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PubMed:17251309 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 10-17 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 373-380 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 400-407 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 961-968 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 988-995 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T6 1211-1218 https://glytoucan.org/Structures/Glycans/G70323CJ denotes Mannose
T7 1387-1394 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T8 1726-1733 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 10-17 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 373-380 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 400-407 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T4 961-968 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T5 988-995 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T6 1211-1218 Glycan_Motif denotes Mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T7 1387-1394 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T8 1726-1733 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
TextSentencer_T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
TextSentencer_T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
TextSentencer_T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
TextSentencer_T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
TextSentencer_T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
TextSentencer_T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
TextSentencer_T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
TextSentencer_T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
TextSentencer_T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
TextSentencer_T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
TextSentencer_T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.
T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.
T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 10-17 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 373-380 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 400-407 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 961-968 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T5 988-995 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T6 1211-1218 https://glytoucan.org/Structures/Glycans/G70323CJ denotes Mannose
T7 1387-1394 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T8 1726-1733 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

DisGeNET

Id Subject Object Predicate Lexical cue
T0 155-167 gene:2629 denotes imiglucerase
T1 221-236 disease:C0017205 denotes Gaucher disease
R1 T0 T1 associated_with imiglucerase,Gaucher disease

uniprot-human

Id Subject Object Predicate Lexical cue
T1 155-167 http://www.uniprot.org/uniprot/Q6I9R6 denotes imiglucerase
T2 988-1010 http://www.uniprot.org/uniprot/Q9UQG6 denotes mannose-binding lectin
T3 988-1010 http://www.uniprot.org/uniprot/Q12907 denotes mannose-binding lectin
T4 988-1010 http://www.uniprot.org/uniprot/Q96TF8 denotes mannose-binding lectin
T5 1012-1015 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T6 1325-1328 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T7 1902-1905 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1468-1476 http://purl.bioontology.org/ontology/STY/T053 denotes behavior
T2 1982-1985 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non

GO-BP

Id Subject Object Predicate Lexical cue
T1 426-432 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T2 1029-1035 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 1248-1254 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T4 1468-1476 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior

GO-MF

Id Subject Object Predicate Lexical cue
T1 988-1003 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding
T2 988-1010 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding lectin
T3 996-1003 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 1228-1235 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1329-1336 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 1906-1913 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 996-1003 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 1228-1235 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 1329-1336 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 1906-1913 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 996-1003 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 1228-1235 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 1329-1336 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 1906-1913 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 996-1003 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16 1228-1235 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 1329-1336 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18 1906-1913 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19 1219-1235 http://purl.obolibrary.org/obo/GO_0005102 denotes receptor binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 296-300 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 1530-1534 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 381-385 http://purl.obolibrary.org/obo/GO_0019013 denotes core
T4 1041-1054 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 982-987 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
17251309-1#38#50#gene2629 155-167 gene2629 denotes imiglucerase
17251309-1#104#119#diseaseC0017205 221-236 diseaseC0017205 denotes Gaucher disease
38#50#gene2629104#119#diseaseC0017205 17251309-1#38#50#gene2629 17251309-1#104#119#diseaseC0017205 associated_with imiglucerase,Gaucher disease

