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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 42-57 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T2 338-353 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T3 484-510 DiseaseOrPhenotypicFeature denotes inflammatory bowel disease 0005265
T4 785-800 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T5 811-829 DiseaseOrPhenotypicFeature denotes ulcerative colitis 0005101|0009960
T7 1099-1117 DiseaseOrPhenotypicFeature denotes ulcerative colitis 0005101|0009960
T9 1162-1177 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T10 1314-1329 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T11 1344-1362 DiseaseOrPhenotypicFeature denotes ulcerative colitis 0005101|0009960
T13 1583-1601 DiseaseOrPhenotypicFeature denotes ulcerative colitis 0005101|0009960
T15 1803-1818 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T16 1832-1847 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
T2 72-83 Sentence denotes OBJECTIVES:
T3 84-283 Sentence denotes In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins.
T4 284-354 Sentence denotes Recent studies indicate that both may be deficient in Crohn's disease.
T5 355-549 Sentence denotes To elucidate the possible functional consequences of this deficiency antimicrobial activity in colonic mucosa from patients with inflammatory bowel disease and healthy controls was investigated.
T6 550-558 Sentence denotes METHODS:
T7 559-1062 Sentence denotes A flow cytometric assay was established to quantitate bacterial killing and test the antibacterial activity of cationic peptide extracts from colonic biopsies taken from patients with active or inactive ileocolonic or colonic Crohn's disease (n = 22), ulcerative colitis (n = 29) and controls (n = 13) against clinical isolates of Bacteroides vulgatus and Enterococcus faecalis or the reference strains Escherichia coli American Type Culture Collection (ATCC) 25922 and Staphylococcus aureus ATCC 25923.
T8 1063-1071 Sentence denotes RESULTS:
T9 1072-1229 Sentence denotes Compared with controls and ulcerative colitis there was a reduced antimicrobial effect in Crohn's disease extracts that was most evident against B. vulgatus.
T10 1230-1363 Sentence denotes The antimicrobial effect against E. coli and E. faecalis was significantly lower in Crohn's disease compared with ulcerative colitis.
T11 1364-1444 Sentence denotes Activity against S. aureus disclosed a similar pattern, but was less pronounced.
T12 1445-1537 Sentence denotes The differences were independent of the inflammation status or concurrent steroid treatment.
T13 1538-1819 Sentence denotes Bacteria incubated with biopsy extracts from ulcerative colitis patients frequently showed a characteristic change in cell size and granularity, compatible with more extensive membrane disintegration, compared with bacteria incubated with extracts from controls or Crohn's disease.
T14 1820-1831 Sentence denotes CONCLUSION:
T15 1832-2002 Sentence denotes Crohn's disease of the colon is characterized by a diminished functional antimicrobial activity that is consistent with the reported low antibacterial peptide expression.
T1 0-71 Sentence denotes Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
T2 72-83 Sentence denotes OBJECTIVES:
T3 84-283 Sentence denotes In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins.
T4 284-354 Sentence denotes Recent studies indicate that both may be deficient in Crohn's disease.
T5 355-549 Sentence denotes To elucidate the possible functional consequences of this deficiency antimicrobial activity in colonic mucosa from patients with inflammatory bowel disease and healthy controls was investigated.
T6 550-558 Sentence denotes METHODS:
T7 559-1062 Sentence denotes A flow cytometric assay was established to quantitate bacterial killing and test the antibacterial activity of cationic peptide extracts from colonic biopsies taken from patients with active or inactive ileocolonic or colonic Crohn's disease (n = 22), ulcerative colitis (n = 29) and controls (n = 13) against clinical isolates of Bacteroides vulgatus and Enterococcus faecalis or the reference strains Escherichia coli American Type Culture Collection (ATCC) 25922 and Staphylococcus aureus ATCC 25923.
T8 1063-1071 Sentence denotes RESULTS:
T9 1072-1229 Sentence denotes Compared with controls and ulcerative colitis there was a reduced antimicrobial effect in Crohn's disease extracts that was most evident against B. vulgatus.
T10 1230-1363 Sentence denotes The antimicrobial effect against E. coli and E. faecalis was significantly lower in Crohn's disease compared with ulcerative colitis.
T11 1364-1444 Sentence denotes Activity against S. aureus disclosed a similar pattern, but was less pronounced.
T12 1445-1537 Sentence denotes The differences were independent of the inflammation status or concurrent steroid treatment.
T13 1538-1819 Sentence denotes Bacteria incubated with biopsy extracts from ulcerative colitis patients frequently showed a characteristic change in cell size and granularity, compatible with more extensive membrane disintegration, compared with bacteria incubated with extracts from controls or Crohn's disease.
T14 1820-1831 Sentence denotes CONCLUSION:
T15 1832-2002 Sentence denotes Crohn's disease of the colon is characterized by a diminished functional antimicrobial activity that is consistent with the reported low antibacterial peptide expression.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 338-353 HP_0100280 denotes Crohn's disease

disease_gene_microbe_small

Id Subject Object Predicate Lexical cue
T0 42-57 DOID:8778 denotes Crohn's disease
T1 339-354 DOID:8778 denotes rohn's disease.
T2 485-511 DOID:0050589 denotes nflammatory bowel disease
T3 786-801 DOID:8778 denotes rohn's disease
T4 812-830 DOID:8577 denotes lcerative colitis
T5 1100-1118 DOID:8577 denotes lcerative colitis
T6 1163-1178 DOID:8778 denotes rohn's disease
T7 1315-1330 DOID:8778 denotes rohn's disease
T8 1345-1363 DOID:8577 denotes lcerative colitis.
T9 1584-1602 DOID:8577 denotes lcerative colitis
T10 1804-1819 DOID:8778 denotes rohn's disease.
T11 1833-1848 DOID:8778 denotes rohn's disease
T12 65-70 taxonomy:1542223 denotes colon
T13 891-911 taxonomy:821 denotes acteroides vulgatus
T14 916-937 taxonomy:1351 denotes nterococcus faecalis
T15 963-979 taxonomy:562 denotes scherichia coli
T16 1030-1051 taxonomy:1280 denotes taphylococcus aureus
T17 1218-1229 taxonomy:821 denotes . vulgatus.
T18 1264-1271 taxonomy:562 denotes . coli
T19 1276-1287 taxonomy:1351 denotes . faecalis
T20 1382-1391 taxonomy:1280 denotes . aureus
T21 1539-1547 taxonomy:2 denotes acteria
T22 1754-1762 taxonomy:2 denotes acteria
T23 1856-1861 taxonomy:1542223 denotes olon