PubMed:17151160
Annnotations
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T16 | 1700-1756 | Sentence | denotes | Olanzapine may have an advantage for motor side effects. |
T17 | 1757-1856 | Sentence | denotes | Both medications caused substantial rapid weight gain, but weight gain was greater with olanzapine. |
T1 | 0-104 | Sentence | denotes | Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: |
T2 | 105-122 | Sentence | denotes | 4-month outcomes. |
T3 | 123-133 | Sentence | denotes | OBJECTIVE: |
T4 | 134-280 | Sentence | denotes | The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders. |
T5 | 281-288 | Sentence | denotes | METHOD: |
T6 | 289-562 | Sentence | denotes | One hundred twelve subjects (70% male; mean age=23.3 years [SD = 5.1]) with first-episode schizophrenia (75%), schizophreniform disorder (17%), or schizoaffective disorder (8%) were randomly assigned to treatment with olanzapine (2.5-20 mg/day) or risperidone (1-6 mg/day). |
T7 | 563-571 | Sentence | denotes | RESULTS: |
T8 | 572-707 | Sentence | denotes | Response rates did not significantly differ between olanzapine (43.7%, 95% CI=28.8%-58.6%) and risperidone (54.3%, 95% CI=39.9%-68.7%). |
T9 | 708-919 | Sentence | denotes | Among those responding to treatment, more subjects in the olanzapine group (40.9%, 95% CI=16.8%-65.0%) than in the risperidone group (18.9%, 95% CI=0%-39.2%) had subsequent ratings not meeting response criteria. |
T10 | 920-1024 | Sentence | denotes | Negative symptom outcomes and measures of parkinsonism and akathisia did not differ between medications. |
T11 | 1025-1148 | Sentence | denotes | Extrapyramidal symptom severity scores were 1.4 (95% CI=1.2-1.6) with risperidone and 1.2 (95% CI=1.0-1.4) with olanzapine. |
T12 | 1149-1385 | Sentence | denotes | Significantly more weight gain occurred with olanzapine than with risperidone: the increase in weight at 4 months relative to baseline weight was 17.3% (95% CI=14.2%-20.5%) with olanzapine and 11.3% (95% CI=8.4%-14.3%) with risperidone. |
T13 | 1386-1581 | Sentence | denotes | Body mass index at baseline and at 4 months was 24.3 (95% CI=22.8-25.7) versus 28.2 (95% CI=26.7-29.7) with olanzapine and 23.9 (95% CI=22.5-25.3) versus 26.7 (95% CI=25.2-28.2) with risperidone. |
T14 | 1582-1594 | Sentence | denotes | CONCLUSIONS: |
T15 | 1595-1699 | Sentence | denotes | Clinical outcomes with risperidone were equal to those with olanzapine, and response may be more stable. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
3660 | 25-35 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3661 | 43-54 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3662 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3663 | 186-196 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3664 | 204-215 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3665 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3666 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | MESH:D012559 |
3667 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | MESH:D011618 |
3668 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | MESH:D011618 |
3669 | 507-517 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3670 | 537-548 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3671 | 624-634 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3672 | 667-678 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3673 | 766-776 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3674 | 823-834 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3675 | 962-974 | DiseaseOrPhenotypicFeature | denotes | parkinsonism | MESH:D010302 |
3676 | 979-988 | DiseaseOrPhenotypicFeature | denotes | akathisia | MESH:D017109 |
3677 | 1025-1047 | DiseaseOrPhenotypicFeature | denotes | Extrapyramidal symptom | MESH:D001480 |
3678 | 1095-1106 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3679 | 1137-1147 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3680 | 1168-1179 | DiseaseOrPhenotypicFeature | denotes | weight gain | MESH:D015430 |
3681 | 1194-1204 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3682 | 1215-1226 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3683 | 1327-1337 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3684 | 1373-1384 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3685 | 1494-1504 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3686 | 1569-1580 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3687 | 1618-1629 | ChemicalEntity | denotes | risperidone | MESH:D018967 |
3688 | 1655-1665 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
3689 | 1700-1710 | ChemicalEntity | denotes | Olanzapine | MESH:C076029 |
3690 | 1799-1810 | DiseaseOrPhenotypicFeature | denotes | weight gain | MESH:D015430 |
3691 | 1816-1827 | DiseaseOrPhenotypicFeature | denotes | weight gain | MESH:D015430 |
3692 | 1845-1855 | ChemicalEntity | denotes | olanzapine | MESH:C076029 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-106 | DiseaseOrPhenotypicFeature | denotes | schizophrenia: 4 | 0010943 |
T2 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T3 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T4 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T5 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | 0001265 |
T6 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | 0005487 |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1244-1255 | GeneOrGeneProduct | denotes | weight at 4 |
T2 | 1386-1401 | GeneOrGeneProduct | denotes | Body mass index |
T3 | 1737-1742 | GeneOrGeneProduct | denotes | motor |
T4 | 1743-1747 | GeneOrGeneProduct | denotes | side |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 281-287 | GeneOrGeneProduct | denotes | METHOD |
T2 | 322-326 | GeneOrGeneProduct | denotes | male |
T3 | 342-347 | GeneOrGeneProduct | denotes | years |
T4 | 426-435 | GeneOrGeneProduct | denotes | (17%), or |
T5 | 519-522 | GeneOrGeneProduct | denotes | 2.5 |
T6 | 526-528 | GeneOrGeneProduct | denotes | mg |
T7 | 554-556 | GeneOrGeneProduct | denotes | mg |
T8 | 889-900 | GeneOrGeneProduct | denotes | not meeting |
T9 | 1244-1255 | GeneOrGeneProduct | denotes | weight at 4 |
T10 | 1386-1401 | GeneOrGeneProduct | denotes | Body mass index |
T11 | 1414-1422 | GeneOrGeneProduct | denotes | and at 4 |
T12 | 1737-1742 | GeneOrGeneProduct | denotes | motor |
T13 | 1743-1747 | GeneOrGeneProduct | denotes | side |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T3 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | D011618 |
T5 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | D011618 |
T6 | 962-974 | DiseaseOrPhenotypicFeature | denotes | parkinsonism | D020734 |
T7 | 979-988 | DiseaseOrPhenotypicFeature | denotes | akathisia | D011595 |
T8 | 1168-1179 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T9 | 1799-1810 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T10 | 1816-1827 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1244-1255 | GeneOrGeneProduct | denotes | weight at 4 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-106 | DiseaseOrPhenotypicFeature | denotes | schizophrenia: 4 | 0010943 |
T2 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T3 | 349-351 | DiseaseOrPhenotypicFeature | denotes | SD | 0011449 |
T4 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | 0005090 |
T5 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | 0001265 |
T6 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | 0014092|0005487|0005090 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T3 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | D011618 |
T5 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | D011618 |
T6 | 962-974 | DiseaseOrPhenotypicFeature | denotes | parkinsonism | D020734 |
T7 | 979-988 | DiseaseOrPhenotypicFeature | denotes | akathisia | D011595 |
T8 | 1025-1047 | DiseaseOrPhenotypicFeature | denotes | Extrapyramidal symptom | DISEASE |
T9 | 1168-1179 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T10 | 1799-1810 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T11 | 1816-1827 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T2 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T3 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 |
T4 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | D011618 |
T5 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | D011618 |
T6 | 962-974 | DiseaseOrPhenotypicFeature | denotes | parkinsonism | D020734 |
T7 | 979-988 | DiseaseOrPhenotypicFeature | denotes | akathisia | D011595 |
T8 | 1025-1047 | DiseaseOrPhenotypicFeature | denotes | Extrapyramidal symptom | DISEASE |
T9 | 1168-1179 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T10 | 1799-1810 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
T11 | 1816-1827 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 25-35 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T3 | 43-54 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T5 | 186-196 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T7 | 204-215 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T9 | 507-517 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T11 | 537-548 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T13 | 624-634 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T15 | 667-678 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T17 | 766-776 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T19 | 823-834 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T21 | 1095-1106 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T23 | 1137-1147 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T25 | 1194-1204 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T27 | 1215-1226 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T29 | 1327-1337 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T31 | 1373-1384 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T33 | 1494-1504 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T35 | 1569-1580 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T37 | 1618-1629 | ChemicalEntity | denotes | risperidone | D018967|http://purl.obolibrary.org/obo/CHEBI_8871 |
T39 | 1655-1665 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
T41 | 1700-1710 | ChemicalEntity | denotes | Olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735 |
T42 | 1845-1855 | ChemicalEntity | denotes | olanzapine | D000077152|http://purl.obolibrary.org/obo/CHEBI_7735 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 219-227 | OrganismTaxon | denotes | patients |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T42 | 1845-1855 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T41 | 1700-1710 | ChemicalEntity | denotes | Olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735 | |
T39 | 1655-1665 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T37 | 1618-1629 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T35 | 1569-1580 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T33 | 1494-1504 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T31 | 1373-1384 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T29 | 1327-1337 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T27 | 1215-1226 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T25 | 1194-1204 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T23 | 1137-1147 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T21 | 1095-1106 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T19 | 823-834 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T17 | 766-776 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T15 | 667-678 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T13 | 624-634 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T11 | 537-548 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T9 | 507-517 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T7 | 204-215 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T5 | 186-196 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T3 | 43-54 | ChemicalEntity | denotes | risperidone | http://purl.obolibrary.org/obo/CHEBI_8871|D018967 | |
T1 | 25-35 | ChemicalEntity | denotes | olanzapine | http://purl.obolibrary.org/obo/CHEBI_7735|D000077152 | |
T78543 | 1244-1255 | GeneOrGeneProduct | denotes | weight at 4 | ||
T11486 | 1816-1827 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 | |
T10 | 1799-1810 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 | |
T17021 | 1168-1179 | DiseaseOrPhenotypicFeature | denotes | weight gain | D015430 | |
T8 | 1025-1047 | DiseaseOrPhenotypicFeature | denotes | Extrapyramidal symptom | DISEASE | |
T19469 | 979-988 | DiseaseOrPhenotypicFeature | denotes | akathisia | D011595 | |
T6 | 962-974 | DiseaseOrPhenotypicFeature | denotes | parkinsonism | D020734 | |
T6309 | 436-460 | DiseaseOrPhenotypicFeature | denotes | schizoaffective disorder | D011618 | |
T4 | 400-425 | DiseaseOrPhenotypicFeature | denotes | schizophreniform disorder | D011618 | |
T55150 | 379-392 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 | |
T2 | 247-260 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 | |
T53300 | 90-103 | DiseaseOrPhenotypicFeature | denotes | schizophrenia | D012559 | |
T71762 | 219-227 | OrganismTaxon | denotes | patients |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 247-260 | HP_0100753 | denotes | schizophrenia |