PubMed:17251309
Annnotations
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 10-17 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T2 | 373-380 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T3 | 400-407 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T4 | 961-968 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T5 | 988-995 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T6 | 1211-1218 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | Mannose |
T7 | 1387-1394 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T8 | 1726-1733 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 10-17 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T2 | 373-380 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T3 | 400-407 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T4 | 961-968 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T5 | 988-995 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T6 | 1211-1218 | Glycan_Motif | denotes | Mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T7 | 1387-1394 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
T8 | 1726-1733 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-116 | Sentence | denotes | Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease. |
TextSentencer_T2 | 117-237 | Sentence | denotes | Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease. |
TextSentencer_T3 | 238-450 | Sentence | denotes | Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages. |
TextSentencer_T4 | 451-627 | Sentence | denotes | Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages. |
TextSentencer_T5 | 628-737 | Sentence | denotes | A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling. |
TextSentencer_T6 | 738-861 | Sentence | denotes | Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9. |
TextSentencer_T7 | 862-1065 | Sentence | denotes | GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life. |
TextSentencer_T8 | 1066-1210 | Sentence | denotes | In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null). |
TextSentencer_T9 | 1211-1314 | Sentence | denotes | Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase. |
TextSentencer_T10 | 1315-1477 | Sentence | denotes | Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior. |
TextSentencer_T11 | 1478-1743 | Sentence | denotes | These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues. |
TextSentencer_T12 | 1744-2004 | Sentence | denotes | The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans. |
T1 | 0-116 | Sentence | denotes | Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease. |
T2 | 117-237 | Sentence | denotes | Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease. |
T3 | 238-450 | Sentence | denotes | Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages. |
T4 | 451-627 | Sentence | denotes | Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages. |
T5 | 628-737 | Sentence | denotes | A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling. |
T6 | 738-861 | Sentence | denotes | Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9. |
T7 | 862-1065 | Sentence | denotes | GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life. |
T8 | 1066-1210 | Sentence | denotes | In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null). |
T9 | 1211-1314 | Sentence | denotes | Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase. |
T10 | 1315-1477 | Sentence | denotes | Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior. |
T11 | 1478-1743 | Sentence | denotes | These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues. |
T12 | 1744-2004 | Sentence | denotes | The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans. |
T1 | 0-116 | Sentence | denotes | Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease. |
T2 | 117-237 | Sentence | denotes | Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease. |
T3 | 238-450 | Sentence | denotes | Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages. |
T4 | 451-627 | Sentence | denotes | Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages. |
T5 | 628-737 | Sentence | denotes | A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling. |
T6 | 738-861 | Sentence | denotes | Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9. |
T7 | 862-1065 | Sentence | denotes | GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life. |
T8 | 1066-1210 | Sentence | denotes | In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null). |
T9 | 1211-1314 | Sentence | denotes | Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase. |
T10 | 1315-1477 | Sentence | denotes | Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior. |
T11 | 1478-1743 | Sentence | denotes | These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues. |
T12 | 1744-2004 | Sentence | denotes | The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 10-17 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T2 | 373-380 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T3 | 400-407 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T4 | 961-968 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T5 | 988-995 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T6 | 1211-1218 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | Mannose |
T7 | 1387-1394 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
T8 | 1726-1733 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 155-167 | gene:2629 | denotes | imiglucerase |
T1 | 221-236 | disease:C0017205 | denotes | Gaucher disease |
R1 | T0 | T1 | associated_with | imiglucerase,Gaucher disease |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 155-167 | http://www.uniprot.org/uniprot/Q6I9R6 | denotes | imiglucerase |
T2 | 988-1010 | http://www.uniprot.org/uniprot/Q9UQG6 | denotes | mannose-binding lectin |
T3 | 988-1010 | http://www.uniprot.org/uniprot/Q12907 | denotes | mannose-binding lectin |
T4 | 988-1010 | http://www.uniprot.org/uniprot/Q96TF8 | denotes | mannose-binding lectin |
T5 | 1012-1015 | http://www.uniprot.org/uniprot/Q96TF8 | denotes | MBL |
T6 | 1325-1328 | http://www.uniprot.org/uniprot/Q96TF8 | denotes | MBL |
T7 | 1902-1905 | http://www.uniprot.org/uniprot/Q96TF8 | denotes | MBL |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1468-1476 | http://purl.bioontology.org/ontology/STY/T053 | denotes | behavior |
