PubMed:17277312 / 0-1141 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/17277312","sourcedb":"PubMed","sourceid":"17277312","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/17277312","text":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.\nInterleukin-17 (IL-17)-producing helper T (TH) cells, named as TH(IL-17), TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage. However, how cytokine signals mediate THi differentiation is unclear. We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development. A hyperactive form of STAT3 promoted THi development, whereas this differentiation process was greatly impaired in STAT3-deficient T cells. Moreover, STAT3 regulated the expression of retinoic acid receptor-related orphan receptor gamma-T (RORgamma t), a THi-specific transcriptional regulator; STAT3 deficiency impaired RORgamma t expression and led to elevated expression of T-box expressed in T cells (T-bet) and Forkhead box P3 (Foxp3). Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T2","span":{"begin":77,"end":241},"obj":"Sentence"},{"id":"T3","span":{"begin":242,"end":311},"obj":"Sentence"},{"id":"T4","span":{"begin":312,"end":428},"obj":"Sentence"},{"id":"T5","span":{"begin":429,"end":511},"obj":"Sentence"},{"id":"T6","span":{"begin":512,"end":651},"obj":"Sentence"},{"id":"T7","span":{"begin":652,"end":952},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T2","span":{"begin":77,"end":241},"obj":"Sentence"},{"id":"T3","span":{"begin":242,"end":311},"obj":"Sentence"},{"id":"T4","span":{"begin":312,"end":428},"obj":"Sentence"},{"id":"T5","span":{"begin":429,"end":511},"obj":"Sentence"},{"id":"T6","span":{"begin":512,"end":651},"obj":"Sentence"},{"id":"T7","span":{"begin":652,"end":952},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T2","span":{"begin":77,"end":241},"obj":"Sentence"},{"id":"T3","span":{"begin":242,"end":311},"obj":"Sentence"},{"id":"T4","span":{"begin":312,"end":428},"obj":"Sentence"},{"id":"T5","span":{"begin":429,"end":511},"obj":"Sentence"},{"id":"T6","span":{"begin":512,"end":651},"obj":"Sentence"},{"id":"T7","span":{"begin":652,"end":952},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":514,"end":525},"obj":"HP_0000752"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20062042","span":{"begin":807,"end":951},"obj":"p(MGI:Stat3) decreases r(MGI:Foxp3)"},{"id":"BEL:20071554","span":{"begin":0,"end":1141},"obj":"tscript(p(MGI:Stat3)) decreases r(MGI:Gata3)"},{"id":"BEL:20071576","span":{"begin":0,"end":1141},"obj":"tscript(p(MGI:Stat3)) increases r(MGI:Rorc)"},{"id":"BEL:20071582","span":{"begin":0,"end":1141},"obj":"tscript(p(MGI:Stat3)) decreases r(MGI:Tbx21)"}],"attributes":[{"subj":"BEL:20062042","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20071554","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20071576","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20071582","pred":"source","obj":"2015-BEL-Sample-2"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":807,"end":823},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0007818"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"Glycosmos15-CL","denotations":[{"id":"T1","span":{"begin":61,"end":75},"obj":"Cell"},{"id":"T2","span":{"begin":643,"end":650},"obj":"Cell"},{"id":"T3","span":{"begin":908,"end":915},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000912"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"subj":"T1","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T2","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T3","pred":"source","obj":"Glycosmos15-CL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Inflammaging","color":"#93ecd4","default":true},{"id":"sentences","color":"#ecba93"},{"id":"PubmedHPO","color":"#a093ec"},{"id":"2015-BEL-Sample-2","color":"#9fec93"},{"id":"mondo_disease","color":"#ec93b9"},{"id":"Glycosmos15-CL","color":"#93d3ec"}]}]}}