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PubMed:17623048 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
17623048_0 117-123 ProteinMutation denotes R1441C rs33939927
17623048_1 1270-1276 ProteinMutation denotes R1441C rs33939927

c_corpus

Id Subject Object Predicate Lexical cue
T2 0-7 6308 denotes Leucine
T3 0-7 SO:0001437 denotes Leucine
T1 0-7 CHEBI:15603 denotes Leucine
T4 0-7 D007930 denotes Leucine
T5 0-7 CHEBI:25017 denotes Leucine
T6 0-7 D007930 denotes Leucine
T7 13-19 SO:0001068 denotes repeat
T8 30-35 PR:Q5S006 denotes LRRK2
T9 30-35 PR:000003033 denotes LRRK2
T10 30-35 PR:Q5S007 denotes LRRK2
T13 37-42 PR:000003033 denotes PARK8
T14 37-42 PR:Q5S007 denotes PARK8
T12 37-42 607060 denotes PARK8
T15 53-59 D020558 denotes GTPase
T16 53-68 GO:0003924 denotes GTPase activity
T21 97-116 D010300 denotes Parkinson's disease
T22 97-116 D010300 denotes Parkinson's disease
T26 148-155 6308 denotes Leucine
T27 148-155 SO:0001437 denotes Leucine
T25 148-155 CHEBI:15603 denotes Leucine
T28 148-155 D007930 denotes Leucine
T29 148-155 CHEBI:25017 denotes Leucine
T30 148-155 D007930 denotes Leucine
T31 161-167 SO:0001068 denotes repeat
T32 178-183 PR:Q5S006 denotes LRRK2
T33 178-183 PR:000003033 denotes LRRK2
T34 178-183 PR:Q5S007 denotes LRRK2
T39 257-276 D010300 denotes Parkinson's disease
T40 257-276 D010300 denotes Parkinson's disease
T43 287-292 PR:Q5S006 denotes LRRK2
T44 287-292 PR:000003033 denotes LRRK2
T45 287-292 PR:Q5S007 denotes LRRK2
T46 287-300 D000071158 denotes LRRK2 protein
T50 293-300 PR:000000001 denotes protein
T47 293-300 GO:0003675 denotes protein
T51 293-300 SO:0000104 denotes protein
T52 345-351 P28829 denotes MAPKKK
T53 368-371 P17610 denotes Rab
T54 368-371 PR:000003829 denotes Rab
T55 368-371 PR:P52594 denotes Rab
T56 377-383 D020558 denotes GTPase
T57 422-427 PR:Q5S006 denotes LRRK2
T58 422-427 PR:000003033 denotes LRRK2
T59 422-427 PR:Q5S007 denotes LRRK2
T60 437-452 GO:0016301 denotes kinase activity
T61 507-512 PR:Q5S006 denotes LRRK2
T62 507-512 PR:000003033 denotes LRRK2
T63 507-512 PR:Q5S007 denotes LRRK2
T64 527-533 D020558 denotes GTPase
T65 527-542 GO:0003924 denotes GTPase activity
T66 546-551 PR:Q5S006 denotes LRRK2
T67 546-551 PR:000003033 denotes LRRK2
T68 546-551 PR:Q5S007 denotes LRRK2
T70 624-631 SO:0001018 denotes epitope
T69 624-631 CHEBI:53000 denotes epitope
T71 639-644 PR:Q5S006 denotes LRRK2
T72 639-644 PR:000003033 denotes LRRK2
T73 639-644 PR:Q5S007 denotes LRRK2
T74 639-652 D000071158 denotes LRRK2 protein
T79 645-652 SO:0000104 denotes protein
T78 645-652 PR:000000001 denotes protein
T75 645-652 GO:0003675 denotes protein
T80 658-668 SO:0000781 denotes transgenic
T81 658-674 D008822 denotes transgenic mouse
T84 675-680 UBERON:6110636 denotes brain
T85 675-680 UBERON:0000955 denotes brain
T86 707-712 UBERON:6110636 denotes brain
T87 707-712 UBERON:0000955 denotes brain
T88 713-718 PR:Q5S006 denotes LRRK2
T89 713-718 PR:000003033 denotes LRRK2
T90 713-718 PR:Q5S007 denotes LRRK2
T91 745-751 D020558 denotes GTPase
T92 745-760 GO:0003924 denotes GTPase activity
T93 775-778 D006160 denotes GTP
