PubMed:17491223 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"T2","span":{"begin":119,"end":130},"obj":"Sentence"},{"id":"T3","span":{"begin":131,"end":230},"obj":"Sentence"},{"id":"T4","span":{"begin":231,"end":242},"obj":"Sentence"},{"id":"T5","span":{"begin":243,"end":615},"obj":"Sentence"},{"id":"T6","span":{"begin":616,"end":624},"obj":"Sentence"},{"id":"T7","span":{"begin":625,"end":713},"obj":"Sentence"},{"id":"T8","span":{"begin":714,"end":816},"obj":"Sentence"},{"id":"T9","span":{"begin":817,"end":908},"obj":"Sentence"},{"id":"T10","span":{"begin":909,"end":1147},"obj":"Sentence"},{"id":"T11","span":{"begin":1148,"end":1156},"obj":"Sentence"},{"id":"T12","span":{"begin":1157,"end":1353},"obj":"Sentence"},{"id":"T13","span":{"begin":1354,"end":1366},"obj":"Sentence"},{"id":"T14","span":{"begin":1367,"end":1625},"obj":"Sentence"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-entities","denotations":[{"id":"4104","span":{"begin":79,"end":89},"obj":"ChemicalEntity"},{"id":"4105","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4106","span":{"begin":191,"end":201},"obj":"ChemicalEntity"},{"id":"4107","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4108","span":{"begin":429,"end":439},"obj":"ChemicalEntity"},{"id":"4109","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4110","span":{"begin":606,"end":614},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4111","span":{"begin":654,"end":662},"obj":"OrganismTaxon"},{"id":"4112","span":{"begin":690,"end":700},"obj":"ChemicalEntity"},{"id":"4113","span":{"begin":799,"end":809},"obj":"ChemicalEntity"},{"id":"4114","span":{"begin":833,"end":841},"obj":"OrganismTaxon"},{"id":"4115","span":{"begin":876,"end":884},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4116","span":{"begin":953,"end":963},"obj":"ChemicalEntity"},{"id":"4117","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"},{"id":"4118","span":{"begin":1597,"end":1605},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"4104","obj":"MESH:D004280"},{"id":"A2","pred":"db_id","subj":"4105","obj":"MESH:D017202"},{"id":"A3","pred":"db_id","subj":"4106","obj":"MESH:D004280"},{"id":"A4","pred":"db_id","subj":"4107","obj":"MESH:D017202"},{"id":"A5","pred":"db_id","subj":"4108","obj":"MESH:D004280"},{"id":"A6","pred":"db_id","subj":"4109","obj":"MESH:D017202"},{"id":"A7","pred":"db_id","subj":"4110","obj":"MESH:D007511"},{"id":"A8","pred":"db_id","subj":"4111","obj":"NCBITaxon:9606"},{"id":"A9","pred":"db_id","subj":"4112","obj":"MESH:D004280"},{"id":"A10","pred":"db_id","subj":"4113","obj":"MESH:D004280"},{"id":"A11","pred":"db_id","subj":"4114","obj":"NCBITaxon:9606"},{"id":"A12","pred":"db_id","subj":"4115","obj":"MESH:D007511"},{"id":"A13","pred":"db_id","subj":"4116","obj":"MESH:D004280"},{"id":"A14","pred":"db_id","subj":"4117","obj":"MESH:D017202"},{"id":"A15","pred":"db_id","subj":"4118","obj":"NCBITaxon:9606"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0024644"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0024644"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0024644"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0024644"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":541,"end":545},"obj":"GeneOrGeneProduct"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":90,"end":97},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":151,"end":156},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":202,"end":209},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":274,"end":279},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":339,"end":344},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":440,"end":447},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":541,"end":545},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":616,"end":623},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":708,"end":712},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":817,"end":822},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":852,"end":859},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1114,"end":1119},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1221,"end":1231},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1232,"end":1237},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1277,"end":1287},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1288,"end":1293},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":1467,"end":1471},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":1487,"end":1491},"obj":"GeneOrGeneProduct"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":606,"end":614},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":876,"end":884},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1023,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D017202"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D017202"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D017202"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D007511"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D007511"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D017202"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":541,"end":545},"obj":"GeneOrGeneProduct"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":166,"end":177},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":606,"end":614},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":876,"end":884},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1161,"end":1172},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1448,"end":1459},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0000605"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0024644"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0000605"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0000605"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0024644"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005053"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005053"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0024644"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0024644"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":606,"end":614},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":876,"end":884},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1023,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D017202"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D017202"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D017202"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D007511"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D007511"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D017202"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":98,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":210,"end":229},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":448,"end":467},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":606,"end":614},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":876,"end":884},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1023,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1562,"end":1581},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"D017202"},{"id":"A2","pred":"#label","subj":"T2","obj":"D017202"},{"id":"A3","pred":"#label","subj":"T3","obj":"D017202"},{"id":"A4","pred":"#label","subj":"T4","obj":"D007511"},{"id":"A5","pred":"#label","subj":"T5","obj":"D007511"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"#label","subj":"T7","obj":"D017202"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":654,"end":662},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":833,"end":841},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1597,"end":1605},"obj":"OrganismTaxon"}],"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.\nBACKGROUND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia.\nOBJECTIVES: To assess the added diagnostic value of a new cardiac performance index (dP/dtejc) measurement, based on brachial artery flow changes, as compared to standard 12-lead ECG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard of comparison to assess the presence or absence of ischemia.\nMETHODS: The study group comprised 40 patients undergoing Sestamibi-SPECT/dobutamine stress test. Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}

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Simultaneous measurements of ECG and brachial artery dP/dtejc were performed at each dobutamine level. In 19 of the 40 patients perfusion defects compatible with ischemia were detected on SPECT. The increase in dP/dtejc during infusion of dobutamine in this group was severely impaired as compared to the non-ischemic group. dP/dtejc outcome was combined with the ECG results, giving an ECG-enhanced value, and compared to ECG alone.\nRESULTS: The sensitivity improved dramatically from 16% to 79%, positive predictive value increased from 60% to 68% and negative predictive value from 54% to 78%, and specificity decreased from 90% to 67%.\nCONCLUSIONS: If ECG alone is used for specificity, the combination with dP/dtejc improved the sensitivity of the test and could be a cost-savings alternative to cardiac imaging or perfusion studies to detect myocardial ischemia, especially in patients unable to exercise."}