PubMed:17687514 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	131-218	DRI_Background	denotes	Bacteria present a variety of molecules either on their surface or in a cell-free form.
T2	219-341	DRI_Background	denotes	These molecules take part in numerous processes in the interactions with their host, with its tissues and other molecules.
T3	342-487	DRI_Background	denotes	These molecules are essential to bacterial pathogenesis either during colonization or the spread/invasion stages, and most are virulence factors.
T4	488-602	DRI_Background	denotes	This review is focused on such molecules using Streptococcus pneumoniae, a Gram-positive bacterium, as an example.
T5	603-759	DRI_Background	denotes	Selected surface proteins are introduced, their structure described, and, whenever available, their mechanisms of function on an atomic level are explained.
T6	760-907	DRI_Background	denotes	Such mechanisms for hyaluronate lyase, pneumococcal surface protein A, pneumolysin, histidine-triad and fibronectin-binding proteins are discussed.
T7	908-1044	DRI_Background	denotes	Elucidation of molecular mechanisms of virulence factors is essential for the understanding of bacteria and their functional properties.
T8	1045-1204	DRI_Background	denotes	Structural biology appears pivotal for these studies, as structural and mechanistic insights facilitate rational approach to the development of new treatments.

Id	Subject	Object	Predicate	Lexical cue
T1	0-130	Title	denotes	Unveiling molecular mechanisms of bacterial surface proteins: Streptococcus pneumoniae as a model organism for structural studies.
T2	131-1204	Paragraph	denotes	Bacteria present a variety of molecules either on their surface or in a cell-free form. These molecules take part in numerous processes in the interactions with their host, with its tissues and other molecules. These molecules are essential to bacterial pathogenesis either during colonization or the spread/invasion stages, and most are virulence factors. This review is focused on such molecules using Streptococcus pneumoniae, a Gram-positive bacterium, as an example. Selected surface proteins are introduced, their structure described, and, whenever available, their mechanisms of function on an atomic level are explained. Such mechanisms for hyaluronate lyase, pneumococcal surface protein A, pneumolysin, histidine-triad and fibronectin-binding proteins are discussed. Elucidation of molecular mechanisms of virulence factors is essential for the understanding of bacteria and their functional properties. Structural biology appears pivotal for these studies, as structural and mechanistic insights facilitate rational approach to the development of new treatments.
T3	62-86	Bacteria	denotes	Streptococcus pneumoniae
T4	535-559	Bacteria	denotes	Streptococcus pneumoniae