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1295-1298 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T2 1354-1357 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T3 1295-1298 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T4 1354-1357 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T5 1295-1298 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T6 1354-1357 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T7 1295-1298 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T8 1354-1357 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T9 1295-1298 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T10 1354-1357 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T11 1295-1298 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T12 1354-1357 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T13 1295-1298 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T14 1354-1357 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T15 1295-1298 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T16 1354-1357 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T17 1295-1298 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T18 1354-1357 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T19 1295-1298 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T20 1354-1357 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T21 1295-1298 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T22 1354-1357 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T23 1295-1298 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T24 1354-1357 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T25 1295-1298 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T26 1354-1357 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T27 1295-1298 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T28 1354-1357 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T29 1295-1298 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T30 1354-1357 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T31 1295-1298 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T32 1354-1357 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T33 1295-1298 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T34 1354-1357 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T35 1295-1298 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T36 1354-1357 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T37 1295-1298 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T38 1354-1357 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T39 1295-1298 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T40 1354-1357 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T41 1295-1298 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T42 1354-1357 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T43 1295-1298 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T44 1354-1357 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T45 1295-1298 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T46 1354-1357 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T47 1295-1298 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T48 1354-1357 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T49 1295-1298 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T50 1354-1357 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T51 1295-1298 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T52 1354-1357 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T53 1295-1298 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T54 1354-1357 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T55 1295-1298 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T56 1354-1357 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T57 1295-1298 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T58 1354-1357 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T59 1295-1298 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T60 1354-1357 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T61 1295-1298 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T62 1354-1357 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T63 1295-1298 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T64 1354-1357 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T65 1295-1298 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T66 1354-1357 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T67 1295-1298 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T68 1354-1357 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T69 1295-1298 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T70 1354-1357 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T71 1295-1298 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T72 1354-1357 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T73 1295-1298 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T74 1354-1357 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T75 1295-1298 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T76 1354-1357 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T77 1295-1298 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T78 1354-1357 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T79 1295-1298 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T80 1354-1357 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T81 1295-1298 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T82 1354-1357 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T83 1295-1298 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T84 1354-1357 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T85 1295-1298 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T86 1354-1357 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T87 1295-1298 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T88 1354-1357 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T89 1295-1298 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T90 1354-1357 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T91 1295-1298 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T92 1354-1357 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T93 1295-1298 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T94 1354-1357 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T95 1295-1298 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T96 1354-1357 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T97 1295-1298 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T98 1354-1357 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T99 1295-1298 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T100 1354-1357 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T101 1295-1298 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T102 1354-1357 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T103 1295-1298 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T104 1354-1357 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T105 1295-1298 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T106 1354-1357 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T107 1295-1298 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T108 1354-1357 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T109 1295-1298 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T110 1354-1357 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T111 1295-1298 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T112 1354-1357 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T113 1295-1298 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T114 1354-1357 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T115 1295-1298 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T116 1354-1357 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T117 1295-1298 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T118 1354-1357 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T119 1295-1298 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T120 1354-1357 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T121 1295-1298 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T122 1354-1357 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T123 1295-1298 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T124 1354-1357 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T125 1295-1298 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T126 1354-1357 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T127 1295-1298 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T128 1354-1357 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T129 1295-1298 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T130 1354-1357 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T131 1295-1298 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T132 1354-1357 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T133 1295-1298 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T134 1354-1357 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T135 1295-1298 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T136 1354-1357 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T137 1295-1298 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T138 1354-1357 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T139 1295-1298 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T140 1354-1357 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T141 1295-1298 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T142 1354-1357 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T143 1295-1298 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T144 1354-1357 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T145 1295-1298 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T146 1354-1357 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T147 1295-1298 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T148 1354-1357 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T149 1295-1298 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T150 1354-1357 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T151 1295-1298 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T152 1354-1357 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T153 1295-1298 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T154 1354-1357 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T155 1295-1298 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T156 1354-1357 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T157 1295-1298 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T158 1354-1357 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T159 1295-1298 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T160 1354-1357 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T161 1295-1298 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T162 1354-1357 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T163 1295-1298 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T164 1354-1357 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T165 1295-1298 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T166 1354-1357 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T167 1295-1298 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T168 1354-1357 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T169 1295-1298 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T170 1354-1357 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T171 1295-1298 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T172 1354-1357 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T173 1295-1298 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T174 1354-1357 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T175 1295-1298 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T176 1354-1357 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T177 1295-1298 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T178 1354-1357 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T179 1295-1298 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T180 1354-1357 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T181 1295-1298 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T182 1354-1357 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T183 1295-1298 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T184 1354-1357 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T185 1295-1298 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T186 1354-1357 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T187 1295-1298 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T188 1354-1357 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T189 1295-1298 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T190 1354-1357 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T191 1295-1298 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T192 1354-1357 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T193 1295-1298 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T194 1354-1357 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T195 1295-1298 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all
GlycanIUPAC_T196 1354-1357 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all
GlycanIUPAC_T197 1982-1985 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T198 1982-1985 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T199 1982-1985 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T200 1982-1985 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T201 1982-1985 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T202 1982-1985 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T203 1982-1985 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T204 1982-1985 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T205 1982-1985 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T206 1982-1985 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T207 1982-1985 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 982-987 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 100-115 Disease denotes Gaucher disease http://purl.obolibrary.org/obo/MONDO_0018150
T2 221-236 Disease denotes Gaucher disease http://purl.obolibrary.org/obo/MONDO_0018150

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 129-134 OrganismTaxon denotes human 9606
T2 274-289 OrganismTaxon denotes Chinese hamster 10029
T3 1185-1190 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 290-295 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 438-449 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T3 615-626 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T4 1018-1028 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 1041-1054 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 1237-1247 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 438-449 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 615-626 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 1018-1028 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T7 1237-1247 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394