T94 775-778 CHEBI:37565 denotes GTP
T95 775-778 D006160 denotes GTP
T96 775-778 CHEBI:15996 denotes GTP
T97 775-786 GO:0005525 denotes GTP binding
T98 779-786 SO:0100018 denotes binding
T99 779-786 SO:0001091 denotes binding
T101 791-801 MOP:0000619 denotes hydrolysis
T102 803-812 UBERON:0000955 denotes The brain
T105 813-818 PR:Q5S006 denotes LRRK2
T106 813-818 PR:000003033 denotes LRRK2
T107 813-818 PR:Q5S007 denotes LRRK2
T108 847-862 GO:0016301 denotes kinase activity
T109 890-900 SO:0000781 denotes transgenic
T110 901-905 UBERON:0002048 denotes lung
T111 979-982 D006160 denotes GTP
T112 979-982 CHEBI:37565 denotes GTP
T113 979-982 D006160 denotes GTP
T114 979-982 CHEBI:15996 denotes GTP
T115 979-993 GO:0006184 denotes GTP hydrolysis
T116 983-993 MOP:0000619 denotes hydrolysis
T117 1032-1038 D020558 denotes GTPase
T118 1039-1045 SO:0000417 denotes domain
T119 1049-1054 PR:Q5S006 denotes LRRK2
T120 1049-1054 PR:000003033 denotes LRRK2
T121 1049-1054 PR:Q5S007 denotes LRRK2
T122 1083-1088 PR:Q5S006 denotes LRRK2
T123 1083-1088 PR:000003033 denotes LRRK2
T124 1083-1088 PR:Q5S007 denotes LRRK2
T125 1089-1095 D020558 denotes GTPase
T126 1125-1130 PR:Q5S006 denotes LRRK2
T127 1125-1130 PR:000003033 denotes LRRK2
T128 1125-1130 PR:Q5S007 denotes LRRK2
T129 1131-1146 GO:0016301 denotes kinase activity
T130 1154-1159 PR:Q5S006 denotes LRRK2
T131 1154-1159 PR:000003033 denotes LRRK2
T132 1154-1159 PR:Q5S007 denotes LRRK2
T133 1160-1175 GO:0016301 denotes kinase activity
T134 1201-1206 PR:Q5S006 denotes LRRK2
T135 1201-1206 PR:000003033 denotes LRRK2
T136 1201-1206 PR:Q5S007 denotes LRRK2
T137 1207-1213 D020558 denotes GTPase
T138 1261-1269 SO:0000109 denotes mutation
T139 1286-1292 D020558 denotes GTPase
T140 1293-1299 SO:0000417 denotes domain
T141 1315-1318 D006160 denotes GTP
T142 1315-1318 CHEBI:37565 denotes GTP
T143 1315-1318 D006160 denotes GTP
T144 1315-1318 CHEBI:15996 denotes GTP
T145 1315-1329 GO:0006184 denotes GTP hydrolysis
T146 1319-1329 MOP:0000619 denotes hydrolysis
T147 1368-1377 SO:0001185 denotes enzymatic
T148 1401-1406 PR:Q5S006 denotes LRRK2
T149 1401-1406 PR:000003033 denotes LRRK2
T150 1401-1406 PR:Q5S007 denotes LRRK2
T151 1501-1506 UBERON:6110636 denotes brain
T152 1501-1506 UBERON:0000955 denotes brain
T153 1516-1521 PR:Q5S006 denotes LRRK2
T154 1516-1521 PR:000003033 denotes LRRK2
T155 1516-1521 PR:Q5S007 denotes LRRK2
T156 1565-1571 D020558 denotes GTPase
T157 1565-1580 GO:0003924 denotes GTPase activity
T158 1615-1621 D020558 denotes GTPase
T159 1615-1630 GO:0003924 denotes GTPase activity
T160 1634-1639 UBERON:6110636 denotes brain
T161 1634-1639 UBERON:0000955 denotes brain
T162 1640-1645 PR:Q5S006 denotes LRRK2
T163 1640-1645 PR:000003033 denotes LRRK2
T164 1640-1645 PR:Q5S007 denotes LRRK2
T165 1663-1668 PR:Q5S006 denotes LRRK2
T166 1663-1668 PR:000003033 denotes LRRK2
T167 1663-1668 PR:Q5S007 denotes LRRK2
T168 1722-1734 GO:0009405 denotes pathogenesis

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 8-12 DiseaseOrPhenotypicFeature denotes rich 0015404
T2 37-42 DiseaseOrPhenotypicFeature denotes PARK8 0011764