T2 | 1982-1985 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 426-432 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
T2 | 1029-1035 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
T3 | 1248-1254 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
T4 | 1468-1476 | http://purl.obolibrary.org/obo/GO_0007610 | denotes | behavior |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 988-1003 | http://purl.obolibrary.org/obo/GO_0005537 | denotes | mannose-binding |
T2 | 988-1010 | http://purl.obolibrary.org/obo/GO_0005537 | denotes | mannose-binding lectin |
T3 | 996-1003 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T4 | 1228-1235 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T5 | 1329-1336 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T6 | 1906-1913 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T7 | 996-1003 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T8 | 1228-1235 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T9 | 1329-1336 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T10 | 1906-1913 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T11 | 996-1003 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T12 | 1228-1235 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T13 | 1329-1336 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T14 | 1906-1913 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T15 | 996-1003 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T16 | 1228-1235 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T17 | 1329-1336 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T18 | 1906-1913 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T19 | 1219-1235 | http://purl.obolibrary.org/obo/GO_0005102 | denotes | receptor binding |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 296-300 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2 | 1530-1534 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3 | 381-385 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
T4 | 1041-1054 | http://purl.obolibrary.org/obo/GO_0005622 | denotes | intracellular |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 982-987 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
17251309-1#38#50#gene2629 | 155-167 | gene2629 | denotes | imiglucerase |
17251309-1#104#119#diseaseC0017205 | 221-236 | diseaseC0017205 | denotes | Gaucher disease |
38#50#gene2629104#119#diseaseC0017205 | 17251309-1#38#50#gene2629 | 17251309-1#104#119#diseaseC0017205 | associated_with | imiglucerase,Gaucher disease |
GlyTouCan-IUPAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
GlycanIUPAC_T1 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G41652MJ" | denotes | all |
GlycanIUPAC_T2 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G41652MJ" | denotes | all |
GlycanIUPAC_T3 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G20761YC" | denotes | all |
GlycanIUPAC_T4 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G20761YC" | denotes | all |
GlycanIUPAC_T5 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G19807HM" | denotes | all |
GlycanIUPAC_T6 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G19807HM" | denotes | all |
GlycanIUPAC_T7 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G20351TE" | denotes | all |
GlycanIUPAC_T8 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G20351TE" | denotes | all |
GlycanIUPAC_T9 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G71957MR" | denotes | all |
GlycanIUPAC_T10 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G71957MR" | denotes | all |
GlycanIUPAC_T11 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G59040AE" | denotes | all |
GlycanIUPAC_T12 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G59040AE" | denotes | all |
GlycanIUPAC_T13 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G14987PW" | denotes | all |
GlycanIUPAC_T14 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G14987PW" | denotes | all |
GlycanIUPAC_T15 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G95064PC" | denotes | all |
GlycanIUPAC_T16 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G95064PC" | denotes | all |
GlycanIUPAC_T17 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G39143AQ" | denotes | all |
GlycanIUPAC_T18 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G39143AQ" | denotes | all |
GlycanIUPAC_T19 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G65149OO" | denotes | all |
GlycanIUPAC_T20 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G65149OO" | denotes | all |
GlycanIUPAC_T21 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G02766SY" | denotes | all |
GlycanIUPAC_T22 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G02766SY" | denotes | all |
GlycanIUPAC_T23 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G26019KJ" | denotes | all |
GlycanIUPAC_T24 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G26019KJ" | denotes | all |
GlycanIUPAC_T25 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G36429CZ" | denotes | all |
GlycanIUPAC_T26 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G36429CZ" | denotes | all |
GlycanIUPAC_T27 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G89633TP" | denotes | all |
GlycanIUPAC_T28 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G89633TP" | denotes | all |
GlycanIUPAC_T29 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G28494FO" | denotes | all |
GlycanIUPAC_T30 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G28494FO" | denotes | all |
GlycanIUPAC_T31 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G06219CP" | denotes | all |
GlycanIUPAC_T32 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G06219CP" | denotes | all |
GlycanIUPAC_T33 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G44237SM" | denotes | all |
GlycanIUPAC_T34 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G44237SM" | denotes | all |
GlycanIUPAC_T35 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G57948RL" | denotes | all |
GlycanIUPAC_T36 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G57948RL" | denotes | all |
GlycanIUPAC_T37 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G64016DN" | denotes | all |
