotes febrile neutropenia MESH:D009503
4820 220-230 DiseaseOrPhenotypicFeature denotes infections MESH:D007239
4821 460-468 ChemicalEntity denotes amikacin MESH:D000583
4822 480-494 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
4823 646-654 OrganismTaxon denotes patients NCBITaxon:9606
4824 690-720 DiseaseOrPhenotypicFeature denotes hematologic/oncologic disorder MESH:D006402|MESH:D009369
4825 753-767 ChemicalEntity denotes aminoglycoside MESH:D000617
4826 828-836 ChemicalEntity denotes amikacin MESH:D000583
4827 856-870 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
4828 904-914 ChemicalEntity denotes creatinine MESH:D003404
4829 946-954 ChemicalEntity denotes amikacin MESH:D000583
4830 1035-1049 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674
4831 1161-1169 OrganismTaxon denotes patients NCBITaxon:9606
4832 1301-1315 DiseaseOrPhenotypicFeature denotes nephrotoxicity MESH:D007674

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 188-199 DiseaseOrPhenotypicFeature denotes neutropenia 0001475

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 145-151 GeneOrGeneProduct denotes double
T2 204-209 GeneOrGeneProduct denotes other
T3 246-254 GeneOrGeneProduct denotes extended
T4 307-321 GeneOrGeneProduct denotes extensively in
T5 372-379 GeneOrGeneProduct denotes lacking
T6 566-570 GeneOrGeneProduct denotes open
T7 810-818 GeneOrGeneProduct denotes extended
T8 1054-1061 GeneOrGeneProduct denotes similar
T9 1091-1099 GeneOrGeneProduct denotes extended
T10 1196-1201 GeneOrGeneProduct denotes had a
T11 1234-1238 GeneOrGeneProduct denotes none
T12 1246-1254 GeneOrGeneProduct denotes extended
T13 1320-1327 GeneOrGeneProduct denotes similar
T14 1390-1397 GeneOrGeneProduct denotes factors

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 145-151 GeneOrGeneProduct denotes double
T2 204-209 GeneOrGeneProduct denotes other
T3 246-254 GeneOrGeneProduct denotes extended
T4 810-818 GeneOrGeneProduct denotes extended
T5 1054-1061 GeneOrGeneProduct denotes similar
T6 1091-1099 GeneOrGeneProduct denotes extended
T7 1234-1238 GeneOrGeneProduct denotes none
T8 1246-1254 GeneOrGeneProduct denotes extended
T9 1320-1327 GeneOrGeneProduct denotes similar

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 26-40 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 180-199 DiseaseOrPhenotypicFeature denotes febrile neutropenia D064147
T3 220-230 DiseaseOrPhenotypicFeature denotes infections D007239
T4 480-494 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T5 856-870 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T6 1035-1049 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T7 1301-1315 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 188-199 DiseaseOrPhenotypicFeature denotes neutropenia 0001475

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 26-40 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 180-199 DiseaseOrPhenotypicFeature denotes febrile neutropenia D064147
T3 220-230 DiseaseOrPhenotypicFeature denotes infections D007239
T4 480-494 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T5 690-720 DiseaseOrPhenotypicFeature denotes hematologic/oncologic disorder DISEASE
T6 856-870 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T7 1035-1049 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T8 1301-1315 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 26-40 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 180-199 DiseaseOrPhenotypicFeature denotes febrile neutropenia D064147
T3 480-494 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T4 690-720 DiseaseOrPhenotypicFeature denotes hematologic/oncologic disorder DISEASE
T5 856-870 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T6 1035-1049 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T7 1301-1315 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 17-25 ChemicalEntity denotes amikacin D000583|http://purl.obolibrary.org/obo/CHEBI_2637
T3 80-88 ChemicalEntity denotes Amikacin http://purl.obolibrary.org/obo/CHEBI_2637
T4 95-109 ChemicalEntity denotes aminoglycoside D000617|http://purl.obolibrary.org/obo/CHEBI_47779
T6 460-468 ChemicalEntity denotes amikacin D000583|http://purl.obolibrary.org/obo/CHEBI_2637
T8 753-767 ChemicalEntity denotes aminoglycoside D000617|http://purl.obolibrary.org/obo/CHEBI_47779
T10 828-836 ChemicalEntity denotes amikacin D000583|http://purl.obolibrary.org/obo/CHEBI_2637
T12 904-914 ChemicalEntity denotes creatinine D003404|http://purl.obolibrary.org/obo/CHEBI_16737
T14 946-954 ChemicalEntity denotes amikacin D000583|http://purl.obolibrary.org/obo/CHEBI_2637

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 646-654 OrganismTaxon denotes patients
T2 1161-1169 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T14 946-954 ChemicalEntity denotes amikacin http://purl.obolibrary.org/obo/CHEBI_2637|D000583
T12 904-914 ChemicalEntity denotes creatinine http://purl.obolibrary.org/obo/CHEBI_16737|D003404
T10 828-836 ChemicalEntity denotes amikacin http://purl.obolibrary.org/obo/CHEBI_2637|D000583
T8 753-767 ChemicalEntity denotes aminoglycoside http://purl.obolibrary.org/obo/CHEBI_47779|D000617
T6 460-468 ChemicalEntity denotes amikacin http://purl.obolibrary.org/obo/CHEBI_2637|D000583
T4 95-109 ChemicalEntity denotes aminoglycoside http://purl.obolibrary.org/obo/CHEBI_47779|D000617
T3 80-88 ChemicalEntity denotes Amikacin http://purl.obolibrary.org/obo/CHEBI_2637
T1 17-25 ChemicalEntity denotes amikacin http://purl.obolibrary.org/obo/CHEBI_2637|D000583
T7 1301-1315 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T36645 1035-1049 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T5 856-870 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T44356 690-720 DiseaseOrPhenotypicFeature denotes hematologic/oncologic disorder DISEASE
T283 480-494 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T2 180-199 DiseaseOrPhenotypicFeature denotes febrile neutropenia D064147
T98453 26-40 DiseaseOrPhenotypicFeature denotes nephrotoxicity DISEASE
T98455 1161-1169 OrganismTaxon denotes patients
T36529 646-654 OrganismTaxon denotes patients