T3 97-116 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T4 156-160 DiseaseOrPhenotypicFeature denotes rich 0015404
T5 257-276 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T6 278-280 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T9 482-484 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T12 901-905 DiseaseOrPhenotypicFeature denotes lung 0021117
T13 1096-1099 DiseaseOrPhenotypicFeature denotes can 0012833
T14 1258-1260 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T17 1416-1418 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180
T20 1738-1740 DiseaseOrPhenotypicFeature denotes PD 0008199|0015873|0005180

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 257-266 HP_0001300 denotes Parkinson

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-134 DRI_Outcome denotes Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
T2 135-282 DRI_Background denotes Mutations in Leucine-rich repeat kinase 2 (LRRK2) are linked to the most common familial forms and some sporadic forms of Parkinson's disease (PD).
T3 283-392 DRI_Background denotes The LRRK2 protein contains two well-known functional domains, MAPKKK-like kinase and Rab-like GTPase domains.
T4 393-513 DRI_Background denotes Emerging evidence shows that LRRK2 contains kinase activity which is enhanced in several PD-associated mutants of LRRK2.
T5 514-588 DRI_Outcome denotes However, the GTPase activity of LRRK2 has yet to be formally demonstrated.
T6 589-623 DRI_Outcome denotes Here, we produced and purified the
T7 624-644 Token_Label.OUTSIDE denotes epitope-tagged LRRK2
T8 645-802 DRI_Outcome denotes protein from transgenic mouse brain, and showed that purified brain LRRK2 possesses both kinase and GTPase activity as assayed by GTP binding and hydrolysis.
T9 803-936 DRI_Background denotes The brain LRRK2 is associated with elevated kinase activity in comparison to that from transgenic lung or transfected cultured cells.
T10 937-1055 DRI_Outcome denotes In transfected cell cultures, we detected GTP hydrolysis activity in full-length as well as in GTPase domain of LRRK2.
T11 1056-1235 DRI_Outcome denotes This result indicates that LRRK2 GTPase can be active independent of LRRK2 kinase activity (while LRRK2 kinase activity requires the presence of LRRK2 GTPase as previously shown).
T12 1236-1438 DRI_Outcome denotes We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations.
T13 1439-1500 DRI_Outcome denotes Therefore, our study shows the biochemical characteristics of
T14 1501-1521 Token_Label.OUTSIDE denotes brain-specific LRRK2
T15 1522-1581 DRI_Outcome denotes which is associated with robust kinase and GTPase activity.
T16 1582-1741 DRI_Background denotes The distinctive levels of kinase/GTPase activity in brain LRRK2 may help explain LRRK2-associated neuronal functions or dysfunctions in the pathogenesis of PD.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 135-282 DRI_Background denotes Mutations in Leucine-rich repeat kinase 2 (LRRK2) are linked to the most common familial forms and some sporadic forms of Parkinson's disease (PD).
T2 283-392 DRI_Background denotes The LRRK2 protein contains two well-known functional domains, MAPKKK-like kinase and Rab-like GTPase domains.
T3 393-513 DRI_Background denotes Emerging evidence shows that LRRK2 contains kinase activity which is enhanced in several PD-associated mutants of LRRK2.
T4 514-588 DRI_Outcome denotes However, the GTPase activity of LRRK2 has yet to be formally demonstrated.
T5 589-623 DRI_Outcome denotes Here, we produced and purified the
T6 645-802 DRI_Outcome denotes protein from transgenic mouse brain, and showed that purified brain LRRK2 possesses both kinase and GTPase activity as assayed by GTP binding and hydrolysis.
T7 803-936 DRI_Background denotes The brain LRRK2 is associated with elevated kinase activity in comparison to that from transgenic lung or transfected cultured cells.
T8 937-1055 DRI_Outcome denotes In transfected cell cultures, we detected GTP hydrolysis activity in full-length as well as in GTPase domain of LRRK2.
T9 1056-1235 DRI_Outcome denotes This result indicates that LRRK2 GTPase can be active independent of LRRK2 kinase activity (while LRRK2 kinase activity requires the presence of LRRK2 GTPase as previously shown).
T10 1236-1438 DRI_Outcome denotes We further found that PD mutation R1441C/G in the GTPase domain causes reduced GTP hydrolysis activity, consistent with the altered enzymatic activity in the mutant LRRK2 carrying PD familial mutations.
T11 1439-1500 DRI_Outcome denotes Therefore, our study shows the biochemical characteristics of
T12 1522-1581 DRI_Outcome denotes which is associated with robust kinase and GTPase activity.
T13 1582-1741 DRI_Background denotes The distinctive levels of kinase/GTPase activity in brain LRRK2 may help explain LRRK2-associated neuronal functions or dysfunctions in the pathogenesis of PD.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
17623048-0#117#123#geners33939927 117-123 geners33939927 denotes R1441C
17623048-0#97#116#diseaseC0030567 97-116 diseaseC0030567 denotes Parkinson's disease
117#123#geners3393992797#116#diseaseC0030567 17623048-0#117#123#geners33939927 17623048-0#97#116#diseaseC0030567 associated_with R1441C,Parkinson's disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17623048-0#0#28#gene120892 0-28 gene120892 denotes Leucine-rich repeat kinase 2
17623048-0#30#35#gene120892 30-35 gene120892 denotes LRRK2
17623048-0#37#42#gene120892 37-42 gene120892 denotes PARK8
17623048-0#97#116#diseaseC0030567 97-116 diseaseC0030567 denotes Parkinson's disease
17623048-9#79#82#gene92170 1315-1318 gene92170 denotes GTP
17623048-9#22#24#diseaseC0030567 1258-1260 diseaseC0030567 denotes PD
17623048-9#180#182#diseaseC0030567 1416-1418 diseaseC0030567 denotes PD
0#28#gene12089297#116#diseaseC0030567 17623048-0#0#28#gene120892 17623048-0#97#116#diseaseC0030567 associated_with Leucine-rich repeat kinase 2,Parkinson's disease
30#35#gene12089297#116#diseaseC0030567 17623048-0#30#35#gene120892 17623048-0#97#116#diseaseC0030567 associated_with LRRK2,Parkinson's disease
37#42#gene12089297#116#diseaseC0030567 17623048-0#37#42#gene120892 17623048-0#97#116#diseaseC0030567 associated_with PARK8,Parkinson's disease
79#82#gene9217022#24#diseaseC0030567 17623048-9#79#82#gene92170 17623048-9#22#24#diseaseC0030567 associated_with GTP,PD
79#82#gene92170180#182#diseaseC0030567 17623048-9#79#82#gene92170 17623048-9#180#182#diseaseC0030567 associated_with GTP,PD