GlycanIUPAC_T38 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G64016DN" | denotes | all |
GlycanIUPAC_T39 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G14536PC" | denotes | all |
GlycanIUPAC_T40 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G14536PC" | denotes | all |
GlycanIUPAC_T41 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G14356FW" | denotes | all |
GlycanIUPAC_T42 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G14356FW" | denotes | all |
GlycanIUPAC_T43 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G34565UO" | denotes | all |
GlycanIUPAC_T44 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G34565UO" | denotes | all |
GlycanIUPAC_T45 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G67124MW" | denotes | all |
GlycanIUPAC_T46 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G67124MW" | denotes | all |
GlycanIUPAC_T47 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G71457ZU" | denotes | all |
GlycanIUPAC_T48 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G71457ZU" | denotes | all |
GlycanIUPAC_T49 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G55228VZ" | denotes | all |
GlycanIUPAC_T50 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G55228VZ" | denotes | all |
GlycanIUPAC_T51 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G31034MJ" | denotes | all |
GlycanIUPAC_T52 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G31034MJ" | denotes | all |
GlycanIUPAC_T53 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G25776IP" | denotes | all |
GlycanIUPAC_T54 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G25776IP" | denotes | all |
GlycanIUPAC_T55 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G64442BV" | denotes | all |
GlycanIUPAC_T56 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G64442BV" | denotes | all |
GlycanIUPAC_T57 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G57018LE" | denotes | all |
GlycanIUPAC_T58 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G57018LE" | denotes | all |
GlycanIUPAC_T59 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G61761GX" | denotes | all |
GlycanIUPAC_T60 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G61761GX" | denotes | all |
GlycanIUPAC_T61 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G76318UX" | denotes | all |
GlycanIUPAC_T62 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G76318UX" | denotes | all |
GlycanIUPAC_T63 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G61906ER" | denotes | all |
GlycanIUPAC_T64 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G61906ER" | denotes | all |
GlycanIUPAC_T65 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G68723GR" | denotes | all |
GlycanIUPAC_T66 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G68723GR" | denotes | all |
GlycanIUPAC_T67 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G19540LE" | denotes | all |
GlycanIUPAC_T68 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G19540LE" | denotes | all |
GlycanIUPAC_T69 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G74944PO" | denotes | all |
GlycanIUPAC_T70 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G74944PO" | denotes | all |
GlycanIUPAC_T71 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G89489ZJ" | denotes | all |
GlycanIUPAC_T72 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G89489ZJ" | denotes | all |
GlycanIUPAC_T73 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G04434YU" | denotes | all |
GlycanIUPAC_T74 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G04434YU" | denotes | all |
GlycanIUPAC_T75 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G21450PB" | denotes | all |
GlycanIUPAC_T76 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G21450PB" | denotes | all |
GlycanIUPAC_T77 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G93629QY" | denotes | all |
GlycanIUPAC_T78 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G93629QY" | denotes | all |
GlycanIUPAC_T79 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G02603TR" | denotes | all |
GlycanIUPAC_T80 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G02603TR" | denotes | all |
GlycanIUPAC_T81 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G40280JP" | denotes | all |
GlycanIUPAC_T82 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G40280JP" | denotes | all |
GlycanIUPAC_T83 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G95259IC" | denotes | all |
GlycanIUPAC_T84 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G95259IC" | denotes | all |
GlycanIUPAC_T85 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G26900FE" | denotes | all |
GlycanIUPAC_T86 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G26900FE" | denotes | all |
GlycanIUPAC_T87 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G21346KK" | denotes | all |
GlycanIUPAC_T88 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G21346KK" | denotes | all |
GlycanIUPAC_T89 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G62509FF" | denotes | all |
GlycanIUPAC_T90 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G62509FF" | denotes | all |
GlycanIUPAC_T91 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G83932AK" | denotes | all |
GlycanIUPAC_T92 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G83932AK" | denotes | all |
GlycanIUPAC_T93 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G96978IB" | denotes | all |
GlycanIUPAC_T94 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G96978IB" | denotes | all |
GlycanIUPAC_T95 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G34275DN" | denotes | all |
GlycanIUPAC_T96 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G34275DN" | denotes | all |
GlycanIUPAC_T97 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G07071JF" | denotes | all |
GlycanIUPAC_T98 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G07071JF" | denotes | all |
GlycanIUPAC_T99 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G80639QD" | denotes | all |
GlycanIUPAC_T100 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G80639QD" | denotes | all |
GlycanIUPAC_T101 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G99460PJ" | denotes | all |
