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PubMed:18305110 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 39-42 DiseaseOrPhenotypicFeature denotes TAR 0010121
T2 149-152 DiseaseOrPhenotypicFeature denotes TAR 0010121
T3 211-244 DiseaseOrPhenotypicFeature denotes frontotemporal lobar degeneration 0017276
T4 293-322 DiseaseOrPhenotypicFeature denotes amyotrophic lateral sclerosis 0004976
T5 324-327 DiseaseOrPhenotypicFeature denotes ALS 0004976
T6 1208-1211 DiseaseOrPhenotypicFeature denotes ALS 0004976
T7 1226-1229 DiseaseOrPhenotypicFeature denotes ALS 0004976

sentences

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
T2 149-329 Sentence denotes TAR DNA-binding protein 43 (TDP-43) is the disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS).
T3 330-496 Sentence denotes Although normal TDP-43 is a nuclear protein, pathological TDP-43 is redistributed and sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites.
T4 497-740 Sentence denotes Here we recapitulate these pathological phenotypes in cultured cells by altering endogenous TDP-43 nuclear trafficking and by expressing mutants with defective nuclear localization (TDP-43-DeltaNLS) or nuclear export signals (TDP-43-DeltaNES).
T5 741-890 Sentence denotes Restricting endogenous cytoplasmic TDP-43 from entering the nucleus or preventing its exit out of the nucleus resulted in TDP-43 aggregate formation.
T6 891-1112 Sentence denotes TDP-43-DeltaNLS accumulates as insoluble cytoplasmic aggregates and sequesters endogenous TDP-43, thereby depleting normal nuclear TDP-43, whereas TDP-43-DeltaNES forms insoluble nuclear aggregates with endogenous TDP-43.
T7 1113-1212 Sentence denotes Mutant forms of TDP-43 also replicate the biochemical profile of pathological TDP-43 in FTLD-U/ALS.
T8 1213-1350 Sentence denotes Thus, FTLD-U/ALS pathogenesis may be linked mechanistically to deleterious perturbations of nuclear trafficking and solubility of TDP-43.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 305-312 http://purl.obolibrary.org/obo/MAT_0000488 denotes lateral

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1343-1349 gene:23435 denotes TDP-43
T1 1226-1229 disease:C0002736 denotes ALS
R1 T0 T1 associated_with TDP-43,ALS

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 64-70 Protein denotes TDP-43
T2 149-175 Protein denotes TAR DNA-binding protein 43
T3 177-183 Protein denotes TDP-43
T4 250-259 Protein denotes ubiquitin
T5 346-352 Protein denotes TDP-43
T6 388-394 Protein denotes TDP-43
T7 589-595 Protein denotes TDP-43
T8 679-685 Protein denotes TDP-43
T9 723-729 Protein denotes TDP-43
T10 776-782 Protein denotes TDP-43
T11 863-869 Protein denotes TDP-43
T12 891-897 Protein denotes TDP-43
T13 981-987 Protein denotes TDP-43
T14 1022-1028 Protein denotes TDP-43
T15 1038-1044 Protein denotes TDP-43
T16 1105-1111 Protein denotes TDP-43
T17 1129-1135 Protein denotes TDP-43
T18 1191-1197 Protein denotes TDP-43
T19 1343-1349 Protein denotes TDP-43

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18305110-6#16#22#gene23435 1129-1135 gene23435 denotes TDP-43
18305110-6#78#84#gene23435 1191-1197 gene23435 denotes TDP-43
18305110-6#88#94#diseaseC0338451 1201-1207 diseaseC0338451 denotes FTLD-U
18305110-6#88#94#diseaseC1843792 1201-1207 diseaseC1843792 denotes FTLD-U
18305110-6#88#94#diseaseC0338451 1201-1207 diseaseC0338451 denotes FTLD-U
18305110-6#88#94#diseaseC1843792 1201-1207 diseaseC1843792 denotes FTLD-U
18305110-7#130#136#gene23435 1343-1349 gene23435 denotes TDP-43
18305110-7#13#16#diseaseC0002736 1226-1229 diseaseC0002736 denotes ALS
16#22#gene2343588#94#diseaseC0338451 18305110-6#16#22#gene23435 18305110-6#88#94#diseaseC0338451 associated_with TDP-43,FTLD-U
16#22#gene2343588#94#diseaseC1843792 18305110-6#16#22#gene23435 18305110-6#88#94#diseaseC1843792 associated_with TDP-43,FTLD-U
16#22#gene2343588#94#diseaseC0338451 18305110-6#16#22#gene23435 18305110-6#88#94#diseaseC0338451 associated_with TDP-43,FTLD-U
16#22#gene2343588#94#diseaseC1843792 18305110-6#16#22#gene23435 18305110-6#88#94#diseaseC1843792 associated_with TDP-43,FTLD-U
78#84#gene2343588#94#diseaseC0338451 18305110-6#78#84#gene23435 18305110-6#88#94#diseaseC0338451 associated_with TDP-43,FTLD-U
78#84#gene2343588#94#diseaseC1843792 18305110-6#78#84#gene23435 18305110-6#88#94#diseaseC1843792 associated_with TDP-43,FTLD-U
78#84#gene2343588#94#diseaseC0338451 18305110-6#78#84#gene23435 18305110-6#88#94#diseaseC0338451 associated_with TDP-43,FTLD-U
78#84#gene2343588#94#diseaseC1843792 18305110-6#78#84#gene23435 18305110-6#88#94#diseaseC1843792 associated_with TDP-43,FTLD-U
130#136#gene2343513#16#diseaseC0002736 18305110-7#130#136#gene23435 18305110-7#13#16#diseaseC0002736 associated_with TDP-43,ALS

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 293-322 Phenotype denotes amyotrophic lateral sclerosis HP:0007354
T2 324-327 Phenotype denotes ALS HP:0007354
T3 1208-1211 Phenotype denotes ALS HP:0007354
T4 1226-1229 Phenotype denotes ALS HP:0007354

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 39-42 Disease denotes TAR http://purl.obolibrary.org/obo/MONDO_0010121
T2 149-152 Disease denotes TAR http://purl.obolibrary.org/obo/MONDO_0010121
T3 211-244 Disease denotes frontotemporal lobar degeneration http://purl.obolibrary.org/obo/MONDO_0017276
T4 293-322 Disease denotes amyotrophic lateral sclerosis http://purl.obolibrary.org/obo/MONDO_0004976
T5 324-327 Disease denotes ALS http://purl.obolibrary.org/obo/MONDO_0004976
T6 1208-1211 Disease denotes ALS http://purl.obolibrary.org/obo/MONDO_0004976
T7 1226-1229 Disease denotes ALS http://purl.obolibrary.org/obo/MONDO_0004976

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 27-38 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T2 764-775 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T3 801-808 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T5 843-850 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T7 932-943 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 305-312 Body_part denotes lateral http://purl.obolibrary.org/obo/MAT_0000488

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 455-463 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 551-565 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010