PubMed:17623048 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/17623048","sourcedb":"PubMed","sourceid":"17623048","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/17623048","text":"Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.\nMutations in Leucine-rich repeat kinase 2 (LRRK2) are linked to the most common familial forms and some sporadic forms of Parkinson's disease (PD). The LRRK2 protein contains two well-known functional domains, MAPKKK-like kinase and Rab-like GTPase domains. Emerging evidence shows that LRRK2 contains kinase activity which is enhanced in several PD-associated mutants of LRRK2. However, the GTPase activity of LRRK2 has yet to be formally demonstrated. Here, we produced and purified the epitope-tagged LRRK2 protein from transgenic mouse brain, and showed that purified brain LRRK2 possesses both kinase and GTPase activity as assayed by GTP binding and hydrolysis. The brain LRRK2 is associated with elevated kinase activity in comparison to that from transgenic lung or transfected cultured cells. In transfected cell cultures, we detected GTP hydrolysis activity in full-length as well as in GTPase domain of LRRK2. This result indicates that LRRK2 GTPase can be active independent of LRRK2 kinase activity (while LRRK2 kinase activity requires the presence of LRRK2 GTPase as previously shown). We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations. Therefore, our study shows the biochemical characteristics of brain-specific LRRK2 which is associated with robust kinase and GTPase activity. The distinctive levels of kinase/GTPase activity in brain LRRK2 may help explain LRRK2-associated neuronal functions or dysfunctions in the pathogenesis of PD.","tracks":[{"project":"PubTator4TogoVar","denotations":[{"id":"17623048_0","span":{"begin":117,"end":123},"obj":"ProteinMutation"},{"id":"17623048_1","span":{"begin":1270,"end":1276},"obj":"ProteinMutation"}],"attributes":[{"id":"17623048_0_ProteinMutation","pred":"proteinmutation","subj":"17623048_0","obj":"rs33939927"},{"id":"17623048_1_ProteinMutation","pred":"proteinmutation","subj":"17623048_1","obj":"rs33939927"},{"subj":"17623048_0","pred":"source","obj":"PubTator4TogoVar"},{"subj":"17623048_1","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"c_corpus","denotations":[{"id":"T2","span":{"begin":0,"end":7},"obj":"6308"},{"id":"T3","span":{"begin":0,"end":7},"obj":"SO:0001437"},{"id":"T1","span":{"begin":0,"end":7},"obj":"CHEBI:15603"},{"id":"T4","span":{"begin":0,"end":7},"obj":"D007930"},{"id":"T5","span":{"begin":0,"end":7},"obj":"CHEBI:25017"},{"id":"T6","span":{"begin":0,"end":7},"obj":"D007930"},{"id":"T7","span":{"begin":13,"end":19},"obj":"SO:0001068"},{"id":"T8","span":{"begin":30,"end":35},"obj":"PR:Q5S006"},{"id":"T9","span":{"begin":30,"end":35},"obj":"PR:000003033"},{"id":"T10","span":{"begin":30,"end":35},"obj":"PR:Q5S007"},{"id":"T13","span":{"begin":37,"end":42},"obj":"PR:000003033"},{"id":"T14","span":{"begin":37,"end":42},"obj":"PR:Q5S007"},{"id":"T12","span":{"begin":37,"end":42},"obj":"607060"},{"id":"T15","span":{"begin":53,"end":59},"obj":"D020558"},{"id":"T16","span":{"begin":53,"end":68},"obj":"GO:0003924"},{"id":"T21","span":{"begin":97,"end":116},"obj":"D010300"},{"id":"T22","span":{"begin":97,"end":116},"obj":"D010300"},{"id":"T26","span":{"begin":148,"end":155},"obj":"6308"},{"id":"T27","span":{"begin":148,"end":155},"obj":"SO:0001437"},{"id":"T25","span":{"begin":148,"end":155},"obj":"CHEBI:15603"},{"id":"T28","span":{"begin":148,"end":155},"obj":"D007930"},{"id":"T29","span":{"begin":148,"end":155},"obj":"CHEBI:25017"},{"id":"T30","span":{"begin":148,"end":155},"obj":"D007930"},{"id":"T31","span":{"begin":161,"end":167},"obj":"SO:0001068"},{"id":"T32","span":{"begin":178,"end":183},"obj":"PR:Q5S006"},{"id":"T33","span":{"begin":178,"end":183},"obj":"PR:000003033"},{"id":"T34","span":{"begin":178,"end":183},"obj":"PR:Q5S007"},{"id":"T39","span":{"begin":257,"end":276},"obj":"D010300"},{"id":"T40","span":{"begin":257,"end":276},"obj":"D010300"},{"id":"T43","span":{"begin":287,"end":292},"obj":"PR:Q5S006"},{"id":"T44","span":{"begin":287,"end":292},"obj":"PR:000003033"},{"id":"T45","span":{"begin":287,"end":292},"obj":"PR:Q5S007"},{"id":"T46","span":{"begin":287,"end":300},"obj":"D000071158"},{"id":"T50","span":{"begin":293,"end":300},"obj":"PR:000000001"},{"id":"T47","span":{"begin":293,"end":300},"obj":"GO:0003675"},{"id":"T51","span":{"begin":293,"end":300},"obj":"SO:0000104"},{"id":"T52","span":{"begin":345,"end":351},"obj":"P28829"},{"id":"T53","span":{"begin":368,"end":371},"obj":"P17610"},{"id":"T54","span":{"begin":368,"end":371},"obj":"PR:000003829"},{"id":"T55","span":{"begin":368,"end":371},"obj":"PR:P52594"},{"id":"T56","span":{"begin":377,"end":383},"obj":"D020558"},{"id":"T57","span":{"begin":422,"end":427},"obj":"PR:Q5S006"},{"id":"T58","span":{"begin":422,"end":427},"obj":"PR:000003033"},{"id":"T59","span":{"begin":422,"end":427},"obj":"PR:Q5S007"},{"id":"T60","span":{"begin":437,"end":452},"obj":"GO:0016301"},{"id":"T61","span":{"begin":507,"end":512},"obj":"PR:Q5S006"},{"id":"T62","span":{"begin":507,"end":512},"obj":"PR:000003033"},{"id":"T63","span":{"begin":507,"end":512},"obj":"PR:Q5S007"},{"id":"T64","span":{"begin":527,"end":533},"obj":"D020558"},{"id":"T65","span":{"begin":527,"end":542},"obj":"GO:0003924"},{"id":"T66","span":{"begin":546,"end":551},"obj":"PR:Q5S006"},{"id":"T67","span":{"begin":546,"end":551},"obj":"PR:000003033"},{"id":"T68","span":{"begin":546,"end":551},"obj":"PR:Q5S007"},{"id":"T70","span":{"begin":624,"end":631},"obj":"SO:0001018"},{"id":"T69","span":{"begin":624,"end":631},"obj":"CHEBI:53000"},{"id":"T71","span":{"begin":639,"end":644},"obj":"PR:Q5S006"},{"id":"T72","span":{"begin":639,"end":644},"obj":"PR:000003033"},{"id":"T73","span":{"begin":639,"end":644},"obj":"PR:Q5S007"},{"id":"T74","span":{"begin":639,"end":652},"obj":"D000071158"},{"id":"T79","span":{"begin":645,"end":652},"obj":"SO:0000104"},{"id":"T78","span":{"begin":645,"end":652},"obj":"PR:000000001"},{"id":"T75","span":{"begin":645,"end":652},"obj":"GO:0003675"},{"id":"T80","span":{"begin":658,"end":668},"obj":"SO:0000781"},{"id":"T81","span":{"begin":658,"end":674},"obj":"D008822"},{"id":"T84","span":{"begin":675,"end":680},"obj":"UBERON:6110636"},{"id":"T85","span":{"begin":675,"end":680},"obj":"UBERON:0000955"},{"id":"T86","span":{"begin":707,"end":712},"obj":"UBERON:6110636"},{"id":"T87","span":{"begin":707,"end":712},"obj":"UBERON:0000955"},{"id":"T88","span":{"begin":713,"end":718},"obj":"PR:Q5S006"},{"id":"T89","span":{"begin":713,"end":718},"obj":"PR:000003033"},{"id":"T90","span":{"begin":713,"end":718},"obj":"PR:Q5S007"},{"id":"T91","span":{"begin":745,"end":751},"obj":"D020558"},{"id":"T92","span":{"begin":745,"end":760},"obj":"GO:0003924"},{"id":"T93","span":{"begin":775,"end":778},"obj":"D006160"},{"id":"T94","span":{"begin":775,"end":778},"obj":"CHEBI:37565"},{"id":"T95","span":{"begin":775,"end":778},"obj":"D006160"},{"id":"T96","span":{"begin":775,"end":778},"obj":"CHEBI:15996"},{"id":"T97","span":{"begin":775,"end":786},"obj":"GO:0005525"},{"id":"T98","span":{"begin":779,"end":786},"obj":"SO:0100018"},{"id":"T99","span":{"begin":779,"end":786},"obj":"SO:0001091"},{"id":"T101","span":{"begin":791,"end":801},"obj":"MOP:0000619"},{"id":"T102","span":{"begin":803,"end":812},"obj":"UBERON:0000955"},{"id":"T105","span":{"begin":813,"end":818},"obj":"PR:Q5S006"},{"id":"T106","span":{"begin":813,"end":818},"obj":"PR:000003033"},{"id":"T107","span":{"begin":813,"end":818},"obj":"PR:Q5S007"},{"id":"T108","span":{"begin":847,"end":862},"obj":"GO:0016301"},{"id":"T109","span":{"begin":890,"end":900},"obj":"SO:0000781"},{"id":"T110","span":{"begin":901,"end":905},"obj":"UBERON:0002048"},{"id":"T111","span":{"begin":979,"end":982},"obj":"D006160"},{"id":"T112","span":{"begin":979,"end":982},"obj":"CHEBI:37565"},{"id":"T113","span":{"begin":979,"end":982},"obj":"D006160"},{"id":"T114","span":{"begin":979,"end":982},"obj":"CHEBI:15996"},{"id":"T115","span":{"begin":979,"end":993},"obj":"GO:0006184"},{"id":"T116","span":{"begin":983,"end":993},"obj":"MOP:0000619"},{"id":"T117","span":{"begin":1032,"end":1038},"obj":"D020558"},{"id":"T118","span":{"begin":1039,"end":1045},"obj":"SO:0000417"},{"id":"T119","span":{"begin":1049,"end":1054},"obj":"PR:Q5S006"},{"id":"T120","span":{"begin":1049,"end":1054},"obj":"PR:000003033"},{"id":"T121","span":{"begin":1049,"end":1054},"obj":"PR:Q5S007"},{"id":"T122","span":{"begin":1083,"end":1088},"obj":"PR:Q5S006"},{"id":"T123","span":{"begin":1083,"end":1088},"obj":"PR:000003033"},{"id":"T124","span":{"begin":1083,"end":1088},"obj":"PR:Q5S007"},{"id":"T125","span":{"begin":1089,"end":1095},"obj":"D020558"},{"id":"T126","span":{"begin":1125,"end":1130},"obj":"PR:Q5S006"},{"id":"T127","span":{"begin":1125,"end":1130},"obj":"PR:000003033"},{"id":"T128","span":{"begin":1125,"end":1130},"obj":"PR:Q5S007"},{"id":"T129","span":{"begin":1131,"end":1146},"obj":"GO:0016301"},{"id":"T130","span":{"begin":1154,"end":1159},"obj":"PR:Q5S006"},{"id":"T131","span":{"begin":1154,"end":1159},"obj":"PR:000003033"},{"id":"T132","span":{"begin":1154,"end":1159},"obj":"PR:Q5S007"},{"id":"T133","span":{"begin":1160,"end":1175},"obj":"GO:0016301"},{"id":"T134","span":{"begin":1201,"end":1206},"obj":"PR:Q5S006"},{"id":"T135","span":{"begin":1201,"end":1206},"obj":"PR:000003033"},{"id":"T136","span":{"begin":1201,"end":1206},"obj":"PR:Q5S007"},{"id":"T137","span":{"begin":1207,"end":1213},"obj":"D020558"},{"id":"T138","span":{"begin":1261,"end":1269},"obj":"SO:0000109"},{"id":"T139","span":{"begin":1286,"end":1292},"obj":"D020558"},{"id":"T140","span":{"begin":1293,"end":1299},"obj":"SO:0000417"},{"id":"T141","span":{"begin":1315,"end":1318},"obj":"D006160"},{"id":"T142","span":{"begin":1315,"end":1318},"obj":"CHEBI:37565"},{"id":"T143","span":{"begin":1315,"end":1318},"obj":"D006160"},{"id":"T144","span":{"begin":1315,"end":1318},"obj":"CHEBI:15996"},{"id":"T145","span":{"begin":1315,"end":1329},"obj":"GO:0006184"},{"id":"T146","span":{"begin":1319,"end":1329},"obj":"MOP:0000619"},{"id":"T147","span":{"begin":1368,"end":1377},"obj":"SO:0001185"},{"id":"T148","span":{"begin":1401,"end":1406},"obj":"PR:Q5S006"},{"id":"T149","span":{"begin":1401,"end":1406},"obj":"PR:000003033"},{"id":"T150","span":{"begin":1401,"end":1406},"obj":"PR:Q5S007"},{"id":"T151","span":{"begin":1501,"end":1506},"obj":"UBERON:6110636"},{"id":"T152","span":{"begin":1501,"end":1506},"obj":"UBERON:0000955"},{"id":"T153","span":{"begin":1516,"end":1521},"obj":"PR:Q5S006"},{"id":"T154","span":{"begin":1516,"end":1521},"obj":"PR:000003033"},{"id":"T155","span":{"begin":1516,"end":1521},"obj":"PR:Q5S007"},{"id":"T156","span":{"begin":1565,"end":1571},"obj":"D020558"},{"id":"T157","span":{"begin":1565,"end":1580},"obj":"GO:0003924"},{"id":"T158","span":{"begin":1615,"end":1621},"obj":"D020558"},{"id":"T159","span":{"begin":1615,"end":1630},"obj":"GO:0003924"},{"id":"T160","span":{"begin":1634,"end":1639},"obj":"UBERON:6110636"},{"id":"T161","span":{"begin":1634,"end":1639},"obj":"UBERON:0000955"},{"id":"T162","span":{"begin":1640,"end":1645},"obj":"PR:Q5S006"},{"id":"T163","span":{"begin":1640,"end":1645},"obj":"PR:000003033"},{"id":"T164","span":{"begin":1640,"end":1645},"obj":"PR:Q5S007"},{"id":"T165","span":{"begin":1663,"end":1668},"obj":"PR:Q5S006"},{"id":"T166","span":{"begin":1663,"end":1668},"obj":"PR:000003033"},{"id":"T167","span":{"begin":1663,"end":1668},"obj":"PR:Q5S007"},{"id":"T168","span":{"begin":1722,"end":1734},"obj":"GO:0009405"}],"attributes":[{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":8,"end":12},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":37,"end":42},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":97,"end":116},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":156,"end":160},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":257,"end":276},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":278,"end":280},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":482,"end":484},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":901,"end":905},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1096,"end":1099},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1258,"end":1260},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":1416,"end":1418},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":1738,"end":1740},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0015404"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0011764"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005180"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0015404"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005180"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0008199"},{"id":"A7","pred":"mondo_id","subj":"T6","obj":"0015873"},{"id":"A8","pred":"mondo_id","subj":"T6","obj":"0005180"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0008199"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"0015873"},{"id":"A11","pred":"mondo_id","subj":"T9","obj":"0005180"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0021117"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0012833"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"0008199"},{"id":"A15","pred":"mondo_id","subj":"T14","obj":"0015873"},{"id":"A16","pred":"mondo_id","subj":"T14","obj":"0005180"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"0008199"},{"id":"A18","pred":"mondo_id","subj":"T17","obj":"0015873"},{"id":"A19","pred":"mondo_id","subj":"T17","obj":"0005180"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"0008199"},{"id":"A21","pred":"mondo_id","subj":"T20","obj":"0015873"},{"id":"A22","pred":"mondo_id","subj":"T20","obj":"0005180"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T12","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T13","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T14","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T17","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T20","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":257,"end":266},"obj":"HP_0001300"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":134},"obj":"DRI_Outcome"},{"id":"T2","span":{"begin":135,"end":282},"obj":"DRI_Background"},{"id":"T3","span":{"begin":283,"end":392},"obj":"DRI_Background"},{"id":"T4","span":{"begin":393,"end":513},"obj":"DRI_Background"},{"id":"T5","span":{"begin":514,"end":588},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":589,"end":623},"obj":"DRI_Outcome"},{"id":"T7","span":{"begin":624,"end":644},"obj":"Token_Label.OUTSIDE"},{"id":"T8","span":{"begin":645,"end":802},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":803,"end":936},"obj":"DRI_Background"},{"id":"T10","span":{"begin":937,"end":1055},"obj":"DRI_Outcome"},{"id":"T11","span":{"begin":1056,"end":1235},"obj":"DRI_Outcome"},{"id":"T12","span":{"begin":1236,"end":1438},"obj":"DRI_Outcome"},{"id":"T13","span":{"begin":1439,"end":1500},"obj":"DRI_Outcome"},{"id":"T14","span":{"begin":1501,"end":1521},"obj":"Token_Label.OUTSIDE"},{"id":"T15","span":{"begin":1522,"end":1581},"obj":"DRI_Outcome"},{"id":"T16","span":{"begin":1582,"end":1741},"obj":"DRI_Background"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T14","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T15","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T16","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":135,"end":282},"obj":"DRI_Background"},{"id":"T2","span":{"begin":283,"end":392},"obj":"DRI_Background"},{"id":"T3","span":{"begin":393,"end":513},"obj":"DRI_Background"},{"id":"T4","span":{"begin":514,"end":588},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":589,"end":623},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":645,"end":802},"obj":"DRI_Outcome"},{"id":"T7","span":{"begin":803,"end":936},"obj":"DRI_Background"},{"id":"T8","span":{"begin":937,"end":1055},"obj":"DRI_Outcome"},{"id":"T9","span":{"begin":1056,"end":1235},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1236,"end":1438},"obj":"DRI_Outcome"},{"id":"T11","span":{"begin":1439,"end":1500},"obj":"DRI_Outcome"},{"id":"T12","span":{"begin":1522,"end":1581},"obj":"DRI_Outcome"},{"id":"T13","span":{"begin":1582,"end":1741},"obj":"DRI_Background"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T12","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T13","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"17623048-0#117#123#geners33939927","span":{"begin":117,"end":123},"obj":"geners33939927"},{"id":"17623048-0#97#116#diseaseC0030567","span":{"begin":97,"end":116},"obj":"diseaseC0030567"}],"relations":[{"id":"117#123#geners3393992797#116#diseaseC0030567","pred":"associated_with","subj":"17623048-0#117#123#geners33939927","obj":"17623048-0#97#116#diseaseC0030567"}],"attributes":[{"subj":"17623048-0#117#123#geners33939927","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"17623048-0#97#116#diseaseC0030567","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"17623048-0#0#28#gene120892","span":{"begin":0,"end":28},"obj":"gene120892"},{"id":"17623048-0#30#35#gene120892","span":{"begin":30,"end":35},"obj":"gene120892"},{"id":"17623048-0#37#42#gene120892","span":{"begin":37,"end":42},"obj":"gene120892"},{"id":"17623048-0#97#116#diseaseC0030567","span":{"begin":97,"end":116},"obj":"diseaseC0030567"},{"id":"17623048-9#79#82#gene92170","span":{"begin":1315,"end":1318},"obj":"gene92170"},{"id":"17623048-9#22#24#diseaseC0030567","span":{"begin":1258,"end":1260},"obj":"diseaseC0030567"},{"id":"17623048-9#180#182#diseaseC0030567","span":{"begin":1416,"end":1418},"obj":"diseaseC0030567"}],"relations":[{"id":"0#28#gene12089297#116#diseaseC0030567","pred":"associated_with","subj":"17623048-0#0#28#gene120892","obj":"17623048-0#97#116#diseaseC0030567"},{"id":"30#35#gene12089297#116#diseaseC0030567","pred":"associated_with","subj":"17623048-0#30#35#gene120892","obj":"17623048-0#97#116#diseaseC0030567"},{"id":"37#42#gene12089297#116#diseaseC0030567","pred":"associated_with","subj":"17623048-0#37#42#gene120892","obj":"17623048-0#97#116#diseaseC0030567"},{"id":"79#82#gene9217022#24#diseaseC0030567","pred":"associated_with","subj":"17623048-9#79#82#gene92170","obj":"17623048-9#22#24#diseaseC0030567"},{"id":"79#82#gene92170180#182#diseaseC0030567","pred":"associated_with","subj":"17623048-9#79#82#gene92170","obj":"17623048-9#180#182#diseaseC0030567"}],"attributes":[{"subj":"17623048-0#0#28#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-0#30#35#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-0#37#42#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-0#97#116#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-9#79#82#gene92170","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-9#22#24#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"17623048-9#180#182#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubTator4TogoVar","color":"#ecc993","default":true},{"id":"c_corpus","color":"#af93ec"},{"id":"PMID_GLOBAL","color":"#93ec95"},{"id":"PubmedHPO","color":"#ec93aa"},{"id":"UseCases_ArguminSci_Discourse","color":"#93c4ec"},{"id":"PubMed_ArguminSci","color":"#deec93"},{"id":"DisGeNET5_variant_disease","color":"#df93ec"},{"id":"DisGeNET5_gene_disease","color":"#93ecc5"}]}]}}