GlycanIUPAC_T102 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G99460PJ" | denotes | all |
GlycanIUPAC_T103 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G22024BZ" | denotes | all |
GlycanIUPAC_T104 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G22024BZ" | denotes | all |
GlycanIUPAC_T105 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G74097ZY" | denotes | all |
GlycanIUPAC_T106 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G74097ZY" | denotes | all |
GlycanIUPAC_T107 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G84439YP" | denotes | all |
GlycanIUPAC_T108 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G84439YP" | denotes | all |
GlycanIUPAC_T109 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G52207WQ" | denotes | all |
GlycanIUPAC_T110 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G52207WQ" | denotes | all |
GlycanIUPAC_T111 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G90695MS" | denotes | all |
GlycanIUPAC_T112 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G90695MS" | denotes | all |
GlycanIUPAC_T113 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G50398QX" | denotes | all |
GlycanIUPAC_T114 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G50398QX" | denotes | all |
GlycanIUPAC_T115 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G12166ZT" | denotes | all |
GlycanIUPAC_T116 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G12166ZT" | denotes | all |
GlycanIUPAC_T117 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G48368BR" | denotes | all |
GlycanIUPAC_T118 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G48368BR" | denotes | all |
GlycanIUPAC_T119 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G57407RW" | denotes | all |
GlycanIUPAC_T120 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G57407RW" | denotes | all |
GlycanIUPAC_T121 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G00386TY" | denotes | all |
GlycanIUPAC_T122 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G00386TY" | denotes | all |
GlycanIUPAC_T123 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G18723JK" | denotes | all |
GlycanIUPAC_T124 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G18723JK" | denotes | all |
GlycanIUPAC_T125 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G93757OR" | denotes | all |
GlycanIUPAC_T126 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G93757OR" | denotes | all |
GlycanIUPAC_T127 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G29006SI" | denotes | all |
GlycanIUPAC_T128 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G29006SI" | denotes | all |
GlycanIUPAC_T129 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G03099OQ" | denotes | all |
GlycanIUPAC_T130 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G03099OQ" | denotes | all |
GlycanIUPAC_T131 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G53739OW" | denotes | all |
GlycanIUPAC_T132 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G53739OW" | denotes | all |
GlycanIUPAC_T133 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G70440ZO" | denotes | all |
GlycanIUPAC_T134 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G70440ZO" | denotes | all |
GlycanIUPAC_T135 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G29951RR" | denotes | all |
GlycanIUPAC_T136 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G29951RR" | denotes | all |
GlycanIUPAC_T137 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G58402TI" | denotes | all |
GlycanIUPAC_T138 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G58402TI" | denotes | all |
GlycanIUPAC_T139 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G39875TP" | denotes | all |
GlycanIUPAC_T140 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G39875TP" | denotes | all |
GlycanIUPAC_T141 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G83439QV" | denotes | all |
GlycanIUPAC_T142 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G83439QV" | denotes | all |
GlycanIUPAC_T143 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G41762RC" | denotes | all |
GlycanIUPAC_T144 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G41762RC" | denotes | all |
GlycanIUPAC_T145 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G91604UI" | denotes | all |
GlycanIUPAC_T146 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G91604UI" | denotes | all |
GlycanIUPAC_T147 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G88447WE" | denotes | all |
GlycanIUPAC_T148 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G88447WE" | denotes | all |
GlycanIUPAC_T149 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G93634BS" | denotes | all |
GlycanIUPAC_T150 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G93634BS" | denotes | all |
GlycanIUPAC_T151 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G02587BH" | denotes | all |
GlycanIUPAC_T152 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G02587BH" | denotes | all |
GlycanIUPAC_T153 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G43511MX" | denotes | all |
GlycanIUPAC_T154 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G43511MX" | denotes | all |
GlycanIUPAC_T155 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G64958DH" | denotes | all |
GlycanIUPAC_T156 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G64958DH" | denotes | all |
GlycanIUPAC_T157 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G30384TR" | denotes | all |
GlycanIUPAC_T158 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G30384TR" | denotes | all |
GlycanIUPAC_T159 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G15624EX" | denotes | all |
GlycanIUPAC_T160 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G15624EX" | denotes | all |
GlycanIUPAC_T161 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G22706ST" | denotes | all |
GlycanIUPAC_T162 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G22706ST" | denotes | all |
GlycanIUPAC_T163 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G57408PI" | denotes | all |
GlycanIUPAC_T164 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G57408PI" | denotes | all |
GlycanIUPAC_T165 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G86403XX" | denotes | all |
GlycanIUPAC_T166 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G86403XX" | denotes | all |
GlycanIUPAC_T167 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G78043YB" | denotes | all |
GlycanIUPAC_T168 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G78043YB" | denotes | all |
GlycanIUPAC_T169 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G18952JK" | denotes | all |
GlycanIUPAC_T170 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G18952JK" | denotes | all |
GlycanIUPAC_T171 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G49020ND" | denotes | all |
GlycanIUPAC_T172 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G49020ND" | denotes | all |
GlycanIUPAC_T173 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G63590YW" | denotes | all |
GlycanIUPAC_T174 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G63590YW" | denotes | all |
GlycanIUPAC_T175 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G22793KS" | denotes | all |
GlycanIUPAC_T176 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G22793KS" | denotes | all |
GlycanIUPAC_T177 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G64134SS" | denotes | all |
GlycanIUPAC_T178 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G64134SS" | denotes | all |
GlycanIUPAC_T179 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G17338HY" | denotes | all |
GlycanIUPAC_T180 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G17338HY" | denotes | all |
GlycanIUPAC_T181 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G99745XF" | denotes | all |
GlycanIUPAC_T182 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G99745XF" | denotes | all |
GlycanIUPAC_T183 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G27782HN" | denotes | all |
GlycanIUPAC_T184 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G27782HN" | denotes | all |
GlycanIUPAC_T185 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G57496DC" | denotes | all |
GlycanIUPAC_T186 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G57496DC" | denotes | all |
GlycanIUPAC_T187 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G93169WB" | denotes | all |
GlycanIUPAC_T188 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G93169WB" | denotes | all |
GlycanIUPAC_T189 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G05518TD" | denotes | all |
GlycanIUPAC_T190 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G05518TD" | denotes | all |
GlycanIUPAC_T191 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G62603DN" | denotes | all |
GlycanIUPAC_T192 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G62603DN" | denotes | all |
GlycanIUPAC_T193 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G59574FS" | denotes | all |
GlycanIUPAC_T194 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G59574FS" | denotes | all |
GlycanIUPAC_T195 | 1295-1298 | "http://rdf.glycoinfo.org/glycan/G47567WC" | denotes | all |
GlycanIUPAC_T196 | 1354-1357 | "http://rdf.glycoinfo.org/glycan/G47567WC" | denotes | all |
GlycanIUPAC_T197 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
GlycanIUPAC_T198 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
GlycanIUPAC_T199 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
GlycanIUPAC_T200 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
GlycanIUPAC_T201 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
GlycanIUPAC_T202 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
GlycanIUPAC_T203 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
GlycanIUPAC_T204 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
GlycanIUPAC_T205 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
GlycanIUPAC_T206 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
GlycanIUPAC_T207 | 1982-1985 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 982-987 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 100-115 | Disease | denotes | Gaucher disease | http://purl.obolibrary.org/obo/MONDO_0018150 |
T2 | 221-236 | Disease | denotes | Gaucher disease | http://purl.obolibrary.org/obo/MONDO_0018150 |
Lectin-Jamboree-Sentence
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-116 | Sentence | denotes | Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease. |
T2 | 117-237 | Sentence | denotes | Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease. |
T3 | 238-450 | Sentence | denotes | Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages. |
T4 | 451-627 | Sentence | denotes | Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages. |
T5 | 628-737 | Sentence | denotes | A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling. |
T6 | 738-861 | Sentence | denotes | Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9. |
T7 | 862-1065 | Sentence | denotes | GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life. |
T8 | 1066-1210 | Sentence | denotes | In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null). |
T9 | 1211-1314 | Sentence | denotes | Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase. |
T10 | 1315-1477 | Sentence | denotes | Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior. |
T11 | 1478-1743 | Sentence | denotes | These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues. |
T12 | 1744-2004 | Sentence | denotes | The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans. |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 129-134 | OrganismTaxon | denotes | human | 9606 |
T2 | 274-289 | OrganismTaxon | denotes | Chinese hamster | 10029 |
T3 | 1185-1190 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 290-295 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
T2 | 438-449 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T3 | 615-626 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
T4 | 1018-1028 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
T5 | 1041-1054 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
T6 | 1237-1247 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 438-449 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T3 | 615-626 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T5 | 1018-1028 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
T7 | 1237-1247 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |